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조민성,진혜영,최진호,김대연,이정주,유한욱 대한소아내분비학회 2010 Annals of Pediatirc Endocrinology & Metabolism Vol.15 No.3
Adrenocortical carcinoma is a very rare condition in childhood. There are only a few reports about adrenocortical carcinomas associated with congenital adrenal hyperplasia. A two-month-old male baby presented at the local clinic with skin hyperpigmentation, dehydration, hyponatremia, and hyperkalemia. He was diagnosed with congenital adrenal hyperplasia and had been treated with hydrocortisone and 9α-fludrocortisone until 1 year of age. At age 5.8 years, he visited an outpatient clinic because of tall stature and secondary sexual characteristics, and hydrocortisone was administered. At age 16 years he was admitted for treatment of an adrenal tumor, incidentally detected during the evaluation of hematuria. Serum adrenocorticotrophic hormone and cortisol levels were 33.5 pg/mL and 5.2 μg/dL, respectively. 17α-hydroxyprogesterone level was 6.3 ng/mL and dehydroepiandrosterone sulfate level was 31.2 μg/dL. Abdominal ultrasonography and computed tomography revealed a solid mass of 7.7 × 5.6 × 6.2 cm in the left adrenal gland. It was totally removed by surgery, and the histopathology was compatible with adrenocortical carcinoma. 선천성 부신피질과형성증 환자에서 부신 피질 종양이 종종 발견되고 있는데 부신피질암은 매우 드물게 보고되고 있다. 생후 2개월에 피부의 과다 색소침착, 탈수와 저나트륨혈증, 고칼륨혈증으로 선천성 부신피질과형성증 진단을 받고 1세까지 스테로이드를 복용하다가 임의로 중단 후, 5세에 성조숙증이 발현하여 다시 스테로이드로 치료받던 환자가 16세경 혈뇨를 주소로 외래 방문하였다. 혈액 검사상 부신피질자극호르몬 33.5 pg/mL, 코티솔 5.2 μg/dL, 17-알파히드록시프로게스테론(17α-hydroxyprogesterone, 17-OHP) 6.3 ng/ mL, dehydroepiandrosterone sulfate (DHEA-S) 31.2 μg/dL 였고 초음파와 복부 전산화단층촬영상 왼쪽 부신에 7.7 × 5.6 × 6.2 cm의 종괴가 발견되어 수술적 제거를 받았고 조직학적으로 부신 피질 암종으로 진단받은 1례를 보고 한다.
Ionic 또는 Nonionic Side Group을 갖는 Polyaniline Suspension의 전기유변특성
조민성,김지우,장원휴,서문석,신민재,최형진 한국유변학회 1999 Korea-Australia rheology journal Vol.11 No.2
반전도성 polyaniline의 유도체들로서 poly(aniline-co-sodium diphenylamine sulfonate), poly(aniline-co-o-ethoxyaniline), poly(o-methylaniline), poly(o-methoxyaniline)를 중합하여 전기유변유체의 입자로 사용하였다. 각 분산액은 전기장하에서 전형적인 전기유변특성을 나타냈으나, 낮은 전단변형률에서의 stress plateau 영역에서 입자의 종류에 따라 다른 흐름특성을 얻었다. 전기유변유체의 전기장에 따른 flow curve 변화와. dynamic yield stress와 전기장 간의 관계로부터 접근한 scaling law를 이용하여 각 전기유변유체의 universal flow curve를 구하였다. Semiconductive polyaniline and its derivatives such as poly(aniline-co-sodium diphenylamine sulfonate), poly (aniline-co-o-ethoxyaniline), poly (o-methylaniline), and poly (o-methoxyaniline) were synthesized, and then adopted as suspending particles of the electrorheological (ER) fluids. All suspensions of these polyaniline derivatives showed typical ER properties under high applied electric fields. However, flow behaviors are observed to be quite different depending on the polyaniline derivatives, especially in the stress plateau regions obtained at low shear rates. Using a scaling law, we also obtained universal cures of ER fluids from the flow curves at each applied electric field based on the relationship between the dynamic yield stress with the applied electric field and flow curve changes according to the electric fields.