저용량 전처치 조혈모세포이식 후 혼합 키메라에서 중간엽줄기세포에 의한 이식편대백혈병 효과의 증진

임지영,김보경,문설경,민창기 대한혈액학회 2008 Blood Research Vol.43 No.4

Background: Mesenchymal stem cells (MSCs) may be useful for reducing graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The GVHD and a graft-versus-leukemia (GVL) effect are inversely related. We therefore wanted to determine whether MSCs can preserve the GVL effect following experimental allo-HSCT. Methods: After non-myeloablative allogeneic hematopoietic stem cell transplantation (NM-HSCT) using C57BL/6 (H-2b)→B6D2F1 (H-2b/d), some mice received donor lymphocyte infusion (DLI) for induction of GVL effects by virtue of complete chimerism (CC), while the other groups did not receive DLI with persistence of mixed chimerism (MC). All mice were inoculated subcutaneously with P815 tumor cells and were intravenously treated with either donor MSCs or diluents. Results: Between the DLI-treated groups with CC, tumor-related deaths and tumor growths were comparable irrespective to the infusion of MSCs. On the contrary, among mice without DLI which showed MC, the administration of MSCs significantly delayed tumor-related deaths compared to those without the administration of MSCs (50-day percent survival, 54.5% vs. 18.1%, P=0.0225). In the MC animals, tumor growth seemed to be more delayed in the mice injected with MSCs than in the controls (P=0.09). Donor MSCs injection was associated with increased donor effector/memory CD62L- T cells in MC but not in CC. Conclusion: In spite of the observed immunosuppressive effects of donor MSCs, our results indicate that the GVL effects were not influenced by the injection of MSCs but that under a given condition such as MC, the injection of donor MSCs could result in enhanced GVL effects. (Korean J Hematol 2008;43:219-231.)

FDDI를 통하여 연결된 이질의 네트워크들에 대한 성능 평가 도구의 개발

임지영 한국시뮬레이션학회 1995 한국시뮬레이션학회 논문지 Vol.4 No.1

Local area networks(LANs) recently become so large that they exceed their architected limits and users on different LANs may need to talk each other. This trend has led to a growth in the practice of interconnecting many heterogeneous LANs. In this paper, we proposed a method to interconnect Ethernets and token rings, which are widely used today, through a fast FDDI network. We also developed a simulation tool to evaluate the performances of the interconnected networks. We used a simulation language SLAM II for modeling and OSF/MOTIF X-window for user interface. The developed tool can be used to make a decision which interconnecting method is suitable for a given environment before interconnecting many heterogeneous LANs.

[#라이프 #키워드] 원도심 재생에 진심인 편_이규영 인천여관X루비살롱 대표

임지영 한국개발연구원 2022 나라경제 Vol.33 No.8

[#라이프 #키워드] 3천 원짜리 김치찌개 레시피는 정성에 마음 한 스푼 : 청년밥상문간 이사장 이문수 신부

임지영 한국개발연구원 2022 나라경제 Vol.33 No.4

시간-동인활동기준원가계산(Time-Driven Activity-Based Costing)을 이용한 일 내과병동 간호단위 원가계산 및 효율성 분석

임지영,김미자,박창기 한국간호과학회 2011 Journal of Korean Academy of Nursing Vol.41 No.4

Purpose: Time-driven activity-based costing was applied to analyze the nursing activity cost and efficiency of a medical unit. Methods: Data were collected at a medical unit of a general hospital. Nursing activities were measured using a nursing activities inventory and classified as 6 domains using Easley-Storfjell Instrument. Descriptive statistics were used to identify general characteristics of the unit, nursing activities and activity time, and stochastic frontier model was adopted to estimate true activity time. Results: The average efficiency of the medical unit using theoretical resource capacity was 77%, however the efficiency using practical resource capacity was 96%. According to these results, the portion of non-added value time was estimated 23% and 4% each. The sums of total nursing activity costs were estimated 109,860,977 won in traditional activity-based costing and 84,427,126 won in time-driven activity-based costing. The difference in the two cost calculating methods was 25,433,851 won. Conclusion: These results indicate that the time-driven activity-based costing provides useful and more realistic information about the efficiency of unit operation compared to traditional activity-based costing. So time-driven activity-based costing is recommended as a performance evaluation framework for nursing departments based on cost management.

[#라이프 #키워드] 세상이 빵처럼 둥글고 달콤하다면 : 임석규 스윗파티시에 대표

임지영 한국개발연구원 2022 나라경제 Vol.33 No.12

[#라이프 #키워드] 나는 채식한다, 고로 존재한다 : 공존을 위한 채식, ‘초식마녀’ 박지혜

임지영 한국개발연구원 2022 나라경제 Vol.33 No.1

인터넷 중독 위험성이 높은 청소년들의 MMPI-A 프로화일

임지영,김명소 한국여성심리학회 2002 한국심리학회지 여성 Vol.7 No.2

Comparison of Benefit Estimation Models in Cost-Benefit Analysis: A Case of Chronic Hypertension Management Programs

임지영,김미자,박창기,Kim, Jung Yun 한국간호과학회 2011 Journal of Korean Academy of Nursing Vol.41 No.6

Purpose: Cost-benefit analysis is one of the most commonly used economic evaluation methods, which helps to inform the economic value of a program to decision makers. However, the selection of a correct benefit estimation method remains critical for accurate cost-benefit analysis. This paper compared benefit estimations among three different benefit estimation models. Methods: Data from community-based chronic hypertension management programs in a city in South Korea were used. Three different benefit estimation methods were compared. The first was a standard deterministic estimation model; second, a repeated-measures deterministic estimation model; and third, a transitional probability estimation model. Results: The estimated net benefit of the three different methods were $1,273.01, $-3,749.42, and $-5,122.55 respectively. Conclusion: The transitional probability estimation model showed the most correct and realistic benefit estimation, as it traced possible paths of changing status between time points and it accounted for both positive and negative benefits

취학전 다문화가정 아동의 단어 의미구조화 특성

임지영,황민아,최경순 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.7

he purpose of the present study was to investigate the characteristics of lexical semantic organization in preschoolers with multicultural background. Fourteen multicultural children and fourteen non-multicultural children who matched both chronological age and language age, total 28 children participated in this study. All Participants’s chronological ages were 4-5, and had normal range IQ. For experiment task, we made contrast questions tasks for 30 words (5 fruits word, 5 vegetables words, 5 clothes words, 5 vehicle words, 5 animal words, and 5 furniture words). All participants were asked to respond to 120 contrast questions consisting of 4 types of semantic categories: functional, physical, local, and categorical. The results of this study are as follows. (1)Multicultrual children performed significantly lower than non-multicultural children. (2) Both groups showed higher performance in order of physical, functional, local and categorical semantic category. The results were discussed in terms of that preschoolers with multicultural background have less word knowledge despite of normal language age. 본 연구의 목적은 취학전 다문화가정 아동의 어휘발달의 질적 측면인 단어의미구조화 특성을 대조질문과제를 이용하여 살펴보고자 함에 있었다. 연구의 대상은 정상범주 지능을 가진 생활연령 4-5세 다문화가정 아동 14명과 생활연령과 언어연령 및 지능을 모두 일치시킨 일반가정 아동 14명 총 28명이었다. 다문화 가정은 모가 아시아권 출신으로 고졸이상 학력의 국내 거주는 6년 이상으로 선정하였다. 단어의미구조화 과제로서 과일, 채소, 의류, 탈것, 동물, 가구 범주당 6개씩 총 30개 단어에 대하여 4가지 의미 속성(기능적, 물리적, 장소적, 범주적)에 따른 대조질문과제를 제작하였다. 실험자는 120개 대조질문(단어별 각 4가지 의미 속성)을 모든 아동에게 들려주고 각 의미유형에 따른 대조 질문에 대하여 수정하여 대답하도록 요구하였다. 다문화가정 아동은 4가지 의미 속성 모두에서 일반아동과 비교하여 유의미하게 저조한 수행을 보였다. 다문화가정 아동들은 비록 정상범위의 언어연령에 있다 할지라도 단어 의미구조화에서 또래 일반가정 아동들과 비교하여 저조한 특성을 보여 어휘의 질적 측면 발달에 어려움이 보이고 있음을 확인하였다. 그러나 의미 속성 유형별 발달양상은 또래 일반가정 아동과 유사한 패턴을 보이고 있었다. 본 연구의 결과를 토대로 연구의 제한점 및 후속연구에 대한 제언을 하였다.