발효 황기 추출물의 항산화, 항염, 콜라게나아제 및 엘라스타아제 활성 저해 효과

박지현(Ji Hyeon Park),신재영(Jae Young Shin),허지환(Ji Hwan Heo),김상준(Sang Jun Kim),강은서(Sang Jun Kim),정세연(Se Yeon Jeong),김태준(ae Joon Kim),장선일(Seon Il Jang),조병옥(Byoung Ok Cho) 한국식품과학회 2024 한국식품과학회지 Vol.56 No.3

본 연구는 발효 황기 추출물이 발효 전 황기 추출물 보다 항산화, 항염, 콜라게나아제 및 엘라스테아제 억제 효과가 뛰어난지 평가하고자 하였다. FAE의 총 폴리페놀 및 플라보노이드 함량이 AE보다 높은 것으로 나타났으며, DPPH, ABTS 및 환원력 측정에서 FAE에서 AE보다 높은 항산화 활성을 보였다. HaCaT 세포에 SIN-1을 처리하여 효소 활성을 측정하였을 때 FAE 추출물의 처리는 감소된 SOD, catalase, GPx 활성을 AE보다 증가시키는 것을 확인하였다. 또한 LPS로 자극된 RAW264.7 세포에서 증가된NO, PGE2 및 IL-6의 발현을 AE보다 FAE에서 더 억제하는 것을 확인하였다. 또한, collagenase와 elastase의 억제활성이 AE보다 FAE에서 우수하였다. 종합하자면, FAE는 AE보다 항산화, 항염, 콜라게나아제 및 엘라스타아제 억제 효능이 있는 천연기능성 소재 및 건강기능식품 등의 소재로 활용될 수 있을 것이라 사료된다. We aimed to evaluate the antioxidant, anti-inflammatory, anti-collagenase, and anti-elastase effects of fermented and non-fermented Astragalus membranaceus extracts (FAE and AE). The total polyphenol and flavonoid contents of FAE were higher than those of AE. DPPH, ABTS, and reducing power assays confirmed that the radical scavenging efficacy and reducing power of FAE were higher than those of AE. In SIN-1-stimulated HaCaT cells, reduced superoxide dismutase, catalase, and glutathione peroxidase activity levels were rescued in the FAE group but not in the AE group. FAE also suppressed increases in NO, PGE2, and IL-6 levels more potently than AE in LPS-stimulated RAW264.7 cells. FAE also exhibited more potent collagenase and elastase inhibitory activities than AE. In summary, this study suggests that FAE can be used in functional foods and cosmetics with antioxidant, anti-inflammatory, anti-collagenase, and anti-elastase properties.

The Clinical Characteristics of Angioedema with Eosinophilia

( Hyo Jung Cho ),( Hye Soo Yoo ),( Mi Ae Kim ),( Yoo Seob Shin ),( Young Min Ye ),( Dong Ho Nahm ),( Joo Hee Kim ),( Jeong Hee Choi ),( Sun Young Park ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1

Angioedema with eosinophilia (AE) is a very rare allergy disease, case reports of which have been published sporadically since 1984. Here, we retrospectively analyzed the clinical features of 10 AE patients in Korea. Nine of the 10 subjects were young females, ranging from 23 to 38 years old. Twenty percent of the subjects had episodic-type AE with high serum IgM and eosinophil counts, while 80% were non-episodic type with normal serum IgM levels but high eosinophil counts. All patients had used systemic corticosteroids to control AE. One patient with refractory EAE was treated with anti-IgE antibody. This is the first study to evaluate the clinical characteristics of AE in a Korean population.

항암화학요법 관련 오심과 구토 완화를 위한 비약물요법에 관한 연구동향

소향숙,최자윤,조인숙,김영재,김지영,김애숙,김옥미,김춘심,김현오,설영애,안정옥,이애리,이영자 성인간호학회 2003 성인간호학회지 Vol.15 No.3

Purpose: Purposes of this study were to understand the current trends on complementary therapy in relieving chemotherapy-induced nausea and vomiting and to suggest the future research direction. Method: Subjects were selected on CINAHL, MEDLINE, Korean Academy Data Base from 1980 to 2001 which used nausea, vomiting, chemotherapy and complementary therapy as key words in experimental studies. Eight korean articles and twenty-one international articles were analyzed in terms of general characteristics, research methods, and types of complementary therapy. Data were analyzed by using descriptive statistical methods. Result: Since 2000, researchers have more actively used complementary therapy. In subject characteristics, mean age was 35.5 years old, 45% of the researchers were performed with high level of incidence of chemotherapy induced vomiting, 14% of them set limit of consecutive cycle during research, and 65% of them did not comment the selecting criteria of sample. About 60% of them were designed post-test only control group: 35% used INV by Rhodes, 31% used Likert scale, and 24% used VAS for dependent variable. Muscle relaxation therapy was mostly applied for relief of nausea and vomiting. Conclusion: Further studies will be needed to control extrinsic variables affecting nausea and vomiting in research design and to accumulate evidence with studies applying various complementary therapies.

공업계 고등학교에서 과제학습요소가 수학성취도에 미치는 영향

조영애,정권수 順天大學校 師範大學 附屬 科學敎育硏究所 1999 科學과 敎育 Vol.7 No.-

This research used a case learning factor has effect on improving the attitude to mathematics and raising achievement degree in mathematics in technical high schools, making an object of the first grade students of technical high schools, The results are as follows: First, the task learning factor improved the attitude to mathematics affirmatively and made the students recognize the usefulness of mathematics by showing various things which can happen daily. Also the study showed that the number of students who tried to do homework for themselves instead of depending on other's help was increasing. Second, it showed that the task learning factor was effective in improving achievement degree of mathematics.

뇌경막내에 위치한 수막성 골종 증례보고

조영도,조준,문창택,장상근,윤상애 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

This case report deals with a 75-year-old female. The patient was admitted for headache due to passenger traffic accident. Plain radiographs of the skull showed the finding of dense calcified lesion in the right parietal bone. In the Brain CT scan, this lesion showed uniformly hyperdense and non-enhancing mass. The clinical examination showed no gross abnormalities. In the operation field, this lesion attached to the inner surface of the dura by the dense fibrous band and protruded into the cerebral cortex. One fragment was about 1cm×1.4cm×1.6cm and the other about 3mm×2mm×3mm. Histologic examination of the surgical specimen(H/E stain) showed a benign osteoma.

자색고구마가 사염화탄소 투여에 의한 흰쥐의 간손상 보호에 미치는 영향

조영자,김현아,방미애,오용비,정병춘,문윤호,정우진 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.3

The purpose of this study was to investigate the effects of dietary purple sweet potato(lpomoea batatas) powder on serum lipid levels and antioxidative enzymes in normal and pretective effect on hepatotoxicity rats induced by carbon tetrachlolide. Four groups of rats (3-week-old inbred Sprague-Dawley male rats) were normal rats fed control diet(C)_(1) induced hepatotoxicity rats fed control diet(EC)_(1) normal rats fed purple sweet potato diet(P), and induced hepatotoxicity rats fed purple potato sweet diet(EP). Rats were induced by single injection of 50% carbon tetrachloide(0.1 mL/100 g B.W., i.p.). The rats were fed ad libitum each of the experimental diet for 5 weeks. After 5 weeks the rats were sacrificed and activities of antioxidant enzymes and lipid peroxidation products were determined in their liver homogenates. But serum concentrations of lipid was not significant in all groups. Serum alanine aminotransferase(ALT/GPT) and aspartate aminotransferase(ALT/GPT)of the EC and EP groups were heigher than the C and P groups. The hepatic glucose 6-phosphatase(G9Pase) activity of the group fed purple potato diet(P) was lower than the other groups(p<0.05). However, The glutathione peroxidase(GPx) activities was not statistically different between the groups. Renal glutathione S-transferase(GST) activity of the EC and EP groups were lower than the C and P groups(p<0.05). In conclusion, these results suggest that purple sweet potato is believed to be possible protective effect on hepatotoxicity rats induced by carbon tetrachlolide.

식이 중 인동초를 섭취한 당뇨유발 흰쥐의 혈당 및 지질대사

조영자,김현아,방미애 목포대학교 생활과학연구소 2000 생활과학논집 Vol.3 No.-

The purpose of this study was to invesgate the effect of L. japonica tumbo(P) on blood glucose level and lipid metabolism in streptozotocin(STZ) induced diabetic rats. Male Sprague-Dawley rats weighing(180~200g)were divided into four groups: control(C), STZ-control(CD), and two experimental groups(P and PD). Diabetes mellitus were induced by single injection of the streptozotocin at tue dose of 60mg/kg B.W. The experimental groups were fed a AIN-76 recomendation diet mixed with the P powder(5%/kg diet). The diet and water were intake determined everyday. The blood glucose level was determined everyweek, and the serum cholesterol was determined every two weeks. After 5 weeks, the rats sacrificed and the blood glucose, serum cholesterol. triglyceride, HDL-cholesterol concentrations were determined. LDL-cholesterol concentrations was calculated by eqation. Diabetic rats showed the lower weight gain compared to the normal rats. The serum glucose level of PD was not lower than C group. However, the serum cholesterol, triglyceride and HDL-cholesterol level of CDI and PD group were heigher than C group. Diabetic rats showed that the hepartic glutathione reductase(GR) was sighificantly heigher than C group, but malondialdehyde level was significantly decreased. P supplymentation was reduced the hepartic malondialdehyde(MDA) level. The glutathione reductase(GR) and HDL-cholestrol level were increased in the diabetic experimental groups compared C group. In comculusion, showing the possibility of preventive and therpeutic use of the wild edible plant(Indong- Cho) to the diabetes mellitus.

[P8-170] Isolation and Chracterization of Visceral Excitatory Neuropeptides from Clody Dogfish (Scyliorhinus torazame) Brain

Young-Sook Cho1,Jung-ae Kim,Se-Kwon Kim 한국식품영양과학회 2007 한국식품영양과학회 학술대회발표집 Vol.2007 No.10

다시마 분말이 당뇨 유발쥐의 혈당과 지질농도 및 항산화 효소계에 미치는 영향

조영자,방미애 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.4

The purpose of this study was to investigate the effect of dietary sea tangle in diabetic rats treated with streptozotocin(STZ). Four groups of rats (Sprague-Dawley male rats, 180-200g) were normal rats fed control diet(C), diabetic rats fed control diet(CD), normal rats fed sea tangl diet(T), and diabetic rats fed sea tangle diet(TD). Diabetes was induced by single injection of streptozotocin(60㎎/㎏ B.W.). High density lipoprotein(HDL) of T and TD group were higher than other groups(C and T groups). And the weekly change of blood sugar was decreased in the 3th and 4th weeks. But serum triglyceride (TG) of diabetic rats fed sea tangle diet(TD) was lower than diabetic rats fed control diet(CD). Activity of hepatic microsomal Glucose 6-phosphatase(G6Pase) was significantly increased CD and TD groups higher than C and T groups. Hepateic glutathione S-transferase(GST) of T, CD and TD groups were significantly lower than C group(p〈0.05), glutathione peroxidase (GPX) of T and TD groups were significantly higher than C and CD groups(p〈0.05).

중소기업조세지원 제도의 개선에 관한연구

曺廷煥,權英愛 경북대학교 1992 논문집 Vol.24 No.-

There are several assistance policies for the small and medium industries like financial, monetary and tax system. This study is limited tax assistance among them. And this study aims at showing the better measures by understanding the problems of the present tax assistance policies concerned to the small and medium industries. The documentary investigation was carried on to achieve the aim of this study. Business expansion orienting policy will drive the small and medium industries's tax revenues in long term point of view and this policy will be succeded by accepting complementary system for investment deficit. Tax system should be modified to improve their financial structure and also to increase deduction ratio to capital increase. Technical development is very important for the Korean economic growth. So the tax assistance policies would be necessary for improving the technical development.