姙娠前期人工中絶時에 前處 置로서 小 Bougie 揷入의 意義

具妊會 大韓産婦人科學會 1960 大韓産婦人科學會雜誌 Vol.3 No.1

數種 Steroid Hormone 投與에 對한 家兎心臟의 病理組織學的 變化에 對한 觀察

具姙會 首都醫科大學 1965 수도 의대 잡지 Vol.2 No.1

Steroid Hormone의 長期投與가 去勢家兎의 子宮 및 골격근에 미치는 影響에 關한 實驗的硏究

具姙會 首都醫科大學 1965 수도 의대 잡지 Vol.2 No.1

Steroid Hormone의 長期投與가 去勢家兎의 子宮 및 골격근에 미치는 影響에 關한 實驗的硏究

具姙會 고려대학교 의과대학 1965 고려대 의대 잡지 Vol.2 No.1

The results of the histopathological observation of uterus and skeletal muscular tissue of castrated female (virgin) rabbits with massive, long-term administration of steroid hormones such as estrogen, testosterone and cortisone are summarized as follows. 1. In the castrated group treated with estrogen, the uterine tissue which was generally atrophied by the castration recovered to almost normal or showed rather partial adenomatous proliferation. The skeletal muscie showed mild degenerative changes superimposed by the slight atrophy. 2. Contrary to the finding of noncastrating, testosterone treated group, in which atrophy of endometrial glands and uterine muscles was observed, mild proliferation of endometrial glands and slight atrophy and degeneration of skeletal muscle were seen in castrated particularly 90 days testosterone administered group. 3. The endometrial glands and the uterine muscle fiber showed prominent atrophy in the castrated group treated with cortisone, and in the skeletal muscle degenerative changes, round-cell infiltration and proliferation of connective tissues were evident. 4. The P.A.S. positive substance was increased or decreased in accordance with proliferative or atrophic changes of uterine glands induced by steroid hormones and it is increased in the area where the pathological changes in the skeletal muscle were produced. 5. Slight proliferative changes of endometrial glands were observed by massive, long-term administration of testosterone to the castrated female rabbits while the atrophic change appeared in the noncastrated testosterone treated group.

數種 Steroid Hormone 投與에 對한 家兎心臟의 病理組織學的 變化에 對한 觀察

具姙會 고려대학교 의과대학 1965 고려대 의대 잡지 Vol.2 No.1

Extensive experiment has been reported on the physiologica1 and biochemical changes of muscular tissue under the disorder of various endocrine organs. Recently, Goldstein reported histochemical changes of human myocardial tissue affected by hormonal dysfunction. Present study has been undertaken to investigate histopathological changes of myocardial tissues in castrated female rabbits induced by prolonged administration of steroid hormones, i.e. estrogen, testosterone and cortisone. The results are summarized as follows: 1) Myocardial degeneration and interstitial connective tissue proliferation had been observed in normal and castrated groups following 45 days of estrogen, testosterone and cortisone administration, and the changes appeared more prominent in the rabbits of 90 days administration. 2) The histopathological changes of the myocardial tissue were relatively mild in the rabbits of testosterone administration, both in control and castrated groups and proliferative changes of connective tissue were relatively mild in cortisone administrated group in comparison with other groups.

임신전기인공중절시에 전처치로서 소 Bougie 삽입의 의미

구임회(IH Koo) 대한산부인과학회 1960 Obstetrics & Gynecology Science Vol.3 No.1

저자는 과거 3년간에서 임신전기환자 110예, 경임부 100예, 초임부 10예, 임신 2~3개월 105예, 임신4개월 5예에 대하여 의학적 인공중절적응증 하에 술전 24시간~48시간전에 소 Bougie(장 7~8cm 직경 0.8cm) 를 삽입하고 quinine 0.2gm씩 2~3시간 간격으로 내복시킨 후에 자궁내용물제거술을 시행하여 다음과 같은 결과를 얻었다. 1. Bougie 삽입후상황 a) 하복통이 있는 예는 8%, 결여한 예는 92% b) 출혈은 11예중 2예에 소량 c) 발열 기타 증상은 없다. 2. 수술시의 상황 a) 마취가 필요한 예수는 86.4%이나 마취제 소량사용으로 가능하다. 잔 13.6%는 무마취로 시행하였다. b) 자궁경관확대가 전예에서 용이하다. c) 술중 출혈에 대하여서는 중등량출혈이 3예, 즉 2.7%이다. 3. 수술후상태 a) 출혈은 술후 소량이 있으나 1주일이내에 완전지혈하였다. b) 재소파술율은 110예중 1예(0.9%)이다. 소 Bougie 삽입전처치 없는 종래의 자궁내용제거술의 결점은 자궁경관확장곤란출혈이 비교적 다량 태아부속물이 잔유하여 재소파가 비교적 다수 자궁경관열상 자궁천공의 위험성등이다. 그러나 소 Bougie 삽입전처치법은 이상의 성적으로서 이러한 결점을 제거할 수 있다. 즉 이 관계를 표시하면 During the past three years the author applied insertion of a short bougie (length 7~8cm, diameter 0.8cm) for 24 to 48 hours before evacuation of uterine content on 110 cases of early pregnant patients who were medically indicated for interruption of the pregnancy (multigravida 100, primigravida 10 cases, .....2-3 months of gestation 105, 4 months of gestation 5 cases). 0.2 Gm of Quinine, every 2-3 hours by mouth was given following bougination and removal of uterine content was performed thereafter. The result is as follows: 1) Condition of patients after insertion of bougie. a. 8% of patients had lower abdominal pain, no pain in 92% of patients. b. Two cases showed slight bleeding in 110 cases. c. No fever or other symotom was noted. 2) Condition during operation. a. 86.4% required a small doses of anesthesia, 13.6% received no anesthesia. b. Dilatation of the cervix was easy in all cases. c. Three cases showed moderate bleeding during the procedure, 2.7% 3) Condition after operation a. there was slight bleeding after operation, which stopped within week. b. Only one case of 110 patients required recurettage (0.9%). The conventional method for evacuation of the uterine content tends to have difficulty in dilatation of the cervix, relatively heavy bleeding, requirement of recurettage due to retained secondine, cervical laceration, perforation, perforation of the uterus ...But the preparation by short bougie insertion may avoid above risks. This relation is summerized in following table.

Confidence Intervals for Artificial Neural Networks with Incremental Learning

Kil, Rhee Man,Koo, Imhoi 한국뇌학회 2002 한국뇌학회지 Vol.2 No.1

본 논문은 점진적 학습을 이용한 실가함수의 회귀에 대하여 일반화 오차와 실험 오차의 차이에 대한 절대값으로 정의된 신뢰구간의 새로운 한계를 제시하였다. 이러한 신뢰구간의 이론적 한계는 확률근사학습을 토대로 전개가 가능하다. 그러나 여기서 유도된 신뢰구간의 이론적 한계는 너무 과잉 추정되며 실험적 자료와 잘 부합하지 않는다. 이러한 배경으로 주어진 자료에 대하여 점진적 학습을 적용하는 학습기계의 신뢰구간에 보다 잘 부합하는 새로운 한계를 제시한다. This paper suggests a new bound of estimating the confidence interval defined by the absolute value of difference between the true (or general) and empirical risks for the regression of real-valued functions using incremental learning algorithms. The theoretical bounds of confidence intervals can be derived in the sense of probably approximately correct (PAC) learning. However, these theoretical bounds are too overestimated and not well fitted to the empirical data. In this sense, a new bound of the confidence interval which can explain the behavior of learning machines using incremental learning more faithfully to the given samples, is suggested.

판정불능을 포함한 안면 체질 분류 방법에 관한 연구

도준형,김성훈,구임회,김근호,김종열,Do, Jun-Hyeong,Kim, Sung-Hun,Koo, Im-Hoi,Kim, Keun-Ho,Kim, Jong-Yeol 사상체질의학회 2009 사상체질의학회지 Vol.21 No.3

1. Objectives: In order to classify an individual into four constitution type, an oriental medical doctor utilizes various information such as face, pulse, voice, and questionnaire. When only one type of information is used, one's constitution may not be decided correctly. 2. Methods: In this paper, we propose a novel four constitution types classifier using facial images which classifies subjects into indecision group as well as Taeumin, Soeumin, and Soyangin. 3. Results: Experimental results show that it increases the classification rate though the decision rate is rather decreased, which is more effective and reliable than conventional classifiers without indecision. 4. Conclusion: For the effective classification, we have found that it is more useful to add an indecision group which requires more information to be properly classified into one constitution type.

사상체질별 Short Tandem Repeat 대립유전자 빈도

박화용,유현주,구임회,김종열,Park, Hwa-Yong,Yu, Hyun-Joo,Ku, Im-Hoi,Kim, Jong-Yeol 사상체질의학회 2009 사상체질의학회지 Vol.21 No.1

1. Objectives As a basic trial for identification of Sasang constitutional gene marker, we genotyped and analysed statistical relationships of STR(short tandem repeat) alleles and its distribution in each constitution. 2. Methods After obtaining basic constitutional data with questionnaire (QSCC II), decision of constitution was made by 3 different constitution specialists' diagnosis, and only the samples of specialists' agreement of each constitution by discussion were taken into this research. Using multiplex PCR kit, total 146 constitutional samples were amplified in 16 autosomal STR marker, genotyped, and analysed statistically. Among 16 markers, 15 were analysed in this study excluding the amelogenin marker is used for in gender identification. 3. Results and Conclusions It is difficult to determine the relationship between constitution and STR marker as the sample size is small, however, Penta D and vWA were shown to be related statistically with constitution. It has been know that STRs has no genetic informations, however there are some recent research results showing STRs as a regulatory element, relationship between microsatellite instability and repeat number and size, and post-transcriptional sigualing. STRs which is not known about its function currently, are proposed to have function and/or regulatory activities anyhow with Sasang constitution. It is believed that the results of this study can halp determine and deatify the markers related to Sasang Constitutional Medicien.

사상체질 의사결정시스템 구축을 위한 체질 진단 자료를 이용한 예비연구

진희정(Jin Heejeong),문진석(Moon Jinseok),고성호(Go Seongho),구임회(Ku Imhoi),이시우(Lee Siwoo),이도헌(Lee Doheon),송미영(Song Miyoung),김종열(Kim Jongyeol) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.2

The need for the study of the revealing Sasang constitution at scientific term is increasing as the application of this discipline to the patient produces more accurate result. To obtain scientific evidence of Sasang constitution, it is crucial to analyze accumulated clinical information and associate them to the biological indices that may classify Sasang constitution. Thus, the analysis of clinical information is the most important stepping stone to go toward to the stage of developing model and decision support system (DSS) for classifying Sasang constitution. This study is a preliminary analysis of 1,109 samples collected with 171 clinical indices. To find meaningful clinical indices for classifying Sasang constitutional medicine, we applied decision tree model for them. The skin of 66.5% within whole Taeeumin is thick and non feeble. In the case of 69.8% within whole Soyangin, the skin is non feeble and slippery. In the case of 64.4% within whole Soeumin, they have feeble skin. Therefore, the property of skin can be suggested to be more important than any other index for the classification of Sasang constitution.