가감좌귀음(加減左歸飮)의 알레르기성 기관지천식(氣管支喘息) 반응(反應) 조절(調節) 효과(效果)

박은정,이해자,박종익,박영주,Park, Eun-Jung,Lee, Hai-Ja,Park, Jong-Ik,Park, Young-Joo 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.2

Objective : KagamJwagwiEum(KJE) has been used for the purpose of prevention and treatment of bronchial asthma and allergic asthma in Korea. To investigate the biological effect of KJE, the author examined cytotoxicity and inflammatory cytokines secretion with human leukemic mast cell line, HMC-1. Methods: HMC-1 was stimulated with phorbol 12-myristate 13-acetate(PMA) and calcium ionophore A23187. KJE by itself had no effect on viability of HMC-l. The effects of KJE on the secretion of tumor necrosis $factor-alpha(TNF-{\alpha})$, interleukin(IL)-6 and IL-8 from HMC-1 were evaluated with enzyme-linked immunosorbent assay. Results : KJE inhibited PMA plus A23187-induced $TNF-{\alpha}$ and IL-6 secretion. But KJE had no effect IL-8 secretion: KJE had immunoregulatory effects on cytokines, increased secretion of NO and $TNF-{\alpha}$ but did not effect IL-12 secretion when the cells were primed and trigged with $IFN-{\gamma}$ in the peritoneal macrophages of C57BL/6 mice. Conclusions : Taken together, these results suggest that KJE inhibit the production of inflammatory cytokines in HMC-1 cells and activate macrophages.

Embedded System Design을 위한 Real-Time System의 최적화된 Timing효과의 구현

박은정,정태경,Park, Eun-Jung,Jeong, Tai-Kyeong 한국정보통신학회 2006 한국정보통신학회논문지 Vol.10 No.3

본 고에서는 임베디드 시스템을 위한 새로운 이벤트 중심의 실시간 시스템의 디자인의 최적화에 대한 연구를 논하고자 한다. 이를 위해서는 대단위의 분산처리시스템을 만족하기 위한 종료시한 초과 처리기의 구현이 필수적이며, 이때 실시간 시스템에서의 타이밍을 조절하고 계측할 수 있는 종료시 한이 사용되어야 한다. 이러한 타이밍의 요소들은 보통 모델과 실제 시스템사이의 인터페이스에서 동작하는데, 여기서 실시간 시스템의 디자인을 위한 다양한 그래픽 언어들이 종료시한을 효과적으로 처리하도록 제고한다. 이 연구를 통하여 사용자수준에서의 임베디드 시스템을 위한 종료시한 초과 처리와 함께, RonRT라는 툴을 이용한 최적화된 종료시한 초과 처리기를 증명해 보이고자한다. This paper presents a new real-time system design methodology for embedded system as well as event-driven real time application. It is required to implement a deadline handling mechanism in order to satisfy a large-scale distributed real time application. When we design real time system, it has handled a deadline and is important to measure / control a timing issue. These timing constraints usually associated with an interface between model and system. There are many case tools that supporting a real time application, for example, UML, graphic language for designing real time system, but they cannot provide efficient way to handle deadline miss. Therefore, users have to design deadline handler manually when they need to use it. This paper contributes solving the problems of user-level deadline handling for an embedded system. Also, it also discusses an efficient deadline handler design mechanism using on RoseRT, which is a graphical CASE tool supporting from UML.

이슈&피플-대만 성품서점 탐방

박은정,Park, Eun-Jeong 대한출판문화협회 2007 출판저널 Vol.376 No.-

랫드 심근세포유래 $H_9C_2$ 세포주에서의 망간화합물의 산화적스트레스 유도작용

박은정,박광식,Park, Eun-Jung,Park, Kwang-Sik 대한약학회 2008 약학회지 Vol.52 No.3

Manganese is a naturally occurring element which is widespread in the environment. Also, manganese is an essential trace element and plays a key role in important biological reactions catalyzed by enzymes. However, exposure to high levels of manganese can cause toxicity in neurone and inhalation system, also damage in various tissues. We investigated the toxicity induced by manganese compound ($MnCl_2$) in cultured rat cardiomyocytes. Treatment of manganese to cultured cardiomyocyte led to cell death, reactive oxygen species (ROS) increase, and cytosolic caspase-3 activation. The ROS increase was related with the decreased level of glutathione. Expressions of ROS related genes such as heme oxygenase-1, thioredoxin reductase, and NADH quinone oxidase were significantly induced in manganese treated cells. These results suggest that manganese induce oxidative stress and apoptosis in cardiomyocytes, and may be the one of risk factors to cause heart dysfunction in vivo.

학습경험을 바탕으로 학생들이 제시하는 고등학교 화학교과 내의 어려운 개념과 문지방개념 분석연구

박은정,Park, Eun Jung 대한화학회 2014 대한화학회지 Vol.58 No.1

본 연구는 과학학습의 어려움이나 낮은 흥미도의 한 원인으로 과학 교과학습에서의 중요한 통로 혹은 입구에 해당하는 문지방개념의 존재를 가정하고 특히 화학의 어떠한 개념들이 여기에 해당하는지를 알아보았다. 또한, 각 개념의 속성이 무엇이며 개념을 이해하고 "아~하"의 깨달음을 얻는 경험은 어떠했는지도 함께 알아보았다. 이를 위해, 화학 II를 학습한 239명의 고등학생이 연구에 참여하였고 설문에 대한 응답으로 화학 교과의 어려운 개념이 무엇인지, 문지방에 해당하는 개념이 무엇인지, 혹은 문지방개념을 이해한 경험이 화학 학습에 어떠한 영향을 주었는지를 설명하였다. 몰과 원자구조가 화학 교과의 문지방개념으로 제시되었고 구체적으로는 제시된 두 개념이 문지방개념이 되는 속성이 무엇인지를 집중적으로 분석하였다. 문지방을 극복하고 이해하는 것은 각자의 경험에 따르지만, 문지방개념을 분석하는 기준은 각각의 경험에 일정한 준거를 제시하여 서로 다른 경험들을 객관화 시킬뿐 아니라 개념의 과학적 의미와 본성을 잘 드러내어 준다. 특히, 교사가 제시하는 화학의 문지방개념을 조사한 사전연구와의 비교는 문지방개념의 통합적 속성이 학생들의 학습과 과학흥미도 증진에 중요함을 보여준다. Concerning the difficulty of learning science and reduced interest in science, the authors of this study searched for potential threshold concepts which are portals or gateways in the field of science (particularly chemistry). The nature of these concepts and how to overcome their troublesomeness were further questioned. For this study, 239 high school students completed chemistry II provided information about what difficult concepts and potential threshold concepts in high school chemistry are and how they affect learning chemistry. In particular, the mastery experience of the threshold concepts was explored in detail. Two, "mole and atomic structure" were selected as threshold concepts in chemistry. Not only as important but also as threshold, this study emphasized the importance of the two concepts in terms of features characterizing them as threshold concepts. In particular, the features objectify subjective experiences of students and provide information describing the scientific meaning and distinctive nature of threshold concepts in science. Along with the data from teachers, this study shows the integrative feature as key criteria for students to make meaningful understanding of the two threshold concepts.

소아한증(小兒汗證)의 병인(病因).병리(病理).치법(治法).치방(治方)에 관한 문헌적(文獻的) 고찰(考察)

박은정,정규만,Park Eun-Jeong,Jeong Gyu-Man 대한한방소아과학회 1992 대한한방소아과학회지 Vol.6 No.1

어촌관광 활성화를 위한 아이디어 4선 - 어촌의 이슈마케팅 전략

박은정,Park, Eun-Jeong 한국어촌어항협회 2014 어항어장 Vol.107 No.-

유비쿼터스 멀티미디어 응용을 위한 그리드 시스템의 서비스 플랫폼

박은정,신현식,Park Eun-jeong,Shin Heon-shik 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.1B

무선 통신의 발전으로 인하여 PDA, 휴대전화 등의 이동기기를 위한 멀티미디어 서비스의 개발 또한 빠르게 발전하고 있다. 이러한 모바일 멀티미디어 서비스의 개발에는 모바일 컴퓨팅의 요구조건을 효율적으로 제어할 수 있는 플랫폼이 필요하다. 본 논문에서는 무선 통신의 잦은 통신단절과 모바일 디바이스의 시스템 자원부족에 대응하기 위하여 모바일 에이전트 기반의 그리드 시스템을 사용하는 적응형 서비스 플랫폼을 제시하고, 서비스 플랫폼의 활용예로 모바일 원격 교육 또는 화상 회의에 사용되는 RtoA (Ready-to-Attend) 프레임워크를 구성하였다. RtoA는 사용자들에게 원활한 유비쿼터스 서비스를 제공하기 위하여 그리드 시스템을 이용한 핸드오프, 스피커, 리스너 서비스를 제공한다. ns-2를 이용한 성능평가의 결과 RtoA는 모바일 디바이스의 에너지 소모량을 줄이고, 응답시간을 향상시키는데 효율적임이 증명되었다. Advances in wireless network are enabling the development of ubiquitous multimedia services. These multimedia services need efficient platforms to comply with the requirements of mobile computing. We introduce an adaptive service platform based on mobile agent and grid systems while specifying the challenges of ubiquitous multimedia services and focusing on frequent disconnections and scarce resources. We applied our platform to framework RtoA (Ready-to-Attend) which supports mobile users to access compute-intensive multimedia service, specifically, mobile education and video conferencing. RtoA includes hand-off, speaker and listener service which enable people to attend a conference or a class with satisfying quality of multimedia service. ns-2 based simulation verifies that our scheme is an efficient way to reduce energy consumption of mobile devices and to improve the response time of mobile applications.

생약으로부터 세포분화유도물질의 검색 및 분리 및 분리 (I)

박은정,김진웅,Park, Eun-Jung,Kim, Jin-Woong 한국생약학회 1997 생약학회지 Vol.28 No.4

300 extracts derived from 100 plants were tested for their potential to induce HL-60 cell differentiation using NBT assay and NSE/SE staining methods. Morphological changes from suspended to adherent state of the cells were also observed by microscopic examination. In result, 55 extracts induced cell differentiation into monocyte/macrophage lineage in the NBT and the NSE assay.

형개연교탕(荊芥連翹湯)과 가미형개연교탕(加味荊芥連翹湯)이 소염(消炎).진통(鎭通) 및 항(抗)알레르기에 미치는 영향(影響)

박은정,신소영,Park Eun-Jeong,Shin So-Young 대한한방소아과학회 1997 대한한방소아과학회지 Vol.11 No.1

Hyunggyeyungyotang has been used for treatment of sinusitis and otitis media in oriental medicine since ancient times. It is reported that Hyunggyeyungyotang has good effects on inflammatory and allergic diseases of otorhinolaryngology in clinical medicine. Kamihyunggyeyungyotang was made by adding several herbs to Hyunggyeyungyotang which has such good effects. To investigate the effects of Hyunggyeyungyotang and Kamihyunggyeyungyotang on inflammatory, algesic and allergic diseases, the author examined the analgesic effect by acetic acid reaction, studied the anti-inflammatory effect through the experiments of the protein thermo-denaturation and circumscribed edema. Besides researched the anti-allergic effect through the vascular permeability response to Chemical Mediator and the delayed type hypersensitivity response to Picryl Chloride. The obtained results were as follows ; 1. In the analgesic effect of Hyunggyeyungyotang and Kamihyunggyeyungyotang extract by acetic acid method, both of the sample groups showed the analgesia, but didn't show useful effect. 2. In the anti-inflammatory effect on the protein thermo-denaturation, the sample groups revealed the inhibitory effect in proportion to concentration as compared with the control group. 3. In the inhibitory action on circumscribed edema induced by Caraggeenin, both of Hyunggyeyungyotang and Kamihyunggyeyungyotang administration showed the significant effect after 4 hours in comparison to the control group. 4. In the delayed type hypersensitivity response to Picryl Chloride, both of the sample groups revealed the significant effects. 5. Both of the sample groups decreased the vascular permeability induced by Histamine in comparison with the control group, but the significancy was admitted in only Hyunggyeyungyotang administration. According to above results, Hyunggyeyungyotang and Kamihyunggyeyungyotang are considered to be used for treament of the inflammatory diseases including sinusitis.