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Bisphosphonate-induced Severe Hypocalcemia - A Case Report -
도원석,이덕현,박진경,박명일,김형석,김성호 대한골대사학회 2012 대한골대사학회지 Vol.19 No.2
Bisphosphonate generally seems to be safe, but hypocalcemia may occasionally develop in the course of bisphosphonate treatment. Hypocalcemia induced by bisphosphonate is usually mild and asymptomatic, but unrecognized or poorly treated hypocalcemia can lead to life-threatening state. A 78-year-old woman who had a history of hip arthroplasty and intravenous zoledronate treatment for femur neck fracture was presented to emergency department with altered mental status. It turned out that her symptom was due to severe hypocalcemia which was caused by intravenous zoledronate treatment. She also had renal dysfunction. She was treated by intravenous calcium gluconate and calcitriol administration. This case supports the need for evaluation of renal dysfunction, vitamin D deficiency and parathyroid gland dysfunction before bisphosphonate treatment and accurate monitoring of plasma calcium and creatinine levels. In addition, vitamin D and calcium supply during treatment with bisphosphonate is mandatory.
도원석,이종학,김경주,한만훈,정희연,최지영,박선희,김용림,김찬덕,조장희,양영애,김민정,황인량,김규연,임태훈,김용진 대한이식학회 2018 Korean Journal of Transplantation Vol.32 No.3
A 38-year-old man, who underwent a second kidney transplantation (KT), was admitted because of antibody-mediated rejection (AMR) complicated by BK virus-associated nephropathy (BKVAN). He was placed on hemodialysis at the age of 24 years because of membranoproliferative glomerulonephritis. At the age of 28 years, he underwent a living donor KT from his father; however, 1 year after the transplantation, he developed a recurrence of the primary glomerular disease, resulting in graft failure 2 years after the first KT. Ten years later, he received a deceased-donor kidney with a B-cell-positive-cross-match. He received 600 mg of rituximab before the KT with three cycles of plasmapheresis and immunoglobulin (0.5 g/kg) therapy after KT. During the follow-up, the first and second allograft biopsies at 4 and 10 months after KT revealed AMR with a recurrence of primary glomerular disease that was reclassified as C3 glomerulonephritis (C3GN). He received a steroid pulse, rituximab, plasmapheresis, and immunoglobulin therapies. The third allograft biopsy demonstrated that the BKVAN was complicated with AMR and C3GN. As the azotemia did not improve after repeated conventional therapies for AMR, one cycle of bortezomib (1.3 mg/m2×4 doses) was administered. The allograft function stabilized, and BK viremia became undetectable after 6 months. The present case suggests that bortezomib therapy may be applicable to patients with refractory AMR, even in cases complicated with BKVAN.
도원석,김경호,김갑성,Do, Won-Seok,Kim, Kyung-Ho,Kim, KaP-sUNG 대한침구의학회 2001 대한침구의학회지 Vol.20 No.4
Objective : The purpose of this study is to investigate the effects on WBC counts and each differential of neutrophils, lymphocytes, monocytes in whole blood sample of each experimental Aqua-acupuncture treated mice groups PCortex Ulmi Pumilae(CU), Ramulus Cinnamomum(RC), Radix Achyranthes(RA), Apitoxin(BV), Calculus Bovis Fel Ursi Moschus compound(BUM). Materials & Method : All the BALB/c mice used in this study were bred and maintained in our pathogen-free mouse facility and were 6 weeks of age at the start of the experiment. The experimental model of arthritis was induced by injecting 300${\mu}g$/kg LPS to all mice knee joint. The each of Aqua-acupuncture(Cortex Ulmi Pumilae, Ramulus Cinnamomum, Radix Achyranthes, Apitoxin, Calculus Bovis Fel Ursi Moschus compound) was injected into GB34(陽陵泉) of mice groups every other day for 6 times. And the WBC counts and each differential of neutrophils, lymphocytes, monocytes were measured at the 3rd, 7th and 14th day after LPS injection. Results : 1. The WBC counts were significantly decreased compared with the control(CON) group in every Aqua-acupuncture groups at all days. And at the 14th day, BV & BUM groups were more significantly decreased than RA group. 2. The Neutrophil's ratio was significantty increased compared with the CON group in CU & RC groups at the 3rd day and RC group was more significant than CU group. But at the 7th and 14th day, every Aqua-acupuncture groups were significantly increased compared with the CON group and at the 7th day, RC group was more significant than RA, BV & BUM groups and at the 14th day, RC, BV & BUM groups were more significant than RA group. 3. The Lymphocyte's ratio was significantly decreased compared with the CON group in RC group at the 3rd day. At the 7th day, CU, RC & BV groups were significantly decreased compared with the CON group. At the 14th day, every Aqua-acupuncture groups were significantly decreased compared with the CON group and RC group was more significant than RA group, 4. The Monocyte's ratio was significantly decreased compared with the CON group in every Aqua-acupuncture groups at the 7th day. At the 14th day, BV & BUM groups were significantly decreased compared with the CON group. Conclusion : According to the above results, it was concluded that CU & RC groups were more effective at the early period of this experiment, and at the latter period, BV & BUM groups were more effective than others. RA group was less effctive than others.
불평형 전원 조건에서 MMC 기반 HVDC 시스템 순환전류에 관한 연구
도원석(Won-Seok Do),김시환(Si-Hwan Kim),김태진(Tae-Jin Kim),김래영(Rae-Young Kim) 대한전기학회 2015 전기학회논문지 Vol.64 No.8
This paper presents a study of circulating current of modular multi-level converter (MMC) based a high voltage direct current (HVDC) system under unbalanced grid conditions. Due to the connection of a dependent DC source in each phase, the MMC system inherently generates the power ripple of double-line-frequency components in the AC-side and as a result, the additional sinusoidal current named circulating current flows through the each arm. Reliability improvement of HVDC system under an unbalanced grid condition is one of the important criteria. Generally, the modeling of the circulating current is based on the power relation between DC-side and AC-side. However, the method is not perfectly matched in the MMC system due to the difference of the structural characteristic. In this paper, improved modeling method of circulating current is proposed, which is based on the inner arm power. The proposed method is verified by several simulations to have good agreement of the circulating current components.
불평형 전원 조건에서 MMC HVDC 시스템 전력제어를 고려한 순환전류 분석 및 제어
도원석(Won-Seok Do),김시환(Si-Hwan Kim),김태진(Tae-Jin Kim),김래영(Rae-Young Kim) 대한전기학회 2014 대한전기학회 학술대회 논문집 Vol.2014 No.4
본 논문은 불평형 계통 전원 조건에서 모듈형 멀티레벨 컨버터를 이용한 HVDC 시스템의 순환전류에 대한 분석을 보여주고 있다. 먼저 모듈형 멀티레벨 HVDC 시스템의 기본 구조 및 시스템 동특성에 대해 해석을 하고, 이러한 해석을 바탕으로 불평형 계통 전원에 사용되는 대표적인 전력 제어기를 대상으로 정상 및 불평형 계통 전원 조건하에서의 순환전류의 모델링과 이에 대한 해석을 제안한다. 이를 통해 전력 제어기의 적용을 위해 실제적으로 고려되어야 할 사항을 시뮬레이션을 통하여 검증한다.
요추관협착증의 한의학적 보존적 치료에 대한 임상적 고찰
황재연,도원석,Hwang, Jae-Yeon,Do, Won-Seok 대한침구의학회 2000 대한침구의학회지 Vol.17 No.3
This clinical study was carried out 15 cases with lumbar spinal stenosis patients, who had been admitted and diagnosed by Computed Tomography from June, 1999 to May, 2000, in the department of acupuncture and moxibustion. Hanseo University Oriental Medical Nospital. The results obtained from this study were as follows; 1. We investigated 10 female and 5 male patients. The age distribution was from early 20's to 70's, among which 30's and 50's were most common. 2. The most common duration of symptom was less than a year(46.7%). 3. Regarding to the number of the involved levels, one was 12 cases(80%), two was 3 cases(20.0%). In the one level cases, L4~5 was the most common involved site. 4. Regarding to the clinical symptoms, low back pain was the most common, followed by lower extremity radiating pain, intermittent claudication, lower extremity paresthesia. 5. In orthopaedic examinations, positive sign in Milgram test was 80.0%, positive sign in straight leg raising test was 40.0%, and positive sign in Braggard test was 33.3%. Inneurologic examinations, sensory loss was seen in 60.0%, motor weakness and decreased deep tendon reflex were 26.7% in each. 6. According to clinical symptom scale proposed by Chae(1989), grade I1I was the most common (53.3%), followed by grade II, grade IV, grade I . 7. According to treatment outcome scale proposed by Chae(1989), Good was the most common (73.3%), followed by Excelleat, Fair and Poor.