조기 위암의 내시경 치료

안지용 대한의사협회 2022 대한의사협회지 Vol.65 No.5

Background: In Korea, the number of screening endoscopies to detect early stage gastric neoplasms has increased exponentially following the active implementation of the National Cancer Screening Program. Current Concepts: Endoscopic treatment, including endoscopic mucosal resection and endoscopic submucosal dissection, is recognized as a minimally invasive treatment method with low morbidity and mortality for gastric dysplasia or early gastric cancer. Owing to improvement in the detection of early gastric cancer and advances in techniques, cases of endoscopic resection have increased and indications have been expanded. Endoscopic resection can preserve gastric function with excellent maintenance of the patient’s quality of life, and previous studies have shown better long-term follow-up outcomes compared to those with surgery. However, the funda mental limitation of endoscopic procedures is that gastric lymph-node dissection is not possible using endoscopic resection. Discussion and Conclusion: Although the usefulness of endoscopic resection is proven for tumors with a very low risk of lymph-node metastasis, follow-up examination using endoscopy and computed tomography should be performed for at least 5 years after curative resection of early gastric cancer.

반복법을 이용한 정전계 문제의 해석 ( On the Analysis of Electrostatic Problems Using an Iterative Method )

안지용,김정기 대한전자공학회 1986 대한전자공학회 학술대회 Vol.1986 No.1

Clinical Characteristics and Etiology of Travelers’ Diarrhea among Korean Travelers Visiting South-East Asia

안지용,정진원,장규진,유명환,채진성,강영아,김성한,정혜숙,천두성,정아용,최은석 대한의학회 2011 Journal of Korean medical science Vol.26 No.2

The morbidity of travelers’ diarrhea (TD) is still high. This study examined the incidence of common pathogens and characteristics of TD among Korean travelers who visited South-East Asian countries. We performed a prospective study involving 479 Korean travelers with diarrheal disease from February 2009 to April 2009 and stool samples were examined and questionnaire surveys were done after arrival. Enterotoxigenic Escherichia coli (ETEC)was found in 36.0% of TD cases, as were the following: Enteroaggregative Escherichia coli (EAEC) in 27.0%, Vibrio parahaemolyticus in 13.1%, and Norovirus in 11.5%. The detected rate of classic TD was higher in men (P = 0.007), in patients who had a shorter duration trip (P = 0.023) and in patients who drank more than 1 liter of water per day (P = 0.037). Positive stool culture rates were higher in men (P = 0.005), in hospitalized patients (P = 0.013). and in those who consumed impure water or raw foods (P = 0.033). A higher severity of disease corresponded to a significantly higher culture positivity rate (P = 0.029). We should consider the possibility of other pathogens in addition to ETEC in patients with TD who visit South-East Asia. Travelers need to educate about risk factors associated with TD.

위장관 림프종

안지용 대한상부위장관ㆍ헬리코박터학회 2022 Korean Journal of Helicobacter Upper Gastrointesti Vol.22 No.1

The gastrointestinal tract is the most common site of extranodal lymphoma, and more than 95% of gastrointestinal lymphoma cases are of the non-Hodgkin type. The stomach is the primary site of extranodal non-Hodgkin lymphoma, and more than 98% of primary gastric lymphoma (PGL) cases are diffuse large B-cell lymphomas (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphomas. Because PGL usually presents with nonspecific clinical symptoms and various endoscopic features, its diagnosis is mainly dependent on histopathologic findings. Chemotherapy is the first-line treatment choice for gastric DLBCL, whereas Helicobacter pylori eradication is the primary treatment for gastric MALT lymphoma. However, some cases of gastric adenocarcinoma resemble PGL endoscopically, complicating treatment decisions. There are various types of gastrointestinal lymphomas, such as natural killer T-cell, lymphomatous polyposis, mantle cell, follicular, immunodeficiency-related gastrointestinal, and Hodgkin. These can invade the small and large intestines. Although these lymphomas are rare, clinical outcomes differ among these types. Therefore, it is necessary for endoscopists to distinguish the clinical and endoscopic findings of the different lymphomas on biopsy to improve diagnostic accuracy.

소화성 궤양 출혈에 대한 에탄올 및 고장식염수-에피네프린 주입법의 효과

안지용,김재규,김정욱,김상중,한상표,김형준,도재혁,장세경,박실무 대한내과학회 2005 대한내과학회지 Vol.68 No.7

한국인 HBV감염 환자에서 질병 단계에 따른 precore, core 및 BCP 돌연변이 분석-예비 연구 결과

안지용,김형준,이현웅,이동호,곽금연,최문석,유병철 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.3(S)

Quantitative Analysis of Artificial Sweeteners by Capillary Electrophoresis with a Dual-Capillary Design of Molecularly Imprinted Solid-Phase Extractor

안지용,Shavkatjon Azizov,쿠마,이용일 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.11

A novel coupling system of capillary electrophoresis (CE) and monolithic molecularly imprinted polymer (MIP) was developed for selective and sensitive determination of sweeteners; sucrose, sucralose, and aspartame, based on an in-column and open-tube molecularly imprinted solid-phase extraction (MISPE) concentrator. The MISPE was fabricated by coating a short layer of MIP material (about 3?mm long) directly at the inlet end of the inner wall of capillaries under the irradiation of light emitting diode (LED). Compared with the conventional methods using hydrodynamic injection by MISPE fiber, the MISPE concentrator provides increase in sensitivity without significant loss of separation efficiency. In this work, LED-induced in-multiple capillary MISPE was used for extraction and determination of artificial sweeteners, sucrose, sucralose, and aspartame, from beverage samples. The results of MISPE showed good extraction ability with the enrichment ratios of >150 for sucrose and sucralose, and of >200 for aspartame with acceptable analytical performance. The reproducibility of on-line MISPE concentrator was 1.6% for sucralose and 2.7% for aspartame under the same fixed set of experimental conditions. The developed multiple MISPE system has been successfully adapted for practical application for commercial soda drink samples.

Quinolone계 항균제와 다가 이온 약제의 병용 현황 분석

안지용,최경숙,이은숙,김홍빈 한국병원약사회 2014 病院藥師會誌 Vol.31 No.3

The co-administration of quinolones with multi-cation drugs impairs the absorptionof quinolones, and may decrease the efficacy and increase the antibiotic resistance. For this reasons,the KFDA recommends the administration of quinolone 2 to 4 hours before or 2 hours afterthe intake of multi-cation drugs. Therefore, this study was designed to analyze the administrationpatterns of combination therapies with quinolones and multi-cation drugs and to evaluatethe effective use of quinolones. From January to July 2013, 249 inpatients older than 12 years were included. The study wasconducted in Seoul National University Bundang Hospital. The patients were given quinolonesand multi-cation drugs on the same day. The co-administration and inappropriate co-administration of the 2 classes of drugs were retrospectively evaluated. There were 213(16.6%), 172(36%), 695(39.9%) and 216(34.5%) co-administration prescriptions ofmoxifloxacin, ciprofloxacin 250 mg, ciprofloxacin 500 mg and levofloxacin with multi-cationdrugs, respectively. There were 177(13.8%), 143(29.9%), 558(32%) and 139(22.2%) inappropriate coadministrationprescriptions, respectively. Dosing intervals for were shorter than 10 minutes for46% of co-administration prescriptions. Magnesium products were the most common used multicationdrugs. There were about 31.4% co-administration prescriptions suggesting a decrease in the efficacy ofquinolones. Therefore, it is required to educate healthcare professionals about drug interactionsand to revise the default standard dosing time for an effective quinolone pharmacotherapy.

Steepest Descent Method를 이용한 정전계 문제의 해석

안지용,정구철,김정기 한국통신학회 1986 韓國通信學會論文誌 Vol.11 No.6

Steepest Descent Method를 정전계 문제의 해석에 적용하였다. 반복법과 moment method와 같은 direct method와의 차이점을 기술하였다. 반복법을 이용하여 정확한 해에 단조적으로 수렴하며 대형 system의 해석에 적합함을 보였다. 정전계 문제에 대해서 해석한 수치결과를 제시하였으며 moment solution과 잘 일치하고 있음을 보였다. The method of steepest descent is applied to the analysis of electrostatic problems. The differences between iterative method and direct method, e.g. the method of moments, are not lined. It is shown that this method converges monotonically to the exact solution and is suitable for solving a problem of large system. Numerical results are presented for electrostatic case which show a good agreement with momet solution.

Point- Connecting Measurements of the Hallux Valgus Deformity: A New Measurement and Its Clinical Application

안지용,서정호,Dimas Boedijono 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.3

Purpose: The aim of this study was to investigate new point-connecting measurements for the hallux valgus angle (HVA) and the first intermetatarsal angle (IMA), which can reflect the degree of subluxation of the first metatarsophalangeal joint (MTPJ). Also, this study attempted to compare the validity of midline measurements and the new point-connecting measurements for the determinationof HVA and IMA values. Materials and Methods: Sixty feet of hallux valgus patients who underwent surgery between 2007 and 2011 were classified in terms of the severity of HVA, congruency of the first MTPJ, and type of chevron metatarsal osteotomy. On weight-bearing dorsal-plantar radiographs, HVA and IMA values were measured and compared preoperatively and postoperatively using both the conventionaland new methods. Results: Compared with midline measurements, point-connecting measurements showed higher inter- and intra-observer reliabilityfor preoperative HVA/IMA and similar or higher inter- and intra-observer reliability for postoperative HVA/IMA. Patients who underwent distal chevron metatarsal osteotomy (DCMO) had higher intraclass correlation coefficient for inter- and intra-observer reliability for pre- and post-operative HVA and IMA measured by the point-connecting method compared with the midlinemethod. All differences in the preoperative HVAs and IMAs determined by both the midline method and point-connecting methods were significant between the deviated group and subluxated groups (p=0.001). Conclusion: The point-connecting method for measuring HVA and IMA in the subluxated first MTPJ may better reflect the severityof a HV deformity with higher reliability than the midline method, and is more useful in patients with DCMO than in patients with proximal chevron metatarsal osteotomy.