HELLP(Preeclampsia Associated with Hemolysis, Elevated Liver Enzymes, Low Platelets) 증후군

오동규,민병혁,김시환,김선행 대한산부인과학회 1984 대한산부인과학회 학술대회 Vol.54 No.-

지역간 철도의 노선계획 최적화 모형

오동규,고승영,강승모 대한교통학회 2013 대한교통학회지 Vol.31 No.2

The purpose of this research is to optimize the line planning of the intercity passenger railway. In this study, the line planning problem has been formulated into a mixed integer programming by minimizing both user costs (passenger’s total travel time) and operator costs (operation, maintenance and vehicle costs) with multiple train types. As a solution algorithm, the branch-and-bound method is used to solve this problem. The change of travel demand, train speed and the number of schedules have been tested through sensitivity analysis. The optimal stop-schedules and frequency as well as system split with respect to each train type have been found in the case study of Kyoung-bu railway line in Korea. The model and results of this research are useful to make a decision for railway operation strategy, to analyze the efficiency of new railway systems and to evaluate the social costs of users and operators. 본 연구는 지역간 여객 철도의 노선계획을 최적화하는 방법에 관한 연구이다. 본 연구의 노선계획 모형은 다양한 차종이 운용되는 철도노선에서 이용자비용(이용자의 총 통행시간)과 운영자비용(열차 운행비용, 유지·보수비용, 차량구입비용)의 합을 최소화하고자 하는 혼합정수계획 수리모형으로 구축되었고, 모형의 해법으로 분기한정법이 사용되었다. 수요의 변화, 열차 속도의 변화, 정차스케줄 수의 변화 등에 대한 민감도 분석 결과도 제시하였고, 국내 경부선의 사례연구를 통하여 각 열차차종의 차종별 수요 분할 뿐만 아니라 최적 정차스케줄과 운행빈도를 동시에 산출할 수 있음을 보여주었다. 본 연구의 모형과 결과는 열차 운영 전략을 수립하거나 새로운 철도 시스템의 효율성을 분석하거나 이용자·운영자의 사회적 비용을 산정하는 경우 등에 적용될 수 있다.

양수배양검사시 Trisomy 20 Mosaicism 1예

오동규,최남수,윤인선,주갑순 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.12

특발성폐섬유증 환자에서 폐기종 동반 여부가 노력성폐활량(FVC)감소 및 생존에 미치는 영향 - 임상연구와 관련된 관점에서의 분석

오동규,도경현,이상민,한승봉,김동순 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.0

목적: 폐기종을 동반한 특발성폐섬유증(CPFE)환자는 노력성폐활량(FVC)의 감소는 적지만 폐확산능(DLco)의 감소가 심하고 폐고혈압의 유병률이 높아 FVC 변화를 주지표로 하는 임상연구에서 이들을 제외해야 한다는 주장이 있다. 하지만 아직까지 이에 대한 근거가 없어 본 연구를 시행하였다. 방법: 서울아산병원에서 IPF로 진단된 환자 중 고해상도흉부전산화단층촬영(HRCT)의 분석이 가능하고 진단 후 12개월의 폐기능검사 결과가 있는 212명을 대상으로 진단시 HRCT 상 폐섬유증및 폐기종의 정도, 진단 후 12개월의 FVC 감소와 생존율의 관계를 조사하였다. 결과: CPFE군은 77명(36.3%)으로 순수 IPF군에 비해 남성과 흡연자가 많았고, 진단 시 두군 사이에 폐섬유화 지수는 차이가 없었으나(7.8 vs. 8.4,p=0.168), FVC 86.3% vs. 74.5% (p<0.001), DLco 65.0% vs. 69.3% (p=0.136)였고, 폐고혈압의 빈도는 23.4% vs 6.1% (p=0.004)였다. 두 군간에 생존률의 차이는 없었고 폐섬유화지수는 중요한 생존예측인자였다. 양군에서 진단 후 12개월의 FVC 감소 정도는 사망의 유의한 예측인자였으나(CPFE군: HR 1.038, p=0.030; 순수IPF군: HR 1.061, p<0.001), FVC 감소 정도는 CPFE군에서 순수 IPF군보다 작았다(120 ml: 4.65% vs 20ml: 0.27%, p=0.008). 결론: CPFE군에서는 진단 후 12개월의 FVC 감소가 적고 사망예측에 미치는 영향도 감소하므로 임상연구에서는 이들을 제외하는 것이 타당할 것으로 사료된다.

Anti-inflammatory Effects of Aroma Oil Complex on DNCB-Induced Allergic Contact Dermatitis in Dogs

오동규,오태호 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.3

Allergic contact dermatitis (ACD) is an inflammatory skin disease and regarded as a prototype of T-cellmediated delayed-type hypersensitivity reactions. Aroma Oil Complex (AOC) is composed of lavender true oil,chamomile roman oil and tea tree oil. This study was performed to assess the effects of AOC in a canine modelof ACD. ACD was induced on the back of dogs induced by sensitization and repeated application by 2,4-dinitro-1-chlorobenzene (DNCB). Topical treatment of AOC was applied once a day for 8 days and skin biophysical parametersincluding transepidermal water loss (TEWL), skin hydration, skin thickness and erythema index, were measured everytwo days during experimental periods. Histopathology and immunohistochemistry were performed to evaluate the antiinflammatoryeffect. In skin biophysical parameters, TEWL, skin hydration, skin thickness and erythema index weresignificantly increased, with a maximum increase appeared on day 2 (p < 0.05). After the completion of AOC treatment,skin biophysical parameters were significantly reached those of baseline in a time-dependent manner (p < 0.05). Inhistopathology, marked increases of epidermal thicknesses were induced after DNCB challenge with numerousinflammatory cell infiltrations and edematous changes, decreases of connective tissue occupied regions in dermis. Inaddition, marked increases of cytokine - tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ)-immunoreactivitiesin the dermis and of apoptotic markers - caspase-3 and PARP-immunoreactivities in the epidermis were observed inDNCB control as compared with intact control, respectively (p < 0.01). The decrease of infiltrated inflammatory cellsand related decreases of pro-inflammatory cytokine immunoreactivities were observed in AOC treated skin (p < 0.01). Based on these findings, AOC may have anti-inflammatory and alleviatory effects in the allergic contact dermatitis.

Lung Regeneration Therapy for Chronic Obstructive Pulmonary Disease

오동규,김유선,오연목 대한결핵및호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.1

Chronic obstructive pulmonary disease (COPD) is a critical condition with high morbidity and mortality. Although several medications are available, there are no definite treatments. However, recent advances in the understanding of stem and progenitor cells in the lung, and molecular changes during re-alveolization after pneumonectomy, have made it possible to envisage the regeneration of damaged lungs. With this background, numerous studies of stem cells and various stimulatory molecules have been undertaken, to try and regenerate destroyed lungs in animal models of COPD. Both the cell and drug therapies show promising results. However, in contrast to the successes in laboratories, no clinical trials have exhibited satisfactory efficacy, although they were generally safe and tolerable. In this article, we review the previous experimental and clinical trials, and summarize the recent advances in lung regeneration therapy for COPD. Furthermore, we discuss the current limitations and future perspectives of this emerging field.

대전트램 추진현황과 향후 과제

오동규 대한교통학회 2018 대한교통학회 학술대회지 Vol.79 No.-

P-18 Age-specific trends in the utilization of medical intensive care unit in a tertiary hospital in Korea

오동규,나원준,박유랑,허진원 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Purpose: Age is an important prognostic factor of the patients treated in the medical intensive care unit (MICU). We performed the study to assess the age-specific trends in the MICU utilization. Methods: Data were obtained from the patients admitted to an MICU of a tertiary hospital between July 2006 and June 2015. Patients were grouped by age and the age-specific trends were analyzed in demographics, comorbidities, disease severities, and MICU admission and mortality rates. Results: Of 8,018 patients, the mean age was 61.1 years and male were 5,094 (63.5%). The most common comorbidity was cancer (42.0%). Interestingly, in the age group < 50 years, the proportion of hematologic malignancy was more common than in the other age group (18.6% vs. 11.0%, p < 0.001). The disease severity assessed by sequential organ failure assessment (SOFA) score was higher in the age group < 50 years than in ≥ 70 years (8.1 [95% CI 7.8 - 8.3] vs. 7.2 [95% CI 7.0 - 7.3], p < 0.001). The MICU admission rates were consistently increased with age, but the MICU mortality rates showed bimodal distribution peaked in the age group < 50 and ≥ 80 years. Contrary to the decreasing temporal trend in the MICU mortality rates in the age group ≥ 80 years (R² = 0.35, p = 0.09), those in < 40 years showed increasing temporal trend (R² = 0.66, p = 0.005). Conclusion: Although the MICU admission rate was much lower in younger age group, the MICU mortality rate in this group was comparable to that in older age group. These might be related to the comorbidities and disease severities.

Clinical outcomes of extracorporeal membrane oxygenation as a bridge to lung transplantation

오동규,심태선,조경욱,박승일,김동관,최세훈,이근동,정성호,최상호,이상오,홍상범 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Introduction: Extracorporeal membrane oxygenation (ECMO) may be considered as a bridge to lung transplantation (BTT) in patients with acutely decompensated end-stage lung disease. However, it has been discussed controversially because of the discouraging results. Herein, we present our experience with this challenging strategy. Methods: We retrospectively analyzed medical records of adult patients who underwent lung transplantation at a tertiary referral center between January 2008 and December 2017 (n=61). Data were compared between patients who required ECMO support as a BTT (BTT group, n=33) and those without such support (non-BTT group, n=28). Results: Of 61 patients, the mean age was 44.2 years and 43 (60.6%) were male. The median bridging time to transplantation was 14 days (IQR, 9-19 days) in BTT group. Despite of the higher baseline simplified acute physiology score II (SAPS II) in BTT group (34.4 vs. 17.5, p<0.001), the 1-year, 3-year, and 5-year survival rates were comparable between the groups (74%, 74%, and 60%, respectively in BTT group vs. 77%, 67%, and 67%, respectively in non-BTT group, p=0.611). In BTT group, the 1-year, 3-year, and 5-year survival rates were worse in patients with ECMO support ≥14 days (n=16) than those with ECMO support <14 days (n=17) (56%, 56%, and 46%, respectively vs. 94%, 94%, and 75%, respectively, p=0.046). Conclusions: Successful lung transplantation may be achieved with ECMO support, even in marginal recipients. Careful patient selection such as bridging time <14 days appears to be important for the successful transplantation.

Low tidal volume mechanical ventilation in patients with ARDS caused by viral pneumonia (초)

오동규,허진원,고윤석,임채만,홍상범 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1