염색체 7번 장완의 부분적 역위 중복 1례

김현지,이소영,김미영,백청순,김원덕,이동석,김두권,최성민,Kim, Hyun Ji,Lee, So Young,Kim, Mi Young,Baek, Chung Sun,Kim, Won Duck,Lee, Dong Seok,Kim, Doo Kwun,Choi, Sung Min 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.5

Duplication of chromosome 7q has been reported as either partial or complete. Partial 7q duplication was first described by Carpentier in 1972. Pure partial duplication of the long arm of chromosome 7 is extremely rare and only 16 cases with a pure partial duplication of different 7q segment have been described in the literature. Pure partial duplication of the long arm of chromosome 7 is characterized by growth and developmental retardation, muscular hypotonia, distinct craniofacial dysmorphic features, a short neck and skeletal abnormalities. A 3 month-old male was referred to our department of Pediatrics because of dyspnea, hypotonia and delayed development. He shows growth and developmental delay, hypertelorism, a depressed nasal bridge, low set ears, a short neck and muscular hypotonia. Karyotype revealed 46, XY, dup(7)(q36q33) by GTC-banding. We report a case of a partial inverted duplication of chromosome 7q. 저자들은 호흡곤란, 근력저하, 발달지체로 병원에 온 3 개윌된 남아의 염색체 핵형분석에서 46, XY, dup(7)(q36q33)으로 진단된 1례를 경험하였기에 보고하는 바이다.

성대 부전 마비의 진단에서 후두 근전도 검사의 유용성

김현지,박혜상,김한수,박기덕,정성민,Kim, Hyun-Ji,Park, Hae-Sang,Kim, Han-Su,Park, Kee-Duk,Chung, Sung-Min 대한후두음성언어의학회 2011 대한후두음성언어의학회지 Vol.22 No.2

Background and Objectives : Vocal fold paresis is a clinical condition and considered as a continuum of neurologic dysfunction encompassing partial denervation and variable degrees and patterns of reinnervation. Its incidence, clinical presentation, significance are incompletely understood and still debated. This study describes the clinical, electromyographic findings in patients who presented with complaints of dysphonia and whose laryngoscopic finding revealed vocal fold paresis. Materials and Method : 47 patients (male : 25, female : 22) who referred to Ewha Womans University Medical Center Voice clinic for evaluation of vocal complaints were enrolled in this study. All patients had undergone a through history and physical examination including strobovideoscopic and laryngoscopic examination. Patients with in the history and/or laryngoscopic examination suggestive of vocal fold paresis were evaluated by laryngeal electromyography (LEMG). Results : Of these patients, 23 (48.9%) were found to have evidence of neuropathy on LEMG. There was no significant difference in voice symptoms and laryngoscopic findings between two groups of patients with evidence of neuropathy and who show normal findings on LEMG. Conclusion : LEMG can clinically help to guide the evaluation and management of vocal fold paresis. Due to some limitations of LEMG, laryngoscopic findings and clinical correlations should also be considered when diagnosing the vocal fold paresis.

한우의 FABP4 유전자 선별에서 사육환경 보정 효과

김현지,이제영,Kim, Hyun-Ji,Lee, Jea-Young 한국통계학회 2015 응용통계연구 Vol.28 No.5

가축의 경제적인 특성은 환경적인 요인과 유전적인 요인의 영향을 복합적으로 받는다. 우리는 한우의 경제적 특성에 영향을 미치는 유전적인 요인에 관심이 있으며, 우리의 목적은 경제형질에서 환경적인 요인을 보정하여 유전효과를 더욱 정확하게 검증하는 것이다. 본 연구에서는 환경적인 요인과 유전적인 요인으로 구성된 통계모형을 구축하고, 이 모형에서 환경적인 요인인 사육농가의 효과와 도축일령의 효과를 제거하여 보정된 경제형질값을 구한다. 그리고 보정 전 후 경제형질값을 다중인자차원축소 방법에 적용하여 각각의 우수 유전자와 유전자조합을 선별하고, 정확도를 비교한다. 그 결과, 우리는 환경요인을 보정한 경제형질값을 활용하여 우수 유전자 선별의 정확도를 높였고, 한우의 등급과 지방산과 깊은 연관이 있는 우수한 FABP4 유전자를 선별하였다. Economic-traits of livestock are affected by environmental and genetic factors. We are interested in genetic factors that influence the economic-traits of Korean cattle. It is necessary to adjust environmental factors in order to enhance the accuracy of the genetic effect analysis. In this paper, we propose a statistical model of Korean cattle that exclude environmental breeding farm and age factors. We formulated an adjusted economic-trait value, and applied multifactor dimensionality reduction (MDR) method to data of before-and-after adjustment to identify major FABP4 genes. We were able to increase the accuracy of the analysis after adjustment and identify superior FABP4 genes that influence grade and fatty acid.

괴화(槐花) 추출물의 투여(投與)가 Streptozotocin으로 유발된 당뇨쥐에 미치는 영향

김현지,김경준,Kim, Hyun-Ji,Kim, Kyung-Jun 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1

Objective : The present study was carried out to investigate the preventive effect of Sophorae Flos on streptozotocin - induced Diabetes mellitus. Method : Sophorae Flos was given to rats with oral administration. The experimental animals were divided into 3groups : normal group of rats, control group of Streptozotocin-induced diabetic rats, sample group with Sophorae Flos . The effect of Sophorae Flos on Streptozotocin-induced diabetes was observed by measuring the survival rate of rats, weight of rats, FER, blood glucose, each organ weight of rat, total cholesterol, HDL, GOT, GPT & creatinine. Result : Streptozotocin caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic ${\beta}-cell$. Sophorae Flos treatment don't protected them from hyperglycemia and hypoinsulinemia. Organ weight liver, kidney, heart & spleen shows no significant changes. Sophorae Flos significantly don't recoverd the increase of several biochemical parameters such as blood glucose, total cholesterol, HDL, GOT, GPT, antioxidant & creatinine is vice versa. Conclusion : Sophorae Flos extract group did not show significant decrease than Streptozotocin control group.

적록 색각 이상자를 위한 HSV색공간을 이용한 색변환 기법

김현지,조재영,고성제,Kim, Hyun-Ji,Cho, Jae-Young,Ko, Sung-Jea 대한전자공학회 2013 전자공학회논문지 Vol.49 No.11

본 논문에서는 적록색각 이상자를 위한 색 변환 알고리즘을 제안한다. 적록색각 이상자는 원추세포의 이상으로 인해 색상과 명도를 일반인과 다르게 인지하기 때문에 적색과 녹색의 구분에 어려움을 겪는다. HSV 색공간은 이러한 특성을 파악할 수 있는 인간의 색지각과 유사한 색 공간으로, 제안하는 방법에서는 HSV 색 공간에서 색상과 명도를 보정하여 색을 변환 한다. 이때 색상과 명도 보정정도는 개개인의 색각이상 심각도에 따라 다르게 결정된다. 색각 이상자 개개인에 따라 다른 보정정도를 적용함으로서 기존 이미지의 자연스러움은 유지 하고 구분하기 힘들었던 색상들도 구분 가능하게 변환된다. 제안하는 방법을 색각 이상자에게 적용하여 시뮬레이션으로 확인한 결과, 색각 이상자가 구분하기 힘든 색상들이 색상의 자연스러움을 유지하면도 색차를 인지할 수 있는 색으로 변환되는 것을 확인할 수 있었다. This paper proposes a new re-coloring method for the people with the red-green color vision deficiency (CVD). These people have difficulty in discriminating the red and green colors since they abnormally perceive the hue and luminance value of the colors. We introduce a color transformation that adjusts the hue and luminance value in HSV color space. The color transformation is determined according to the severity of CVD. Our aim is to maintain the color differences in original image while maintaining the recolored image to be natural to the people with normal color vision. Experimental results show that the proposed method can yield more comprehensible images for the people with red-green CVD while maintaining the naturalness of the recolored images.

전호(前胡)가 Bleomycin에 의한 폐 섬유화에 미치는 영향

김현지,이해자,박은정,Kim, Hyun-Ji,Lee, Hai-Ja,Park, Eun-Jung 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : Idiopathic pulmonary fibrosis (IPF) is chronic fibrotic interstitial pneumonia and the pathogenesis is unknown. Peucedani Radix is well-known for the treatment of respiratory diseases and pulmonary hypertension. This study was to evaluate the effectiveness of Peucedani Radix on the bleomycin-induced lung fibrosis model (BLFM) in mouse. Methods : We induced lung fibrosis by intratracheal instillation of bleomycin in C57BL/6J. We compared two groups BLFM without Peucedani Radix (group I) and BLFM with Peucedani Radix (group II). We performed bronchoalveolar lavages (BAL) and obtained lung specimens from both group I and II on the 7th (A) and 21st (B) day, and also for the normal group. We compared with group I and II to find BAL by using ANOVA test and to find pathologic symptoms by using semiquantitative histological index (SHI). Results : In BAL, total cell counts, lymphocytes, and neutrophils was increased in both group I and II comparing with normal group. However, lymphocyte level was decreased more in group IIB than group IB. It was statistically significant. In microscopic findings, scores of SHI in normal group, group IB and IIB were 0.33, 4.47, and 1.96 each. Conclusions : Peucedani Radix might have inhibitory effect on lung fibrosis by reducing inflammatory cells in bleomycin-induced lung fibrosis model in mouse.

빛공해의 인식 및 문제점에 관한 조명전문가 의식조사

김현지,Kim, Hyun-Ji 한국조명전기설비학회 2010 조명.전기설비 Vol.24 No.5

대학생들의 탄산수 효능에 대한 인식과 지식이 섭취 행태 및 만족도에 미치는 효과

김현지,장재선,홍명선,서화정,Kim, Hyun Ji,Jang, Jae Seon,Hong, Myung Sun,Seo, Hwa Jeong 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.4

The purpose of this study was to determine the effects of awareness and knowledge of the efficacy of carbonated water on consumption patterns and satisfaction for college students, who are the principal consumers of carbonated water. A survey was conducted with 502 college students in the Metropolitan area from May 13 to 18, 2015 and 455 questionnaires were analyzed. As for the differences in awareness and knowledge of the efficacy of carbonated water according to gender, females (14.60 and 0.76) had better awareness and knowledge than males (13.40 and 0.58) (p=0.000 and p=0.036). The more positive the awareness of carbonated water, the greater the knowledge (p=0.000); the greater the knowledge of carbonated water, the higher level of consumption satisfaction (p=0.006). The odds ratio of awareness for carbonated water was 11.98; that is, positive awareness led to higher levels of satisfaction than negative awareness (p=0.003). Since awareness of the efficacy of carbonated water was found to affect carbonated water drinking and satisfaction, it is necessary to provide correct information about the efficacy of carbonated water.

골연령 측정을 통한 한방 성장 치료의 임상적 연구

김현지,이해자,박은정,Kim, Hyun-Ji,Lee, Hai-Ja,Park, Eun-Jung 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.3

Objectives : The object of this study was to evaluate the effect of oriental medical treatment to the growth of children using bone age as measurer. Methods : This clinical study has been carried out with 32 cases(male 15, female 17 of children) aging from 7 to 15 years old, who visited to the Department of Pediatrics growth clinic, ○○ medical center from January 2004 to August 2006 and were treated for more than 12 months. Their height, body weight, body mass index(BMI) and bone age were estimated at two points: Before and after oriental medical treatment was applied. Bone age is measured by X-ray image of growth plate in inferior radiocarpal joint. Results : Bone age correlated with choronological age, height, weight. Difference between bone and choronological age was correlated with percentile of height and weight. The mean growth of children showed 4.03 percentile upwardly(p=.046), and difference between bone and choronological age was reduced from $0.23{\pm}1.62$ to $-0.026{\pm}1.64(p=.040)$ after treatment. Conclusions : This study shows that oriental medical treatment helped growth of children using bone age as measurer.

수질(水蛭)이 THP-1세포의 사이토카인 유전자 발현에 미치는 영향

김현지,김경준,Kim, Hyun-Ji,Kim, Gyung-Jun 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.1

Objective : This study was performed to evaluate the effect of immune reaction inductive substances such as PMA, LPS, DPE, DNCB and WP, the whitman pigra extracting substance at simultaneously on the translocation of $NF{\kappa}B$ towards to the nucleus and the mRNA expression patterns of various cytokine genes in THP-1 cells, monocytes of human. Methods : To analyze the cytokine genes expressions, the RT-PCR method was used, and measuring TNF-${\alpha}$ that had been secreted during cell culture by the ELISA method. The morphological changes were observed during THP-1 cell by a scanning electron microscope and the quantitative distribution of $NF{\kappa}B$ in the cell that was analyzed through immunocytochemistry and a confocal microscopy. Results : WP showed different influences onto the mRNA expression patterns of cytokine genes with PMA, LPS. DPE and DNCB according to the types of immune inductive substances in the THP-1 cells. Upon treating PMA and DPE on the THP-1 cells at the same time or either additionally treating WP thereon, the movement of $NF{\kappa}B$ increase towards the nucleus from cell cytoplasm was able to be observed. The expressions of IL-$1{\alpha}$ and IFN-${\gamma}$ induced by PMA and PMA+DNCB were suppressed by WP while the expression of TGF-${\beta}$ was promoted. Regarding the secretion pattern of TNF-${\alpha}$ according to the treatment of PMA, its secretion amount was incredibly increased by concurrent treatment of WP, however, in case of co-treatment of WP with PMA and DNCB, it was found that the secretion amount of TNF-${\alpha}$ decreased. Conclusions : In this study, the WP extracting substance was confirmed that it had an influence on expression patterns of cytokine genes according to the actions of a variety kinds of immune reaction inductive substances treated on the THP-1 cells. Especially, WP co-treatment with PMA and DNCB was suppressed the expression of inflammatory cytokines, such as IL-$1{\alpha}$, IFN-${\gamma}$ and TNF-${\alpha}$.