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Cilostazol attenuates kainic acid-induced hippocampal cell death
박영섭,김진,정은애,이친옥,이종열,박인성,노구섭 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.1
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol’s effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity.
박영섭,현승재,김기정,장태안 대한척추신경외과학회 2016 Neurospine Vol.13 No.1
Intradural disc herniation is a very rare condition, and multiple intradural disc herniations have not been reported to date. The latter may be confused with intradural extramedullary (IDEM) spinal tumors. Here, we report a case of multiple intradural disc herniations masquerading as multiple IDEM tumors and review the relevant literature. We retrospectively reviewed the patient’s medical chart, reviewed the intraoperative microscopic findings, and reviewed of PubMed articles on intradural disc herniation. The masses considered to be IDEM tumors were confirmed to be multiple intradural disc herniations. A nonenhancing mass was found to have migrated along the intra-arachnoid space. Two enhancing masses could not migrate because of adhesion and showed peripheral neovascularization. We report an extremely rare case of multiple intradural lumbar disc herniations showing diverse enhancing patterns and masquerading as multiple IDEM tumors. In case of multiple enhancing IDEM masses suspected preoperatively, surgeons should consider the possibility of intradural disc herniation.
한자어 비교분석연구 : 개화기교과서와 현중고국어교과서를 중심으로
박영섭 강남대학교 국어국문학과 1992 江南語文 Vol.7 No.1
우리나라의 문자생활에서 한자 폐지론의 문제가 개화기부터 줄곧 논의되어 오고 있다. 그러나 그러한 논의 보다 선행되어야 할 문제가 한자어에 대한 근원적 연구이다. 이러한 연구없이 단지 감상적 애국론에서 한자 폐지론이 발상되었다는 것을 생각한다면, 한자어에 대한 연구는 국어 어휘뿐 아니라 어문정책에도 중요한 문제이다. 따라서 본고는 개화기국어교과서와 개정전 중고교 국어교과서에 사용된 한자어를 비교분석하여 그 사용빈도를 나타냄으로서 우리나라 어문정책의 일관성의 문제나 올바른 어문정책수립에 일조를 바라는 측면에 본연구의 목적이 있다.
박영섭 강남대학교 1999 論文集 Vol.33 No.-
본 고에서는 초간본 두시언해에서 나타나고 있느 한자 대역어 연구를 수록하였으며, 앞으로 본 논제명으로 기획한 논문을 발표할 예정이다.