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      • KCI등재

        손바닥선인장 줄기 methanol 추출물의 항균활성

        김해남,권도훈,김해,전홍기,Kim Hae-Nam,Kwon Do-Hoon,Kim Hae-Yun,Jun Hong-Ki 한국생명과학회 2005 생명과학회지 Vol.15 No.2

        손바닥선인장 추출물은 한의학에서 항염증 작용, 화상, 부종, 소화 불량 등 몇 가지의 생리학적 기능이 확인되었다. 본 연구에서는 손바닥선인장 줄기를 메탄올을 이용하여 추출한 후 그 추출물을 이용하여 항균활성을 확인한 결과 병원균 등 일반 세균에서 항균활성을 확인하였다. 특히, 약제내성균 및 혐기성 균인 여드름 원인균 뿐만 아니라 효모, 곰팡이 등 진균류에서도 항균활성을 나타내어 넓은 항균 스펙트럼을 가지고 있음을 확인할 수 있었다. 또한 열 처리, 저장온도 및 저장기간이 항균활성에 영향을 미치지 않았으므로 온도 및 기간에 안정함을 확인할 수 있었고, 식품 보존제로서의 가능성 확인 시험에서도 기존의 식품 보존제보다 안전성이 있는 항균활성 물질로 평가되었다. The Opuntia ficus-indica var. saboten Makino (Cactus) is a tropical or subtropical plant, which is cultivated or grows naturally in Jeju island. It has been widely used as folk medicine for burned wound, edema and indigestion. In addition, its extract has been claimed to have several biological activities including anti-inflammation in oriental medicine. In this study, we examined the antimicrobial activities of the methanol extract of Opuntia ficus-indica var. saboten Makino. The extract showed a broad spectrum of antimicrobial activity against pathogenic bacteria, including antibiotics resistant bacteria (MRSA, R-P. aeruginosa, VRE) and Propionibacterium acnes, yeast, and fungi. The extract retained the activity after heat treatment for 15 min at $100^{\circ}C$ and $121^{\circ}C$ and after extended storage, up to 10 weeks storage period at $4^{\circ}C$ and $25^{\circ}C$, also stably retained its activity. It showed a better inhibitoring effect to the growth of E. coli than sodium benzoate did it at the same concentration. Addition of various salts or metal ions did not affect on its antimicrobial activity. Therefore, the antimicrobial characteristics of the extract can be applicable as a natural preservative and an antimicrobial agent for bacterial disease.

      • KCI등재

        MBT-01108 물질에 의한 일반 소독제 및 항생물질 내성균주의 생육억제

        김해남,박진영,김삼웅,전홍기,Kim, Hae-Nam,Park, Jin-Young,Kim, Sam-Woong,Jun, Hong-Ki 한국생명과학회 2007 생명과학회지 Vol.17 No.9

        시중에서 사용되고 있는 일반 소독제를 대상으로 하여 병원 미생물의 내성 빈도를 검토한 결과는 약 30%였다. 그 중에서 푸드세프 (산화제 중 할로겐 계 소독약)와 동인테고 (양성 계면 활성제) 및 Iodo 175 (양성 계면 활성제)는 병원 미생물에 대해 낮은 감수성을 나타냈었을 뿐 아니라, 시험에 사용된 다른 소독제에 비하여 높은 내성 빈도를 나타내었다. 소독제 내성 균주를 사용해서 항생제 내성을 MIC test와 paper disc 방법으로 확인한 결과 30%의 내성 빈도를 나타내었다. 다른 항생제에 비해 aminoglycoside 계의 항생제인 gentamycin, kanamycin, streptomycin에서 높은 내성 빈도를 나타냄을 확인할 수 있었다. 본 연구실에서 제주도 손바닥 선인장으로부터 추출${\cdot}$분획한 MBT-01108 물질을 소독제와 항생제에 내성을 획득한 내성균에 상용했을 경우 내성이 생기지 않을 뿐 아니라, 내성균이 자라지 못하였다. 또한 현재 문제시되고 있는 다제 내성균인 MRSA, R-Pseudomonas aeruginosa, VRE, E. coli O157에 사용했을 경우에도 마찬가지의 결과를 얻을 수 있었다. 이상에서 살펴 본 바와 같이 손바닥 선인장에서 추출 ${\cdot}$ 분획한 MBT-01108 물질은 기존의 항생제와는 다른 기작으로 작용을 할 것으로 생각되고, 신규 항균 활성 물질의 약제 개발에 그 유용성이 매우 클 것으로 기대되며 여러 가지 항균성 생활 제품의 개발에도 유용할 것으로 기대된다. The 30% resistant frequencies of pathogenic bacteria were identified against generally utilizing disinfectants. Among the used disinfectants, foodsef, Taego, and Iodo 175 were dictated by lower sensitivities against pathogenic bacteria, as well as higher resistant frequencies when compared with other disinfectants. The resistant frequencies against antibiotics were also dictated by 30% through MIC (minimal inhibitory concentration) and paper disc methods. Especially, the used bacteria exhibited resistances against gentamycin, kanamycin, and streptomycin, which included in all aminoglycoside group. The MBT-01108 material, which extracted and purified from a powder obtained by processing of Opunita ficus-indica var. saboten Makino trunk, did not develop or grow resistant bacteria. Interestingly, the multi-drug resistant bacteria such as MRSA, resistant Pseudomonas aeruginosa, VRE, and E. coli 0157 did not resistant against MBT-01108 material. These results suggest that MBT-01108 material uses as an anti-microbial agent.

      • KCI등재
      • 논문 : 아유르베다(Ayurveda)의 과학적 근거에 대한 고찰

        김해남 ( Hae Nam Kim ) 국제통합대체의학협회 2005 국제통합대체의학회지 Vol.1 No.2

        Ayurveda, the traditional natural healing system of India, is quickly gainig popularity in the Western world. Ayurveda has a many thousand year-old clinical tradition and a comprehensive natural method of treatment from diet, herbs, and massage to life-style counseling and meditation. The world "Ayurveda" is composed of two Sanskrit terms, ``ayus`` meaning ``life`` and ``veda`` meaning the ``knowledge`` and taken together, it means the ``Science of Life``. Contrary to the present trend of specialisation for the treatment of diseases in different parts of the body in isolation, Ayurveda belives in the functional unity of the body as a whole. There are two objects of Ayurveda - one preservation of health in the healthy and the other, cure of illness in the diseased. Equilibrium of psycho - somatic elements is health and dis - equilibrium is disease. Ether, air, fire, water and earth are the five elements having lightness. roughness, hotness, coldness and heaviness as specitic qualities respectively. When parna enters into the material body, the three doshas-vata, pitta and kapha emerge to take up the physiological function vata consists of air and ether. pitta of fire and kapha of water in combination with earth. Because the disharmony of menatal dosha and body doshas are major cause of illness the goal of illness manegement in Ayurveda is to bring back harmony among the doshas. Ayurvedic therapy includes clinical examination diagnosis and dietary and lifestyle, excercise, massage and treatment. There are massage-, oil-, formentation- and cleansing therapy in Ayurvedic system. Massage has a greater use than these two areas, yet massage is extermly important in lifestyle treatments and in preparing for pancha karma. The treatment consists of cleansing therapy(pancha karma), palliation(improve digestion, remove toxic waste, fasting, observe thirst, exercise, sunbathing and meditation), mental numuring and spiritual healing depending on the disturbed doshas and the patients constitution. This review suggests a great potential for integration of Ayurvedic therpies into the health care system in the korea.

      • 계층적 클러스터링에서 분류 계층 깊이에 관한 연구

        김해남 ( Hai-nan Jin ),이신원 ( Shin-won Lee ),안동언 ( Dong-un An ),정성종 ( Sung-jong Chung ) 한국정보처리학회 2004 한국정보처리학회 학술대회논문집 Vol.11 No.1

        Fast and high-quality document clustering algorithms play an important role in providing data exploration by organizing large amounts of information into a small number of meaningful clusters. In particular, hierarchical clustering provide a view of the data at different levels, making the large document collections are adapted to people’s instinctive and interested requires. Many papers have shown that the hierarchical clustering method takes good-performance, but is limited because of its quadratic time complexity. In contrast, K-means has a time complexity that is linear in the number of documents, but is thought to produce inferior clusters. Think of the factor of simpleness, high-quality and high-efficiency, we combine the two approaches providing a new system named CONDOR system [10] with hierarchical structure based on document clustering using Kmeans algorithm to “get the best of both worlds”. The performance of CONDOR system is compared with the VIVISIMO hierarchical clustering system [9], and performance is analyzed on feature words selection of specific topics and the optimum hierarchy depth.

      • 원유비축기지용 유중펌프의 형상설계

        정경(Kyung-Nam Chung),김진영(Jin-Young Kim),박종후(Jong-Hwoo Park),김용균(Yong-Kyun Kim),김해천(Hae-Cheon Kim) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11

        This study deals with hydraulic design of a submergible pump which is installed near the bottom of Ulsan oil stockpiling site. It is used to unload crude oil to a tanker and is run by a 2,800 ㎾ electric motor. This pump has the largest size in the world so far and is a vertical pump with diffuser. Pump design has been carried out by using the analyzed results obtained from the numerical calculations for the effects of several design parameters such as impeller diameter, exit breadth, impeller leading-edge profile, diffuser inlet blade angle, etc. Pump efficiency has been improved by getting rid of flow separation which is generated on the impeller blade due to high pump head and limitation of pump size. NPSH required performance has been improved by applying the above mentioned numerical studies. It has been confirmed from full-scale tests that the pump design is performed satisfactorily.

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