전주시 청소년 생활만족도와 문제행동에 관한 연구

최말례,은헌정,이선미,박경훈 전북대학교 사회과학연구소 2003 지역과 세계 Vol.29 No.-

防腐劑가 消化酵素 Amylase 의 作用에 미치는 영향

최말례 이화여자대학교 약학회 1963 梨花藥學會誌 Vol.- No.4

백서 해마절편에서 Methamphetamine의 Norepinephrine 유리효과

최말례,정은용,김완호 의과학연구소 2000 全北醫大論文集 Vol.24 No.1

防腐劑가 消化酵素 Amylase 의 作用에 미치는 영향

최말례 梨花女子大學校 藥學硏究所 1963 梨花藥學硏究 Vol.- No.4

백서 해마절편에서 Methamphetamine의 Noreponephrine 유리효과

최말례 ( Mal Rye Choi ),최수진 ( Soo Jin Choi ),이진희 ( Jin Hee Lee ) 전북대학교 의과학연구소 2003 全北醫大論文集 Vol.27 No.1

Methamphetamine (MAP) is a well known psychostimulant, It has been reported that MAP induces release of various neurotransmitters from brain regions, and is capable of enhancement of cognitive function. Hippocampal noradrenergic system is involved in momory process. We examined the mechamism of MAP-induced [3H]norepinephrine([3H]NE) release in rat hippocampal slices. MAP induced the release of [3H]NE in a dose dependent manner (1-100 uM). At 10 uM concentration of MAP, [3H]NE was released over 85% of resting period. In the presence of 1 uM yohimbine, MAP-induced [3H]NE release was potentiated. MAP-induced [3H]NE release was not inhibited by 1 uM tetrodotoxin, indicating that the action site of MAP is located on the presynaptic terminal. The amount of MAP-induced [3H]NE release was not altered in the absence of Ca2, but was significantly increased in the absence of NaCI (replaced by equimolar N-methyl-glucamine) in the incubation media. MAP-induced [3H]NE release was not altered by voltage-sensitive calcium channel blockers (nitrendipine and ω-conotoxin GVIA). Desipramine (1 uM) and nisoxetine (0.1 uM), NE transporter blockers, significantly inhibited MAP-induced NE release. MAP-induced NE-release was inhibited by MK-801 (1 and 10 uM), but not by D-AP5 or removal of Mg2+ in the incubation media. Also, MAP failed to stimulate the release of [3H]aspartate even in 100 uM, and 10 uM of MAP failed to displace the specific binding of [3H]MK-801 in rat cerebral cortex membrane. Our results suggest that MAP induces NE release by reversal of NE transporter which is located in presynaptic terminal, and that glutamate is not involved as reported in other neurotransmitter system, such as dopamine in striatum.

폐쇄성수면무호흡증에 대한 지속적 양압치료가 삶의 질에 미치는 영향 : 단일기관 연구

신현석,최말례,김신일,홍세연,은헌정,Shin, Hyun Suk,Choi, Mal Rye,Kim, Shin il,Hong, Se Yeon,Eun, Hun Jeong 대한수면의학회 2020 수면·정신생리 Vol.27 No.2

목 적 : 본 연구에서는 OSA환자의 임상적 특징과 CPAP 사용 전·후의 삶의 질 정도를 비교하여 CPAP 사용에 따른 삶의 질의 개선 정도를 알아보고자 하였다. 방 법 : 진료기록부를 통한 나이, 성별, 신장, 체중, 체질량지수, 앱워스 주간졸림척도, 수정된 말람파티척도, 한국판 몬트리올 인지평가, 피츠버그 수면의 질 지수를 조사하여 분석하였다. CPAP 사용에 따른 삶의 질의 개선정도를 알아보기 위해 연구대상자에게 전화 연락을 취하여 CPAP 사용 전·후의 삶의 질에 대해 시각형 아날로그 척도(VAS)를 이용하여 조사하였다. 결 과 : 신장(Z = -4.525, p < 0.001), 체중(Z = -2.844, p < 0.05), 수면의 질(Z = -2.671, p < 0.05)과 각성 지수(Z = -2.105, p < 0.05)에서 통계학적으로 남·녀 간에 차이(p < 0.05)가 있으며 나머지 변수에서는 차이가 없음이 확인되었다. 교차분석에서 χ2 = 7.724, p = 0.024로 p < 0.05보다 작으므로 OSA의 수준별 심각도와 성별 간에 차이가 있음이 확인이 되었다. PreCPAP QOL, PostCPAP QOL, CPAPUse Months, CPAP4Hr/d (%)의 OSA의 수준별 심각도에 따른 크기에는 통계적으로 유의미한 순서가 존재하지 않는 것으로 확인되었다(p > 0.05). CPAP 사용 전 AHI와 사용 후 AHI의 차이가 36.48 ± 21.54 (t = 11.609, p < 0.001)이었고, CPAP 사용 전 QOL과 사용 후 QOL의 차이가 -25.43 ± 22.06 (t = -7.901, p < 0.001)이었으며 통계적으로 의미 있는 차이(p < 0.001)를 보였다. 결 론 : OSA환자 중 남녀간 임상적으로 신장(HT), 체중(BW), 수면의 질(PSQI), 각성지수(AI), OSA의 수준별 심각도에서 남녀 간의 차이가 있었다. 그러나 CPAP전·후에 삶의 질은 남녀간 차이가 없었다. 또한 OSA환자에서 CPAP 사용 후 삶의 질이 개선되었음을 확인하였다. Objectives: In this study, the clinical characteristics of OSA patients and the quality of life before and after CPAP use were compared to determine the degree of improvement in quality of life according to CPAP use. Methods: Age, sex, height, weight, body mass index, Epworth Sleepiness Scale, Modified Mallampatti Score, Montreal Cognitive Assessment-Korean, and Pittsburgh Sleep Quality Index were compared between men and women through medical records. To understand the degree of improvement in quality of life resulting from use of CPAP, a personal telephone call was made to compare the VAS scores for quality of life before and after CPAP use. Results: In height (HT) (Z = -4.525, p < 0.001), weight (BW) (Z = -2.844, p < 0.05), sleep quality (PSQI) (Z = -2.671, p < 0.05), and arousal index (AI) (Z = -2.105, p < 0.05), there was a difference between men and women (p < 0.05). There was no difference in the remaining variables. Cross-analysis (Chi-square test) confirmed a difference between severity and sex of OSA. It has been found that there is no statistically significant order in size according to level-specific severity of OSA for PreCPAP QOL, PostCPAP QOL, CPAPUse Months, and CPAP4Hr/d (%) (p > 0.05). The difference between AHI before and after CPAP was 36.48 ± 21.54 (t = 11.609, p < 0.001) and the difference between QOL before and after CPAP was -25.43 ± 22.06 (t = -7.901, p < 0.001), both of which were significant (p < 0.001). Conclusion: Among OSA patients, there were differences in height (HT), weight (BW), sleep quality (PSQI), arousal index (AI), and severity of OSA between men and women, but the quality of life before and after CPAP was different. However, there was no difference between men and women in quality of life before and after CPAP. In addition, quality of life in OSA patients improved after using CPAP.

한국판 성격장애 검사(Personality Disorder Questionnaire-4+ : PDQ-4+)의 신뢰도와 타당도에 관한 예비적 연구

김동인,최말례,조은정 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 본 연구의 목적은 한국판 성격장애 검사(PDQ-4+)의 신뢰도와 타당도를 알아보고자 하였다. 방 법 : 540명의 정상군과 39명의 성격장애군에 대하여 성격장애 검사를 실시하였다. 신뢰도 평가를 위하여 내적 일치도, 반분 신뢰도, 검사-재검사 신뢰도, 성격장애별 소척도들의 각문항과 평균간의 상관, 등을 구하였다. 또한 타당도 평가를 위해서 요인분석, 정상군과 성격 장애군의 총점 간의 차이를 보이기위해 t-test를 하였다. 결 과 : 540명의 정상군과 39명의 성격장애군에서 내적 일치도는 대부분의 성격장애 항목에서 .500이상(Cronbach alpha의 범위 : .4007에서 .6693까지)이었다. 반분 신뢰도는 짝수문항과 홀수문항 사이에서 .839 이었다. 2주 간격으로 시행한 검사-재검사 신뢰도는 .868이었다. 성격장애별 소척도들의 각문항과 평균간의 상관은 높은 상관계수를 보여 주었다. 정상군과 정격장애군의 총점 간의 차이는 매우 의미있는 차이를 보여 주었다. (t=9.146, df=76, p=.000). 결 론 : 성격장애 검사는 충분한 신뢰도와 타당도를 가지고 있으며 모든 성격장애를 선별하는데 유용한 도구라고 할 수 있다. Objectives : The purpose of this study was to examine the reliability and the validity of the Korean version of Personality Disorder Questionnaire-4+(PDQ-4+). Methods : PDQ-4+ was administered to 540 subjects of general population group and 37 subjects of personality disorder group. For measuring concurrent reliability, we tested internal consistency, split-half reliability, test-retest reliability and correlation of item score of subscale and mean of subscale. And also, we performed factor analysis for the evaluation of validity, and t-test to group difference of the total scores between general population group and personality disorder group. Results : In general population group and personality disorder group, internal consistency was above .500(range of Cronbach alpha : .4007 to .6693) in most of the Personality disorder categories. Split-half reliability was .839 between even and odd items. Test-retest reliability done 2 seeks interval was .868. Item scores of subscales and mean of subscales showed high correlation coefficient. Group difference of the total scores between general population and personality disorder group showed very significant difference(t=9.146, df=76, p=.000). Conclusion : The PDQ-4+ shows a reasonable degree of reliability and validity and could be a valuable tool in screening for overall personality disturbances.

일 병원의 순환교대근무와 주간고정근무 여성 간호사의 근무형태에 따른 정신신체 증상

김병조,최말례,김태형,김형욱,은헌정,Kim, Byoung-Jo,Choi, Mal-Rye,Kim, Tae-Hyung,Kim, Hyeong-Wook,Eun, Hun-Jeong 한국정신신체의학회 2014 정신신체의학 Vol.22 No.2

연구목적 일 종합병원에 근무하는 여성 간호사 중 순환교대자와 주간고정근무자 두 군 간의 정신신체 증상의 차이를 조사하였다. 방 법 일 종합병원에서 근무하는 여성 간호사의 인구학적 정보를 수집하여, 두통의 강도(VAS), 두통의 유형, 두통의 빈도를 알기위한 질문지와 우울척도(BDI), 전반적 수면평가지(GSAQ)를 사용하였다. 통계분석은 Mann-Whitney test와 ${\chi}^2$ test를 사용하였다. 결 과 전체 대상군 84명 중 순환군이 37명, 주간군이 47명이었다. 순환군이 주간군보다 젊고 미혼이 많았고 근무연수가 적었다. 순환군이 주간군보다 두통, 불면, 과다 주간졸리움증, 우울, 불안과 같은 정신신체 증상이 통계학적으로 유의하게 많았다. 결 론 종합병원의 순환교대근무 여성간호사가 주간근무자보다 더 많은 두통, 불면, 과다 주간졸리움증, 우울, 불안을 보였다. Objectives : Shift work disorder occurs when you have difficulties adjusting to a work schedule that takes place during a time which most people sleep. Some people may have diverse psychosomatic symptoms, such as sleep problems, depression, anxiety, and headaches even after the shift work schedule ends. The aims of this study are to compare difference of psychosomatic symptoms between rotating shift and daytime working nurse groups. Methods : Volunteer nurses working in a general hospital were recruited in a general hospital. We collected sociodemographic data. We used questionnaires for headache type, headache frequency, and VAS(Visual Analog Scale) for headache intensity, BDI(Beck depression Inventory) and GSAQ(Global Sleep Assessment Questionnaire). We used Mann-Whitney test and Chi-square test for hypothesis testing. Results : Data collected from 84 women nurses. Rotating shift(N=37) working nurses showed younger, more unmarried, and shorter work periods than daytime working nurses (N=47). Also rotating shift group showed more problems of headache, insomnia, excessive daytime sleepiness, depression and anxiety than daytime group. The above results were statistically significant. Conclusions : The rotating shift work women nurses produced more headache, insomnia, excessive daytime sleepiness, depression, and anxiety than daytime working ones.

중동호흡기증후군에 대한 공포감이 병원종사자와 일반인의 사회심리적 건강에 미치는 영향 : 외상 후 스트레스의 매개효과

김신일,김태형,최말례,정주리,권혁민,김형욱,김병조,은헌정 대한불안의학회 2019 대한불안의학회지 Vol.15 No.1

Objective : The objective of this study is to determine the effects of fear of Middle East respiratory syndrome (MERS) on socio-psychological health during an outbreak of MERS and the post-traumatic stress as a mediator on the relationship between stress and socio-psychological health. Methods : Visual Analog Scale, Impact of Event Scale -Revised, Psychosocial well-being index short form was implemented for 150 medical persons who worked at the hospital in which exposure to MERS cases had been confirmed and 96 ordinary people. A Pearson correlation coefficient and a hierarchical multiple regression was carried out to confirm the effect of fear of MERS and the mediating effect of post-traumatic stress between fear and socio-psychological health. Results : The higher the fear, the lower the socio-psychological health in both healthcare workers and the public (r=0.32, p<0.01) and the higher post-traumatic stress (r=0.32, p<0.01). But, the research results showed that only healthcare workers had a partially mediating effect of post-traumatic stress in the relationship between fear and socio-psychological health (β=0.45, t=6.33 p<0.001), (β value : 0.39>0.26). Conclusion : This study demonstrated that the post-traumatic stress can indirectly lead to a negative effect on the socio-psychological health of healthcare workers when under the fear of MERS and shows adverse effects on psycho-social wellbeing. This suggests that clinical intervention and psycho-social approach aiming at reducing post-traumatic stress is important to maintain mental health during crisis development. (Anxiety and Mood 2019;15(1):45-52)

메르스(Middle East Respiratory Syndrome)사태에 따른병원종사자와 일반인의 스트레스 정도가 사회심리적 건강에미치는 영향과 회복탄력성의 매개효과

권혁민,김태형,최말례,김병조,김형욱,송옥선,은헌정 한국정신신체의학회 2017 정신신체의학 Vol.25 No.2

Objectives:The purpose of this study is to investigate the effects of stress on psychosocial wellbeing at the time of an outbreak of Middle East respiratory syndrome(MERS) and to investigate the effect of resilience as a mediator on the relationship between stress and psychosocial wellbeing. Methods:Perceived Stress Scale, Psychosocial Wellbeing Index Short Form, and the Conner-Davidson Resilience Scale was implemented for 156 medical persons who worked at the hospital in which exposure to MERS cases had been confirmed and 127 ordinary people. We conducted a Pearson correlation coefficient and a hierarchical multiple regression to confirm the effect of stress on psychosocial wellbeing and the mediating effect of resilience between stress and psychosocial wellbeing. Results:The higher the perceived stress, the lower the psychosocial wellbeing in both healthcare workers and the public. The higher the perceived stress, the lower the resilience and the research results showed that there was a partially mediating effect of resilience in the relationship between stress and psychosocial wellbeing. Conclusions:This study demonstrated that the degree of individual resilience can indirectly give a positive effect on the psychosocial wellbeing when people under the stress by MERS shows adverse effects on psychosocial wellbeing. This suggests that clinical intervention and psychosocial approach aiming at strengthening resilience is important to maintain mental health during crisis development. 연구목적: 본 연구는 메르스(Middle East Respiratory Syndrome, MERS(Middle East Respiratory Syndrome, 이하MERS) 사태 발생 당시에 받은 스트레스가 사회심리적 건강에 미치는 영향을 알아보고, 회복탄력성이 매개효과로서 사회심리적 건강에 영향을 주는지를 알아보고자 하였다. 방 법: MERS가 발생한 병원의 병원종사자 156명과 일반인 127명을 대상으로 스트레스 자각척도, 사회심리적 건강측정 도구, 코너-데이비슨 리질리언스 척도를 시행하였다. 스트레스가 사회심리적 건강에 미치는 영향 및 회복탄력성의 매개효과를 확인하기 위해 피어슨 상관관계분석과 위계적 다중회귀분석을 실시하였다. 결 과: 병원종사자와 일반인 모두에서 지각된 스트레스가 높을수록 사회 심리적 건강이 좋지 않음을 보였고, 지각된스트레스가 높을수록 낮은 회복탄력성을 나타냈으며, 스트레스와 사회심리적 건강 사이의 관계에서 회복탄력성이 부분 매개를 하는 것으로 나타났다. 결 론: 본 연구는 MERS 사태로 인해 받은 스트레스가 사회심리적 건강에 영향을 미침에 있어서 개인의 회복탄력성의 정도가 간접적으로 사회심리적 건강에 긍정적 효과를 끼칠 수 있고, 회복탄력성 강화를