BMB Reports : Binding model for eriodictyol to Jun-N terminal kinase and its anti-inflammatory signaling pathway

( Eun Jung Lee ),( Ki Woong Jeong ),( Areum Shin ),( Bong Hwan Jin ),( Hum Nath Jnawali ),( Bong Hyun Jun ),( Jee Young Lee ),( Yong Seok Heo ),( Yang Mee Kim ) 생화학분자생물학회 2013 BMB Reports Vol.46 No.12

The anti-inflammatory activity of eriodictyol and its mode of action were investigated. Eriodictyol suppressed tumor necrosis factor (mTNF)-α, inducible nitric oxide synthase (miNOS), interleukin (mIL)-6, macrophage inflammatory protein (mMIP)-1, and mMIP-2 cytokine release in LPS-stimulated macrophages. We found that the anti-inflammatory cascade of eriodictyol is mediated through the Toll-like Receptor (TLR)4/CD14, p38 mitogen-activated protein kinases (MAPK), extracellular-signalregulated kinase (ERK), Jun-N terminal kinase (JNK), and cyclooxygenase (COX)-2 pathway. Fluorescence quenching and saturation-transfer difference (STD) NMR experiments showed that eriodictyol exhibits good binding affinity to JNK, 8.79 × 105 M-1. Based on a docking study, we propose a model of eriodictyol and JNK binding, in which eriodictyol forms 3 hydrogen bonds with the side chains of Lys55, Met111, and Asp169 in JNK, and in which the hydroxyl groups of the B ring play key roles in binding interactions with JNK. Therefore, eriodictyol may be a potent anti-inflammatory inhibitor of JNK. [BMB Reports 2013; 46(12): 594-599]

Repellent efficacy of essential oils and plant extracts against Tribolium castaneum and Plodia interpunctella

Lee Hwa‐Eun,Hong Su Jung,Hasan Najmul,Baek Eun Joo,Kim Jun Tae,Kim Young‐Duk,Park Mi‐Kyung 한국곤충학회 2020 Entomological Research Vol.50 No.9

This study was conducted to investigate the repellent efficacy of essential oils (Origanum vulgare, Pimpinella anisum, and Tanacetum cinerariifolium) and four plant extracts (Agastache rugosa, Capsicum annuum, Citrus reticulata, and Ginkgo biloba) against Tribolium castaneum (adults and larvae) and Plodia interpunctella (larvae). Gas chromatography/mass spectrometry analysis revealed the presence of carvacrol, anethole, and jasmolin I as the predominant constituent in O. vulgare, P. anisum, and T. cinerariifolium, respectively. Furthermore, ethyl hexopyranoside, 9,12‐octadecadienoic acid, cyclopentanol, and 2‐cresol were identified in A. rugosa, C. annuum, C. reticulata, and G. biloba, respectively. The repellent efficacy of each essential oil, plant extract, and the combination of oils was evaluated using a specially designed cylinder trap for 120 h. Among the three oils, O. vulgare and T. cinerariifolium had greatest repellent efficacy against P. interpunctella larvae. T. cinerariifolium exhibited effective repellence against the adults and larvae of T. castaneum. Therefore, O. vulgare (O) and T. cinerariifolium (T) were selected for further investigation of combined effects. Two essential oils were mixed in three different ratios of OT1 (1:3), OT2 (1:1), and OT3 (3:1). The repellent efficacies of OT1 and OT2 against the adults of T. castaneum were significantly greater than that of OT3. OT1 was effective against the larvae of T. castaneum, whereas OT2 was effective against the larvae of P. interpunctella. OT1 enhanced the repellent efficacy by approximately five times against larvae of T. castaneum, compared with that of T. cinerariifolium. Overall, OT1 was selected as the best repellent substance against all the tested insects.

지하철역과의 거리와 건물의 가치, 그리고 보행상권 : 종로구와 중구의 비주거용 건물을 중심으로

정은상(Jung, Eun-Sang),김준형(Kim, Jun-Hyung) 대한국토·도시계획학회 2020 國土計劃 Vol.55 No.3

The general view is that the more accessible a subway station, the higher the value of the building. However, the existing empirical analyses indicate that the relationship between distance to the subway station and building value is not consistently negative. Therefore, this study carries out various analyses based on the hypothesis that the price of the building is affected by the presence of a pedestrian commercial area and the width of the road. According to a survey of 746 non-residential buildings located in Jongno-gu and Jung-gu (in Seoul), this study finds that the closer the subway station, the higher the price of the building. However, buildings located in a pedestrian area showed a positive relationship between distance from the subway station and price of the building. Based on the results, we can infer that the assumption that a building is worth more when it is closer to a subway station cannot be generalized for all regions. In some areas, less accessible but walkable environments should be welcomed in light of the value of buildings and districts.

원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

저출산･고령사회 이슈에 대한 정책대응 과제 : 인천시 사례를 중심으로

문은영,권미애,전혜정 이화여자대학교 젠더법학연구소 2016 이화젠더법학 Vol.8 No.1

This study was conducted with the need for preparing active measures of the central government and the local government to deal with low fertility and aging society issues and with the purpose of setting the related policy direction. The issues of recent low fertility and aging are experienced globally and the decline of population is detected in Korea as well. Therefore, multilateral efforts are taken to deal with the imminent phenomenon at the governmental level. Incheon Metropolitan City, with its population of 3 million, is one of the big cities in rapid progress of low fertility and aging phenomenon. While the total fertility rate of Incheon is 1.21 (Statistics Korea, 2015) which is the similar level with the national average, it is far below the population replacement level and has continuously been recording the low figures since 2000. Besides, the elderly population rate in 2014 was 10.3%, a 5.5% increase compared to the previous year. It is expected that the population aging would be accelerated for the next 30 years and it is forecasted that the elderly population rate of Incheon would reach around 30% by 2040. According to the survey results of general citizens on this population change, more than half of the respondents seriously recognized the shift to the low fertility and aging society and demanded the measures to deal with the issues. To set the policy direction in association with the central government within the local region, this study explores the tasks to deal with the policy and the demands for the policy in Incheon Metropolitan City. 본 연구는 저출산・고령사회 이슈에 대응하여 중앙정부와 더불어 지자체의 적극적 대책마련의 필요성과 정책방향성 수립을 위한 목적으로 시도되었다. 최근 저출산과 고령화의 문제는 전 세계적으로 경험되는 문제이며 또한 우리나라에서도 인구의 변화가 감지되고 있는 상황이다. 이에 정부차원에서 이미 저출산과 고령화 문제를 경험하고 대처하고 있는 선진국의 사례를 검토하면서, 다가올 현상에 대해 대응할 수 있기 위한 다각적 노력이 진행되고 있다. 인천시는 인구 300만 시대가 임박하는 상황에서 저출산과 고령화 현상이 빠르게 진행되고 있는 대도시중 하나이다. 인천시의 합계출산율은 1.21명으로 전국평균과 동일한 수준에 있지만 인구대체수준에는 크게 못 미치는 상황이며, 2000년 이래 지속적으로 낮은 수치를 기록하고 있다. 또한 2014년 노인인구 구성비는 10.3%로 전년대비 5.5% 증가되었으며, 향후 30년간 고령화가 빠른 속도로 진행될 것으로 전망되며 오는 2040년 인천의 고령인구비율이 약 30%로 예측되고 있다. 이러한 인구변화에 대해 일반 시민들에게 저출산・고령화 사회로의 변화는 실태조사결과 절반 이상이 심각하게 인지하고 있는 상황이며, 이에 대한 대책마련을 요구하고 있는 것으로 나타났다. 본 연구에서는 중앙정부와 연계성 있는 지역 내 정책방향 수립을 위해 인천시 사례를 들어 지역에서의 정책에 대한 시민체감도와 정책 수요, 또 정책대응의 과제를 살펴보고자 한다.

개의 아토피 피부염에 대한 Leflunomide의 임상적 적용 1례

홍은지,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

A Shih-tzu(8-year-old, castrated male) was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of relapsing pruritus, recurrent dermatitis. On the physical examination, generalized erythema, otitis externa, alopecia and lichenification were observed. Using Favrot's criteria for diagnishing atopic dermatitis, 7 criteria were satisfied out of 8 criteria. After treatment for infection, intradermal skin test was performed(positive allergen : Df, Dp). And then immunotherapy was performed, but clinical signs were not getting better. Next treatment of glucocorticoid shown little improvement of clinical signs, and adverse effect(diarrhea) was shown after cyclosporine application. So application of leflunomide which is used for human atopic dermatitis treatment in some case was planned. After 6 months of application of leflunomide, clinical signs were decreased gradually.

돼지감자 에탄올 추출물의 구강편평세포암 YD-10B 사멸효과

안예준, 김은정 상지대학교 한의학연구소 2022 尙志韓醫論文集 Vol.10 No.1

Jerusalem artichoke (Helianthus tuberosus L.) is a perennial plants, its natural compound is known to exhibit blood sugar control. In this study, we investigated the growth inhibitory effect of ethanol extract of Jerusalem artichoke on oral squamous carcinoma YD-10B cells. Jerusalem artichoke tubers were extracted by ethanol and treated for cell viability. The ethanol extract of Jerusalem artichoke showed the most significant growth inhibitory effect at 1000 Lg/ml concentrations. It was confirmed that apoptosis was induced in the Sub-G1 step by treating the ethanol extract of Jerusalem artichoke, at a concentration of 1000 Lg/ml. As a result, it was more than twice as high as that of the control group. In conclusion, it is suggested that the ethanol extract of Jerusalem artichoke exhibits high inhibition of proliferation and apoptosis of YD-10B cells, and thus has a possibility as an anticancer drug.

[논문]플라이 애쉬의 알칼리-실리카 반응에 대한 팽창 억제효과

김정은,전쌍순,서기영,진치섭 釜山大學校生産技術硏究所 2004 生産技術硏究所論文集 Vol.63 No.-

본 연구의 목적은 플라이 애쉬가 알칼리-실리카 반응에 미치는 영향을 알아보는 데 있다. 이를 위해서 시벤트를 플라이 애쉬로 치환한 모르타르 바를 제작하였다. 플라이 애쉬 치환률은 시멘트 줌량비에 대해 0, 5, 10,15, 25 및 35% 를 치환하였고 골재는 반응성 골재인 변성암과 퇴적암을 사용하였다. 플라이 애쉬로 치환한 모르타르 바의 알칼리-실리카 반응은 ASTM C 1260 시험법으로 조사하였다. ASTM C 1260 시험법은 16일이라는 짧은 기간동안 알칼리-실리카 반응을 알아 볼 수 있는 장점이 있다. 시험 결과I 알칼리-실리카 반응에 의한 모르타르 바의 팽창은 플라이 애쉬 치환율이 증가함에 따라서 감소하였고 플라이 애쉬의 치환율이 클수록 초기 강도가 낮아지고 유동성이 저하되는 것으로 나타났다. 플라이 애쉬 치환율은 알칼리-실리카 반응 억제효과와 강도 및 유동성 측면을 모두 고려할 때 25% 가 가장 적절한 것으로 판단된다.

애엽, 지각, 아교주 및 목향의 투여가 임신중 생쥐의 생식능력에 미치는 효과

정형민,차수경,임정묵,신태은,박찬,장준복,이경섭,송병기 경희대학교 2000 慶熙醫學 Vol.16 No.2