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KubEVC-Agent : 머신러닝 추론 엣지 컴퓨팅 클러스터 관리 자동화 시스템
송무현,김규민,문지훈,김유림,남채원,박종빈,이경용,Moohyun Song,Kyumin Kim,Jihun Moon,Yurim Kim,Chaewon Nam,Jongbin Park,Kyungyong Lee 대한임베디드공학회 2023 대한임베디드공학회논문지 Vol.18 No.6
With the advancement of artificial intelligence and its various use cases, accessing it through edge computing environments is gaining traction. However, due to the nature of edge computing environments, efficient management and optimization of clusters distributed in different geographical locations is considered a major challenge. To address these issues, this paper proposes a centralization and automation tool called KubEVC-Agent based on Kubernetes. KubEVC-Agent centralizes the deployment, operation, and management of edge clusters and presents a use case of the data transformation for optimizing intra-cluster communication. This paper describes the components of KubEVC-Agent, its working principle, and experimental results to verify its effectiveness.
정상 인체 멜라닌세포 및 B-16 흑색종 세포주에서 상지(桑枝) 추출물의 티로시나제 활성 억제 효과에 관한 연구
송무현,황재영,박영립,황규왕 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
Background : Recently, the undesirable effects of UV exposure have been increasing because of destruction of ozone layer and excessive solar exposure in enjoying leisure. Therefore, the chance to have uneven skin pigmentations has been increasing. To keep away from the unwanted skin pigmentation, melanogenesis inhibitors have been developed for use in cosmetic preparations for the purpose of skin whitening. Plant extracts having an inhibitory effect in melanin synthesis may be a good choice as a cosmetic ingredient because they have relatively fewer side effects. Objective : In this study, the inhibitory effects of ramulus mori (young twigs of Morus alba L) on tyrosinase activity were investigated cultured normal human melanocytes and B-16 melanoma cells by using enzyme assay and RT-PCR. Methods : Tyrosinase activity was determined by spectrophotometry. The effects of whitening agents (kojic acid, arbutin, licorice extracts and ramulus mori extracts) on mushroom tyrosinase was compared by measuring the IC_(50), the concentration of the compound at which half of the original tyrosinase activity is inhibited. Normal human melanocytes taken from neonatal foreskin and B-16 melanoma cells, tyrosinase activity inhibition was measured by spectrophotometry. We observed tyrosinase volume in B-16 melanoma cells by using PT-PCR. Results : Ramulus mori extracts showed strong inhibitory effect on tyrosinase activity in both normal human melanocytes and B-16 melanoma cells. We also confirm that they have a inhibitory effect on tyrosinase expression in the RT-PCR. Conclusion : This study showed that ramulus mori extracts had strong inhibitory effect against tyrosinase activity. The results suggests that ramulus mori extracts can be used as a new whitening agent.
우리나라 남해안과 제주 근해에서 자생하는 해조류 추출물의 Melanogenesis에 대한 억제 효과
송무현,황규왕 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Backgroung: Many people have a great interest on skin pigmentation due to melnin production which is caused by UV exposure, hormone, physical and chemical injury from the cosmetic viewpoint. Therefore, need of new depigmenting agent which has safety and potency has been recently increasing. Traditionally, sea weeds have been considered as whitening agents in Korea. We screened sea weeds which was grown in southern parts of Korean sea whether they had tyrosinase inhibition activities by mushroom tyrosinase inhibition assay. Objective:Our purpose was to examine the inhibitory effects of Seaweed extracts on tyrosinase activity and melanin synthesis and compating with other depigmenting agents such as kojic acis, arbutin, licorice extract. Methods: Tyrosinase activity was determined by spectrophotometry, the effects of whitening agents(Kojic acid, arbutin, licorice extracts, Seaweed extracts) on mushroom tyrosinase was compared by measuring the IC_(50), the concentration of the compound at which half of the original tyrosinase activity was inhibited. B-16 melanoma cells were cultured in a pair of 6-well plate 37℃, 5% CO_(2), with DMEM plus 10% FCS contaning of various concentrations of Seaweed extracts. After 24 hours B-16 cells were harvested with trypsinization. B-16 cell pellets were used for measurement of mRNA expression for tyrosinase, TRP-1 and TRP-2 by RT-PCR. Results: 1. Seaweed extracts has relatively strong inhibitory effect on tyrosinase according to increment of concentration. 2. Seaweed extracts has relatively strong inhibitory effect on tyrosinase as compared with kojic acid, arbutin, licorice extract. 3. Seaweed extracts showed inhibitory effect on Tyrosinase and TRP-2 gene transcription but didn't showed inhibitory effect on TRP-1 gene transcription. Conclusion This study provided that Seaweed extracts has strong inhibitory effects aganise melanogenesis. The results suggest that Seaweed extracts will be able to use as a new whitening agent.
송무현,이찬녕,오경미,한진규,고성범,박만규,박건우,이대희 대한신경과학회 2004 대한신경과학회지 Vol.22 No.5
Background: Cerebral infarction as a complication of tuberculous meningitis (TBM) is not uncommon, but has been rarely reported. The purposes of this study were to evaluate the clinical characteristics of cerebral infarction secondary to TBM and investigate the predictive values for cerebral infarction in patients with TBM. Methods: We prospectively collected patients with TBM for 24 months. Patients were divided into two groups, either patients with stroke or without stroke. We compared the demographic features, clinical, laboratory, and neuroradiologic findings between the two groups. We classified the stroke subtype with neuroimaging findings. Results: The 26 patients were diagnosed as TBM, and 6 patients had complications with cerebral infarction. The neutrophil percentage in the cerebrospinal fluid (CSF) leukocyte were significantly higher in patients with stroke than in patients without stroke (p=0.0098). On initial CT scan, meningeal enhancement was found in 9 patients, and 4 of them complicated with stroke. However, there were no significant differences in the other clinical and laboratory features such as demographic features, interval between meningitis onset time and treatment initiation time, peripheral white blood cell count, and CSF findings. In six patients with stroke, lacunar infarctions and non-lacunar territorial infarctions were found in 3 patients, respectively. In territorial non-lacunar infarction patients, one patient died due to herniation. Conclusions: We suggest that the possibility of cerebral infarction under the treatment of TBM should be considered, when the patient shows focal neurologic signs, meningeal enhancement on the CT scan and sustained polymorphic CSF pleocytosis.