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남현열,전성민,박경준,김인주 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.2
Objective: Concurrent low brain and high liver uptake are sometimes observed on fluorine-18-labeled fluoro-2-deoxy-Dglucose (FDG) positron emission tomography (PET). We investigated the potential clinical significance of this uptake pattern related to metabolic syndrome (MS). Materials and Methods: We retrospectively reviewed data from 264 consecutive males who had undergone general health check-ups, including FDG PET/CT scans. After an overnight fast, the men had their peripheral blood drawn and the levels of various laboratory parameters measured; an FDG PET/CT scan was performed on the same day. We measured the maximum standardized uptake values of the brain and liver from regions of interest manually placed over the frontal cortex at the level of the centrum semiovale and the right lobe of the liver parenchyma, respectively. Results: Fasting blood glucose (FBG; odds ratio [OR] = 1.063, p < 0.001) and glycated hemoglobin (HbA1c; OR = 3.634, p = 0.010) were the strongest predictive factors for low brain FDG uptake, whereas waist circumference (OR = 1.200, p < 0.001) and γ-glutamyl transpeptidase (OR = 1.012, p = 0.001) were the strongest predictive factors for high liver uptake. Eleven subjects (4.2%) showed concurrent low brain and high liver FDG uptake, and all but one of these subjects (90.9%) had MS. Systolic blood pressure, waist circumference, FBG, triglyceride, alanine aminotransferase, insulin resistance (measured by homeostasis model assessment), insulin, HbA1c, and body mass index were higher in subjects with this FDG uptake pattern than in those without (all, p < 0.001). Conclusion: Concurrent low brain and high liver FDG uptake were closely associated with MS. Moreover, subjects with this pattern had higher values for various cardiovascular risk factors than did those without.
분화성갑상선암에서 최초 고용량 방사성요오드 치료시 혈청 갑상선글로불린 수치 변화의 의의
남현열 ( Hyun Yeol Nam ),김인주 ( In Joo Kim ),김용기 ( Yong Ki Kim ),김성장 ( Seong Jang Kim ),전성민 ( Sung Min Jun ),김범수 ( Bum Soo Kim ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.4
목적: 이 연구에서는 고용량 방사성요오드 치료 시행 전, 각각 rhTSH 전처치를 시행한 환자군(rhTSH군)과 갑상선호르몬 투여 중단 시행한 환자군(THW군)에서 방사성요오드 투여 후 단기 혈청 갑상선글로불린(Tg) 상승 정도가 성공적인 잔여갑상선 제거(RRA)를 예측할 수 있는지, 그리고 두 군 사이에서 동등한 잔여갑상선 제거 효과를 보이는지 알아보았다. 대상 및 방법: 분화성갑상선암으로 수술 후 방사성요오드 치료를 받은 환자들 중, rhTSH군은 2003년 1월에서 2006년 12월까지 39명, THW 군은 2005년 1월에서 2005년 6월까지 46명을 대상으로 후향적으로 평가하였다. 이들은 방사성요오드 투여하는 날, 방사성요오드 투여 후 9일째 되는 날 및 6개월에서 12개월 사이에 시행한 추적 검사에서 갑상선기능검사를 시행하였다. 결과: 85명 중 64명에서 성공적인 RRA를 보였다. rhTSH 군에서는 27명, THW 군에서는 37명에서 RRA 성공을 보였고 이 두 군의 결과는 유의한 차이를 보이지 않았다(p=0.347). rhTSH군 및 THW군에서 TgD9/TgD0은 RRA 성공군에서 실패군보다 유의하게 높은 값을 보였다(p=0.03, p=0.04). TgD0와 TgD9/TgD0의 절단값을 결합하였을 경우, TgD0가 5.28이하이면서 TgD9/TgD0이 4.37 초과인 경우 96.7%(29/30)의 RRA 성공률을 보였고, rhTSH군과 THW군에서도 각각 92.9%(13/14)와 100%(16/16)의 높은 RRA 성공률을 나타냈다. 로지스틱 회귀분석에서는 오직 TgD0만 성공적인 RRA와 유의한 연관성을 보였다(p=0.001). 결론: THW군 뿐 아니라 rhTSH군에서도 RRA를 위한 고용량 방사성요오드 치료 도중의 혈청 갑상선글로불린의 변화 양상으로 향후 성공적인 RRA를 예측할 수 있다. Purpose: The purpose of this study was to evaluate if short-term serum thyroglobulin (Tg) elevation after radioiodine administration can predict successful radioiodine remnant ablation (RRA) and whether comparable RRA effectiveness is exhibited between a group administered with recombinant human thyrotropin (rhTSH) and a group experiencing thyroid hormone withdrawal (THW), in preparation for RRA. Materials and Methods: A retrospective chart review was performed on 39 patients in the rhTSH group and 46 patients in the THW group. They were treated for differentiated thyroid carcinoma by total or near total thyroidectomy, and referred for RRA between 2003 and 2006 (the rhTSH group) and between January and June of 2006 (the THW group). They were assessed for serum Tg levels just before I-131 administration (TgD0), reassessed 9 days later (TgD9), and again 6-12 months later. Results: RRA was successful in 64 (37 from the THW group and 27 from the rhTSH group) of the total 85 patients. The success rates of RRA had no statistically significant differences between the two groups. In both groups, TgD9/TgD0 values were significantly higher in the RRA success group (the rhTSH group; P=0.03, the THW group; P=0.04). By combining cutoff values of TgD0 and TgD9/TgD0, the successful RRA value was determined to be 96.7% (29/30) with TgD0≤5.28 ng/mL and TgD9/TgD0>4.37 in both groups (the rhTSH group; 100% (16/16), the THW group; 92.9% (13/14)). Using logistic multivariate analysis, only TgD0 was independently associated with successful RRA. Conclusion: We may predict successful ablation by evaluating short-term serum Tg elevation after I-131 administration for RRA, in both rhTSH and THW patients. (Nucl Med Mol Imaging 2009;43(4):294-300)
Effect of rs3910105 in the Synuclein Gene on Dopamine Transporter Availability in Healthy Subjects
서영득,박경준,남현열,석주원,이명준,김은주,이재민,김성장,김인주 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.6
Purpose: The present study investigated associations between dopamine transporter (DAT) availability and α-synuclein levels incerebrospinal fluid, as well as synuclein gene (SNCA) transcripts, and the effect of single nucleotide polymorphism of SNCA onDAT availability in healthy subjects. Materials and Methods: The study population comprised healthy controls who underwent 123I-FP-CIT single-photon emissioncomputed tomography screening. Five SNCA probes were used to target the boundaries of exon 3 and exon 4 (SNCA-E3E4), transcriptswith a long 3’UTR region (SNCA-3UTR-1, SNCA-3UTR-2), transcripts that skip exon 5 (SNCA-E4E6), and the rare shorttranscript isoforms that comprise exons 1–4 (SNCA-007). Results: In total, 123 healthy subjects (male 75, female 48) were included in this study. DAT availability in the caudate nucleus(p=0.0661) and putamen (p=0.0739) tended to differ according to rs3910105 genotype. In post-hoc analysis, DAT availability inthe putamen was lower in subjects of TT genotype than those of CC/CT (p=0.0317). DAT availability in the caudate nucleus alsoshowed a trend similar to that in the putamen (p=0.0597). Subjects of CT genotype with rs3910105 showed negative correlationswith DAT availability in the putamen with SNCA-E3E4 (p=0.037, rho=-0.277), and SNCA-E4E6 (p=0.042, rho=-0.270), but notthose of CC/TT genotypes. Conclusion: This is the first study to investigate the association of rs3910105 in SNCA with DAT availability. rs3910105 had an effecton DAT availability, and the correlation between DAT availability and SNCA transcripts were significant in CT genotypes ofrs3910105.
정윤정,팽진철,남현열,이지선,이상민,유철규,김영환,한성구,임재준 대한의학회 2014 Journal of Korean medical science Vol.29 No.3
The presence of radiographic lesions suggesting old healed tuberculosis (TB) is one of thestrongest risk factors for the subsequent development of active TB. We elucidated themetabolic activity of radiographic lesions suggesting old healed TB using18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDGPET/CT). This cross-sectional study included 63 participants with radiographic lesionssuggesting old healed TB and with available 18F-FDG PET/CT scans. The maximumstandardized uptake value (SUVmax) measured in the lesions, the clinical characteristics,results of the tuberculin skin test (TST) and interferon-γ release assay (IGRA) were analyzed. The SUVmax in old healed TB was 1.5 or higher among nine (14.3%) participants. Age(adjusted odds ratio [aOR], 1.23; 95% CI, 1.03-1.46), history of previous TB (aOR, 60.43;95% CI, 1.71-2131.65), and extent of the lesions (aOR, 1.34; 95% CI, 1.02-1.75) wereassociated with higher SUVmax. The positive rates for the TST and IGRA were not differentbetween groups with and without increased FDG uptake. Increased FDG uptake on 18F-FDGPET/CT was observed in a subset of patients with radiographic lesions suggesting old healedTB. Given that the factors associated with increased FDG uptake are known risk factors forTB development, the possibility exists that participants with old healed TB lesions withhigher SUV on 18F-FDG PET/CT scans might be at higher risk for active TB.