1920年代 朝鮮共産黨의 組織的 展開와 活動 : 제3차 朝鮮共産黨을 中心으로

박철규 부산대학교 사학회 1993 釜大史學 Vol.17 No.-

A Phase II Trial of Osimertinib as the First-Line Treatment of Non–Small Cell Lung Cancer Harboring Activating EGFR Mutations in Circulating Tumor DNA: LiquidLung-O-Cohort 1

박철규,조현주,최유덕,오인재,김영철 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1

Purpose Osimertinib is a potent, irreversible third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for both EGFR-activating and T790M resistant mutation. The treatment efficacy of osimertinib was assessed in previously untreated patients with metastatic non–small cell lung carcinoma (NSCLC) harboring activating EGFR mutations in circulating tumor DNA (ctDNA) as well as tumor DNA. Materials and Methods Patients with activating EGFR mutations in their tumor DNA underwent screening with ctDNA analysis using Mutyper and Cobas v2 assays. Enrolled subjects received osimertinib 80 mg, once daily. Primary endpoint was objective response rate (ORR) and secondary endpoints were ctDNA test sensitivity, progression-free survival (PFS), duration of response (DoR), and safety. Results Among 39 screened patients, 29 were ctDNA positive for activating EGFR mutations and 19 were enrolled (ex19del, n=11; L858R/L861Q, n=7; G719A, n=1). Median age was 70 and most patients had brain metastases (15/19, 79%). ctDNA test sensitivity for activating EGFR mutations was 74% using both methods and 62% (Mutyper) or 64% (Cobas v2) for individual methods. ORR was 68% (13/19), median PFS was 11.1 months (95% confidence interval [CI], 0.0 to 26.7), and median DoR was 17.6 months (95% CI, 3.5 to 31.7). ORR and median PFS were significantly superior with ex19del (91%; 21.9 months; 95% CI, 5.5 to 38.3) than with L858R/L861Q (43%; 5.1 months; 95% CI, 2.3 to 7.9). One patient discontinued the drug because of drug-related interstitial pneumonitis. Conclusion Osimertinib had favorable efficacy in the first-line treatment of metastatic NSCLC harboring activating EGFR mutations in ctDNA as well as tumor DNA.

Report : Teufel과 Hexe의 役分割

박철규 성균관대학교 독어독문학회 1971 獨逸文學論考 Vol.4 No.1

과학기술법령체계의 개선방향

박철규,Park, Cheol-Gyu 한국과학기술단체총연합회 2007 과학과 기술 Vol.40 No.4

(기획논문) 부산ㆍ경남지역의 제헌국회의원 분석

박철규 부산광역시 시사편찬위원회 2008 항도부산 Vol.24 No.-

체계적 분류틀을 이용한 한국과 미국 고등학교 생물교과서 실험활동의 탐구수준 비교

박철규,신재영,곽대오 이화여자대학교 사범대학 교과교육연구소 2011 교과교육학연구 Vol.15 No.2

The main purposes of this study were to discover qualitative differences among laboratory activities in Korean and U.S. high school biology textbooks, and then to reclassify inquiry levels for them. Typical samples were sorted into highest and lowest inquiry level groups for comparison between the two countries through constituent analysis. Two main constituents were identified as having a significant impact on determining the inquiry level of laboratory activities. They were the constituents of ‘demanding for formulation of a hypothesis’ and of ‘demanding for application’. Based on these efforts, a new classification scheme was developed and applied to the inquiry level groups for reclassification and comparison. The results were as follows. The higher level Korean samples from the structured inquiry were reclassified into the structured inquiry b which asks students to make either a ‘hypothesis’ or an ‘application’, or structured inquiry c which asks for neither a ‘hypothesis’ nor an ‘application’. U.S. counterparts were reclassified into structured inquiry a which asks for both a ‘hypothesis’ and an ‘application’. The higher level Korean samples of the guided inquiry were reclassified evenly into guided inquiries b and c, while all of the U.S. counterparts were sorted into guided inquiry a. The lower level samples of both the structured and guided inquiries showed obvious inquiry level differences between Korean and U.S. textbooks, which supported the main purpose of this study. 한국과 미국의 생물교과서 내 실험활동의 탐구수준을 체계적인 방식으로 비교하였다. 실험활동의 탐구수준은 학습자로 하여금 직접 수행하게 하는 정도에 따라 네 가지로 구분되는데, 제반 탐구과정이 해설로 제공되는 확인탐구에서부터 구조화된 탐구, 안내된 탐구, 그리고 학자들의 연구활동에 대비되는 열린 탐구 등이다. 기존의 탐구수준 분류틀을 이용한 저자들의 선행 비교연구에서 한국과 미국의 고등학교 생물교과서 내 실험활동들이 대부분 구조화된 탐구수준과 일부 안내된 탐구수준에 집중되어 실질적인 비교가 곤란하였다. 대안으로서 본 연구에서 새로운 탐구수준 분류틀을 구축하였고 이를 통해 구체적인 차이 비교가 가능하였다. 새 분류틀은 실험활동 각 단계의 하위 구성요소들을 내용분석을 통해 도출하고 이를 신교육목표분류학의 인지과정차원(기억<이해<적용<분석<평가<창안)과 상응시켜 내부 탐구수준 위계를 판별하는 준거를 마련하는 방식으로 이루어졌다. 새 분류틀에서 상위인지차원에 해당하는 ‘가설설정’ 요소와 ‘적용’ 요소가 세부 탐구수준 위계를 좌우하는 핵심요인으로 나타났다. 구조화된 탐구수준과 안내된 탐구수준은 새 분류틀에서 각각 a, b, c 세 수준(상위수준 순)으로 세분되었다. 약호화 작업을 통해 문제, 과정, 해답 영역별, 그리고 탐구수준별 최상·최하 비교군을 추출하였고 여기에 새로운 분류틀을 적용하여 탐구수준 재분류 작업을 수행하였다. 재분류 결과 한국의 생물교과서는 미국에 비해 실험활동 서술 및 구성에 있어 세부 탐구수준이 여실히 낮은 것으로 나타났다. 구조화된 탐구수준에서 비교를 위해 선별된 최상·최하 사례들(한국 도합 29 사례, 미국 도합 27사례) 중 한국의 경우 상위 탐구수준인 a수준은 없고 b수준은 7개, c수준 22개로 판별되었고, 미국은 a수준 11개, b수준 3개, c수준 1개로 나타났다. 안내된 탐구수준에서는 선별된 최상·최하 사례들(한국 도합 3사례, 미국 도합 15사례) 중 한국은 a수준은 없고 b수준 1개, c수준 2개로 나타났고, 미국의 경우 a수준 11개, b수준 3개, c수준 1개로 판별되었다.

A Case of Ischemic Colitis Associated with Paclitaxel Loaded Polymeric Micelle (Genexol-PMⓇ) Chemotherapy

박철규,Hyun-Wook Kang,Tae-Ok Kim,Ho-Seok Ki,Eun-Young Kim,Hee-Jung Ban,Byeong-Kab Yoon,오인재,최유덕,권용수,김유일,임성철,김영철,김규식 대한결핵및호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.2

Paclitaxel has been widely used for treating many solid tumors. Although colonic toxicity is an unusual complication of paclitaxel-based chemotherapy, the reported toxicities include pseudomembranous colitis, neutropenic enterocolitis and on rare occasions ischemic colitis. Genexol-PMⓇ, which is a recently developed cremophor-free, polymeric micelle-formulated paclitaxel, has shown a more potent antitumor effect because it can increase the usual dose of paclitaxel due to that Genexol-PMⓇ does not include the toxic cremophor compound. We report here on a case of a 57-year-old man with advanced non-small cell lung cancer and who developed ischemic colitis after chemotherapy with Genexol-PMⓇ and cisplatin. He complained of hematochezia with abdominal pain on the left lower quadrant. Colonoscopy revealed diffuse mucosal hemorrhage and edema from the sigmoid colon to the splenic flexure. After bowel rest, he recovered from his symptoms and the follow-up colonoscopic findings showed that the mucosa was healing. Since then, he was treated with pemetrexed monotherapy instead of a paclitaxel compound and platinum.

A Normalized Metal Artifact Reduction Method Using an Artifact-Reduced Prior for Dental Computed Tomography

박철규,이동연,임영환,김건아,김규석,조효성,서창우,임현우,이헌우,박소영,강석윤,박정은,전두희,김우성 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.74 No.3

In dental computed tomography (DCT), metal artifact reduction (MAR) is a critical issue to improve the clinical usefulness of DCT and remains a challenging problem. Although various MAR methods have been developed in medical CT, those methods may not work robustly in DCT because teeth themselves, as well as metallic objects, have high X-ray attenuation. In this study, we investigated an MAR method that was based on sinogram normalization interpolation with an artifact-reduced prior for DCT. The method consisted of three main steps: segmentation of a metal trace, generation of an artifact-reduced prior image, and sinogram completion followed by DCT reconstruction. We performed a computational simulation and performed an experiment on a teeth phantom with several metal inserts to validate the proposed method. With respect to the root-mean-square error and the structural similarity, we compared our results with the ones obtained by using the combined prior-based MAR (CP-MAR) method. Our results indicate that the proposed MAR method reduced metal artifacts considerably in DCT images and showed an image performance that was better than that obtained by using the state of the art method (CP-MAR) in reducing streak artifacts without introducing any contrast anomaly.

철도 르네상스시대에 대비한 인력 양성

박철규 한국철도학회 2003 철도저널 Vol.6 No.3

지역난방 중온수 펌프의 현장 성능평가를 위한 열역학적 측정법 적용

박철규,유호선,Park, Cheol Gyu,Yoo, Hoseon 한국플랜트학회 2021 플랜트 저널 Vol.17 No.1

수력학적 효율측정 방법만으로는 펌프시스템 부속장치들의 개별효율 및 펌프 자체효율을 명확하게 산출해내기 매우 어렵다. 이에 본 연구에서는 국내 최초로 지역난방 중온수용 펌프시스템에 최신 열역학적 펌프 효율측정방법을 도입, 수력학적 방법과의 효율 병행측정 결과를 검토하였고, 그 결과 기존 수력학적 펌프효율 측정방법만으로는 데이터 불확실성이 높은 반면, 열역학적 및 수력학적 방법 병행측정 데이터를 적용한 펌프 및 유체커플링 효율값은 상호보완적 역할수행에 의해 펌프성능 측정방법의 신뢰성 및 적정성이 검증되는 의미 있는 결과를 도출할 수 있었다. 또한, 지역난방시스템에 열역학적 펌프효율 측정방법을 적용한 결과, 최대 120 ℃ 고온 환경에도 불구, 매우 안정적인 데이터 측정 및 측정장비의 내구성이 검증되는 등 열역학적 측정방법의 신뢰성을 검증할 수 있었다. It is very difficult to accurately calculate efficiency of each accessory device constituting the pump system and pump efficiency by the Conventional efficiency measurement method only. Therefore, this study introduced the lastest Thermodynamic pump efficiency measurement method in the district heating pump system for the first time in Korea. As a result, data uncertainty was high by the Conventional method, but the pump and Hydraulic Coupling efficiency values applied the Thermodynamic and Conventional method parallel measurement data were able to derive meaningful results that verified the reliability and adequancy of the pump performance measurement method by performing complementary roles. In additon, as a result of applying the Thermodynamic method to the distirct heating pump system, despite the high temperature environment of up to 120 ℃, it was possible to verify the reliability of the Thermodynamic method, such as high stable data mesurement, and durability of the measurement equipment.