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Predicting heat transfer performance in a complex heat exchanger for LNG FGSS development
허재원,최윤환,김성훈,이승현,최홍영,유동인,이연원 한국마린엔지니어링학회 2023 한국마린엔지니어링학회지 Vol.47 No.2
In this study, a reasonable design option for improving the thermal performance of a newly designed complex heat exchanger that can simultaneously heat LNG) and BOG) is analyzed and evaluated. The relative heat transfer rates are compared according to the changes in the steam supply method, and the flow characteristics, heat transfer rate, and internal pressure of the steam inside the shell of the complex heat exchanger are interpreted using computational fluid analysis. Without distribution plates, the heat transfer rate to LNG increases as the steam supply inlet in the complex heat exchanger increases. However, if distribution plates are present, then the heat transfer rate decreases. It is discovered that there is a significant difference in the heat transfer rates for BOG depending on the presence or absence of distribution plates, and the impact of the steam supply inlet is almost negligible. These results confirm that selecting an appropriate combination based on the design conditions is necessary for the optimal design of a complex heat exchanger.
허재원,김희수 한국생명과학회 2002 생명과학회지 Vol.12 No.6
긴팔원숭이는 영장목, 유인원 아목, 좁은코원숭이 상과, 사람과에 속하는 영장류로써 소형 영장류라고 불린다. 이들은 동남 아시아 일대의 열대 우림에서 종 분화에 성공한 영장류로써 현재 4속 12종이 동정 되어 있지만 이들 중 10종이 멸종 위기에 있다. 다양한 영장류 중에 가장 높은 멸종 위기에 있으면서도 아직도 정확하게 많은 종 또는 아종의 동정이 되지 않고 있는 실정이며 많은 연구가 필요한 종이다. 그러므로 정확한 지리학적 분포와 종의 동정을 통해 이들 긴팔원숭이의 계통 관계를 파악 하는 것이 긴팔원숭이의 종분화의 이해 및 보존을 위해 무엇 보다 중요하다고 사료된다. Gibbons are called lesser apes and classified hominoidae, catarrhini, anthropoidea, primates. They are successfully speciated with 12 species, 4 generas, in tropical forest of Southeast Asia. Ten species among them are endangered. Compared to other primates, gibbons are highly endangered. However, we do not know exact geographical distributions of gibbons and their subspecies numbers. Therefore further investigations are needed for lesser apes. It is of great important to know exact phylogenetic relationships with the information of distribution and identification of gibbon species in order to understand speciation and conservation of gibbons.
허재원,하홍석,김윤지,이자랑,김대수,조병욱,김희수 한국유전학회 2007 Genes & Genomics Vol.29 No.2
sent a potential infectious risk in pig-to-human transplantations. Solitary long terminal repeat (LTR) elements from the PERVs are investigated by PCR amplification, methylation analyses, and promoter asays. Among 6 diferent hybrid individuals (KYP1-6) of KDP (Korean domestic pig)× Yorkshire, a haploid genome of KYP1 and KYP5, while the LTRs from PERV-A5, -A7, and -A8 loci were detected in the diploid genome of all hybrid pigs. Methylation analyses of those solitary LTR elements using genomic DNAs of various tisues from pigs indicated that the solitary LTR element from the PERV-X9 locus was hypomethylated, whereas the solitary LTR elements froloci were hypermethylated in most tisues examined. The solitary LTR element of the PERV-X9-KYP1 clone that had recently integrated into the haploid genome showed les promoter activity than the older PERV-A5-KYP1, PERV-A7-KYP1, PERV-A8-KYP1 LTRs detected in diploid genome of pigs. Our data suggest that the LTR elements having high al activity in various tissues of pigs.
청력 소실과 이명, 현훈을 동반한 진성 적혈구증가증 1예
허재원,김상준,이동근,강명구 대한이비인후과학회 부산,울산,경남 지부회 2021 임상이비인후과 Vol.32 No.2
Polycythemia vera (PV) is a chronic myeloproliferative neoplasm (MPN) which is characterized by proliferation of red blood cells, white blood cells and platelets. PV is associated with the JAK2 V617F mutation. The presenting symptom of PV is variable. Headache, weakness, fatigue, pruritus, dyspepsia, dizziness, visual disturbances may be seen in PV patients. Severe complications such as stroke, acute myocardial infarction and pulmonary embolisms are attributed to a red blood cells and platelets causing hyperviscosity and thrombosis. Even though hearing loss, tinnitus and dizziness are belong to symptoms of PV, they are very rare initial presentation for patients with PV. We report a 49-year-old man with PV, whose first symptoms of PV were hearing loss, tinnitus and dizziness.
Expression analysis of RBMY1, CDY1, and VCY2 genes in Korean male infertility
허재원,김우영,김대수,하홍석,박남철,최욱환,남기만,최진,김희수,Huh, Jae-Won,Kim, Woo-Young,Kim, Dae-Soo,Ha, Hong-Seok,Park, Nam-Chul,Choi, Ook-Hwan,Nam, Ki-Man,Choi, Jin,Kim, Heui-Soo Korean Society of Life Science 2007 생명과학회지 Vol.17 No.5
무정자증에 영향을 미치는 AZFa, b, c 영역은 남성불임환자에서 잦은 미세결실이 발견됨으로써 정자형성과정에서 중요한 역할을 할 것으로 주목 받아왔다. 이들 영역에 있는 유전자중 RBMY1, CDY1 그리고 VCY2유전자는 고환에서 남성의 생식선 세포의 분화와 연관되어 있는 것으로 알려졌다. 42명의 무정자증 환자의 고환조직을 RT-PCR법으로 분석해본 결과 RBMY1, CDY1 그리고 VCY2 유전자는 각각 34%, 66%, 그리고 27%의 환자에서 발현되지 않는 것으로 조사되었다. RBMY1 과 VCY2유전자가 발현되지 않는 개체는 CDY1유전자도 역시 발현이 되지 않았다. 세르토리 세포만 가진 환자에서는 CDY1 유전자가 발현되지 않았다. 따라서, CDY1 유전자는 한국인 집단에서 정자형성과정의 필수적인 요인인 것으로 사료된다. Azoospermia factor(AZFa, b, and c) regions have been focused on their involvement in the spermatogenic process by frequent observation of microdeletion in male infertility. Among the azoospermia factors, RBMY1, CDY1, and VCY2 genes are strongly associated with the male germinal cell differentiation and development in testis. Using RT-PCR approach, expression patterns of RBMY1, CDY1, and VCY2 genes are examined in testicular biopsy specimens from 42 Korean azoospermic patients. No expression of RBMY1, CDY1, and VCY2 genes appeared as 34%, 66%, and 27% of the male infertility, respectively. Patients who had no expression of RBMY1 and VCY2 genes also showed negative expression of the CDY1 gene in their testis tissues. All Sertoli cell-only syndrome patients showed no expression of the CDY1 gene. Taken together, the CDY1 gene expression seems to be necessary factor to complete spermatogenesis in Korean population.
Post-marketing Surveillance Study of an Inactivated Split-Virion Influenza Vaccine in Korea
허재원,마상혁,김현균,바바슈리 구나팔라이아,한스 복 대한소아감염학회 2011 Pediatric Infection and Vaccine Vol.18 No.1
Purpose:This post-marketing surveillance study (NCT00750360) assessed the safety and reactogenicity of an inactivated, trivalent split-virion influenza vaccine licensed for use in the Korea since 2002. Methods:Eight hundred and eighty three subjects aged ≥6 months received a single dose of the vaccine; an additional dose was administered to those aged <9 years and unprimed with an influenza vaccine. Four hundred and eleven subjects used diary cards to record safety information; this report presents data from these subjects. Incidence of solicited local, general and unsolicited adverse events (4-days and 21-days post-vaccination follow-up periods, respectively) were recorded. Serious adverse events (SAEs) were recorded throughout the study period. Results:Injection site pain (subjects aged <6 years: 12.6% of subjects, ≥6 years: 34.7%), fever (<6 years: 1.3%) and myalgia (≥6 years: 13.9%) were the most frequently recorded solicited local and general adverse events. Grade 3 solicited adverse events were reported by ≤4.0% subjects. No vaccine-related SAEs were recorded (KFDA criteria). Conclusion:Considering the vaccine’s well-established immunogenicity and its favourable safety and reactogenicity profile across all age groups and its high coverage rate in Korea, it may be recommended as a candidate to facilitate annual seasonal influenza vaccination for all ages as part of the Korean National Immunization Program.
허재원,김상준,박민경,강명구 대한이비인후과학회 부산,울산,경남 지부회 2022 임상이비인후과 Vol.33 No.2
Hamartomas are malformations resulting in an inappropriate overgrowth of normal adult tissue. They are composed of an abnormal mixture of tissues indigenous to their site of origin. Hamartomas are usually found in the lung, liver, kidney and spleen but are rarely seen in head and neck areas. Symptoms vary according to their location and surgical resection is recommended to relieve the symptoms. We experienced a case of hamartoma in the middle ear which was misconceived as congenital cholesteatoma, and report it with a review of the related literature.