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Glycolate Oxidase 에 관한 흡광 및 형광의 분광학적 연구
최정도,박금수,양덕조 ( Jung Do Choi,Kum Soo Park,Duk Jo Yang ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.3
Absorption and fluorescence spectroscopic studies of glycolate oxidase were carried out to elucidate the properties of the active site of the enzyme. The electronic spectrum of FMN bound to the enzyme consists of two bands centered around 450 nm and 340 nm in the region of 300-500 nm. Comparing with the spectra of model systems, it is suggested that the bound FMN existes almost as non-hydrogen-bounded species, and the environment of the FMN is much less polar than water medium. The fluorescence of the bound FMN is only about 5% as great as that of free FMN indicating strong interactions between flavin moiety and aromatic amino acid residues of the protein. The fluorescence quenching data of free FMN and bound FMN suggest that the coenzyme FMN is not exposed on the surface and most likely located in a crevice whose dimensions are not large enough for large hydrated ions to enter it. The cysteine residue, a subunit of the enzyme is known to have one cysteine, is accesible to silver ion and probably located not at active site but near active site.
Absorption and Fluorescence spectroscopic Studies of Glycolate Oxidase
최정도,박금수,양덕조,Choi, Jung-Do,Park, Kum-Soo,Yang, Duk-Jo Korean Society for Biochemistry and Molecular Biol 1990 한국생화학회지 Vol.23 No.3
Glycolate oxidase의 활성부위의 성질을 규명하기 위하여 흡광 및 형광의 분광학적 연구를 수행하였다. 효소에 결합한 FMN의 전자전이 스펙트럼은 300-500nm 영역에서 450nm과 340nm에 정점을 가진 두 개의 띠를 갖고 있었다. 모델계의 흡수 스펙트라와 비교한 결과, 효소에 결합한 FMN은 거의 수소결합을 하지 않은 상태로 존재하며, 주위 환경은 물보다 훨씬 극성이 낮은 것으로 추측된다. 효소에 결합한 FMN의 형광은 비결합 FMN 형광의 5% 정도이며, 낮은 형광 수율은 FMN과 단백질내의 방향성 아미노산과 강력한 작용이 있음을 시사한다. 비결합 FMN과 결합 FMN의 형광의 ?봬た? 관한 연구결과로 부터 조효소 FMN은 표면에 노출되어 있지 않고 효소내의 좁은 틈 사이에 존재하며 수화상태의 큰 이온이 접근하기 어려운 것으로 추측된다. 효소 분자를 구성하는 각 단위내에 한 개의 cysteine이 존재하며, 이 cysteine에 은 이온의 접근이 가능하며, 이 아미노산은 효소의 활성부위에 위치하지 않고 그 근처에 있을 것으로 생각된다. Absorption and fluorescence spectroscopic studies of glycolate oxidase were carried out to elucidate the properties of the active site of the enzyme. The electronic spectrum of FMN bound to the enzyme consists of two bands centered around 450 nm and 340 nm in the region of 300-500 nm. Comparing with the spectra of model systems, it is suggested that the bound FMN existes almost as non-hydrogen-bounded species, and the environment of the FMN is much less polar than water medium. The fluorescence of the bound FMN is only about 5% as great as that of free FMN indicating strong interactions between flavin moiety and aromatic amino acid residues of the protein. The fluorescence quenching data of free FMN and bound FMN suggest that the coenzyme FMN is not exposed on the surface and most likely located in a crevice whose dimensions are not large enough for large hydrated ions to enter it. The cysteine residue, a subunit of the enzyme is known to have one cysteine, is accesible to silver ion and probably located not at active site but near active site.
이홍재(Hong Jai Lee),심영학(Young Hak Shim),김남동(Nam Dong Kim),임채선(Chae Seon Lim),이광훈(Kwang Hoon Lee),박금수(Kum Soo Park) 대한내과학회 1988 대한내과학회지 Vol.34 No.3
N/A In a study of about 1,000 bone marrow examinations performed in our haspital from 1981 to 1985, we selected 23 instances having 10 or more phagocytic histocytes in one bone marrow slide. The diagnosis, clinical features, laboratory findings and outcome of the patients with the phagocytic histiocytes were examined, and the results are as follows; 1) The disease were mainly infectious in orign, including typhoid fever, septicemia, leptospirosis, tuberculous pericarditis and EH fever, and the others were liver cirrhosis, Wilson's disease with hemolytic anemia, malignant lymphoma, myelodysplastic syndrome and agranulocytosis. 2) The clinica1 features were fever (86.8%), hepatomegaly (43.4%), splenomegaly (43.4%), lymphadenopathy (4.3%) and hemorrhagic tendency (4.3%). 3) The peripheral blood showed anemia in 82.6%, leukopenia in 39.1% and thrombocytopenia in 90.4% and reticulocytosis in some eases. 4) In blood chemistry studies, hypoalbuminemia was found in 86.8% and an increase of SGOT and alkaline phosphatase was noted in 95.7% and 78.9% respectively. LDH was increased in 100% (7/7). 5) The clinical courses of the patients with infectious diseases were good except 3 cases with fatal septicemia, and the other cases were not followed affer discharge.
박금수,용석중,김원천,최경훈,성낙억 대한내과학회 1987 대한내과학회지 Vol.33 No.2
Left ventricular thrombosis is found in up to 30%. of cases with dilated cardiomyopathy. The main risk consists of unpredictable systemic embolization which is one of the cause of sudden death. The favorite site for lodgement of cardiac emboli is the middle cerebral artery and consequently cardiogenic cerebellar infarction without evidence of cerebral infarction is very rare. Recently we discovered a case of cerebellar infarction and large left ventricular thrombus by two-dimensional echocardiography in a 26 year old male patient who was previously diagnosed as idiopathic dilated cardiomyopathy. We treated the patient with anticoagulant therapy and found significant resolution of left ventricular thrombus by two-dimensional echocardiography about 1 month later. Therefore this case is reported along with a brief review of the literature.
박금수,나흥식,남숙현 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.1
To determine the cause of genesis of reperfusion arrhythmias, the left anterior descending coronary artery was cannulated and perfused by a carotid-coronary bypass wlth slde branch in 29 open-chest pentobarbital-anesthetized cats . Ischemia was produced by shunt occlusion during 20min. Thereafter the side branch was opened and the ischemic myocardium reperfused with unmodified arterial blood (13 cats). acidlc blood(pH 6.73-7.10, 8 cats), hypocalcemic blood(Ca^(++) 0.13-0.37mM, 3 cats), and venous blood(PO_2, 29.5-47.ImmHg, 3 cats). Each group was evaluated with respect to the incidence of ventricular premature beats, ventricular tachycardia, and ventricular fibrillation and the onset time of first arrhythmia of each arrhythmia in cats. The incidence of ventricular tachycardia was much lower in the acidic reperfusion group (three of 8 cats,38%) than in the unmodilfed reperfusion group(eleven of 13 cats. 85%), (p<0.O5) hypocalcemic reperfuslon group(three of 3 cats. 100%), and hypoxic reperfusion group(three of 3 cats, 100% ). And the incidence of ventricular fibrillation was much lower in the acidic reperfusion group(none of 8 cats, 0%) than in the unmodified reperfusion group(eleven of 13 cats, 85%),(p<0.O5) hypocalcemic reperfusion group(three of 3 cats, 100%), and hypoxic reperfusion group(two of 3 cats, 67%). The onset time of ventricular premature beat and ventricular tachycardia is later in acidic reperfusion group(158.9 ± 117.5sec., 70.8±54.70sec. (mean±S.E) than unmodified reperfusion group(6.78±1.29sec., 24.7±7.5sec. (mean±S.E.)). These results indicate that acidic reperfusion can prevent reperfusion-induced arrhythmias, presumably owing to a reduction of Ca^(++) influx into cells through Na^(++) -Ca^(++) exchange.
한지숙,박금수,조철호,고윤웅,윤진우,전상일 대한내과학회 1986 대한내과학회지 Vol.30 No.1
We retrospectively analyzed clinical and laboratory features of 58 patients with SLE for the survival and the factors which may have influenced the outcome from 1970 through 1983. The survival was calculated using the method of Merill and Shulman, taking the time of diagnosis and the onset of symptom as the starting point. We divided 58 patients with SLE into 2 groups, those whose survival was less than or equal to 2 years and those greater than 2 years, and compared clinical and laboratory features between them with particular emphasis on those factors which may have influenced the outcome. The results obtained as follows: 1) The estimated survival from diagnosis was 76.7% in 1 year, 62.3% in 2 years, 62.3% in 3 years, 59.6% in 4 years, 53.8% in 5 years and 50.6% in 10 years. The estimated survival from the onset of symptom was 65.5%, in 1 years, 59.54% in 2 years, 56.2% in 3 years, 52.2% in 4 years, 52.5% in 5 years, and 46.l% in 10 years. 2) There was a statisticaly significant difference in prognosis between 2 groups with regard to CNS involvement, serositis, and increased serum creatinine level(≥3.0mg/dl).