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박성윤,최재봉,김상희 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
Non-invasive cell-substrate impedance sensing technique was used to monitor cancer cell attachment, spreading and proliferation as function of culture time. Impedance values were measured with cells cultured on collagen coated surface which exhibited moderate contact angle (54.5) and positively charge surface with the zeta potential (ζ) of +3.91 mV. Impedance was gradually increased and reached steady state after 2.6 hrs and 2.9 hrs with different impedance for SCC7 (2.7 Ω) and HeLa cells (1.1 Ω) respectively. Modified Gompertz mathematical growth model was used to determine growth kinetics, and showed maximum growth rate (μm) for SCC7 (7.9× 10-4 hr-1) and HeLa cells (2×10-5 hr-1) as well as both cells showed exponential increase of impedance following the lag period (λ) which required for cells to recover from the trypsinization and initiate attaching on electrode surface. The duration of lag period for SCC7 (0.7 hr) and HeLa cells (0.25 hrs ) demonstrated that HeLa cells exit lag period earlier than SCC7 cells and enter exponential growth which supports the rapid attachment and spread on substrate. Our result supported that the impedance measurement revealed cell-type specific growth characteristics and electrophysical properties that would be used to determine meaningful fingerprint for cancer cell study.
항암제 사용 환아에서 수두에 대한 Acyclovir 치료 효과
박성윤,이신종,오무영,이순용 인제대학교 1988 仁濟醫學 Vol.9 No.3
수두는 면역 기능이 저하된 소아에서는 전신성 감염과 사망까지 초래하는 질환으로 알려져 있다. 최근에 Aryclovir가 효과적인 약물로 사용되고 있다. 본원 소아과에서 면역 기능이 저하된 9명의 환아를 대상으로 Acyclovir를 사용하여 만족할만한 결과를 얻었기에 이를 문헌 고찰과 함께 보고하는 바이다. Primary varicella infection has usually a benign clinical course in the normal healthy population, but in the immunocompromised patients it may frequently progress to visceral dissemination and even to death. Since acyclovir is recently known to be an effective antiviral agent to chickenpox, we performed a clinical study to evaluate the effect of acyclovir therapy on the chickenpox in the immunocompromised patients. Nice immunocompromised patients wish chickenpox were treated wish intravenous administration of acyclovir 30-60 mg/kg daily for five to eight days. Eight patients entered to the study within 72 hours after onset of skin lesion. One of them had abnormal liver function at entry and another one had pneumonia as a complication during treatment. Only one patient of nine, to whom acyclovir treatment was delayed until five darts after onset of skin lesion, died of extensive dissemination of the disease. The duration of vesicle formation was shorter among acyclovir recepients on the first day of onset than on the third day of onset(p<0.05), but no difference was found on the duration of fever between two groups(p>0.2). No clinical or laboratory adverse reactions were found during acyclovir therapy. These data suggest that acyclovir is effective on the treatment of chickenpox in the immunocompromised patients when it is given early in the course of the infection.
Prostate Imaging-Reporting and Data System Version 2: Beyond Prostate Cancer Detection
박성윤,조남훈,정대철,오영택 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.2
The main purpose of Prostate Imaging-Reporting and Data System Version 2 (PI-RADSv2) is to effectively detect clinically significant prostate cancers (csPCa) using multiparametric magnetic resonance imaging. Since the first introduction of PI-RADSv2, researchers have validated its diagnostic performance in identifying csPCa, and these promising data have influenced biopsy and treatment schemes. However, in this article, we focused on the potential of PI-RADSv2 in relation to various aspects of PCa such as Gleason score, tumor volume, extraprostatic extension, lymph node metastasis, and postoperative biochemical recurrence, beyond prostate cancer detection.
박성윤,김완중,최재봉,김상희 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.1
The effects of different cross-linkers on mechanical and physical properties of alginate hydrogel films were determined to use prepared films as potential carrier structure for rapid detection system. Xylitol and d-mannitol cross-linked hydrogel films improved mechanical properties and generated more rigid, tough and stretchable film than uncross-linked film. Results exhibited increased tensile strength by 2.3 folds (58.3±5.8 MPa) and 1.8 folds (47.4±4.9MPa) when compared to uncross-linked film (25.8±7.3 MPa) respectively. Young’s modulus of d-mannitol cross-linked film was slightly greater (16.8±2.1 MPa) than that of xylitol (15.7±2.7 MPa) whereas the elongation at break (E%) value of xylitol cross-linking (5.46±1.2%) was greater than d-mannitol (2.72±0.8%) cross-linking. Altered mechanical properties were investigated in terms of different amount of % cumulative release of AchI and DTNB that were immobilized in film matrix. Results showed different release amount depending on types of cross-linkers as following: xylitolcrosslinked (71.5%) > d-mannitol (64.9%) > uncross-linked (58.3%) at 10 min of release period. The exponent value n which determined based on power-law expression was ranged between 0.56 and 0.98, and indicates the release was mediated by anomalous Non-Fickian diffusion.
촉지되지 않고 우연히 발견되는 갑상선 결절에서초음파 유도하 세침흡인검사의 의의
박성윤,위민우,조항선,이세영,양훈식 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.7
Background and Objectives:With the availability of more sensitive ultrasonography, a larger number of nonpalpable thyroid d nodule. The purpose of this study is to investigate the clinical significance of thyroid incidentaloma and the usefulnes of the USG-FNA in the management of thyroid incidentaloma. Subjects and Method:A retrospective study was performed on 208 pa-tients who underwent USG-FNA for thyroid incidentaloma smaller than 1.5 cm from 2001 to 2005. The cytologic findings were compared with the ultrasonographic findings and the surgical pathology. Results:Suspicious malignant sonographic findings cytologicaly diagnosed as benign lesion (76.4%), 7 cases as follicular neoplasm (3.3%), 33 cases as malignancy (15.8%), and 9 cases as inadequate specimen (4.4%). Of the 40 cases with folicular neoplasm and malignant cytology, 37 cases underwent sur-gery and 30 cases were confirmed to malignancy on the postoperative pathologic diagnosis. In the cases diagnosed to malig-nancy on pathology, extracapsular extension was present in 9 cases (30% ) (26.7%). The sensitivity, specificity, and accuracy of the USG-FNA for malignancy were 93.3%, 71.4%, and 89.1%, respectively. Conclusion:USG-FNA is a useful diagnostic tol in the management of thyroid incidentaloma especially when more than two suspicious malig-nant sonographic findings need to be detected. The clinical characteristics is not significantly diferent between palpable and nonpalpable nodules. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :622-6)
박성윤,김건우,이평연,김종훈,박성백,김영미 전력전자학회 2019 전력전자학회 논문지 Vol.24 No.5
The emergency power supplies (EPSs) are required to increase battery sizing for protecting power source loss above designed criteria. This study proposes a sizing method for lithium-based batteries for EPSs in nuclear power plants on the basis of the calculation method for the required energy under variable conditions. The variable conditions are related with the characteristics of lithium-based batteries, such as the temperature of the location of EPS installation, aging, and design margin. The usage of lithium-based battery reduces the cost and installation space and enables the safe and long-term supply of power compared with the use of lead-acid battery.
박성윤,김성민,이승열,강호철 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.
The purpose of this study was to investigate the performance of the recumbent bicycle. The recumbent bicycle is a type of bicycle usually used to train or exercise a patient or the elderly. A recumbent bicycle was specially constructed for this study by researchers. The speed and power can be recorded and displayed on the monitor of the recumbent bicycle. The experiments consisted of four steps with different start-knee angle (α=85°, 105°, 125°, 145°). The activation and force of lower limb muscles were measured and calculated using an electromyography (EMG) and a computer simulation respectively. The maximum of intraclass correlation coefficients (ICC) and their differences were calculated to compare between the data of different muscles. The data obtained from test and retest was shown to have a good reliability on all of the measured muscles. The ICC is 0.93 for biceps femoris (BF) of step 2 (α=105°). The maximum muscle activation and muscle force were also measured at step 2. The BF EMG of step 2 was shown to be significantly different (p<0.05) from other steps. Overall, the recumbent bicycle was shown to be similar in function with an upright bicycle. The frequency use of the recumbent bicycle is predicted to increase for a patient and the elderly due to stable seat structure which have bucket shape.