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권혁찬,김기웅,이용호,김진목,임현균,박용기,정남식,고영국,정보영,김진배,조정래,Kwon, H.,Kim, K.,Lee, Y.H.,Kim, J.M.,Lim, H.K.,Park, Y.K.,Chung, N.,Ko, Y.G.,Joung, B.,Kim, J.B.,Cho, J.R. 한국초전도학회 2007 Progress in superconductivity Vol.9 No.1
Myocardial ischemia causes heterogeneity of ventricular repolarization and sometimes produces changes of the ST-T wave in ECG. Therefore, morphological changes of ST-T waveform in ECG have a clinical significance in diagnosing myocardial ischemia. In this study, we investigated the ST-T changes caused by myocardial ischemia in magnetocardiography (MCG). We analyzed MCG patterns of biphasic T, ST segment deviations from baseline, main current angle of $T_{peak}$ and $T_{peak}$ dispersion in 300 CAD patients without ST elevation in ECG, 122 symptomatic patients and 48 normal subjects. MCGs were recorded by multichannel SQUID system in a magnetically shielded room. As results, we found that appearances of the abnormality were strongly correlated with the severity of myocardial ischemia. Also we found that the percentage of the patients showing MCG changes were higher than those in ECG. These results show that morphological changes of ST-T waveform in MCG can be used as a marker of myocardial ischemia.
고압산소챔버 중재가 알코올에 의한 산화적 스트레스 및 숙취 해소에 미치는 영향
권혁찬,박순원,조현정,강지현,이현주,태기식,Kwon, Hyeok Chan,Park, Soon Won,Cho, Hyun Jeong,Kang, Ji Hyun,Lee, Hyun Ju,Tae, Ki Sik 대한의용생체공학회 2018 의공학회지 Vol.39 No.5
The purpose of this study is to evaluate the reliability and effectiveness of hyperbaric oxygen chamber on alcohol-induced oxidative stress and hangover. In order to evaluate them, 20 healthy adults were tested for blood and hangover stress tests. When an exponential change was examined after 3 interventions (hangover drink, hyperbaric oxygen chamber, and normal chamber as placebo effect) of 1 hour, the heart rate of subjects experiencing a hyperbaric oxygen chamber showed a statistically significant decrease (p < 0.001). The tests of blood alcohol concentration (BAC) as for exquisite hematology analysis, glucose, creatinine, and AST (aspartate aminotransferase) as well as ALT (alanine aminotransferase) used as liver-damage indicator show that the hyperbaric chamber has the effective effect. In the test of lactic acid, CRP (c-reactive protein), cortisol, and creatinine, the hyperbaric chamber shows much more excellent effect than the hangover drink and normal chamber as control groups. Further studies on hyperbaric oxygen chamber intervention including this study could be very helpful for improving lives of both the patients and healthy people.
급성 외측 상과염 치료를 위한 휴대용 미세전류자극기 개발 및 효과 검증
권혁찬,이현주,태기식 대한의용생체공학회 2019 의공학회지 Vol.40 No.2
Lateral epicondylitis is caused by repeated use of the wrist, which causes inflammation and pain in the wrist extensor and tendon of the humerus. Delayed onset muscle soreness (DOMS) caused by repetitive resistance exercise affects the tendons connected in series with the muscle, leading to lateral epicondylitis. Although microcurrent stimulation has been suggested as a possible treatment for tendinitis, there are insufficient studies on specific variables such as frequency. In this study, 15 healthy adult males and females developed DOMS in the wrist extensor and tendon in the humerus. The experimental group consisted of a low frequency group applying 20 Hz and a high frequency group applying 100 Hz according to the micro-current frequency. Each subject underwent an experiment for 5 days after DOMS, and the recovery rates were compared by measuring AROM, GPT, MST, PPT, and VAS. As a result, the 20 Hz group showed significant changes in AROM, MST, and VAS compared to the control group on the 4th day, and the recovery rate was also higher than that of the 100 Hz group. On the 5th day, recovery rate of 100 Hz group was higher than 20 Hz in AROM and PPT, and MST showed higher recovery rate than 20 Hz group, but there was no significant difference. These results indicate that microcurrent stimulation is effective for the treatment of delayed myalgia and tendon inflammation and that the 100 Hz group has faster recovery than the 20 Hz group.
자연 월경주기와 Clomiphene Citrate 유도주기를이용한 체외수정 및 배아이식술의 의의
권혁찬,임성호 대한산부인과학회 1993 Obstetrics & Gynecology Science Vol.36 No.4
Ovulation induction with various hormonal agents has become a standard component of in vitro fertilization (IVF) cycles to obtain multiple oocytes. Among the advantages of controlled ovarian hyperstimulation are the increased numbers of oocytes and thus embryos that are available for embryo transfer (ET) and the enhanced cycle control that is achievable, especially with the concurrent use of the gonadotropin-releasing hormone analogues(GnRH-a) However, controlled ovarian hyperstimulation increases the cost of the cycle and is associated with decreased endometrial receptivity. In addition, some patients, including those with regular ovulatory cycles, do not respond to ovarian stimulatory drugs. Recent communications have reported successful pregnancies after IVF in unstimulated cycles and clomiphene citrate stimulation cycle, triggered with or without human chorionic gonadotropin(hCG). In this study, our objections is to describe the clinical experience of our center with in vitro fertilization(IVF) in unstimulated cycles and clomiphene stimulated cycles and to provide a comparison to each other. We report our results in 67 patients, 96 cycles spontaneously ovulatory women with predominatly pelvic and tubal factor as their principal cause of infertility, under the age of 40 and no male factor, and 26 patients, 34 cycles clomiphene citrate stimulated ovulatory women with additional ovulatory factor. In the ninty six spontaneously ovulatory cycles, sixty six follicle aspirated cycles(oocyte retrieval rate ; 68.8%) resulted in nine clinical pregnancies(18.4%)and in the thirty four clomiphene citrate stimulated ovulatory cycles, twenty seven follicles aspirated cycles(oocyte retrieval rate ; 79.4%) resulted in three clinical pregnancies(15.8%). There was no statistically significance in pregnancy rate between two groups.
권혁찬,임도형,최지성,장석빈,박건우,박재석,이순일 대한노인병학회 2014 Annals of geriatric medicine and research Vol.18 No.1
Tuberculous peritonitis is one of the most common extrapulmonary tuberculosis. The presenting signs and symptoms, together with the carbohydrate antigen (CA) 125 status and imaging findings may resemble the primary peritoneal carcinoma or ovarian carcinoma. We herein report a case on a 71-year-old woman who is presented with abdominal distension, abdominal pain, nausea, anorexia. Abdomino-pelvic computed tomography scans reveal large amounts of ascites and mottled omentum with diffuse nodular masses, and the serum CA 125 level is elevated. The initial clinical diagnosis is the primary peritoneal carcinoma, but the final histological diagnosis confirms the tuberculous peritonitis. Thus, we discuss the differential diagnosis of tuberculous peritonitis from primary peritoneal carcinoma and also the problems especially found in old aged patients. In conclusion, although the elderly patients are suspected with malignancy, we should keep in mind the possibility of curable diseases and perform laparoscopic biopsy during the early stage aggressively.