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Research ABC 1 (RE 1) : Introduction to lab works
김창덕 ( Chang Deok Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Investigation using in vitro system is an important way to understand the biological events especially in independent cells. For example, to understand the mechanism underlying skin barrier formation, cultured keratinocytes can be a good model. Similarly, cultured fibroblasts can be used for the dissecting the mechanism underlying extracellular matrix formation. In addition, in vitro system can be usefully used for strengthening in vivo experimental data. Thus, it is important to set up the in vitro system for biological research. In this presentation, I will talk about how to set up the in vitro system. 1. Equipment for cell culture 2. Which cell type? 3. Culture media 4. Introducing the gene into the cells 5. Analysis of gene expression
건축공사 마감공기 단축을 위한 택트공정관리 프로세스 모델
김영재(Kim Young-Jae),한주연(Han Ju-Yeon),신동우(Shin Dong-Woo),김경래(Kim Kyung-Rai),김창덕(Kim Chang-Deok),서상욱(Seo Sang-Wook) 대한건축학회 2003 大韓建築學會論文集 : 構造系 Vol.19 No.1
Besides cost and quality, time is an important management point in the construction projects. It may be considered a competitive power as well as a cost reduction effect that a contractor shortens as possible the construction duration with keeping the requirement. But in case of investigation into the actual data of construction projects, it is especially highlighted that finishing work duration of domestic construction projects is much longer than that of in other advanced construction industry. Through reviewing the existing literature related to the schedule management and performing the questionnaire survey and the expert interview, this study proposes a process model to manage the finishing work of building construction effectively and also to reduce the required duration of the finishing work. The model consists of three steps. The first step is a basic planning process, the second step is a detail planning process, and the last step is a operation and maintenance process.
보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구
이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7
Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)
이미퀴모드로 유발된 건선양 쥐 모델에서 건선 연관 유전자 발현에 대한 면역조직화학적 연구
김지영 ( Ji-young Kim ),최미라 ( Mi-ra Choi ),최종원 ( Chong-won Choi ),박경덕 ( Kyung-duck Park ),이영 ( Young Lee ),김창덕 ( Chang-deok Kim ),서영준 ( Young-joon Seo ),이증훈 ( Jeung-hoon Lee ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.10
Background: Psoriasis is a chronic inflammatory skin disease with an incidence of 0.5∼3% of the worldwide population. The pathogenesis of psoriasis is related to dysregulated keratinocyte function and immune reactions. Notably, genetic factors are considered important etiological contributors. Globally, several researchers have recently performed genome-wide association studies (GWAS) to identify the genes related with psoriasis. Objective: We aimed to investigate the expression pattern of 2 candidate genes that were identified by GWAS. These include interleukin 28 receptor alpha (IL28RA) and CUB and Sushi multiple domains 1 (CSMD1). Methods: We applied imiquimod cream to develop a psoriasis-like mouse model and obtained skin tissue. We performed immunohistochemistry to detect the expression of IL-28A and CSMD1. Results: IL28RA expression increased at an early time point such as 1 day after the topical application of 5% imiquimod cream. However, its expression returned to baseline levels 2 weeks after the topical application of imiquimod cream. CSMD1 expression also increased after the topical application of imiquimod, with increased expression particularly observed in the upper epidermal layer. Notably, CSMD1 expression decreased 7 days after imiquimod cream application. Conclusion: These results suggest that IL28RA and CSMD1 may play key roles in the pathogenesis of psoriasis. (Korean J Dermatol 2018;56(10):609∼613)
여성형탈모에서 두타스테리드의 임상적 치료 효과 및 작용 기전에 대한 연구
김수정 ( Soo Jung Kim ),황율례 ( Yul-lye Hwang ),임수혁 ( Su-hyuk Yim ),홍동균 ( Dong Kyun Hong ),최종원 ( Chong Won Choi ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),신정민 ( Jung Min Shin ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.4
Background: Female-pattern hair loss (FPHL) is a common hair loss disorder in women. The various treatments include topical minoxidil and 17α-estradiol, as well as oral anti-androgens. However, the clinical efficacy of 5α -reductase inhibitors remains controversial. Objective: We evaluated the clinical utility of dutasteride in FPHL patients and how dutasteride promotes hair growth. Methods: We evaluated hair follicle density and thickness before and after oral dutasteride treatment in 24 patients with FPHL. We measured β-catenin activity in primary cultures of human dermal papilla cells (DPCs) using the TOP Flash reporter assay and Western blotting. The expression levels of genes promoting hair growth were quantitatively assessed using quantitative polymerase chain reaction (Q-PCR). Results: The mean vertex hair density increased significantly from 67±14 to 76±13/cm<sup>2</sup> (p=0.001) and the mean occipital hair density increased from 89±11 to 94±13/cm<sup>2</sup> (p=0.012) after dutasteride treatment. However, the mean hair thickness did not increase. When DPCs were treated with dutasteride, TOP Flash activity increased in a dose-dependent manner, and the protein level of non-phosphorylated (active) β-catenin also increased. The mRNA level of vascular endothelial growth factor increased, but the mRNA levels of the keratinocyte growth factor, insulin growth factor-1, and Noggin were not affected by dutasteride. Conclusion: This study shows a novel mechanism of dutasteride in promoting hair growth and provides support for the possible clinical application of 5α-reductase inhibitors for the treatment of FPHL. (Korean J Dermatol 2020;58(4):231∼238)
595 nm Pulsed Dye Laser로 치료한 조갑 건선
장인규 ( In Kyu Chang ),김수정 ( Sue Jeong Kim ),이영 ( Young Lee ),김창덕 ( Chang Deok Kim ),서영준 ( Young Joon Seo ),이증훈 ( Jeung Hoon Lee ),임명 ( Myung Im ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.3
Nail psoriasis is a common finding in psoriatic patients and is associated with substantial adverse effects on the patient`s quality of life. Although several treatment options are available, nail psoriasis tends to be persistent and refractory to therapy. Pulse dye laser (PDL) has been demonstrated to be effective for plaque-type psoriasis, but there are no reports on nail psoriasis being successfully treated with PDL in the Korean literature. We here report on a 46-year-old woman presenting with nail psoriasis recalcitrant to conventional treatment modalities, showing pitting, nail bed discoloration, and crumbling. We successfully treated the symptoms with 595 nm PDL, supporting the hypothesis that PDL may be a safe and effective therapeutic option in patients with recalcitrant nail psoriasis. (Korean J Dermatol 2014; 52(3):195∼197)