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후두 편평세포암종에서 Galectin-1 및 -7의 발현 의의
김건형,강차영,윤혁수,도남용,조성일,임성철 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Background and Objectives: The role of different Galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of Galectin-1 and -7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Methods: Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007, were immunohistochemically stained for Galectin-1 and -7. Results: Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion: Expression of Galectin-1 and -7 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.
임종현,윤일규,도재원,배학근,이경석,이인수 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.3
We analysed a series of 35 patients with primary cerebellar hemorrhage, diagnosed by computerized tomography scanning from 1985 to 1988. They constituted 6.6% of spontaneous intracerebral hemorrhages (35 out of 530) who were admitted during the same period. There were 13 men and 22 women. The site of hemorrhage was vermis in 15 patients and hemisphere in 20 patients. On admission, the Glasgow Coma Scale(GCS) value was less than 10 in 15 patients(42.3%) and not less than 10 in 20 patients(57.1%). Quadrigerminal cistern was normal in 11 patients(31.4%), partially obliterated in 15 patients(42.9%), and completely obliterated in 9 patients(25.7%). The largest diameter of the hematoma was less than 3cm in 15 patients(42.9%) and larger than 3cm in 20 patients( 57.2%). Hydrocephalic change was observed in 21 patients( 60%). The hematoma was removed via suboccipital craniectomy in 16 patients(45.7%) and managed conservatively in II patients(31.4%). In 8 patients(22.9%), external ventricular drainage was performed. The method of treatment was different according to the GCS value on admission, the status of the quadrigeminal cistern, the presence of hydrocephalic change, and the size of hematoma. Overall mortality rate was 22.9%. These results suggested that the conservative treatment can be done in patients with (1) high GCS value(not less than 10), (2) patent quadrigeminal cistern, (3) absent hydrocephalic change, and (4) small sized hematoma(less than 3cm). If not, surgical treatment should be considered.
Lim, Sung Mook,Jang, Sung Hwan,Oh, Se Heang,Yuk, Soon Hong,Im, Gun Il,Lee, Jin Ho WILEY-VCH Verlag 2010 Advanced Engineering Materials Vol. No.
<P>Polycaprolactone/Pluronic F127 porous scaffolds are prepared using a modified melt-molding particulate-leaching method. The scaffolds are highly porous (about 90% porosity) and have open-cellular pore structures. Growth factors (TGF-β<SUB>2</SUB>, BMP-7 or dual TGF-β<SUB>2</SUB>/BMP-7) can be easily immobilized on the pore surfaces of the PCL/F127 scaffolds via binding with heparin. The growth-factor-immobilized scaffolds can induce the chondrogenesis of ATMSCs seeded onto them. Using TGF-β<SUB>2</SUB> and BMP-7 growth factors together leads to a better chondrogenic differentiation behavior than using single-growth-factor immobilized scaffolds.</P> <B>Graphic Abstract</B> <P>Dual-growth-factor (TGF-β<SUB>2</SUB>/BMP-7)-immobilized PCL/Pluronic F127 porous scaffolds were fabricated using a modified melt-molding particulate-leaching method followed with the binding of heparin and growth factors onto the pore surfaces of the scaffolds. From the in vitro chondrogenesis study, it was observed that the dual TGF-β<SUB>2</SUB>/BMP-7-immobilized scaffold induced better chondrogenic differentiation than the single-growth-factor-immobilized scaffolds or control scaffold (without growth factor), probably owing to the synergistic effect of both growth factors. <img src='wiley_img/14381656-2010-12-1-2-ADEM200980153-content.gif' alt='wiley_img/14381656-2010-12-1-2-ADEM200980153-content'> </P>
Risk Factors for Renal Impairment at One-Year after Liver Transplantation
( Hae Lim Lee ),( Jung Hyun Kwon ),( Sun Hong Yoo ),( Sung Won Lee ),( Soon Woo Nam ),( Jong Youl Lee ),( Young Chul Yoon ),( Jun Suh Lee ),( Gun Hyung Na ),( Il Young Park ),( Jeong Won Jang ),( Jong 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Renal dysfunction before and after liver transplantation (LT) is common and may progress to chronic kidney disease which significantly affects post-LT mortality. The aims: of the study were to identify serial changes in estimated glomerular filtration rate (eGFR) in the first year after LT and to determine peri-LT risk factors for the development of renal impairment at one year after LT. Methods: A total of 96 consecutive patients who underwent LT at two tertiary centers between 2013 and 2017 were enrolled, and 62 patients who fully followed over one year after LT were finally analyzed. Renal function was measured by eGFR. Results: Forty-two (67.7%) patients underwent deceased donor LT and 26 (41.9%) patients had hepatocellular carcinoma at baseline. Sixteen patients (25.8%) had episodes of acute kidney injury (AKI) within a month before LT and 12 patients (19.4%) received de-novo renal replacement therapy (RRT) within a month before and after LT. The proportion of patients who had eGFR< 60 ml/min/1.73㎡ was 40.3% at baseline and decreased to 27.4% at 1 month after LT. However, it increased gradually to 37.1% at one year after LT. Three patients eventually started maintenance RRT during follow-up period. MELD score >30, eGFR <60 ml/min/1.73㎡ and ascites at baseline, de-novo RRT within a month before and after LT and large blood loss during operation were significantly associated with renal impairment (eGFR<60 ml/min/1.73m) at one year after LT. Among them, eGFR <60 ml/min/1.73㎡ at baseline remained an independent factor on multivariate analysis. DM, HBP and AKI episodes at pre-LT did not affect the development of renal impairment at one year after LT. Conclusions: The mean eGFR of LT recipients was improved shortly after LT, though it gradually decreased with time. Baseline eGFR <60 ml/min/1.73㎡ was the strongest factor for renal impairment at one year after LT. Personalized care considering eGFR in LT recipients may improve post-transplant outcomes.