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Structure-based drug discovery using NMR spectroscopy
윤지혜,이원태 한국구조생물학회 2014 Biodesign Vol.2 No.2
The structural information of biomolecules is essential for novel drug discovery. Recently, several new high-throughputdrug-screening methods have been established. Nuclear magnetic resonance (NMR) spectroscopy is one of the mostpowerful techniques for drug development, providing critical information on molecular interactions for drug design insolution. Knowledge of the 3D structure and dynamic properties of drug target molecules is mandatory in performinginitial hit selection and lead optimization. For this purpose, NMR spectroscopy has been developed and widely used. Inparticular, NMR is ideal for the fragment-based drug discovery (FBDD) strategy, because molecular interactions betweentarget proteins and small ligands can be quickly identified at the atomic level. In this review, NMR techniques used forstructure-based drug design will be discussed together with practical examples.
D. H. 황의 『칭글리시』에 나타난 소수화된 언어와 상호문화주의
윤지혜 한국영미어문학회 2018 영미어문학 Vol.- No.131
This paper aims at examining a minoritized language and interculturalism in D. H. Hwang’s Chinglish. Chinglish gives humorous examples mistranslated into English in China. These mistranslated phrases indicate that a minor practice of major language has the subversive power against the power of English as a major language and causes miscommunications between the two countries. According to intercultural discourses in the age of globalization, Hwang decides to make a great change in the background of his play in an international perspective, which is from the United States to China. The playwright develops racial identity politics and interculturalism not in the United States but in China without geographical limitations. In Chinglish, main character Caucasian Daniel can manage his business in China after he can come to appropriate the Chinese relationship 'guanxi' and to make an inappropriate relationship with Chinese woman Xian who in turn comes to manipulate the men around her for her own purpose. With Chinglish, Hwang attempts to reveal the dynamic of translation and communication in terms of the minoritization of major language and interculturalism.
10대를 위한 가상세계 활동 콘텐츠 : 10대에게 인기 있는 가상세계 분석을 바탕으로
윤지혜,오규환 디지털스토리텔링학회 2008 디지털스토리텔링연구 Vol.3 No.-
가상세계를 이용하는 다양한 연령층 가운데 가상세계의 가장 열렬한 애호가 집단은 어린이와 10대이다. comScore World Metrix에 따르면 세계적으로 가장 유명한 <세컨드라이프(Second Life)>보다 <클럽펭귄(Club Penguin)>이나 <스타돌(Stardoll)> 같은 어린 연령층을 대상으로 한 가상세계 각각의 이용자 수가 많다. 인터넷 시장 조사 기관인 eMarketer에 따르면 2008년에는 미국의 어린이와 10대 인터넷 사용자 3천4백30만 명 중 34%가 적어도 한 달에 한번 이상은 가상세계에 방문할 것이며, 2011년에는 이 인구가 53%까지 늘어날 것이라고 한다.