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Unveiling the Functions of the VosA-VelB Target Gene vidD in Aspergillus nidulans
( Ye-eun Son ),( Hee-soo Park ) 한국균학회 2021 Mycobiology Vol.49 No.3
The velvet regulators VosA and VelB are primarily involved in spore maturation and dormancy. Previous studies found that the VosA-VelB hetero-complex coordinates certain target genes that are related to fungal differentiation and conidial maturation in Aspergillus nidulans. Here, we characterized the VosA/VelB-inhibited developmental gene vidD in A. nidulans. Phenotypic analyses demonstrated that the vidD deleted mutant exhibited defect fungal growth, a reduced number of conidia, and delayed formation of sexual fruiting bodies. The deletion of vidD decreased the amount of conidial trehalose, increased the sensitivity against heat stress, and reduced the conidial viability. Moreover, the absence of vidD resulted in increased production of sterigmatocystin. Together, these results show that VidD is required for proper fungal growth, development, and sterigmatocystin production in A. nidulans.
Fungal Distribution in Traditional Meju and Characterization of Isolated Strains
Ye-Eun Son,Ye-Jin Kang,Sun-Young Choi,Yoon-Kyung Choi,Ju-Eun Lee,Junyoung Kim,박희수 한국균학회 2023 韓國菌學會誌 Vol.51 No.3
This study was conducted to analyze the distribution and characteristics of fungal speciesin meju using the traditional method. Fungal distribution in meju was investigated usingmetagenomic and morphological analyses, based on which Aspergillus flavus/oryzae strainswere identified as the dominant fungi in all meju samples, followed by Pichia, Rhizopusand Lichtheimia spp. As A. flavus/oryzae was dominant, we further evaluated the aflatoxinproduction ability and enzymatic activity of the isolates. Thin-layer chromatography andpolymerase chain reaction revealed that the A. flavus/oryzae strains isolated from meju arenon-aflatoxigenic fungi. Based on the analyses of amylase and protease activities, strainswith high activities of amylase or protease were identified, which are proposed to be used asstarters for meju fermentation.
Genetic Manipulation and Transformation Methods for Aspergillus spp.
Son, Ye-Eun,Park, Hee-Soo The Korean Society of Mycology 2021 韓國菌學會誌 Vol.49 No.2
Species of the genus Aspergillus have a variety of effects on humans and have been considered industrial cell factories due to their prominent ability for manufacturing several products such as heterologous proteins, secondary metabolites, and organic acids. Scientists are trying to improve fungal strains and re-design metabolic processes through advanced genetic manipulation techniques and gene delivery systems to enhance their industrial efficiency and utility. In this review, we describe the current status of the genetic manipulation techniques and transformation methods for species of the genus Aspergillus. The host strains, selective markers, and experimental materials required for the genetic manipulation and fungal transformation are described in detail. Furthermore, the advantages and disadvantages of these techniques are described.
Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species
( Ye-eun Son ),( Hee-soo Park ) 한국균학회 2019 Mycobiology Vol.47 No.4
MonA is a subunit of a guanine nucleotide exchange factor that is important for vacuole passing and autophagy processes in eukaryotes. In this study, we characterized the function of MonA, an orthologue of Saccharomyces cerevisiae Mon1, in the model fungus Aspergillus nidulans and a toxigenic fungus A. flavus. In A. nidulans, the absence of AnimonA led to decreased fungal growth, reduced asexual reproduction, and defective cleistothecia production. In addition, AnimonA deletion mutants exhibited decreased spore viability, had reduced trehalose contents in conidia, and were sensitive to thermal stress. In A. flavus, deletion of AflmonA caused decreased fungal growth and defective production of asexual spores and sclerotia structures. Moreover, the absence of monA affected vacuole morphology in both species. Taken together, these results indicate that MonA plays conserved roles in controlling fungal growth, development and vacuole morphology in A. nidulans and A. flavus.
Genetic Manipulation and Transformation Methods for Aspergillus spp.
( Ye-eun Son ),( Hee-soo Park ) 한국균학회 2021 Mycobiology Vol.49 No.2
Species of the genus Aspergillus have a variety of effects on humans and have been considered industrial cell factories due to their prominent ability for manufacturing several products such as heterologous proteins, secondary metabolites, and organic acids. Scientists are trying to improve fungal strains and re-design metabolic processes through advanced genetic manipulation techniques and gene delivery systems to enhance their industrial efficiency and utility. In this review, we describe the current status of the genetic manipulation techniques and transformation methods for species of the genus Aspergillus. The host strains, selective markers, and experimental materials required for the genetic manipulation and fungal transformation are described in detail. Furthermore, the advantages and disadvantages of these techniques are described.
Mon1 Is Essential for Fungal Virulence and Stress Survival in Cryptococcus neoformans
( Ye-eun Son ),( Won-hee Jung ),( Sang-hun Oh ),( Jin-hwan Kwak ),( Maria E. Cardenas ),( Hee-soo Park ) 한국균학회 2018 Mycobiology Vol.46 No.2
Mon1 is a guanine nucleotide exchange factor subunit that activates the Ypt7 Rab GTPase and is essential for vacuole trafficking and autophagy in eukaryotic organisms. Here, we identified and characterized the function of Mon1, an ortholog of Saccharomyces cerevisiae Mon1, in a human fungal pathogen, Cryptococcus neoformans. Mutation in mon1 resulted in hypersensitivity to thermal stress. The mon1 deletion mutant exhibited increased sensitivity to cell wall and endoplasmic reticulum stress. However, the mon1 deletion mutant showed more resistance to the antifungal agent fluconazole. In vivo studies demonstrated that compared to the wild-type strain, the mon1 deletion mutant attenuated virulence in the Galleria mellonella insect model. Moreover, the mon1 deletion mutant was avirulent in the murine inhalation model. These results demonstrate that Mon1 plays a crucial role in stress survival and pathogenicity in C. neoformans.
이달의 X-선 : 다발 전이성 농양을 일으킨 편평상피세포암성 농양 1예
임주은 ( Ju Eun Lim ),김은영 ( Eun Young Kim ),장지은 ( Ji Eun Jang ),손지영 ( Ji Young Son ),정지예 ( Ji Ye Jung ),박병훈 ( Byung Hoon Park ),이경종 ( Kyung Jong Lee ),윤여운 ( Yoe Wun Yoon ),변민광 ( Min Kwang Byun ),이사라 ( Sa 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.66 No.5
기관지폐쇄에 의한 폐농양 혹은 공동성 병변에 발생한 암성 농양은 임상 양상 및 방사선학적 소견이 흡인성 폐농양과 흡사하여 감별이 어려워서 폐암을 조기 진단할 수 있는 기회를 놓치기 쉽다. 따라서 항생제에 대한 반응이 뚜렷하지 않거나 선행 요인이 없고 비전형적인 위치에 발생한 폐농양의 경우 악성 병변의 동반 가능성을 염두에 두고 적극적인 검사가 필요하다. 저자들은 발열, 기침, 혈담, 호흡곤란을 주소로 내원하여 폐농양 의심하에 항생제치료에도 불구하고 병변이 악화된 67세 남자 환자에서 간세침흡인생검을 통해 다발 전이성 농양을 일으킨 편평상피세포암성 농양으로 진단된 예가 있어 문헌 고찰과 함께 보고하는 바이다. Among the bronchogenic carcinomas, especially squamous cell carcinoma and large cell carcinoma frequently present with cavitation, which may result from tumor necrosis. Cavitary lesions of the tumor are occasionally associated with infection and misdiagnosed as benign lung abscess owing to the partial responsiveness to antibiotics. It is very difficult to distinguish the carcinomatous abscess from the benign lung abscess, because of their similar clinical and radiologic features. Delay in diagnosis of underlying lung cancer may result in poor outcome. Therefore, clinicians should remember that the patients with highly suspicious carcinoma of the lung should undergo further precise examinations to find out malignant cells.
Son, Dong Ju,Park, Ye Oak,Yu, Chengguang,Lee, Sung Eun,Park, Young Hyun Taylor & Francis Health Sciences 2014 NATURAL PRODUCT RESEARCH Vol.28 No.24
<P>Platelet aggregation is fundamental to a wide range of physiological and pathological processes, including the induction of thrombosis and arteriosclerosis. Anti-platelet activity of a crude methanol extract and solvent fractions of Ashitaba roots (Angelica keiskei Koidz.) was evaluated using a turbidimetric method using washed rabbit platelets. We identified the anti-platelet activities of two chalcones, 4-hydroxyderricin and xanthoangelol, isolated from the ethyl acetate-soluble fraction of Ashitaba roots by using a bioassay-guided isolation method. 4-Hydroxyderricin and xanthoangelol effectively inhibited platelet aggregation induced by collagen (IC50 of 41.9 and 35.9?μM, respectively), platelet-activating factor (IC50 of 46.1 and 42.3?μM, respectively) and phorbol 12-myristate 13-acetate (IC50 of 16.5 and 45.9?μM, respectively). These compounds did not inhibit thrombin-induced platelet aggregation (IC50 of>80?μM). The results suggest that the chalcones 4-hydroxyderricin and xanthoangelol may be potent anti-thrombotic components of A. keiskei Koidz.</P>