과민성 장 증후군의 증상 경감을 위한 비약물적 접근 고찰

최명애,김금순,안경주,채영란,최정안,홍해숙,박미정,이경숙,신기수,정재심 대한기초간호자연과학회 2005 Journal of korean biological nursing science Vol.7 No.2

There have been many trials of clinical efficacy of multicomponent and single component treatments for irritable bowel syndrome(IBS). We reviewed effects of non phamacological treatments in the IBS. Though the efficacy of multi-component approaches was unclear, several results suggest that cognitive behavioral therapy was effective in improving gastrointestinal symptoms of IBS. As a single component, cognitive therapy and relaxation with or without biofeedback could improve the symptoms and psychological health of IBS patients. Yoga, meditation, self-help information and hypnotherapy could be applicable to IBS.

스테로이드 치료 후 회복기의 규칙적인 운동이 쥐의 스테로이드 유발성 위축 뒷다리근에 미치는 영향

최명애,변영순,황애란,김희승,홍해숙,최스미,서화숙,이경숙,박미정,신기수,안경주,이윤경,임지회 대한기초간호자연과학회 2002 Journal of korean biological nursing science Vol.4 No.1

This study was conducted to determine whether low intensity regular exercise following steroid treatment could attenuate steroid-induced muscle atrophy. Thirty-eight Sprague-Dawley rats weighing 165~175g were divided into six groups;control group(C), dexamethasone administration group(D), sedentary after normal saline administration group(C+Se), exercise after normal saline administration group(C+Ex), sedentary group after dexamethasone administration(D+Se), exercise group after dexamethasone administration(D+Ex). Either dexamethasone(5mg/kg) or normal saline was injected for 7days accordingly. Exercise was started at 10m/min on the 10?grade treadmill and gradually increased up to 15m/min by the 7th day for 60minutes/day(20min×3). The data were analyzed by Kruskal-Wallis test and Mann-Whitney U test using the SPSS WIN 9.0 program. Body weight, muscle weight and myofibrillar protein content of both plantaris and gastrocnemius, Type I, II muscle fiber cross-sectional area of plantaris, and Type II muscle fiber cross-sectional area of gastrocnemis in D group were significantly lower than those of C group(p<.05) respectively. Hindlimb muscle weight, myofibrillar protein content of both plantaris and gastrocnemius, Type I muscle fiber cross-sectional area of soleus and Type I, II muscle fiber cross-sectional area of plantaris in D+Ex group tended to increase compared to those of D+Se group. Myofibrillar protein content of both plantaris and gastrocnemius, Type I muscle fiber cross-sectional area of plantaris in D+Ex group tended to increase compared to those of C+Se group. Based on these results, it is suggested that regular low-intensity exercise during recovery period after steroid treatment might facilitate the recovery from steroid-induced muscle atrophy.

기초간호자연과학의 인체구조와 기능 내용별 필요도에 대한 연구

최명애,변영순,서영숙,황애란,김희승,홍해숙,박미정,최스미,이경숙,서화숙,신기수 대한기초간호자연과학회 1999 Journal of korean biological nursing science Vol.1 No.1

The purpose of this study was to define the content of requisite human structure and function knowledge needed for clinical knowledge of nursing practice. Subjects of human structure and function were divided into 10 units, and each unit was further divided into 21 subunits, resulting in a total of 90 items. Contents of knowledge of human structure and function were constructed from syllabus of basic nursing subjects in 4 college of nursing, and textbooks published by nurse scholars prepared with basic nursing sciences. The degree of need of 90 items was measured with a 4 point scale. The subjects of this study were college graduated 136 nurses from seven university hospitals in Seoul and three university hospitals located in Chonnam Province, Kyungbook Province, and Inchon. They have been working at internal medicine ward, surgical ward, intensive care unit, obstetrics and gynecology ward, pediatrics ward, opthalmology ward, ear, nose, and throat ward, emergency room, rehabilitation ward, cancer ward, hospice ward, and their working period was mostly under 5 years. The results were as follows : 1. The highest scored items of human structure and function knowledge necessary for nursing practice were electrolyte balance, blood clotting mechanism and anticoagulation mechanism, hematopoietic function, body fluid balance, function of plasma, and anatomical terminology in the order of importance. The lowest scored items of human structure and function knowledge necessary for nursing practice was sexual factors of genetic mutation. 2. The highest order of need according to unit was membrane transport in the living unit, anatomical terminology in movement and exercise unit, mechanism of hormone function in regulation and integration unit, component and function of blood in oxygenation function unit, structure and function of digestive system in digestive and energy metabolism unit, temperature regulation in temperature regulation unit electrolyte balance in body fluid and electrolyte unit, concept of immunity in body resistance unit, and genetics terminology in genetics unit. The highest order of importance according to subunit was membrane transportation in cell subunit, classification of tissues in tissue unit, function of skin and skin in skin subunit, anatomical derivatives of the skeleton subunit, classification of joints in joint subunit, an effect of exercise on muscles in muscle subunit, function of brain in nervous system subunit, special sense in sensory subunit mechanism of hormone function in endocrine subunit, structure and function of female reproductive system in reproductive system unit, structure and function of blood in blood unit, structure of heart, electrical and mechanical function in cardiovascular system unit, structure of respiratory system in respiratory system subunit, structure and function of digestive system in digestive system subunit, hormonal regulation of metabolism in nutrition and metabolism subunit, function of kidney in urologic system subunit, electolyte balance in body fluid, electolyte and acid-base balance subunit. 3. The common content of human structure and function knowledge need for all clinical areas in nursing was structure and function of blood, hematopoietic function, function of plasm, coagulation mechanism and anticoagulation mechanism, body fluid, electrolyte balance, and acid-base balance. However, the degree of need of each human structure and function knowledge was different depending on clinical areas. 4. Significant differences in human structure and function knowledge necessary for nursing practice such as skin and derivatives of the skin, growth and development of bone, classification of joint, classification of muscle, structure of muscle, function of muscle, function of spinal cord, peripheral nerve, structure and function of pancrease, component and function of blood, function of plasma, structure and function of blood, hemodynamics, respiratory dynamics, gas transport, regulation of respiration, chemical digestion of foods, absorption of foods, characteristics of nutrients, metabolism and hormonal regulation, body energy balance were demonstrated according to the duration of work. 5. Significant differences in human structure and function knowledge necessary for nursing practice such as classification of tissue, classification of muscles, function of muscles, muscle metabolism, classification of skeletal muscles, classification of nervous system, neurotransmitters, mechanism of hormone function, pituitary and pituitary hormone, structure and function of male reproductive organ, structure and function of female reproductive organ, component and function of blood, function of plasma, coagulation mechanism and anticoagulation mechanism, gas exchange, gas transport, regulation of respiration, characteristics of nutrients, energy balance, function of kidney, concept of immunity, classification and function of immunity were shown according to the work area. Based on these findings, all the 90 items constructed by Korean Academic Society of Basic Nursing Science should be included as contents of human structure and function knowledge.

초산모의 분만유형과 모성관련지식에 관한 연구

김혜란,노진아,손은정,이명아,김증임 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Purpose: This study was to know primipara's general characteristics, delivery type, delivery characteristics, maternity related knowledge level, and relation of delivery type and maternity related knowledge level. Method: This is a survey. Subjects were sixty primiparas who had admitted to a pediatric outpatient clinic at general hospital in Seoul. Subject's age was ranged from 15 to 44 and it was lapsed 10 weeks after delivery of their first baby. Maternity related knowledge level was measured by "primipara's maternity related knowledge level". Data was nalyzed using frequency. percentage, mean, standard deviation, ANOVA, t-test by SPSS 11.0. Result: Relation of delivery type and maternity related knowledge in primipary did not show a statistically significant. But the relation of natural delivery and maternity related knowledge in primipara was a littlehig than that of caesarean section. Conclusion: There is no significant diference of maternity related knowledge between natural delivery and caesarean section. We suggest for randomized clinical trials with a larger sample size.

신체만족도와 심리적 특성이 외모향상태도에 미치는 영향

전경란,이명희 한국의류학회 2003 한국의류학회지 Vol.27 No.6

The purpose of this study was to investigate the relation of desire for aesthetic surgery and clothing attitude of female with their body satisfaction, need, and self-esteem. Subjects were 813 females of 10‘s to 40's living in Daejeon Metropolitan City and Gongju City, Chungchungnamdo. Results form this research revealed that the correlation of desire for aesthetic surgery with body satisfaction was negative so that female satisfying one's body shape didn't want to have aesthetic surgery. However, aesthetics and sexual attractiveness of clothing had positive correlations with body satisfaction. It was also shown that the need and self-esteem of female affected directly on the desire for aesthetic surgery and the pursuit of clothing aesthetics. Women with higher need for exhibition and dominance were not only concerned about the elevation of their appearance through their clothing but also recognized the value of modifying their appearance through aesthetic surgery. Women with higher self-esteem were interested in the elevation of their appearance through clothing, but the other hand, they showed negative attitude toward modifying their appearance via aesthetic surgery. This result revealed the fact that women with higher self-esteem had a tendency to keep the traditional sense of value and as a result, showed negative attitude toward the aesthetic surgery.

기초간호자연과학의 병태생리학, 병원미생물, 약물의 기전과 효과 내용별 필요도에 대한 연구

최명애,변영순,서영숙,황애란,김희승,홍해숙,박미정,최스미,이경숙,서화숙,신기수 대한기초간호자연과학회 2000 Journal of korean biological nursing science Vol.2 No.1

The purpose of this study was to define the content of the requisite knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs needed for clinical knowledge for nursing practice. Contents of knowledge on pathological physiology, clinical microbiology, and mechanisms and effects of drugs were constructed from syllabus of basic nursing subjects in 4 colleges of nursing, and textbooks. The degree of need of 72 items was measured with a 4 point scale. The subjects of this study were college-graduated 136 nurses from seven university hospitals in Seoul and three in Chonnam Province, Kyungbook Province, and Inchon. They have been working at internal medicine ward, surgical ward, intensive care unit, obstetrics and gynecology ward, pediatrics ward, opthalmology ward, ear, nose, and throat ward, emergency room, rehabilitation ward, cancer ward, and hospice ward. The results were as follows : 1. The highest scored items of the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs necessary for nursing practice were side effects of drugs, anticoagulants, mechanisms of drugs, antihypertensive drugs, tolerance and addiction of drugs, interactions among drugs, hospital infection in the order of importance. The lowest scored item was structure of microrganisms. 2. The highest order of need according to unit was repair in tissue injury unit, definition·etiology·classification of inflammation in inflammation unit, trasplantation and immunologic response in alterations in immunity unit, thrombus and thrombosis in disorders of cardiovascular function unit, gene disorders in genetic disorders unit, hospital infection in infection unit, virus in microrganisms unit, side reactions of drugs in introduction unit, anticonvulsants in drugs for central nervous system unit, local anesthesia in anesthesia unit, anticoagulants in drugs for cardiovascular system unit, anti-inflammatory drugs in antibiotics unit, anti-ulcer drugs in drugs for digestive system unit, and bronchodilators in drugs for respiratory system unit. 3. The common content of the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs needed for all clinical areas in nursing were side effects of drugs, anticoagulants, interactions among drugs, and hospital infection. However, the degree of need of each pathological physiology, clinical microbiology, and mechanisms and effects of drugs was different depending on clinical areas. 4. Significant differences in the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs necessary for nursing practice such as tissue changes due to injurious stimuli, degenerative changes of tissue, alterations in metabolism of carbohydrates, ischemia, hyperemia and congestion, hospital infection, structure of microorganism, classification of microorganism, bacteria, virus, antidepressants, antipsychotic drugs, antiemetic drugs, antiparkinsonism drugs, antianxiety drugs, antibiotics, tuberculostatics, antiviral drugs, antifungal drugs, parasiticides, antiulcer drugs, antidiarrheais, and anti constipation drugs were shown according to the work area. 5. Significant differences in the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs necessary for nursing practice such as transplantation and immunologic response, alterations in the metabolism of uric acid, structure of microorganism, classification of microorganism, immunosuppresants, drugs for congestive heart failure were demonstrated according to the duration of work. Based on these findings, all the 72 items constructed by Korean Academic Society of Basic Nursing Science should be included as contents of the knowledge of pathophysiology, clinical microbiology. and mechanisms and effects of drugs

Polyurethane의 혈전방지처리가 Staphylococcus epidermidis의 정착에 미치는 영향

김성민,이규백,백경란,오명돈,민병구,최강원 대한감염학회 1996 감염 Vol.28 No.1

목적 : 최근 생체재료로 만든 각종 카테타와 인공관절, 인공심장 등 인공장치의 사용이 점차 증가하고 있으며, 인공장치의 사용을 제한하는 가장 큰 합병증은 생체재료를 중심으로 일어나는 감염과 혈전증이다. 그러므로 인공장치를 장기간 사용하기 위해, 이들 합병증을 예방할 수 있는 생체재료를 개발하는 것이 중요한 과제가 되고 있다. 인공장치는 체내에 들어가서 혈액과 접촉하게 되면, 혈장단백질과 혈소판이 부착하고 활성화되어 혈소판-섬유소 혈전을 만든다. 이렇게 형성된 혈전은 세균의 부착을 촉진하고, 부착한 세균이 인체방어기전이나 항균제의 영향을 받지 않고 증식 할 수 있는 공간이 된다. 또한 정착한 세균은 혈액과 접촉하여, 혈전의 형성을 촉진한다. 즉, 혈전과 세균정착은 서로 영향을 주면서 인공자치의 오랜 사용을 제한하게 된다. 폴리우레탄에 설폰산과 알부민을 표면처리하면 혈전의 형성이 감소하는 효과가 있다는 것은 보고된 바 있으나, 혈전방지를 위해서 표면처리에 사용한 설폰산, 알부민이 세균 정착 및 감염에 미치는 영향에 대해서는 아직 잘 알려져 있지 않다. 이에 저자들은 설폰산, 알부민, 파라벤으로 처리한 폴리우레탄이 세균의 정착에 미치는 영향에 대해 알고자 본 연구를 시행하였다. 방법 : S. epidermidis RP12 부유액(?/mL)에 대조 폴리우레탄과 설폰산과 알부민, paraben으로 각각 처리한 폴리우레탄을 원반모양으로 만들어 담근 다음, 24시간 또는 48시간 동안 배양하였다. 세균 정착의 정도는 세균 집락수 및 SEM 소견으로 판정하였다. 결과 : 24시간 째 및 48시간 째의 세균집락수는 대조 폴리우레탄이 각각 8.3x10⁴/mL, 1.1×?/mL이었고, 파라벤 처리 폴리우레탄이 각각 9.3x10⁴/mL, 2.1x10⁴/mL (p<0.05), 설폰산 처리 폴리우레탄이 각각 1.2×?/mL, 8.2x10⁴/mL,(p<0.05), 알부민 처리 폴리우레탄이 각각 7.3×?/mL, 1,4×?/mL (p<0.05)이었다. 즉, 세균 집락수가 파라벤 처리 폴리우레탄에서는 유의하게 감소하였으나, 설폰산 처리 폴리우레탄에서는 증가하였다. SEM 소견에서는 설폰산 및 알부민 처리 폴리우레탄에서 세균 정착의 감소를 관찰하지는 못하였다. 결론: 본 연구는 in vitro 실험으로, 파라벤으로 처리한 폴리우레탄은 세균의 정착을 감소시키는 효과가 있었으나, 항혈전성 폴리우레탄은 세균 정착을 감소시키지 못하였다. 인체내에서는 세균과 혈소판, 혈장단백질이 복잡하게 반응을 하면서 혈전과 세균 정착이 서로 영향을 주므로, 인체내에서는 항혈전성 폴리우레탄이 혈전 형성을 감소시키고, 2차적으로 세균 정착을 감소시키고 감염을 예방하는 효과가 있을 가능성도 있으므로 이에 대한 연구가 진행되어야 하겠다. Background : Infection and thromboembolism are major complications of prolonged use of prosthetic devices, such as various catheters, prosthetic joints, and artificial hearts, frequently resulting in severe morbidity, or death. Therefore, the prevention of infection and thrombosis is an important subject in developing new biomaterials of prosthetic devices. The first event on insertion of a prosthetic device into the blood is protein adsorption and activation with platelet adhesion, activation and aggregation, leading to the formation of platelet-fibrin thrombi. The thrombi are susceptible to bacterial incorporation and protect the bacteria from the effects of circulating antibodies, phagocytic cells, and antibiotics. Furthermore, adherent bacteria may induce fibrin and platelet adhesion. Sulfonated polyurethane and albumin-immobilized polyurethane were documented to diminish the adhesion and shape-change of platelet on the polymer in comparison with plain polyurethane, in vitro. The objective of this study was to evaluate the effect of these antithrombotic biomaterials on the bacterial colonization. Methods : Plain, sulfonated, albumin-immobilized, and paraben-incorporated polyurethane(PU) films were prepared as a disk form. Staphylococcus epidermidis RP12 was suspended at a concentration of ?/mL and four types of polymeric disks were immersed in the bacterial suspension. After incubation for 24 and 48 hours, the bacterial colonization on the each disk was determined by the colony forming units(CFU) counting method. The colonized disks were examined by scanning EM. Results : The paraben decreased significantly the number of CFU on PU surface to 2.1x10⁴/mL after 48 hours, compared with 1.1×?/mL on plain polymers. The number of CFU on sulfonated or albumin-immobilized PU was 8.2x10⁴/mL, and 1.4×?/mL, respectively. SEM micrographs showed no reduction of colonization on antithrombotic PUs. Conclusion : Antithrombotic treatments of polymers did not decrease the bacterial colonization on polymers, in vitro, that was compared to the decreasing effect of paraben. However, because the thrombi and bacteria interact with each other, the overall effect of the antithrombotic polyurethanes on the bacterial colonization and infection should be studied in vivo.

스트레스와 면역반응에 대한 국내 논문분석

채영란,김금순,최명애,안경애,김명애,서순림,홍해숙,정재심,박금화,이성희 대한기초간호자연과학회 2002 Journal of korean biological nursing science Vol.4 No.2

This study was aimed to analyze the variables measuring stress and imnnune responses, to identify the relationship between stress and imnnune responses, and to find out the effect of nursing interventions associated with stress and immune responses by reviewing thirty-four published articles since 1970 in Korea. The articles were selected in the field of nursing, stress management, and masters or doctoral dissertations and limited to human subject. Among these, the thirty-one articles were published since 1996 and mainly distributed in nursing(44.1%) and medicine(44.1%). The prevailing research design was nonequivalent control pre-post experimental design (41.1%). The research subjects were 55.9% for patients and 44.1% for healthy general persons including 20.6% of university students. To evaluate stress, both physiologic and psychosocial measures were adapted together in 35.3% of the articles. The most frequent two variables measuring stress and immune response were cortisol leve1(15.9%) and number or activity of natural killer ce11(25.9%). The relation between stress and immune responses was positive in 4 articles, negative in 9 cases, and none in 12 cases. Decreased stress and enhanced immune function have been found when massage, abdominal breathing, exercise, relaxation, and touch were provided as nursing interventions. The articles to investigate the relationship between stress and immune function were limited and the tested variables were diverse. Also there was no consistent evidence to correlate the stress and immune function at present. Further studies are needed to construct a valid research design and to investigate the relationship between stress and immune responses. Nursing interventions to decrease stress should be developed to result in the increased immune function and the effect of these interventions would be verified.

관해유도 항암요법을 받는 백혈병 환자에서 진균 감염증의 예방 : 무작위 배정법과 이중 눈가림법에 의한 Fluconazole과 Nystain의 효과에 관한 다기관 공동연구 A Randomized, Double-blind, Multicenter Trial to Compare Fluconazole with Nystatin

최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2

Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.

보리순의 영양성분 조성

서혜지,최용민,김상천,이준수,이기택,정명근,천지연,황진봉,남진식,서우덕,황영,김행란,김세나 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2