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랫드 전암 간세포의 증식성과 c-myc, ras의 발현에 관한 연구
조호성,박남용,Cho, Ho-seong,Park, Nam-yong 대한수의학회 2000 大韓獸醫學會誌 Vol.40 No.1
This study was carried out to examine proliferative activity and expression of c-myc oncoprotein and p2lras in normal and preneoplastic rat livers induced by an in vivo mid-term chemical carcinogenesis assay. Sixty, six-week-old male specific pathogen free Sprague-Dawley male rats were randomly divided into five groups. Group I was received a single intraperitoneal(IP) dose(200mg/kg) of diethylnitrosamine(DEN). Group 2(10 rats) was operated partial hepatectomy(PH) and Group 3 was received IP(200mg/kg) DEN, fed two weeks later with 500ppm of phenobarbital(PB). Group 4 was received IP(200mg/kg) DEN, fed two weeks later 500ppm(PB) and PH at week 3 after the onset of experiment. While group 5(20 rats) was not treated and used as a control group. All the rats were sacrificed at age 14 weeks except 10 rats from group 5 were sacrificed at the onset of experiment. Livers of all rats were examined for 5-bromo-2'-deoxyuridine(BrdU) incoporation, proliferating cell nuclear antigen(PCNA), silver-binding nucleolar organizer regions(AgNORs) counts per nucleus and expression of c-myc oncoprotein and p21ras. Both the number and area of the preneoplastic lesions were significantly(p<0.01) compared to other groups. A significant(p<0.01) increase in immunoreactive cells were detected in preneoplastic hepatocytes in Groups 3 and 4 by PCNA and BrdU immunohistochemical stain. The number of the positive cells were significantly(p<0.05) lower in normal 14-week-old rats than those of 6-week-old rats. The results showed that proliferative activity of the hepatocytes was increased by treatment with DEN, PH and PB. Meanwhile, AgNORs counts per nucleus were significantly(p<0.05) increased in the preneoplastic hepatocytes of rats in both groups 3 and 4. The expression of c-myc oncoprotein and p21ras were more readily localized within the hepatic preneoplastic lesions such as hyperplastic nodules. Especially, group 4 showed significantly (p<0.05) overexpressed levels compared to groups 1 and 3. These findings suggest that PCNA, BrdU and AgNORs are significantly increased and c-myc oncoprotein and p21ras are significantly overexpressed in hepatic preneoplastic lesions induced by mid-term carcinogenesis. So these parameters can be an effective markers for hepatic prencoplastic lesions.
개의 잠복고환된 단 고환에서 정상피종과 세르토리 세포종의 동시 발생
조호성,Jordan Masangkay,박남용 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.2
A 9-year-old male poodle dog exhibited a white to yelow 3.0. 2.0. 3.9 cm mass in the left testicle withHistopathologically the mas consisted of seminoma and sertoli cell tumor (SCT). Seminoma was characterized withdiffuse solitary pattern in which tumor cells had polygonal nuclei and clear cell border. SCT was composed of compactneoplastic cells with small nuclei and indefinite cytoplasm. The tumor was occupied mainly with SCT. SCT and seminomawere observed occasionally in the same lesion. From these results, this case was diagnosed as concurrent seminomaand SCT in the left cryptorchidism and monorchidism. To our knowledge, this is the first report of concurrent occurrenceof seminoma and SCT in a dog with cryptorchidism and monorchidism in Korea.
조호성,이낙운 강원대학교 조형예술연구소 2006 조형예술논문집 Vol.7 No.-
Loius I. Kahn thinks many inspiration and realized it, and seeks development being influenced from various things, is an architect who made his idea by philosophical value and idea. The thought about his light is suggestion of many thing to us. Design by Loius I. Kahn that teaches method that value and ideals which he believed philosophical truth that is hidden designing Form through Order and philosophy understand, and discovers beauty in the most ordinary target being possessed by passion for truth found essence of space with pure function through geometrical plane composition, and the outside form was by revelation of structure and plane by rule of order that any decoration does not exist, and found essence the architecture in form that is designed like this. As a result, outside form was consisted of geometrical repeatability of opening by use of essential material that displays purity mass built limit in plane and structural construction and use of light. Exposed structure of building directly because is grafted together to concept of ruins that find self-consciousness in essence of light and space in solid geometry form that structure combines as one unit with each space are appeared. Later, Khan's expression about faun was ripened and polished. He was designed naturally from fog in according to intuitional response of building essence without taking specification about some form. Did not show from expression to external form about light. To grasp change process of ideas how concept of order as essence of architecture which he seeks arrives from form to design is beaconed to organize new paradigm even if speak that we are living within new order system now.