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Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
권오찬,김수현,홍석찬,이창근,유빈,장은주,김용길 대한면역학회 2018 Immune Network Vol.18 No.3
IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation of the functions of IL-32 has mainly focused on its inflammatory properties, such as involvement in the pathogenesis of various autoimmune diseases. Recently, IL-32 was shown to be involved in bone metabolism, in which it promotes the differentiation and activation of OCs and plays a key role in bone resorption in inflammatory conditions. IL-32γ also regulates bone formation in conditions such as ankylosing spondylitis and osteoporosis. In this review, we summarize the results of recent studies on the role of IL-32γ in bone metabolism in inflammatory arthritis.
권오찬,전태주,박민찬 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.9
Purpose: To evaluate whether vascular uptake on 18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT) during the clinically inactive state of Takayasu arteritis (TAK) is associated with disease relapse. Materials and Methods: Patients with TAK who underwent 18F-FDG PET/CT during the clinically inactive state of the disease between2006 and 2019 were included. Clinically inactive disease was defined as a status not fulfilling the National Institutes of Health(NIH) criteria for active disease in TAK. Relapse was defined as recurrence of clinically active disease after a clinically inactive period,requiring change in the treatment regimen. Vascular uptake on 18F-FDG PET/CT was assessed using target/background ratio(TBR), calculated as arterial maximum standardized uptake value (SUV)/mean SUV in venous blood pool. Multivariable Coxregression analysis was performed to identify factors associated with relapse. Results: A total of 33 patients with clinically inactive TAK were included. During a median observation period of 4.5 (0.9–8.1)years, relapse occurred in 9 (27.3%) patients at median 1.3 (0.7–6.9) years. Notably, TBR [1.5 (1.3–1.8) vs. 1.3 (1.1–1.4), p=0.044]was significantly higher in patients who relapsed than in those who did not. On multivariable Cox regression analysis, the presenceof NIH criterion 2 [adjusted hazard ratio (HR): 7.044 (1.424–34.855), p=0.017] and TBR [adjusted HR: 11.533 (1.053–126.282),p=0.045] were significantly associated with an increased risk of relapse. Conclusion: Vascular uptake on 18F-FDG PET/CT and the presence of NIH criterion 2 are associated with future relapse in patientswith clinically inactive TAK.
Enhancement of Cyclic Stability in Secondary Zinc Air Batteries by Selective Ion Transport Separator
권오찬,황호정,이진구,설용건 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Elongating the cycle stability has been the holy grail of all secondary ZAB research. While much of the precedent work has been focused on developing catalysts for the air cathode and indeed, found thirst quenching success, not much attention has been focused on separators and extracting their potential. The control of zincate ions is a major factor in durability. In this aspect, former membranes which are widely used in research is insufficient. The micropores of the commercial membrane allow nonspecific flow of ions, thus results in zincate migration which deteriorates the cathode by ZnO formation or decreases the conductivity of the separator/electrolyte. By applying a coating of PEBIH-PBMA polymer, we eliminate existing pores while conserving the ionic conductivity of the membrane. This allows selective hydroxyl ion transportation and limits the free diffusion of zincate ion by the preferred solubility of hydroxyl ions in the ionic liquid copolymer and the size exclusion effect.
갑상선암 환자에서 RAIT 후 발생한 저나트륨혈증 4례
권오찬,이훈희,오경환,김태용 대한갑상선학회 2016 International Journal of Thyroidology Vol.9 No.1
Radioactive iodine treatment (RAIT) after surgery reduces local recurrence and cancer related death. Cases of hyponatremia after preparation for RAIT have rarely been reported. We report 4 cases of hyponatremia which developed after RAIT. The cause of hyponatremia seemed to be related with over ingestion of free water which is recommended during RAIT. These cases highlighted the importance of weight adjusted water ingestion during RAIT.