소아에서의 광절열두조충 감염 1례

이진수,김백남,손영모,이종원,임경일,Lee, Jin Soo,Kim, Baek Nam,Sohn, Young Mo,Lee, Jong Won,Im, Kyung-Il 대한소아감염학회 2001 Pediatric Infection and Vaccine Vol.8 No.1

기생충 감염이 거의 없는 최근, 저자들은 5세 여아에서 소아에서는 드문 광절열두조충 감염을 경험하였기에 문헌 고찰과 함께 보고하는 바이며, 생선회의 소비가 급증하고 쉽게 사먹을 수 있는 시장의 형성으로 환자의 증가가 예상되어 전국민적인 보건교육과 함께 비특이적 소화기 증상을 가진 환아에 대한 소아과 의사들의 자세한 문진과 의심이 요구된다고 본다. We experienced one rare case of Diphyllobothrium latum infection in childhood. It was proved by collection of worm after praziquantel treatment. Human diphyllobothriasis is chiefly caused through eating raw or unproperly cooked fish such as trout or salmon. This case was a 5-year old girl residing in Seoul, from whom a kind of pseudophyllidean tapeworm was detected in the feces. She would often eat sushi(raw fish) and had abdominal pain, but not revealed any sign of anemia. Obtained chain of worm segments that sized $0.25{\times}1.25cm$ was compatible with D. latum. Including the present 31 cases, total number of human D. latum infections proven by worms in Korea becomes 32 cases, and total number of child D. latum infections proven by worms in Korea becomes 4 cases.

고속도로 건설현장의 산성배수 발생개연성평가 및 피해저감대책: ○○고속도로건설현장

이진수,김재곤,박정식,전철민,남인현,Lee, Jin-Soo,Kim, Jae Gon,Park, Jeong-Sik,Chon, Chul-Min,Nam, In-Hyun 대한자원환경지질학회 2013 자원환경지질 Vol.46 No.5

${\bigcirc}{\bigcirc}$고속도로 건설현장 ${\bigcirc}$공구에 분포하는 암석에 대하여 산성배수 발생개연성을 평가하고 피해 저감대책을 검토하였다. 고속도로건설구간의 지반은 이천리층에 해당하는 사암과 중성내지 산성 화산암으로 구성되어 있으며 이들은 주변의 화강암관입에 수반된 열수 용액에 의해 황화광물을 산점상으로 함유하고 있다. 황화광물의 함량이 높은 화산암과 사암은 산성배수 발생개연성이 높고 중금속(Zn, Pb, As)을 많이 함유한 산성배수가 주변지역으로 유출되어 환경오염을 유발할 개연성이 높은 것으로 나타났다. 건설공사과정중 산성배수가 발생될 개연성이 높은 구역에서 배출되는 배수는 중화 및 중금속 제거처리 후 배수가 이루어져야 하며, 절취면의 안정성 확보를 위하여 산성배수의 발생을 근원적으로 억제할 수 있는 코팅처리기술을 적용한 후 숏크리트, 앵커 등 사면보강공법이 적용되어야 할 것으로 판단된다. 화산암과 사암은 골재로서 활용이 어려우며 지반성토재로 사용할 경우 지하수와 우수의 접촉을 최소화할 수 있는 성토층의 구조를 갖춘 후 활용하여야 한다. Assessment and damage reduction strategy of acidic rock drainage were conducted in a section of ${\bigcirc}{\bigcirc}$ highway construction site. The geology of the studied section consists of Icheonri sandstone and intermediate to acidic volcanic rocks. Sulfides occur as a disseminated type in sandstone and volcanics which were altered by the hydrothermal solution of granite intrusion. Volcanics and sandstone with a high content of sulfide were classified as a potentially acid rock drainage(ARD) forming rock. The drainage originated from those rocks may acidify and contaminate the surrounding area during the highway construction. Therefore, the drainage should be treated before it is discharged. A slope landslide hazard due to the ARD was also expected and the coating technology was recommended for the reduction of ARD generation as a preemptive measure before reinforcement work for enhancing slope stability such as shotcrete and anchor. According to the ARD risk analysis, those rocks should not be used as cement aggregate, but only to be used as a bank fill material of a filling-up system that allows minimal contact with rainfall and groundwater.

전이성 유두상 갑상선암 환자를 대상으로 투여한 알러젠 제거 옻나무 추출물의 종양 소퇴 1례

이진수,정의민,정종수,박재우,정현식,윤성우,Lee, Jin-Soo,Jerng, Ui-Min,Jeong, Jong-Soo,Park, Jae-Woo,Jung, Hyun-Sik,Yoon, Seong-Woo 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3

Papillary thyroid carcinoma is the most common type of thyroid malignancy. It has better prognosis and rarer incidence of distant metastasis than other types of thyroid malignancy. However, once distant metastasis happens, its result will be bad. They mostly spread to the lungs and bones. and rarely to the brain. We report a patient with a papillary thyroid carcinoma metastasis to the lymph nodes. the ribs. the brain, and the lungs. The patient underwent total thyroidectomy, radioiodine ablation, rib partial resection, and lung wedge resection. However, upon progress of metastasis. the patient insisted on being treated with traditional Korean medical treatment using allergen-removed Rhus Verniciflua Stokes (A-RVS) instead of the conventional treatment including chemotherapy. The size of the tumor partly decreased, and the patient showed no side effects. This case report brings forth the importance of a thorough study in papillary thyroid carcinomas and their metastasis from the traditional Korean medical point of view, along with the long-term effect of allergen-removed Rhus Verniciflua Stokes (A-RVS).

경피용 건조 B.C.G. 백신(Tokyo 172주) 접종 후 국소 반응과 투베르쿨린 양전율에 관한 연구

이진수,손영모,Lee, Jin Soo,Sohn, Young Mo 대한소아감염학회 2000 Pediatric Infection and Vaccine Vol.7 No.2

목 적 : 관침관을 이용한 분산난자 경피용으로 접종하는 일본에서 제조한 Tokyo 172주 냉동건조 비시지 백신의 투베르쿨린 양성율과 피부국소 반응 및 부작용 빈도를 알아보기 위하여 본 조사를 시행하였다. 방 법 : 신생아, 영유아, 소아를 대상으로 영동세브란스병원과 7개 개인 소아과 의원에서 접종 후 3일, 4~6주, 36주, 48주째 국소 변화 및 림프절 종창 여부를 관찰하였다. 접종 후 4개월 후에 5TU 0.1mL를 전박 내측에 피내주사하여 48~72시간 후 판독하였다. 결 과 : 관찰기간 중 총 138명의 접종자 중 96명에서의 48주간 추적이 가능하였으며 5TU 투베르쿨린 반응검사 결과 경결 크기의 분포는 5mm 미만이 6명으로 6.3%, 10mm 이상이 67명으로 70.0%, 12mm 이상이 46명으로 47.9%였다. 접종자 모든 례에서 접종 부위 피부에 염증 반응이 관찰되었으며 대부분 4~6주 후에 구진과 작은 농포 및 궤양이 생겼다. 모든 례에서 8~12주 후에 가피를 형성한 후 증상이 사라졌으며 접종 후 48주에 관찰한 접종 부위 반흔 조사에 의하면 전체의 4.2%(4명)에서는 아무런 흔적도 발견할 수 없었고 약 70% 이상에서 10개 이상의 반흔이 관찰되었다. 접종 후 16주에 관찰된 5TU 투베르쿨린 검사의 경결 크기와 48주에 관찰한 접종부위 반흔의 개수와는 상관관계가 관찰되지 않았다. 접종 후 48주까지 추적한 96례 모두에서 액와부 림프절의 종창이나 화농성 염증 등의 이상 반응은 관찰되지 않았다. 결 론 : 본 연구에 사용된 관침관을 이용한 분산난자 경피용 접종법은 이상 반응이 관찰되지 않았으며, 통상적으로 피내 접종 후에 초래되는 어깨 부위의 작은 흉터는 한 례에서도 관찰되지 않았다. 모든 례에서 접종 후 48주 후가 되면 희미한 접종 자국만이 관찰되어 기존의 피내 접종으로 인한 흉터의 우려에 대한 보호자의 만족도는 비교적 높았다. Purpose : We observed response to PPD skin test and local side reactions among subjects who received inoculation with Tokyo 172 BCG strain by percutaneous method using multiple puncture device. Methods : 138 infants and young children were enrolled at Yongdong Severance Hospital and 7 private clinics. 5TU PPD skin test were performed at 4 months after inoculation. The local reactions at multiple puncture site were observed in 3 days, 4~6 weeks, 36 weeks, and 48 weeks after inoculations and physical check up was done for evaluation of lymphadenopathy. Results : During 48 weeks of observation period, 96 subjects among 138 who were enrolled were followed up completely with records of PPD skin test and observation of local side reactions, presenting with the photos. The size of the induration after 48 hours of PPD skin test, was less than 5mm in six subjects(6.3%), greater than 10mm in sixty seven subjects(70.0%) and greater than 12mm in forty six subjects(47.9%). All subjects showed inflammatory reaction and pustules at multiple puncture sites and only just small papules, ulcer and pustules remained 4-6 weeks later. Eight to twelve weeks later, all local inflammatory skin reactions disappeared with remaining crust. After 48 weeks, 4(4.2%) subjects showed no scar with only faint stain on the puncture site. More than 70% of subjects showed more than 10 faint pin-point scars on the sites. However, the size of scar was clearly smaller compared to that of intradermal inoculation. There were no cases of lymphadenopathy. Conclusion : We observed good immune response to 5TU PPD skin test among the infant and young children who were immunized with percutanous inoculation of Tokyo 172 BCG strain. We could not find any severe local scar at inoculation sites. A degree of satisfaction of the parents whose children received the percutaneous injection was very high.

보은지역 흑색셰일 분포지역에서의 암석-토양-식물계내 잠재적 독성원소들의 분산과 이동

이진수,전효택,김경웅,Lee, Jin-Soo,Chon, Hyo-Taek,Kim, Kyoung-Woong 대한자원환경지질학회 1997 자원환경지질 Vol.30 No.6

This study had three purposes: (1) to investigate the enrichment levels and dispersion patterns of potentially toxic elements in the rock-soil-plant system; (2) to evaluate the uptake ratios of heavy metals from soils into plants and (3) to assess the chemical speciation of heavy metals in soils. Rock, surface soil and plant samples were collected in the Boeun area underlain by black shales of the Okchon Zone. These samples were analyzed for multi-elements using INAA, ICP-AES and AAS. The maximum abundance of U in black shales is 16 mg/kg and radioactivity counts up to 300 cpm. In particular, Mo, V, Ba, Cd, Pb and U are enriched in black shales. Most of soils derived from black shales show high concentrations of U, As, Mo, Ba, Cu, Cd, Pb, Zn and mean concentrations of As and Mo in soils (20 mg/kg of As and 6.6 mg/kg of Mo) are higher than the permissible level suggested by Kloke (1979). Enrichment index values of soils are calculated and higher than 1.0 in the black shale area with the highest value of 6.4. Mean concentration of Cd in plants is higher than those of Cu, Pb and Zn. The concentration of Cd in plant species decreases in the order of Chinese cabbage > red pepper > soybean=sesame > rice stalk > com > rice grain. The biological absorption coefficients (BAC) in plants are in the order of Cd > Zn=Cu > Pb, which suggests that Cd is more bioavailable to plants than Cu, Pb and Zn. From the results of sequential extraction analysis of soils, relatively high proportion of Cu, Pb and Zn are present as residual fractions whereas that of Cd as non-residual fractions. Cadmuim occurs predominantly as exchangeable/water-acid soluble phase in soils, and Cd is more mobile and bioavailable than Cu, Pb and Zn.

제주도 우도 화산섬의 서브알칼리 현무암의 지화학적 특징에 대하여

이진수,Lee, Jin-Soo 대한자원환경지질학회 2014 자원환경지질 Vol.47 No.6

제주도 동편의 부속섬인 우도는 일윤회 분출에 의해 형성된 단성화산체로서 해저에서 초기 서쩨이언형(Surtseyan-type)의 폭발성 화산분화에서 시작되고 마지막 용암분출로 섬 전체의 형태가 완성되었다. 섬의 대부분을 차지하는 소머리현무암은 서브알칼리계열로서 미량원소 및 희토류원소의 지화학적 특성은 섭입대에서 생성되는 쏠레이아이트일 가능성보다는 지각판내부에서 생성된 쏠레이아이트임을 지시하며, 이는 마이오세 말기 이후의 한반도의 화산활동은 태평양판과 필리핀해판인 해양판의 섭입 영향을 받지 않는 지구조적 환경으로 변했음을 시사한다. Udo is the site of a short-lived monogenetic submarine volcanic vent which builts basaltic clastic deposits below sea level, by early Surtseyan-type explosive eruption and later effusive lava eruptions. Mineral assemblage, major and trace element chemistry indicate that the Someori sub-alkaline lava flows were related to the WPTB(within plate tholeiitic basalt) rather than IAT(island-arc tholeiite) and that the geotectonic regime of Korean Peninsula went away from the subduction zone after the Later Miocene.

Polyhydroxyamide/MWNT 나노복합체의 제조와 특성분석

이진수,지민호,이민호,백두현,Lee, Jin-Soo,Jee, Min-Ho,Lee, Min-Ho,Baik, Doo-Hyun 한국섬유공학회 2010 한국섬유공학회지 Vol.47 No.1

Polyhydroxyamide(PHA), a precursor polymer of polybenzoxazole(PBO), was synthesized by low temperature polymerization of 3,3'-dihydroxybenzidine(DHB) and isophthaloyl chloride(IPC) in N,N-dimethylacetamide (DMAc) medium. MWNT dispersions were prepared by ultrasonication of pristine MWNT(p-MWNT) and acid-modified MWNT(a-MWNT) in DMAc. PHA/a-MWNT and PHA/p-MWNT nanocomposite films were prepared by casting of mixed solution. The tensile properties of PHA/a-MWNT nanocomposite films were enhanced compared with those of pure PHA. DSC and TGA analyses revealed that the PHA/a-MWNT nanocomposites cyclized at lower temperature and showed better thermal stability compared to the pure PHA film.

MMR 백신 부작용 발생 실태 - 보건소 전화 조사를 통한 전향적 연구 -

이진수,기모란,손영모,Lee, Jin Soo,Ki, Mo Ran,Sohn, Young Mo 대한소아감염학회 2000 Pediatric Infection and Vaccine Vol.7 No.2

Purpose : Adverse events(AE) associated with vaccination have not been systematically monitored in Korea. But since 1994, several deaths after inactivated mouse brain derived Japanese encephalitis vaccine injection arouse the safety problem of immunization in the public, and a evaluation of vaccination program including the effectiveness and safety problem had been started. We have been using MMR vaccine containing Japanese mumps vaccine strains, which are known to be associated with the high rate of adverse events including aseptic meningitis, for the last decade. Methods : We conducted a prospective study of vaccine adverse events associated with MMR vaccine through a tracking system using telephone calls. We followed up 7,594 cases of MMR vaccinees. Results : Reported adverse events included fever, couvulsion, parotitis, and aseptic meningitis. Nine cases of parotitis and seven cases of aseptic meningitis were recognized during follow up period. The incidence of both parotitis and aeptic meningitis was $85.1/10^5$, for Urabe mumps strain. For Hoshino strain, the incidence of parotitis and aseptic meningitis was $158.0/10^5$ and $94.8/10^5$, respectively. Conclusions : The incidence of adverse events was to be a higher than that of natural infection in Korea and was comparable to the results of studies done in other countries. 목 적 : 일본산 볼거리 백신주를 포함한 MMR 백신의 부작용을 알아보기 위하여 전화 조사라는 전향적인 방법을 통해 백신 부작용의 양상과 빈도, 부작용이 백신주 별로 차이가 있는지 알아보고자 하였다. 방 법 : 보건소 전화 조사를 통한 전향적 방법으로, 접종 후 2주, 4주에 백신 접종자들에게 전화로 부작용 여부를 조사하고 증상이 있을 때에 PCR이나 배양 검사를 통해 확인하였다. 결 과 : 발열 반응은 2차 조사에서 Urabe주 3.9%, Hoshino주 4.6%, Rubini주 0.3%로 백신주에 따라 유의한 차이를 보였다. 경련은 5례로 0.07%였으나 Rubini주 접종자 수가 적어 비교가 어려웠고 이하선염은 8례로 0.12%였으며 백신주간에 차이는 없었으나 1997년의 자연 발생률보다 높았다. 뇌수막염이 의심되었던 7례 중 1례에서 검사가 가능하였고 뇌척수액에서 볼거리 바이러스를 확인하였다. MMR 백신 접종자에서 임상 증상 기준으로 진단된 무균성 뇌수막염 발생률은 1998년 바이러스성 뇌막염 환자 발생률 보다 높았다. 결 론 : 전향적 연구 결과 MMR 백신 접종 후의 부작용으로는 무균성 뇌막염, 이하선염, 경련, 발열 등이 조사되었고 현재 사용되고 있는 일본산 MMR 백신에 함유되어 있는 볼거리주는 외국에서의 연구결과와 동일한 이하선염 및 무균성 뇌막염을 일으킬 생물학적 가능성을 지니고 있으므로 국내에서 MMR 백신 접종 후 상당수에서 이하선염이나 무균성 뇌막염 환자가 발생하였을 가능성이 있을 것으로 사료되나 부작용 발생 보고 체계를 갖추고 있지 않은 관계로 실제 부작용 발생 실태를 파악하지 못하고 있는 것으로 사료된다.

충주지역 흑색셰일 분포지역에서의 잠재적 독성원소들의 분산과 부화

이진수,전효택,김경웅,Lee, Jin-Soo,Chon, Hyo-Taek,Kim, Kyoung-Woong 대한자원환경지질학회 1996 자원환경지질 Vol.29 No.4

This study had three purposes: (1) to investigate dispersion and enrichment level of potentially toxic elements; (2) to identify uranium-bearing minerals in black shales; and (3) to assess the chemical speciation of heavy metals in soils and sediments. Rock, surface soil and stream sediment samples were collected in the Chungjoo area covered with black shales in Korea. These samples were analyzed for multi-elements using INAA and ICP-AES. The maximum abundance of U in black shales is 56 ppm and radioactivity counts up to 240CPM. Molybdenum, V, Ba, Cu, and Pb are enriched in black shales and most of soils show high concentrations of U, Mo, Ba, Cu, Pb and Zn. Concentrations of potentially toxic elements decrease in the order of mountain soil > farmland soil > paddy soil. Enrichment index of soils and sediments are calculated and higher than 1.0 in the black shale area with the highest value of 6.1. In order to identify U-bearing minerals, electron probe micro analysis was applied, and uraninite and brannerite in black shale were found. Uraninite grains are closely associated with monazite or pyrite with the size of $2{\mu}m$ to $10{\mu}m$ in diameter whereas brannerite occurs as $50{\mu}m$ euhedral grains. With the results of sequential extraction scheme, residual fractions of Cu, Pb and Zn in soils are mainly derived from weathering of black shale but Cu, Pb and Zn in sediments are present as non-residual fractions. Lead is predominantly present as oxidizable phase in soils whereas Zn is in exchageable/water-acid soluble phase in sediments.

항암화학요법과의 순차적, 그리고 병행적 요법으로서의 aRVS 투여로 장기 생존과 좋은 삶의 질을 유지한 전이성 비소세포폐암 증례보고

이진수,박형준,채진,김경석,정현식,이상헌,최원철,전성하,Lee, Jin-Soo,Park, Hyeong-Jun,Chae, Jean,Kim, Kyung-Suk,Jung, Hyun-Sik,Lee, Sang-Hun,Choi, Won-Choel,Cheon, Seong-Ha 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.1

This report documents a case in which the administration of an herbal product, an extract of the lacquer tree, Rhus verniciflua Stokes, as sequential and concurrent treatment with chemotherapy was associated with a long term survival and good quality of life in a patient with metastatic non-small cell lung cancer(NSCLC). A 51-year-old Korean female was referred to the $M{\cdot}{\mu}$ Integrative Cancer Center, East-West Neo Medical centrer, Kyung Hee University for stage IV, metastatic NSCLC. She was treated with aRVS alone for 19 months and then received 1st line paclitaxel/carboplatin combined with aRVS, 2nd line gefitinib, and 3rd line pemetrexed. The number of cycles of pemetrexed administered was seventeen. aRVS was restarted as the 13th pemetrexed was administered. Pemetrexed with aRVS is currently ongoing. This patient has been alive for 41 months, and has been keeping a good performance status so far. We suggest aRVS as sequential and concurrent treatment with chemotherapy is an effective alternative treatment strategy.