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한국인 주의력결핍 과잉행동장애와 세로토닌 1B 수용체 유전자 다형성의 관련성:가족기반 연구 및 환자-대조군 연구
박태원,김붕년,임명호,유희정,강대희,정영철,Park, Tae Won,Kim, Boong Nyun,Im, Myung-Ho,Yoo, Hee Jeong,Kang, Daehee,Chung, Young-Chul 대한생물정신의학회 2004 생물정신의학 Vol.11 No.2
Objective:Attention deficit hyperactivity disorder(ADHD) is the most common childhood psychiatric disorder, affecting 3-5% of school-aged children. Although the biological basis of ADHD is unknown, family studies provide strong evidence that ADHD has a genetic basis. Recent genetic studies have suggested associations between ADHD and serotonin 1B(5HT1B) receptor gene G861C polymorphism. The aim of this study is to test for the association between ADHD and 5HT1B receptor gene G861C polymorphism in Korean population. Method:We processed DNA extraction and genotyping. 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test(TDT) and haplotype-based haplotype relative risk (HHRR). And the ADHD children were compared with 212 age and gender matched normal controls. Results:There was no statistical difference of distributions between ADHD cases and controls. We did not observe any preferential transmission of alleles of 5HT1B receptor gene G861C polymorphism in ADHD. Conclusions:Though there is the possibility of failing to detect small genetic effects, our results show no evidence of an association between ADHD and 5HT1B receptor gene G861C polymorphism in the Korean population and indicate that it is unlikely that the 5HT1B receptor is implicated in the susceptibility to ADHD.
열분석법에 의한 Cu 를 함유한 HSLA 강의 시효 거동에 관한 연구
박태원,김영우,심인옥,강창윤 대한금속재료학회(대한금속학회) 1995 대한금속·재료학회지 Vol.33 No.1
The aging behavior of Cu-bearing HSLA steels was studied by using differential scanning calorimetry (DSC), transmission electron microscopy and hardness tester. Two heat evolution peaks were observed during DSC scans over the temperature range of 25∼590℃ at a heating rate of 5℃/min. The peaks appeared in low(241∼319℃ : HSLA-A, 224∼310℃ : HSLA-B) and high temperature (514℃∼ 590℃ : HSLA-A, 451∼558℃ : HSLA-B) are attributed to the formation of coherent Cu-clusters and noncoherent ε-Cu phase, respectively. And at a rapid heating rate over 7.5℃/min, another peak between these two peaks was observed in the temperature range of 300∼370℃. This peak is conjectured to be due to the formation of 9R martensite structures proposed by Othen et al. It will be necessary further research to identify this peak clearly. It was confirmed that as aging proceeds, the coherent bcc Cu-clusters transform to noncoherent fcc ε-Cu phase. In the case of the aging to peak hardness at 300℃ and 400℃, the coherent Cu-clusters contributed to the hardening. As aging time and temperature increase over peak hardness, noncoherent ε-Cu are formed and hardness decreases. The activation energy due to the formation of coherent bcc Cu-clusters in HSLA-B steel is 55㎉/mole. And those due to the formation of nonchorent ε-Cu phase in HSLA-A and HSLA-B steels are 59㎉/mole and 51㎉/mole, respectively. These are similiar to the activation energy(58㎉/mole) for the solute diffusion of Cu in α-Fe.