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폐색성폐질환에서 FEF 50%/FIF 50% 의 진단적 의의
김원동,유지홍,강홍모 대한내과학회 1988 대한내과학회지 Vol.35 No.1
Differential diagnosis of chronic bronchitis and emphysema is clinically not easy and requires expensive tests. It was suggested that expiratory flow is more limited than inspiratory flaw in emphysema because of peripheral airway collapse by loss of elastic recoil. Therefore, it is expected that the FEF50%/FIF50% ratio in emphysema would be lower than that in chronic bronchitis which shows fixed obstruction. If this is true, measurement of the FEF50%/FIF50% ratio would be useful in the differential diagnosis of emphysema and chronic bronchitis. Therefore, we compared the FEF50%/FIF50% ratio that measured by a simple spirometric test in patients with bronchial asthma, chronic bronchitis and pulmonary emphysema and in normal control subjects. The results were as follows; 1) The FEF50%/FIF50% ratios in the three disease groups were significantly lower than that in the control group. 2) The FEF50%/FIF50% ratio in the emphysema group was significantly lower than that in the asthma and chronic bronchitis group (p$lt;0.01, p$lt;0.005), even though there were no significant differences in FEV, (% predicated). This study suggests that measurement of the FEF50%/FIF50% ratio by simple spirometry could be clinically useful in distinguishing a patient with emphysema from one with chronic bronchitis.
The Effect of Pentoxifylline on Radiobiological Parameters in the Rat Radiation Myelopathy
김원동,박우윤 대한암학회 2006 Cancer Research and Treatment Vol.38 No.4
Purpose: There is great recent interest in the potential value of using pentoxifylline (3,7-dimethyl-1(5-oxyhexyl)- xanthine, PTX) as an inhibitor of radiation-induced late normal tissue damage. The effects of PTX on the radiobiological parameters (α/β ratio, repair half time T1/2) of radiation myelopathy were studied in a rat model.Materials and Methods: Anesthetized Sprague-Dawley rats received irradiation to 2 cm of their cervical spines with using a 6MV LINAC (dose rate: 3 Gy/min). Radiation was administered in single, two, four and eight fractions with a fraction interval of 24 h with or without PTX. PTX was added to the rats’ distilled drinking water at a concentration of 2 g/L; the water was consumed ad libitum. After tabulation of the ED50 (the estimated dose needed to produce 50% paralysis in a group of irradiated animals), α/β could be estimated from the ratio of the slope to the intercept of the reciprocal-dose plot. Subsequently, the repair half time T1/2 was obtained from the data of the experimental group that received a pair of 7 Gy fractions on each day, separated by intervals of 4 and 8 h.Results: The α values calculated for RT alone and RT+PTX were almost the same. We noticed that the β value for the RT+PTX was lower than that for RT alone. So, the α/β ratio for the RT+PTX was higher. The T1/2 obtained from monoexponential model was 3.27 and 2.58 h for RT alone and RT+PTX, respectively.Conclusion: PTX increased the α/β ratio and it decreased the T1/2 of radiation myelopathy, suggesting that a decreasing fractionation sensitivity occurred. This implies that PTX, which distinctly acts upon the bending region of the high dose, may be expected to protect the spinal cord with a larger fraction size. (Cancer Res Treat. 2006;38:229-233)