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Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
( Jung Kyu Lee ),( Hee Jung Choi ),( Sun Mi Choi ),( Jin Woo Lee ),( Young Sik Park ),( Chang Hoon Lee ),( Jae Joon Yim ),( Chul Gyu Yoo ),( Young Whan Kim ),( Sung Koo Han ),( Sang Min Lee ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: There is limited data on serum activin-A level as a biomarker in the sepsis patients. We aimed to elucidate the diagnostic and prognostic values of serum activin-A in the management of critically ill patients with sepsis. Methods: Seventy-seven adult patients who were clinically diagnosed as sepsis and admitted in the intensive care unit (ICU) from January 2013 to March 2014, were investigated and compared with age- and sex-matched controls with tuberculosis. Serum concentration of activin-A was determined from blood sampled within 48 hours after ICU admission. Primary and secondary outcomes were the diagnostic value as biomarker of sepsis, and the prognostic value to predict the clinical outcomes of sepsis, respectively. Results: Serum activin-A level showed insignificant differences between mild sepsis and severe sepsis, but significant differences between non-sepsis and mild sepsis, and between severe sepsis and septic shock. The risk of sepsis and septic shock was significantly higher in patients with serum activin-A level more than 255 pg/mL and 432 pg/mL, respectively (aOR 50.8, 95% CI 14.8-173.8; aOR 18.8, 95% CI 2.8-124.7). Serum activin-A level had a positive correlation with SOFA score (β±SE 58.3±20.7, P=0.006), and significantly associated with ICU mortality (aOR 3.57, 95% CI 1.05-12.15). Conclusions: Serum activin-A has a diagnostic and prognostic value in critically ill patients with sepsis, and discriminant power for the sepsis severity. Serum activin-A level in early phase of sepsis is associated with SOFA score on ICU admission and ICU mortality.
Optimal Design of Thinned Array Using a Hybrid Genetic Algorithm
Sang-Hoon Jung,Kang-In Lee,Hyun-Su Oh,Hyun-Kyo Jung,Hoongee Yang,Young-Seek Chung 한국전자파학회JEES 2021 Journal of Electromagnetic Engineering and Science Vol.21 No.4
In this paper, a hybrid genetic algorithm (GA) is proposed for thinning a two-dimensional planar array by combining the conventional GA with moving least squares (MLS). This enhances the convergence rate and the global search performance. The MLS method is used to estimate local interpolation functions from non-uniform sample data (the population and the value of the objective function in the GA), and to find new and better populations from the interpolated functions. By incorporating these improved populations into the next generation, the MLS-GA achieves improved search performance of the global optimum and a faster convergence rate compared to conventional GA alone. Moreover, a nonlinear chirp function is used for an efficient thinning design. To verify the proposed MLS-GA, it is applied to a test function and the results are compared to that of the GA. The algorithm is then applied to thin an array with a rectangular grid and circular boundary. The design objectives are to minimize the peak side-lobe level and gain loss while satisfying a given thinning coefficient and to compare the results with the GA.
( Jung Mo Lee ),( Sang Hoon Lee ),( Youngmok Park ),( Chi Young Kim ),( Eun Kyoung Goag ),( Eun Hye Lee ),( Ji Eun Park ),( Chang Young Lee ),( Se Kyu Kim ) 영남대학교 의과대학 2015 Yeungnam University Journal of Medicine Vol.32 No.2
Lymphangioma is a congenital abnormality of the lymphatic system detected primarily in early childhood. There are rare reports of mediastinal lymphangioma in older adults. We hereby report on a 66-year-old female patient who underwent kidney transplantation 20 years previously and who developed pathologically confirmed solitary mediastinal lymphangioma 1 year ago. Chest radiography showed a mediastinal nodule, which was not observed 2 year previously, therefore she was referred to the pulmonary division. She had no symptoms, and chest computed tomography demonstrated a 25-mm, well-defined, low-density nodule located at the anterior mediastinum. The size of the nodule had increased from 25 mm to 34 mm 1 year later, and it was completely resected via video-assisted thoracic surgery. The histological diagnosis was cystic lymphangioma. Therefore, we recommend that clinicians consider cystic lymphangioma as a possible diagnosis even in older patients with a mediastinal cystic mass that shows progressive enlargement.
( Jung Yoon Choe ),( Sung Hoon Park ),( Hwa Jeong Lee ),( Hyun Hee Kwon ),( Seong Kyu Kim ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.4
Background/Aims: Increased resting energy expenditure (REE) in rheumatoid arthritis (RA) patients is thought to be caused by hypermetabolism associated with production of proinflammatory cytokines. Our aim in the present study was to explore the possible association between REE and disease activity in females with RA. Methods: A total of 499 female RA patients were recruited to this cross-sectional study assessing REE scores on disease activity indices (the routine assessment of patient index data 3 [RAPID3], the disease activity score 28, and the clinical/simplified disease activity index [CDAI/SDAI]) and the levels of RA-associated autoantibodies (rheumatoid factor and anticyclic citrullinated peptide [anti-CCP] antibodies). Age-matched healthy female controls (n = 131) were also enrolled. Results: REE did not differ between RA patients (all patients, and those in remission or not) and controls, or between RA patients in remission or not (p > 0.05 for all comparisons). Increased REE in total RA patients was associated with younger age and a higher body mass index (BMI) (p < 0.001 and p < 0.001, respectively), but not with disease activity index scores on any of RAPID3, CDAI, or SDAI. BMI was the only clinical parameter exhibiting a significant relationship with REE quartiles (Q1 to Q4; p < 0.001); none of disease duration, functional status, or anti-CCP antibody titer in RA patients was significantly related to REE, based on analysis of covariance. Conclusions: We found no association between REE and disease activity in RA patients, implying that energy metabolism in RA patients might be independent of RA-associated systemic inflammation.