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농존지역 거주노인의 연령,성별,교육수준이 한국판 MMSE 점수에 미치는 영향에 관한 연구
우종인,이정희,홍진표 대한신경정신의학회 1996 신경정신의학 Vol.35 No.1
In order to observe the sociodemographic effects on Mini-Mental State Examination-Korean version(MMSE-K), MMSE-K was administered to the residents aged 65 and older in Yonchon county, Kyungki-Do. Following results were found : 1) Forty percent of the variance in MMSE-K scores was accounted by educatonal level, age and sex. 2) Educational levels were closely correlated with MMSE-K scores(r=0.49). The group of elementary school graduates and over scored higher scores of 5-6 points and 1- 3 points higher in comparison to the noneducated group and the elementary school failure group, respectively. 3) Men received higher MMSE-K scores than women, especially in the noneducated group and the elementary school failure group. In conclusion, readjustments of MMSE-K scores for demographic variables, especially for educational level, are necessary in order to use the MMSE-K as a screening measure for dementia.
禹鍾仁,延炳吉,徐維憲,朴贊雄,李定均 대한신경정신의학회 1991 신경정신의학 Vol.30 No.6
The uptake of C3H ) choline into synaptosomes prepared from rat corpus striatum and frontal cortex was studied at choline concentration varying from 0.05 to 2.0 |iM. The sodiumdependent high affinity choline uptake in these brain regions exhibited saturation kinetics with Km values o f 0.37 (iM in corpus striatum and 0.35(iM in frontal cortex. A l3+ inhibited total choline uptake at concentrations greater than 10-4 M. Double-reciprocal plots indicated that A l3+ was a noncompetitive inhibitor o f high affinity choline uptake with Ki values of 2.17X10 3 M in corpus striatum and 0.82 X10 3 M in frontal cortex. The presence of 1 m M Ca2+ neither influenced high affinity choline uptake, nor antagonized the inhibitory effects of A l3+. A l3+ did not alter the activities of choline acetyltransferase and acetylcholinesterase at all substrate and inhibitor concentrations studied. These data suggest that high A l3+ levels modify cholinergic transmission by inhibition of high affinity choline uptake