치명적인 Amiodarone 폐독성 4예

이승우,이상학,여동승,이숙영,김석찬,김관형,문화식,송정섭,박성학,정은선,Lee, Seung-Woo,Lee, Sang-Haak,Yeo, Dong-Seung,Lee, Sook-Young,Lee, Seok-Chan,Kim, Kwan-Hyoung,Moon, Hwa-Sik,Song, Jeong-Sup,Park, Sung-Hak,Jung, Eun-Sun 대한결핵및호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.53 No.6

Amiodarone 폐독성은 약제 복용력이 있는 환자에서 새로운 증상과 X-선의 변화가 있을 때 의심하여야 하며 울혈성 심부전이나 폐감염증, 폐색전증, 악성종양 등과 감별하는 것이 중요하다. 진단은 임상적, 방사선학적, 조직학적 소견을 종합하여 내릴 수 있으며 대부분의 경우에는 약제 중단을 통해서 폐독성의 호전을 기대할 수 있으나 일부에서는 호흡부전으로 진행하거나 기존의 심부정맥의 재발 등으로 인하여 사망하는 경우도 있다. 저자들은 심부정맥으로 amiodarone을 사용하던 환자에서 치명적인 폐독성이 발생한 4예를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다. The lungs are frequently the site of adverse drug reactions because of their higher oxygen concentration, the distinctive properties of the pulmonary circulation, and the close proximity of the alveolar epithelium to the blood. Amiodarone, an iodinated benzofuran derivative, is an effective antiarrhythmic drug commonly used for refractory tachyarrhythmia. However, it has a wide range of adverse effects, the most serious of which is lung disease. Most patients present with the insidious onset of dyspnea and a nonproductive cough, and generally recover after withdrawing the drug. We recently experienced four fatal cases of amiodarone pulmonary toxicity. Therefore, we discuss these unusual drug-induced pulmonary toxicity cases with a review of the relevant literature.

각막의 화학손상에 대한 임상적 고찰

이승우,김홍균,김광수,강정훈,Seung-Woo Lee,Hong-Kyun Kim,Kwang-Soo Kim Jung-Hun Kang 대한안과학회 2005 대한안과학회지 Vol.46 No.9

Purpose: To establish a treatment regimen and preventive measures through clinical study and demographic profile of chemical corneal injury cases. Methods: The records of all patients presenting with chemical corneal injuries from January 1 1997 to December 31 2003 were evaluated. One hundred forty-three chemical corneal injuries in seventy-eight patients presenting to the Dongguk University Hospital were analyzed. Patients was divide into three groups in accordance to occupation (Group I, farmer, Group Ⅱ, directly chemical-agents exposure occupation, Group Ⅲ, others). The records were examined to extract information about age, sex, extent of injury, chemical substances involved, place of injury, delay time of arrival at hospital and visual acuity. Classification of corneal burns was scored according to Roper-Hall.1 Results: The patient consisted of 63 males (80.8%) and 15 females (19.2%), with a mean age of 39.21±13.27 years. The most common agent causing corneal injuries was pesticide, followed NaOH. Ninety-eight (68.5%) eyes showed Grade 1 burns, 27 (18.9%) eyes showed Grade 2, 15 (9.1%) eyes Grade 3 and 5 (3.5%) Grade 4. The severity of chemical corneal burn and deterioration of the visual acuity was more severe in group Ⅱ than in the other groups. Conclusions: Chemical ocular injuries may lead to serous visual impairment. Therefore, proper education for appropriate handling of chemicals to prevent the accidents is important.

탄소나노튜브 전자 필름을 이용한 고감도-고선택성 전기화학 글루코스 센서

이승우,이동욱,서병관,Lee, Seung-Woo,Lee, Dongwook,Seo, Byeong-Gwuan 한국공업화학회 2022 공업화학 Vol.33 No.2

This work presents a non-destructive and straightforward approach to assemble a large-scale conductive electronic film made of a pre-treated single-walled carbon nanotube (SWCNT) solution. For effective electron transfer between the immobilized enzyme and SWCNT electronic film, we optimized the pre-treatment step of SWCNT with p-terphenyl-4,4"-dithiol and dithiothreitol. Glucose oxidase (GOx, a model enzyme in this study) was immobilized on the SWCNT electronic film following the positively charged polyelectrolyte layer deposition. The glucose detection was realized through effective electron transfer between the immobilized GOx and SWCNT electronic film at the negative potential value (-0.45 V vs. Ag/AgCl). The SWCNT electronic film-based glucose biosensor exhibited a sensitivity of 98 ㎂/mM·cm². In addition, the SWCNT electronic film biosensor showed the excellent selectivity (less than 4 % change) against a variety of redox-active interfering substances, such as ascorbic acid, uric acid, dopamine, and acetaminophen, by avoiding co-oxidation of the interfering substances at the negative potential value.

기상측정(機上測定) 시스템 개발

이승우,김선호,Lee, Seung-Woo,Kim, Sun-Ho 대한산업공학회 1998 산업공학 Vol.11 No.1

This paper describes the development of on-the-machine measuring(OMM) system which can directly measure the two and three dimensional machined accuracy using a scanning probe in milling machine. Two algorithms, NC program based continuous path(CP) measurement and CAD data assisted point to point(PTP) measurement, are developed for three dimensional measurements, with consideration of the characteristics of the scanning probe. The algorithms are used to develop an auto measuring system. The delveloped system is compared with the CMM (Coordinate Measuring Machine) in terms of accuracy and repeatability. The OMM system is expected to realize measurement time reduction and hence result in high productivity.

저수축 시멘트 안정처리 기층의 특성분석

이승우,전범준,김종원,Lee, Seung-Woo,Jeon, Beom-Jun,Kim, Jong-Won 한국도로학회 2004 한국도로학회논문집 Vol.6 No.2

시멘트 안정처리는 우수한 강도발현, 내구성, 강성, 동상저항 등의 우수한 능력을 발휘하지만 건조수축으로 인해 표층부로의 반사균열을 발생시키는 단점을 가지고 친다. 이에 본 연구에서는 시멘트의 건조수축을 억제하여 표층부로의 반사균열을 억제할 수 있는 저수축 시멘트 안정처리기법에 대한 타당성을 연구하였다. Cement treated Soil has superior characteristics as pavement-base including strength, curability, hardness, freezing resistance. However drying shrinkage of Cement treated base has been indicated as disadvantage, since reflection crack of surface layer is induced from drying shrinkage of cement treated base. This study propriety about low-shrinkage cement treated base that can control shrinkage of cement and control reflection crack at asphalt overlay & concrete slab.

NaOH 처리한 Fe 첨가된 Ti alloys의 아파타이트 형성관찰

이승우,김윤종,류재경,김택남,Seung-Woo Lee,Yun-Jong Kim,Jae-Gyeoung Ruy,Taik-Nam Kim 배재대학교 공학연구소 2004 공학논문집 Vol.6 No.2

현재까지 사용되어가지고 있는 임플란트 재료 중 commercially pure titanium (순수티탄; Cp-Ti)과 Ti-alloy들은 생체재료로 폭넓게 사용되어지고 있는데, Ti 금속들은 경도가 강하고 점도가 높기 때문에, 치과나 정형외과 등의 하중에 잘 견디는 곳에 이용되어지고 있다고 한다. 이것들은 생체적합성과 부식에 대한 저항성도 좋은 것으로 알려져 있다. 일반적으로 Ti은 4종류의 Grade로 강도의 차이에 의하여 분류되고 Ti의 강도에 영향을 미치는 것으로는 산소, 철, 질소등이 있다. 따라서 본 연구에서는 O와 Fe의 함량을 달리한 Ti alloy시편을 사용하여 생체적합성 실험을 하였다. 먼저 실험은 시편을 micropolishing하고 5M NaOH에서 $60^{\circ}C$에서24시간 처리하여서 비표면적을 넓혔으며, 표면의 $TiO_2$을 만들어주기 위하여 $600^{\circ}C$에서 열처리하였다. 그런 시편을 $36.5^{\circ}C$의 SBF에 넣어 1~14일까지 침적한 후에 표면에 형성된 apatite를 SEM과 EDAX로 조사하였다. 조사 결과 모든 시편에서 apatite가 생성되었지만, 시편의 조성에 따라서 apatite의 형성양이 다름을 확인하였다. Metals, ceramics and polymers are widely used as bioimplant materials. However, Ti and Ti alloys are widely used because of its high strength to weight ratio and good biocompatibility when implanted in the body. In this experiment, Ti alloys of Grade-4 (gr4), 0.2 wt % Fe, 0.5 wt % Fe and 2 wt % Fe were studied for their surface morphology and HAp forming ability on the metal substrate for different treatments. Intially, the samples were mechanically polished on silicone carbide paper (No.-2000). The polished samples were treated with 5M NaOH solution at $60^{\circ}C$ for 24 hours. The NaOH treated samples were washed gently with distill water and dried at $40^{\circ}C$ for 1 day. The dried samples were heated in air at $600^{\circ}C$ for 1 hour. The surface morphology of these samples were studied using SEM. The SEM studies showed network of pores in all samples. These samples were immersed in stimulated body fluids (SBF) kept at $36.5^{\circ}C$ for different periods over the length of 1 to 14 days. The apatite formation was confirmed on all Ti-alloys using EDAX.

입자크기를 달리한 Cp-Ti의 미세구조 관찰 및 SBF하에서의 부식거동

이승우,김윤종,류재경,박중근,김원수,김택남,Lee Seung-Woo,Kim Yun-Jong,Ruy Jae-Gyeoung,Park Joong-Keun,Kim Won-Soo,Kim Taik-Nam 한국재료학회 2005 한국재료학회지 Vol.15 No.9

Titanium and Titanium alloys are widely used as an orthopedic and dental implant material because of their excellent biocompatibility and mechanical strength. In this study, ECAP Cp-Ti and Cp-Ti were heat treated for different annealing time of 30 min, 90 min and 3 hours. The grain size for each condition was studied. The micro-Vicker hardness test was carried out f3r each different heat treated samples. The micro-Vicker hardness test for ECAP Cp-Ti, Cp-Ti and Cp-Ti (3hr) revealed hardness values of 239.5, 182 and 144 Hv, respectively. The grain size was increased from approximately $70{\mu}m\;to\;300{\mu}m$ with the increase in heat treatment time from 30 min to 3 hours. The heat treated samples were tested for their biocompatibility in simulated body fluid (SBF) and corrosion rates was determined using Polarization Curve test (PCT). The PCT results showed Cp-Ti with comparatively high corrosion potential of -0.18 V and corresponding corrosion current of $2\times10^{-6}$ A, while the corrosion rate in ECAP Cp-Ti and Cp-Ti (30 min annealed) showed very similar results of corrosion potential about -0.47 V with corresponding corrosion current of $7\times10^{-8}$ A.

Multi SHA 구조의 파이프라인 아날로그-디지털 변환기 설계

이승우,나유찬,신홍규,Lee, Seung-Woo,Ra, Yoo-Chan,Shin, Hong-Kyu 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.2a

In this paper, Pipelined A/D converter with multi SHA structure is proposed for high speed operation. The proposed structure incorporates a multi SHA block that consists of multiple SHAs of identical characteristics in parallel to improve the conversion speed. The designed multi SHA is operated by non-overlapping clocks and the sampling speed can be improved by increasing the number of multiplexed SHAs. Pipelined A/D converter, applying the proposed structure, is designed to satisfy requirement of analog front-end of VDSL modem. The measured INL and DNL of designed A/D converter are $0.52LSB{\sim}-0.50LSB\;and\;0.80LSB{\sim}-0.76LSB$, respectively. It satisfies the design specifications for VDSL modems. The simulated SNR is about 66dB which corresponds to a 10.7 bit resolution. The power consumption is 24.32mW. 본 논문에서는 고속 동작을 위한 multi SHA(ammple and hold amplifier) 구조의 파이프라인 A/D 변환기 (analog-to-digital converter)를 제안하였다. 제안된 구조는 변환 속도를 높이기 위해, 동일한 SHA를 병렬로 연결하여 multi SHA를 구성하였다. 이를 비중첩 클럭(nonoverlapping clock)에서 동작하도록 하여 셀을 구성하는 SHA의 수와 비례한 빠른 샘플링 속도를 얻을 수 있도록 하였다. 제안된 구조를 적용하여 VDSL(very high-speed digital subscriber line) 모뎀의 아날로그 front-end단의 요구 사항을 만족하는 파이프라인 A/D 변환기를 설계하였다. 설계된 A/D 변환기의 DNL(differential nonlinearity)과 INL(integral nonlinearity)은 각각 $0.52LSB{\sim}-0.50LSB,\;0.80LSB{\sim}-0.76LSB$의 특성을 나타내어 설계 사양을 만족함을 확인하였다. 또한 2048 point에 대한 FFT를 수행한 결과 SNR이 약 66dB로 10.7 비트의 해상도가 얻어짐을 확인하였으며, 전력 소모는 24.32mW로 측정되었다.

공작기계 핵심부품의 신뢰성 평가 ${\cdot}$ 분석에 관한 연구

이승우,송준엽,이화기,Lee, Seung-Woo,Song, Jun-Yeob,Lee, Hwa-Ki 한국신뢰성학회 2003 신뢰성응용연구 Vol.3 No.1

Recently, the reliability evaluation and analysis are applied for many industrial products, and many products are required to guarantee in quality and in efficiency. The purpose of this paper is to present some of reliability prediction methodologies that are applicable to machine tools. Especially ATC (Automatic Tool Changer) and Interface Card of PC-NC, which are core components of the machine tools, were chosen as the target of the reliability evaluation and analysis. The results of this research has shown the failure rate, MTBF(Mean Time Between Failure), and reliability for those components. It is expected that proposed methodologies will be applicable to evaluation of reliability for other industrial products.

컴퓨터프로그래밍과 관련된 교과목 내용분석

이승우,Lee, Seung-Woo 한국수학사학회 2009 Journal for history of mathematics Vol.22 No.2

컴퓨터프로그래밍은 문제해결능력 향상과 논리적 사고력 함양을 위한 도구로서, 본 연구에서는 컴퓨터교육의 방향설정과 문제해결과정에서의 프로그래밍 교육의 역할을 알아보고자한다. 또한 수학/통계학과의 컴퓨터프로그래밍 특성화를 위하여 수학/통계학과와 IT학과를 연계한 프로그래밍 교과목을 분석한다. 이를 통하여 컴퓨터프로그래머로서 능력 있는 인재를 양성해서 사회에 배출하고자 한다. The computer programming is a useful tool to cultivate the logical thinking and encourage the problem solving competence. With the purpose of specifying the computer programming, this study mainly concerns with what the computer programming is in the Math/Stat education, and the role of the computer programming when it regards the problem solving procedure. This provides the possibility of Math/Stat major to be specified with the connection of IT related courses, and eventually the specified Math/Stat major enables more qualified graduates to be educated.