치매전문요양시설의 치매증상별 공간구성에 관한 연구

송혜정,오은진,김종인 대한건축학회 2001 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.21 No.2

The purpose of this study is to suggest appropriate architectural space in accordance with symptoms of dementia patients. The methods of the study are based on consideration of behavioral characteristics of dementia patients and comparative analysis of facility types through the case study. The results of case study show that patient units are separated by the stage of dementia patients. However, unit plans are almost similar. Conclusion suggests that availability of different unit space for different status of dementia patients would improve the quality of dementia care in the facilities.

Newly Formed Hepatic Masses in Children with Biliary Atresia after Kasai Hepatic Portoenterostomy

송혜정,서연림 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.2

Background: This report describes the clinicopathologic findings of six hepatic masses that de­veloped after Kasai hepatic portoenterostomy (HPE) in six patients with longstanding biliary atre­sia (BA). Methods: Hepatic masses were found in six of 55 pediatric patients who underwent liver transplantation for BA after Kasai HPE from 1997 to 2009. Clinicopathologic analysis was per­formed and immunohistochemical staining was carried out for CD34, smooth muscle actin (SMA) and cytokeratin 7. Results: Of the six hepatic masses, two were diagnosed as focal nodular hy­perplasia (FNH)-like lesions, two were large regenerative nodules (LRN), one was a mesenchymal hamartoma (MH) and one was a cholangiocarcinoma. The immunohistochemical staining find­ings for SMA and CD34 were more prominent for the FNH-like nodules than for the cirrhotic back­ground liver. Dysplastic biliary epithelium arising from intestinal metaplasia was found in the chol­angiocarcinoma. Conclusions: Our findings suggest that FNH-like lesions, LRNs and MH are the results of vascular hemodynamic changes after Kasai HPE and that cholangiocarcinoma is due to recurrent cholangitis after BA. All the lesions in this series must be included in the differential diagnosis of a newly formed hepatic mass in patients after portoenterostomy.

Comparison of the performance of the PANArray™ HPV test and DNA chip test for genotyping of human papillomavirus in cervical swabs

송혜정,이정원,김병기,송상용,배덕수,김대식 한국바이오칩학회 2010 BioChip Journal Vol.4 No.3

The aim of this study was to evaluate the recently developed PANArray™ Human papilloma virus (HPV) kit for detection and genotyping of 19 high-risk and 13 low-risk HPV types, and compare it with the commercially available DNA chip kit geno-typing of 24 HPVs. We llected cervical swabs from 741 patients with various stages of invasive cervical carcinoma being treated at the Samsung Medical Center. The overall HPV positivity rate was 73% using PANArray™ HPV and 72.1% with the DNA chip, and no statistically significant differences were found with respect to the cytology grade. Comparing the results of the two chips, concordant results were found in 637/741 samples (85.9%), compatible in 69/741 (9.3%) and discordant in 35/741(4.7%). Type-specific sequencing analysis of all samples revealed a 99.7% confirmation of PANArray™ HPV genotyping results, compared to 91.0% of DNA chip. The PANArray™ HPV test thus proved to be highly sensitive and accurate even when multiple HPV infections were present.

Carney Triad in an Adult with Aggressive Behavior: The First Case in Korea

송혜정,박철근,김경미,최동일 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.5

Carney triad is a rare syndrome of unknown etiology characterized by having at least two out of three following neoplasms: gastrointestinal stromal tumor, pulmonary chondroma and extra-adrenal paraganglioma. About 100 cases have been reported worldwide. We report a case of Carney triad in a 42-year-old woman presented with a gastrointestinal stromal tumor in the stomach and a malignant functioning paraganglioma in the retroperitoneum that was fatal five years after diagnosis. The gastrointestinal stromal tumor was diagnosed as intermediate-risk of aggressive behavior and diffusely positive for c-kit whereas the retroperitoneal paraganglioma was negative for ckit. Genetic analyses showed no mutations of KIT, PDGFRA, SDHB, SDHC, and SDHD genes in both tumors. To our best knowledge, this is the first case of Carney triad in Korea. Carney triad is a rare syndrome of unknown etiology characterized by having at least two out of three following neoplasms: gastrointestinal stromal tumor, pulmonary chondroma and extra-adrenal paraganglioma. About 100 cases have been reported worldwide. We report a case of Carney triad in a 42-year-old woman presented with a gastrointestinal stromal tumor in the stomach and a malignant functioning paraganglioma in the retroperitoneum that was fatal five years after diagnosis. The gastrointestinal stromal tumor was diagnosed as intermediate-risk of aggressive behavior and diffusely positive for c-kit whereas the retroperitoneal paraganglioma was negative for ckit. Genetic analyses showed no mutations of KIT, PDGFRA, SDHB, SDHC, and SDHD genes in both tumors. To our best knowledge, this is the first case of Carney triad in Korea.

고등학생의 무단행위에 영향을 미치는 변인 분석

송혜정,류방란,신희경 한국교육개발원 2011 한국교육 Vol.38 No.3

This paper examines the impact of personal, family and school factors on truancy in secondary schools in Korea. We use the data collected from 9,692 students in 140 high schools in 2007. For the statistical analysis, a zero-inflated model is applied, taking into account the data distribution particularity. The results of the analysis are as follows. First, truancy is influenced by the students' prior truancy. This suggests that earlier educational intervention is needed to reduce the probability of truancy. Second, the impact of the students' personal family experiences, such as family violence, on truancy is found to be significant. This result tells us that the earlier educational intervention is conducted to reduce the negative impact of family background on truancy, the more effective it could be. Finally, truancy is related to the students' negative experiences in school, and also to the school climate. This implies that more efforts to lessen the effect of experiences of negative teachers' expectancy on students and to enhance positive experiences of meaningful learning in school is needed to reduce truancy. Although a school climate that emphasizes academic achievement tends to reduce the probability of truancy, care should be taken in interpreting this result, considering the dynamics with the other variables. 이 글은 학교부적응이나 학업중단의 징후로 간주되는 무단행위(무단으로 수업빼먹기, 무단결석)를 하느냐의 여부에 그리고 그 빈도에 영향을 미치는 변인들을 탐색하고 정책적 시사점을 발견하는 것을 목적으로 한다. 분석을 위해 활용한 자료는 한국교육개발원에서 2007년도에 수행한 한 선행연구에서 수집한 것으로 일반계와 실업계 고등학생을 대상으로 조사하여 회수된 9,692명의 것이다. 분석대상이 된 자료에 의하면 1년 간 무단으로 수업빠지기를 해본 경험이 있는 학생은 14.6%, 무단결석을 해본 경험이 있는 학생은 8.9%였다. 이렇듯 대다수가 무단 수업빠지기와 무단결석을 하지 않는, 0의 값이 과도한 분포(Zero Inflated Poisson)를 지닌 자료의 특성에 적합한 방법을 동원하였다. 무단행위를 할 집단과 그렇지 않을 두 잠재집단을 설정하여 응답자가 각 집단에 속할 확률을 추정하고, 특정 집단에 속할 경우 빈도에 영향을 미치는 변인을 추정하는 분석 모형을 적용하였다. 분석결과 무단으로 수업빠지기와 무단결석을 하는 것에 영향을 미치는 변인과 이들의 빈도에 영향을 미치는 변인들이 대체로 공통된다는 것을 알 수 있었다. 이전의 무단행위 경험이나 친구 무단행위, 가정폭력 경험, 학교에서의 교사의 부정적 관심, 수업 소외감, 성취경쟁 압력 등은 무단 수업빠지기나 무단결석을 하는 데, 그리고 그 빈도에 공통된 영향을 미쳤다. 이밖에 무단으로 수업빠지기 행위를 하느냐의 여부나 빈도에 부모자녀의 관계나 교사의 열의가 유의미한 영향을 미쳤다. 무단결석의 경험여부에는 부모의 교육기대가 유의한 영향을 미쳤다. 이러한 결과를 기초로 무단행위를 예방하기 위하여 가정의 부정적 경험을 극복할 수 있도록 지원하는 방안, 학교에서 유의미한 학습경험 등 긍정적인 경험을 제공하는 방안 등을 제안하였다.

Prednislolne이 골조직에 미치는 영향에 관한 형태학적 연구

송혜정,김무강,김원식,이영호 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

To study the effects of corticosteroids to the bone tissues, author grouped young(3 weeks affter birth) and adult ICR mouse by dosage, injected intramusculaily prednisolone, a series of corticosteroids, to posterior leg during 6 weeks per day, obtained femurs and tibias, measured the lengths of tibias and femurs. The portions of the distal end of tibial crests were cross-sectioned, general H-E stain was perpormed. The adjacent distal portions of femoral neck were sectioned longitudinally, observed endosteal surface by scanning electron micrscope The results were followings: 1. The adult group injected by large dosage (0.56mg/100g body weight/day) and the young group injected by small dosage(0.14mg/100g body weight/day) from 3 weeks after birth were significantly shorter than the normal group according to statistics. And the adult group injected by small dosage (0.14mg/100g body weight/day) was not different from normal group according to statistics. 2. In the light microscopic sutdy, the adult group injected by large dosage decreased in bone mass of compact bone severely, the adult group injected by small dosage changed a little grade. The young group injected by small dosage from 3 weeks after birth was not severe in bone change, but bone thickness decreased. 3. In the scanning elctron microscopic study, the adult group injected by large dosage and the young group iniected by small dosage from 3 weeks after birth decreased in trabeculae. The trabeculae of the adult group injected by small dosage were decreased slightly. 4. Integrating above all, the changes by prednisolone injection osteoporosis, of young period were more severe than those of adult, too.

고등학교 팽창과 실업계 교육 쇠퇴

송혜정,강태중 중앙대학교 한국교육문제연구소 2002 한국교육문제연구 Vol.- No.17

Solitary Pulmonary Lymphangioma in an Adult- A Brief Case Report -

송혜정,한정호,김관민,이경수,서진원 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.2

Solitary pulmonary lymphangiomas are extremely rare. We report here on an unique case of solitary pulmonary lymphangioma in an adult. A well-circumscribed, 6 cm-sized, pleural based lesion with fluid attenuation was found in a 50-year-old Korean male. He had no previous history of disease or trauma. The wedge-resected lung revealed an ill-demarcated lesion with multiple microscopic cysts and the cystic walls had loose intervening stroma. Solitary pulmonary lymphangiomas are extremely rare. We report here on an unique case of solitary pulmonary lymphangioma in an adult. A well-circumscribed, 6 cm-sized, pleural based lesion with fluid attenuation was found in a 50-year-old Korean male. He had no previous history of disease or trauma. The wedge-resected lung revealed an ill-demarcated lesion with multiple microscopic cysts and the cystic walls had loose intervening stroma.

고등학교 팽창과 실업계 교육 쇠퇴

송혜정,강태중 中央大學校 韓國敎育問題硏究所 2002 韓國敎育問題硏究所論文集 Vol.- No.17

지역적 특성을 갖는 동적 선택 방법에 기반 한 다중 인식기 시스템

송혜정,김백섭 한국정보과학회 2003 정보과학회논문지 : 소프트웨어 및 응용 Vol.30 No.4

This paper proposes a multiple classifier system having massive micro classifiers. The micro classifiers are trained by using a local set of training patterns. The k nearest neighboring training patterns of one training pattern comprise the local region for training a micro classifier. Each training pattern is incorporated with one or more micro classifiers. Two types of micro classifiers are adapted in this paper : SVM with linear kernel and SVM with RBF kernel.Classification is done by selecting the best micro classifier among the micro classifiers in vicinity of incoming test pattern. To measure the goodness of each micro classifier, the weighted sum of correctly classified training patterns in vicinity of the test pattern is used. Experiments have been done on Elena database. Results show that the proposed method gives better classification accuracy than any conventional classifiers like SVM, k-NN and the conventional classifier combination/selection scheme. 본 논문에서는 지역적 특성을 가지는 작은 인식기(마이크로 인식기)의 모음으로 인식기를 구현하는 다중 인식기 시스템을 제안한다. 각 학습패턴에서 k개의 이웃한 학습패턴을 추출해서 학습한 인식기를 마이크로인식기라고 한다. 각 학습패턴에는 한개 이상의 마이크로 인식기를 부여한다. 본 논문에서는 선형 커널을 사용한 SVM과 RBF 커널을 사용한 SVM등 두 가지 형태의 마이크로 인식기를 사용한다.테스트 패턴이 인가되면 테스트패턴 주변의 마이크로인식기들 중에서 성능이 가장 좋은 것 하나를 선택한 후 선택된 인식기로 최종 클래스를 결정한다. 테스트패턴 주변에 있는 학습패턴들을 인식한 결과를 성능 측정 척도로 사용한다.Elena 데이타베이스를 사용하여 기존의 단일 인식기, 다중 인식기 결합, 다중 인식기 선택 방법들과 인식률을 비교한 결과 제안된 방법이 우수함을 알 수 있다.