만성 폐쇄성 폐질환 환자에서 발기부전장애

이승룡,이나리,김진호,이양덕,이홍범,이용철,이양근 대한결핵 및 호흡기학회 2002 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.95 No.0

김수육군전(金水六君煎)이 $SO_2$에 의한 흰쥐의 호흡기조직손상(呼吸器組織損傷)에 미치는 영향(影響)

이승룡,박동일,Lee, Sung-Yong,Park, Dong-Il 한국한의학연구원 1996 한국 한의학연구소 논문집 Vol.2 No.1

This experiment was performed in order to study the effects of Gyumsuyukgunjun on the injured tracheal tissue induced $SO_2$ in rats. Healthy adult male rats weighting about 250g were divided into 4 groups - the Normal group, the Control group, the group of Gyumsuyukgunjun administration for 5 days after $SO_2$ gas exposure (Sample I), and the group of Gyurnsuyukgunjun administration for 10 days before and for 5 days after $SO_2$ gas exposure (Sample II). The results were obtained as follows ; 1. In the trachea Control group, the lesion of the ciliated epithelium was severe and the mucus secretion of the respiratory tract was increased significantly. 2. In the trachea of Sample I group, the lesion of the ciliated epithelium and the mucus secretion of the respiratory tract were decreased compared with Control group. 3. In the trachea of Sample II group, the lesion of the ciliated epithelium and the mucus secretion of the respiratory tract were decreased compared with Control and Sample I group. According to the above results, Gyumsuyukgnjun has significant effects on the injuried tracheal tissue caused by $SO_2$ in rats.

담즙산과 베타싸이클로덱스트린의 용해도에 관한 연구

이승룡 충북대학교 약품자원개발연구소 1993 약학논문집 Vol.8 No.-

노인케어서비스에서의 플랫폼 중요성

이승룡 한국노인복지학회 2018 한국노인복지학회 학술발표논문집 Vol.2018 No.11

내장형 미들웨어 연구 동향

이승룡 한국정보처리학회 2001 정보처리학회지 Vol.8 No.5

가변형 박판에 대한 촉감 제시

이승룡,최혁렬 제어로봇시스템학회 1996 제어로봇시스템학회 국내학술대회 논문집 Vol.1 No.10

A Phase II Open-Label, Multicentre Study to Assess the Anti-tumour Activity of Afatinib in Patients with Activating Epidermal Growth Factor Receptor mutation (EGFRm) from Circulating Tumor DNA (CtDNA)

이승룡,박철규,오인재,이재철,최창민,이신엽,장태원,김영철 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.0

About 70% of activating EGFRm can be detected using CtDNA in patients with activating EGFRm in their Tumor DNA. The treatment efficacy of afatinib was assessed in patients with lung cancer harboring EGFRm which were detected from CtDNA. Primary objective was to prove overall response rate (ORR) in response evaluable population, and the secondary endpoints were progression free survival, overall survival and safety. Ten mL of venous blood was withdrawn and plasma preparation was finished as soon as possible, no more than 4 hours after draw. Plasma samples were stored at -20℃ until delivered to Panagene. EGFRm analyses for CtDNA were performed by PANA Mutyper® EGFR kit (Panagene, Korea). EGFRm testing for tumor DNA were performed by in-house testing in each hospital with PNA clamp EGFR mutation kit or PANA Mutyper® EGFR kit. A total of 340 (331 without missing values) patients were screened for this trial from 2015 July to 2018 March. Tumor genotyping showed 24.5% (81/331), while CtDNA showed 20.5% (68/331) of positivity to detect activating EGFRm (exon 19 deletions, exon 21 and exon 18 point mutations). Among 81 subjects with tumor DNA EGFRm positive subjects, 48 showed EGFRm in their CtDNA (59% sensitivity). Types of EGFRm were completely matched between tumor DNA and CtDNA in 48 subjects. Among 21 subjects enrolled in this trial, 11 subjects had EGFRm only in CtDNA (tumor DNA EGFR wild or unknown, Group 1), and 10 subjects had same EGFRm in their CtDNA and tumor DNA (Group 2). Afatinib (40mg) was initiated in 21 (female:17, adenocarcinoma:20, NSCLC-NOS:1) subjects with mean age of 68.5 years (standard deviation 8.7). Dose modifications were made in 13 subjects (62%). Partial remission was observed in 13 subjects, stable disease in 6 subjects, and response was not evaluated in 2 subjects (ORR : 68.4%). There was no significant difference (p=0.35) in ORR between Group 1 (80%) and Group 2 (55.6%). As of July 25 2018, treatment is ongoing in 15 subjects, progression was confirmed in 3 subjects and 1 withdrew consent, 2 discontinued treatment due to serious adverse events (SAEs). A total of 5 SAEs including 2 subjects with possible drug induced lung disease were reported. In conclusion, afatinib showed favorable efficacy in subjects with NSCLC harboring EGFRm in their CtDNA. Acknowledgement: This study was funded by Boehringer Ingelheim and Panagene. ClinicalTrials.gov Identifier: NCT02629523.

유화조건이 홍화적색소의 물성에 미치는 영향

이승룡,장규섭,이석건,윤혜현,한태룡 충남대학교 농업과학연구소 2000 농업과학연구 Vol.27 No.1

상기 실험으로부터 얻어진 결과를 요약하면 다음과 같다. 1. Hunter-value를 측정한 결과 hunter L-value 즉, 백색도에 있어서는 glycerin+carthamin+locithin의 경우가 실온저장 및, 열악조건 그리고 광조사시에 있어서 모두 8 시간이 경과하면서부터는 급격하게 상승하는 모습을 보였다. 2. 실온하에서 hunter a-value 즉, 적색도에 있어서는 carthamin 첨가구가, b-value 즉, 황색도에 있어서는 paprika 첨가구가 더 강하게 나타났다. 열악조건에서는 실온저장의 경우와 다소 다른 양상을 보여주었는데. D.W+carthamin+lecithin의 경우에 있어서도 hunter L-value가 낮은 값을 나타냈으며, hunter a-value의 경우 soybean oil+paprika에서도 높은값을 보여주었다. 3. 유변학적 특성에 대한 실험에서 비교적 고점도를 가지고 있는 glycerin을 base material로하였을 때는 이에 비해 저점도라고 할 수 있는 soybean oil이나 증류수가 쓰여졌을 때보다 spindle의 rpm에 따른 viscosity나 shear rate 및 shear stress등의 같이 월등히 높은 값을 나타냈다. 그리고, 일반적으로 spindle의 rpm에 대한 shear rate 및 shear stress의 값은 비례적으로 증가하는 경향을 나타냈다. 유화제의 사용여부에 있어서는 lecithin을 사용했을 경우. 사용하지 않았을 때보다 높은 점도를 나타냈고, 동일한 조건에서 carthamin보다는 paprika가 두 배 정도 더 높은 점도를 나타냈다. 4. soybean oil을 사용한 실험구에 있어서는lecithin의 첨가유무가 점도에 아무런 영향을 미치지 않는 것으로 나타났으나, glycerin을 사용한 실험구에 있어서는 유화제인 lecithin을 병행했을 경우, 특이하게도 오히려 paprika에서보다 carthamin에서 더 높은 점도를 나타냈다. 5. Shear stress의 경우 soybean oil 첨가구와 glycerin 첨가구가 현저한 차이를 보이며 증가한 반면, shear rate에 있어서는 두 가지 경우모두 거의 같은 경향을 나타낸 점이 특이했다. This study was peformed to evaluate the food technological properties according to different emulsion state of carthamus red pigment. For making emulsion, lecithin was used as an emulsifier and polyglycerol monooleate(PGMO) and polyoxyethylene sorbitan monooleate(Tween 80) were used as an assistant, and glycerin, distilled water and soybean oil were used as base materials respectively. Paprika stock solution was used for comparing carthamin on the rheological properties. The results were described as following; 1. Hunter L-value was not drastically increased until passed by 8 hours for glycerin, carthamin, and lecithin mixed sample. 2. Hunter a-value was higher at carthamin added sample than others, and b-value was higher to paprika added sample than others. 3. The viscosity, shear rate and shear stress levels in which glycerin was used as base material were higher than soybean oil or distilled water. 4. In which soybean oil was used as base material, lecithin was not affected on the rheological properties. But, in which glycerin was used, the lecithin was higher affected on carthamin than paprika. 5. The value of shear stress was increased both carthamin and soybean oil. However, that of shear rate was shown similar trends.

골육종의 흉곽내 전이형태

이승룡,정규식,오경승,고지호,허진도,조영덕 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

The purpose of this study is to evaluate findings of altered patterns of thoracic metastasis in patients treated for osteosarcoma with adjuvant chemotheapy. The author reviewed medical records and image findings of 60 osteosarcoma patients from 1991 to 1997. 18 patients had thoracic metastasis confirmed by needle biopsy(n=1) and clinical evidence of tumor progression(n=17). CT was available in 17 patients. In 6 patients, mean 3 times serial CT were obtained during follow-up period. Two radiologists retrospectively reviewed the CT findings of parenchymal lesion, pleural lesion, mediastinal lesion, lymphadenopathy, calcification, and the follow-up change. In 16 cases, single or multiple nodules, suggesting typical appearance of hematogeneous metastasis, were present. Pleural plaque or mass was present in seven cases. In two of these cases, small curvilinear calcification or calcific dot was noted along the pleura, initially. On serial follow up CT scans, these calcifications was gradually increased in size, which resulted in huge calcified pleural mass. One patient showed only diffuse pleural thickening without other involvement, which proved pleural metastasis of osteosarcoma by means of pleural biopsy. Linear calcification or calcified nodule along the bronchial wall was noted in three cases this finding gradually changed to huge calcified mass with associated atelectasis of lung parenchyma. Other sites of metastasis were pericardium, 3 patients, and lymph node, 4 patients. Interlobular septal thickening suggesting lymphangitic metastasis was noted in 2 patients. Calcification within parenchymal nodule and metastatic lymph node was seen in 7 patients. Pneumothorax was noted in 2 patients. Interestingly, parenchymal lesion was slowly increased in size and number, while pleural and endobronchial lesion revealed rapid change and affressive invasion into the parenchyma, mediastinum and chest wall on follow-up CT scans. Thoracic metastasis of osteosarcoma commonly presents hematogenous parenchymal nodules. However, adjuvant chemotherapy has resulted in prolonged survival, and may raised the unusual appearance of thoracic metastasis, which is more aggressive nature. We carefully concluded that any type of calcification should be suspected metastasis in osteosarcoma patient.

유도철선과 Stiffener를 이용한 기능부전 복막투석 카테터의 투시하 교정

이승룡 대한영상의학회 1997 대한영상의학회지 Vol.37 No.5

Purpose : To determine the efficacy of correction of a malfunctioning peritoneal dialysis catheter withguidewire and stiffener under fluoroscopic guidance. Materials and Method : Between November 1994 and March 1997,we performed 15 manipulations in 12 patients in whom a dual-cuff, straight Tenckhoff peritoneal dialysis catheterhad been implanted due to chronic renal failure. The causes of catheter malfunctioning were inadequate drainage ofthe dialysate(n=14) and painful dialysis(n=1). Under fluoroscopic guidance, adhesiolysis and repositioning of themalfunctioning catheter were performed with an Amplatz Super Stiff guidewire and the stiffener from a biliarydrainage catheter. The results of procedures were categorized as either immediate or durable success, this latterbeing defined as adequate catheter function for at least one month after the procedure. Results : Immediatesuccess was achieved in 14 of 15 procedures (93%), and durable success in 7 of 15 (47%). The mean duration ofcatheter function was 157 (range, 30 to 578) days. After manipulation, abdominal pain developed in eight patientsand peritonitis in two, but with conservative treatment, these symptoms improved. Conclusion : The correction of amalfunctioning peritoneal dialysis catheter with guidewire and stiffener under fluoroscopic guidance is aneffective means of restoring catheter function and may be an effective alternative to surgical reimplantation ofthe catheter, or hemodialysis.