Poor Responder 환자에서 Clomiphene Citrate 주기와 Controlled Ovarian Hyperstimulation 주기의 체외수정 결과 비교

송지홍,궁미경,Song, Ji-Hong,Koong, Mi-Kyoung 대한생식의학회 1998 Clinical and Experimental Reproductive Medicine Vol.25 No.3

The purpose of this study is compare IVF cycle outcome in poor responders between clomiphene citrate (CC) stimulated and controlled ovarian hyperstimulation (COH) protocol. A total of 94 patients responding poorly in previous IVF cycles (estradiol<600 pg/ml or less than 3 oocytes retrieved) subsequently underwent either COH (COH group: 122 cycles, 68 patients) or CC-stimulated cycles (CC group: 43 cycles, 26 patients). CC was administered for five consecutive days starting on cycle day 3 at a dose of 100 mg daily. Serial transvaginal ultrasound examination was done from cycle day 8. Urine was collected $3\sim4$ times before hCG injection for the detection of LH surge. The hCG was administered when serum estradiol reached greater than 150 pg/ml and mean follicle diameter>16 mm. In COH group, ovarian stimulation was done using short protocol (GnRH-a/FSH/HMG/hCG). No difference in age or number of transferred embryos was found between CC group and COH group. COH group had significantly (p<0.05) higher mean peak level of $E_2$ ($810{\pm}112$ vs $412{\pm}55$ pg/ml) and greater number of retrieved oocytes ($3.0{\pm}0.2$ vs $2.0{\pm}0.2$) than CC group. CC group had transferred embryos $(1.8{\pm}0.2)$ compared with $(2.1{\pm}0.2)$ in COH group. However, CC group had higher pregnancy rate than COH group per retrieval [26.9% (7/26) vs 6.2% (6/97)], or per transfer [31.8% (7/22) vs 7% (6/86)]. Although cycle cancellation rate in CC group (48.8%) was higher than that of COH group (21.3%), the pregnancy rate per cycle in CC group was still higher (16.3%) than COH group (4.9%). In addition, implantation rate in CC group was 17.5% (7/40), which was significantly (p<0.01) higher than 3.9% (7/180) in COH group. These data suggest that oocyte and embryo quality are lower in COH cycles of poor responders than CC cycles. We suggest that clomiphene citrate stimulated IVF cycle may be more efficient than COH IVF cycle in poor responders in terms of lower costs and higher pregnancy performance.

난소암과 합병된 뇌종양 2예

송지홍,김재욱,최인철,양오승,김동규 대한산부인과학회 1994 대한산부인과학회 학술대회 Vol.73 No.-

포스타 : 산과학 ; 정상 산모에서 모체혈청의 면역세포아형의 변화에 관한 고찰

송지홍,김은성,김문영,류현미,노건웅,박애자,이미경,백은찬,강인수,전종영 대한산부인과학회 1999 대한산부인과학회 학술대회 Vol.84 No.-

제 73 차 춘계학술대회 : 증례보고 ( 부인과학 ) ; 난소암과 합병된 뇌종양 2 예

송지홍,김재욱,최인철,양오승,김동규 대한산부인과학회 1994 춘계학술대회 Vol.- No.-

습관성유산 및 불임환자에서 자궁중격절제술 후 임신의 결과

송지홍(Ji Hong Song),유근재(Keun Jai Yoo),송인옥(In Ok Song),백은찬(Eun Chan Paik),최범채(Bum Chae Choi),손일표(Il Pyo Son),전종영(Jong Young Jun),박인서(In Sou Park),궁미경(Mi Kyoung Koong),강인수(In Soo Kang) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12

N/A Uterine anomalies have been reported in 4% of women with infertility and in up to 15% of those with recurrent abortion. One of the major intrauterine disorder associated with infertility and recurrent abortions is intrauterine septum, The reproductive outcome of 41 patients of intrauterine septum (7 complete, 34 incomplete) with repeated abortions or infertility was assessed after the uterine septotomy. 5 of 7 patients with comlete uterine septum undergone uterine septotomy (3; hysteroscopic metroplasty, 2; abdominal metroplasty) had total 6 pregnancies and all of them had live biths. 28 patients with incomplete uterine septum got the hysteroscopic intrauterine septotomy and the viable pregnancy rate was 62% (3 ongoing pregnancies, 13 live biths of total 26 pregnancies). 6 patients with incomplete uterine septum had not the operation and 5 patients had 5 live births after total 6 pregnancies with 1 spontaneus abortion. Even though, the number of cases were small, the live birth rate in the group of septotomy of the patients of complete uterine septum (100%, 6/6) was higher than that in the group of not-done (50%, 1/2). The live birth rate in the group of not-done of the patients with incomplete uterine septum (83%, 5/6) was higher than that in the group of hysteroscopic uterine septotomy (62%, 16/26), but 5 of 6 had short uterine septal length (<1 cm), 1 had 1.5 cm septal length in the group of not-done. All the patients with successful pregnancy outcome had no other co-factors at the diagnostic laparoscopy, but the 5 primary infertility patients with no live birth even after treatment (all were with incomplete septum; 3 undergone hysteroscopic septotomy, 2 not-done with one abortion) had other co-factors such as endometriosis, peritoneal or tubal facor. In conclusion, hysteroscopic uterine septotomy would be useful for the patients with habitutal abortion or infertility and more advanced managemnet protocols should be applied to the patients having other co-factors if there was no pregnancy even after the uterine septotomy.

조형놀이를 통한 유아의 감성발달 특성 연구

송지홍 ( Ji Hong Song ),최경란 ( Kyung Ran Choi ) 한국기초조형학회 2015 기초조형학연구 Vol.16 No.1

현대 사회는 인간의 성공과 행복이 이성적인 지능만으로는 해결되지 않는다는 인식의 변화를 맞이하여 인간이 지닌 잠재력을 활용하고자 감성지능(EI)의 중요성을 강조하기 시작하였다. 조형놀이는 유아의 감성지능 발달과 깊은 연관성을 가진다. 본 연구에서는 조형놀이 놀잇감의 감성지능적 특성을 분석하고 이를 바탕으로 유아의 감성지능 발달을 위한 조형놀이 놀잇감의 방향을 탐색하고자 한다. 선행연구와 문헌연구를 통하여 감성지능(Emotional Intelligence)과 유아의 인지적, 사회·정서적 발달특성에 대해 살펴보았다. 그리고 조형놀이의 개념과 조형놀이의 구성요소, 놀이 유형을 살펴본 후, 조형놀이가 가지는 교육적 가치를 바탕으로 조형놀이의 감성지능적 특성을 추출하였다. 조형놀이의 감성지능적 특성을 중심으로 조형놀이의 두 가지 유형인 조작놀이와 구성놀이의 놀잇감을 분석하였다. 조형놀이의 두 가지 유형인 조작놀이와 구성놀이의 놀잇감이 가지는 감성지능적 특성을 분석한 결과 조작놀이 놀잇감은 형태, 색채, 질감에 대한 유아의 인지적 발달에 초점이 맞추어져 있었고 그에 비해 구성놀이 놀잇감은 형태, 색채, 질감의 조형적 요소를 통한 유아의 정서적 표현 활동이 활발히 일어날 수 있는 특성을 가지고 있었다. 구성놀이 놀잇감을 통한 유아의 정서적 표현은 유아의 정서인지를 촉진시킬 뿐 아니라 또래 친구와의 교류를 활성화시켜 대인관계기술을 향상시킨다. 유아의 조형놀이의 유형 중 형태, 색채, 질감의 요소를 활용한 구성 활동이 유아의 정서적 표현을 촉진시켜 감성지능 발달에 더욱 도움을 준다. 하지만 유아의 균형적 성장을 위해 조형놀이는 구성활동과 인지활동이 적절히 이루어져야 한다. Modern society has begun to emphasize the importance of emotional intelligence(EI) to encounter changes that human just happiness and success alone does not solve with the rational intelligence. Formative arts play has a close relationship with early childhood’s emotional intelligence development. In this study, analyzed the formative arts play-toy’s characteristics of emotional intelligence. Based on this, we explore the direction of the formative arts play-toy’s for emotional intelligence development of children. For the study, the first, through previous research and literature about emotional intelligence(EI) and children cognitive and socio-emotional development. The Second, we study about concept and element of formative arts play and organize type of formative arts play. After this study, we educe of formative arts paly’s Emotional Intelligence characteristics based on formative arts play’s educational value. Through this process we analyzed manipulatable play-toys and constructive play-toys that two types of formative arts play focused on formative arts play’s Emotional Intelligence characteristics. The results of analyze the manipulatable play-toys and constructive play-toys that two types of formative arts play, manipulatable play-toys are focused on cognitive development of children. On the other hand, constructive play-toys are focused on children’s emotional expression activity. Emotional expression activity encourage child’s emotion recognition and activate emotional exchanges with friends to improve interpersonal skills. The formative arts play with constructive play-toys are more help on Emotional Intelligence that are promotive of children’s emotional expression. But for children’s balanced growth, constructive play and manipulatable play should be done properly.

GPU Library CUDA를 이용한 효율적인 Delaunay 격자 생성에 관한 연구

송지홍(J.H. SONG),강상현(S.H KANG),김경민(G.M. KIM),김병수(B.S. KIM) 한국전산유체공학회 2011 한국전산유체공학회 학술대회논문집 Vol.2011 No.5

In this study, an efficient algorithm for Delaunay triangulation of a number of points which can be used on a GPU-based parallel computation is studied. The developed algorithm is programmed using CUDA library, and the program takes full advantage of parallel computation which are concurrently performed on each of the threads on GPU. The results of partitioned triangulation collected from the GPU computation requires proper stitching between neighboring partitions and calculation of connectivities among triangular cells on CPU. In this study, the effect of number of threads on the efficiency and total duration for Delaunay grid generation is studied. And it is also shown that GPU computing using CUDA for Delaunay grid generation is feasible and it saves total time required for the triangulation of the large number points compared to the sequential CPU-based triangulation programs.

난소과자극 증후근의 예측인자와 임상 양상에 관한 연구

송지홍(Ji Hong Song),유근재(Keun Jai Yoo),송인옥(In Ok Song),백은찬(Eun Chan Paik),최범채(Bum Chae Choi),궁미경(Mi Kyoung Koong),손일표(Il Pyo Son),전종영(Jong Young Jun),강인수(Inn Soo Kang),박인서(In Sou Park) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11

N/A Objeetive: Ovarian hyperstimulation syndrome (OHSS) is one of the well known complication of conttolled ovarian hyperstimulation. Though there have been numerous protocols for the prevention of OHSS, it has not been completely preventable until now. This study was performed to identify clinical predictors for early and late OHSS. Methods: A retrospective analysis of all IVF cycles in 1993 up to June 1996 was performed. OHSS was diagnosed using the criteria of Rabau modified by Schenker. All cases of OHSS reported in this study presented with marked ovarian enlargement, ascites, oliguria, hemoconcentration and electrolyte disturbance. Ovarian stimulation was carried out using a combination of gonadotrophin releasing hormone-agonist, follicle-stimulation hormone and human menopausal gonadotrophin. 27 patients has moderate or severe OHSS presenting 3-7 days post-human chorionic gonadotrophin (hCG), and 21 patients had severe OHSS presenting 12-17 days post-hCG. Results: No patient with early OHSS went onto develop late OHSS, and no patient with late OHSS had demonstrated early OHSS. Logistic regression showed that early OHSS was predicted by the number of oocytes retrieved and the estradiol concentration on the day hCG injection (P<0.05). Late OHSS was predicted by the transferred embryos, B-hCG on 14 day after hCG injection (P<0.05). Conclusion: Early OHSS was an acute effect of the hCG administered prior to egg retrieval in women with high estradiol and large number of retrieved oocytes. Our analysis of the risk factors for early OHSS indicates that cryopreservation of all embryos will not alter the risk of early OHSS even though it should prevent late OHSS. Late OHSS was induced by the rising serum concentration of hCG produced by the early pregnancy, the number of transferred embryos must be adjusted carefully, since it was associated with multiple gestation.

습관성 유산환자에서 정맥내 면역글로불린 치료의 효과

송지홍(Ji Hong Song),백은찬(Eun Chan Paik),전종영(Jong Young Jun),강인수(Inn Soo Kang),노건웅(Keun Woong Noh),조동희(Dong Hee Cho) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11

N/A The aim of this study was to evaluate the efficacy of intravenous immunoglobulin treatment for recurrent spontaneous abortion. Immunologic causes in either alloimmune or autoimmune type have been suggested for more than 80% of these patients. Various immunotherapy including paternal leukocyte transfusion has been used, but there is controversy on its efficacy and side-effects. The proposed immunomodulatory mechanism of intravenous immunoglobulin includes passive transfer of blocking or anti-idiotype antibody, blockade of Fc receptors, enhancement of supressor T-cell function, down regulation of B cell function. In this study, we used intravenous immunoglobulin for the prevention of spontaneous abortion. Five patients with a history of two or more spontaneous abortions were enrolled in this study. Other etiologic factors such as anatomical, chromosomal, hormonal factors were excluded. Three of them were positive for anti-cardiolipin antibody (ACA). When the pregnancy was diagnosed at about five weeks of gestation, 30 g intravenous immunoglobulin was administered and continued up to 28 weeks with three weeks. Ongoing pregnancy beyond 20 weeks was considered successful. Four among five patients (80%) was successful in maintaining pregnancy now ongoing 20, 31, 33, 39 weeks. One patient with ACA positive had abartion due to anembryonic pregnancy. No adverse reaction was observed during the treatment. From these preliminary data, it is suggested that intravenous immunoglobulin treatment may be effective in maintaining pregnancy in patients with unexplained recurrent spontaneous abortion, Further studies are needed to clarify the its immunomodulatory mechanism and establish a more simplified protocol limiting the use at certain critical period of time.

아동 색채조형 놀이기구 디자인 제안

송지홍(Ji Hong Song),최경란(Kyung Ran Choi) 한국가구학회 2014 한국가구학회지 Vol.25 No.4

Color is an important subject of interest for cognitive developmental stages of children and it also correlate to emotional and physical development. Children can acquire concept of color by ‘play’. Color play can be experienced to children through diversity activity and theses activities contain creative craft art activity. The color-paly with art activity for kids can be called ‘kids color-design play’. Recently, indoor playgrounds are rapidly grow-up because parent’s concern degree that about play activity get higher. The indoor playground being enlargement and it contains various paly contents. Color-design play is also enacted animatedly in kids indoor playground. The great part of color-design plays are enacted through program that needs teaching. On the other hand, color-design play facility that children can play spontaneously is not composed sufficiently. Therefore this study aim at design proposal of ‘Kids color-design playground apparatus’ in indoor playground.