제 20 차 대한신장학회 춘계학술대회 : 급성 충수염으로 오인하여 충수 절제술을 시행한 쯔즈가무시병 1례와 출혈성 신증후군 1례

서정필,김영옥,윤선애,김병수,이승헌,방병기 대한신장학회 2000 춘계학술대회 초록집 Vol.2000 No.-

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인터뷰 - "명목적 공정성·익명성만으론 그저 그런 보통 건축물만… 공공건축 품격 구현 힘들어"

서정필,Seo, Jeong-Pil 대한건축사협회 2022 建築士 Vol.636 No.-

월간 <건축사>가 지난 3월 21일 함인선 광주광역시 총괄건축가를 만났다. 그는 인터뷰를 통해 의무가입 시대를 맞아 건축사 윤리 확립을 위한 윤리강령 제정, 신뢰 기반의 공공건축 설계공모 심사 도입 및 건축 인허가 제도에 대한 평소 생각을 전했다. 또 건축계가 의무가입 건축사법 시행과 새 정부 출범 등 변화의 시기를 겪는 상황에서 좋은 건축을 위해서는 건축사에 대한 사회적 신뢰를 더욱 두텁게 해야 한다는 뜻을 전했으며, 공공건축 설계공모에 대해선 명목적 공정성에 집착하기보다 심사위원 재량을 강화하고 문제가 생길 경우 책임을 확실히 묻는 '신뢰 기반 심사제도' 도입 필요성을 강조했다. 또한 현행 건축심의 관련 건축물의 성능과 디자인에 관련된 사항은 건축사 재량에 맡기고 공공성에 대한 것을 심의 대상으로 삼는 방향으로 제도가 개선돼야 한다는 생각도 밝혔다. 함인선 총괄건축가의 저서로는 '구조의 구조', '정의와 비용 그리고 도시와 건축', '건물이 무너지는 21가지 이유' 등이 있다.

응급실에서 소아환자의 진정제로서 케타민(Ketamine)의 사용

서정필,박준석,황태식,장석준,김승호 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: Ketamine use in emergency room has been increased. It has rapid onset of action and appropriate duration of action. It does not need endotracheal intubation and produces potent analgesia, sedation, and amnesia. The object of this study is to determine the safety and the degree of physician's satisfaction in relation to ketamine use. Materials and Methods: This is a prospective study using protocol. Pediatric trauma patients who need sedation were given IM ketamine(4 ㎎/㎏) and atropine(0.01 ㎎/㎏) in a same syringe. Monitoring of patients was done by EM residents and complications of ketamine use were recorded. Physician's satisfaction was also recorded after the procedure. Results: Intramuscular ketamine was administered 54 times, mainly for laceration repair. Physicians completed protocol for 51 of treated children. The median time for onset of sedation was 6.5±2.4 min, and duration of action was 32.4±10.8 min. Hypersalivation occurred in 9.8%(n=5); random movement 3.9%(n=2), emesis during procedure(n=1), emesis at home(n=1), and transient oxygen desaturation(n=1). All were quickly identified and treated without specific airway management and sequelae. Of 84% of physicians was satisfied with ketamine use for pediatric sedation. Conclusion: Intramuscular ketamine can be administered safely and satisfactorily in emergency room to facilitate pediatric procedures in conjunction with a defined protocol and appropriate monitoring.

분자육종법을 이용한 벼멸구 저항성 고품질 자포니카 벼 신품종 ‘안미’ 육성

서정필,정지웅,김연규,크시로드제나,조영찬,이점호,김명기,홍하철,이종희,김정주,최임수,정응기,황흥구,오세관,양창인,신문식 한국육종학회 2014 한국육종학회지 Vol.46 No.2

‘안미’는 농촌진흥청 국립식량과학원과 국제미작연구소 간의 협력으로 분자육종법을 이용하여 2010년에 육성한 중만생 고품질 복합내병충성 품종이다. 지역적응시험을 3개년(2008~2010)간 수행한 결과, ‘안미’는 중부평야지에서 보통기 보비재배 시 출수기는 8월 15일로 ‘화성’보다 5일 늦은 중만생종으로 쌀수량은 보통기 표준재배에서 5.76 MT/ha로 ‘화성’보다 11% 증수되었다. ‘안미’는 ‘화성’에 비해 간장(77 cm)은 작고 수당립수는 많으나 등숙비율은 다소 낮았다. ‘안미’는 현미 장폭비가 1.84인 단원형이며 백미는 심복백 발현이 거의 없어 맑고 투명하다. ‘안미’의 알카리 붕괴도와 단백질 함량은 ‘화성’과 비슷하고 아밀로스 함량은 조금 낮았반면, 식미평가에서 밥맛은 매우 양호하였다. ‘안미’의 재배시험 과정 중 위조현상은 관찰되지 않았으며 성숙기 하위엽 노화는 늦은 편이었다. ‘안미’는 ‘화성’에 비해 수발아에 둔감하였고 내랭성 평가 중 적고는 나타나지 않았으나 임실율은 다소 낮았다. ‘안미’는 도열병, 벼흰잎마름병(K₁, K₂, K₃), 줄무늬잎마름병 및 벼멸구에 강한 저항성을 발현하였다. ‘Anmi’ is a new BPH (Brown planthopper) resistant japonica rice cultivar possessing the Bph18 gene derived from wild rice, Oryza australiensis and high yield potential with good grain quality. ‘Anmi’ was derived from a cross ‘Junam’ and ‘IR65482-7-216-1-2’ by a molecular marker assisted backcross breeding. The introgression line ‘IR65482-7-216-1-2’, the source of the Bph18 gene, was used as the donor parent for BPH resistance and ‘Junam’, a BPH-susceptible elite japonica cultivar with good grain quality, was used as the recurrent parent. ‘Anmi’ was developed by three times backcross the F1 plants with ‘Junam’.The heading date of ‘Anmi’ is August 15 in central plain area, which is 5 days later than that of ‘Hwaseong’. It has 77 cm in culm length, 21 cm in panicle length. The number of spikelets per panicle is more than that of ‘Hwaseong’ and 1,000 grain-weight of brown rice is 22.1 g which is less than 22.7 g of ‘Hwaseong’. Milled rice kernel of ‘Anmi’ is clear in appearance, low in amylase content and excellent in palatability of cooked rice. ‘Anmi’ shows resistance to BPH, leaf blast disease, bacterial blight, rice stripe disease but susceptible to other virus disease and insect pest. The milled rice yield performance of ‘Anmi’ is about 5.76 MT/ha in local adaptability test for three years. This cultivar is adaptable to central plain area of Korea.

간이식 후 담관 협착과 화농성 담관염이 동반된 담관 원주 증후군 1예

서정필,이인석,장재혁,권정현,허원행,배시현,최명규,정인식,김동구 대한소화기내시경학회 2007 Clinical Endoscopy Vol.35 No.4

Biliary complications after liver transplantation occur in 13∼35% of patients. Biliary cast syndrome, cast formation of biliary sludge along the bile duct, can develop in 4∼18% of liver transplant recipients, although the incidence rate is significantly decreasing due to the improvement of graft harvesting and preservation. It is very important that early diagnosis and effective management of biliary cast syndrome be performed when there is a bile duct stricture or dilatation associated with jaundice and cholangitis in the recipient after liver transplantation, due to the possibility of retransplantation and death of the patient from graft loss. We report a case of a biliary cast formed with suppurative cholangitis and extracted incidentally with a plastic biliary stent during an endoscopic procedure after cadaveric liver transplantation, in which the ERCP findings revealed a stricture at the anastomosis site of the common bile duct and cholangitis. (Korean J Gastrointest Endosc 2007;35:281-286) 간이식 후 담관계 합병증은 13∼35%의 환자에서 발생하는 것으로 알려져 있다. 이중 담관 원주 증후군(biliary cast syndrome)은 담관의 슬러지가 담관의 형태를 따라 종괴를 형성하는 것으로 간이식 환자의 4∼18%에서 발생하며 간이식 도입 초기에 비해 장기적출 및 보관기술 등의 발전으로 최근 발생빈도는 감소하고 있지만 발생 시 경우에 따라 이식편의 손실 및 재이식이 필요하거나 환자의 사망으로까지 이어질 수 있으므로 조기 진단 및 효과적인 치료가 필요하다. 저자들은 사체 간이식 후 황달과 담관염이 발생하여 시행한 내시경 역행 담췌관 조영술에서 문합부 담관 협착 및 담관염의 소견을 보였으며 화농성 담관염과 동반하여 생성된 담관 원주가 내시경시술로 플라스틱 담관 스텐트와 함께 배출된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

벼에서 분자마커를 이용한 내냉성 잡종강세에 관한 유전연구

서정필,권수진,최임수,조영찬,안상낙,황흥구,서학수,최해춘 한국작물학회 2001 한국작물학회 학술발표대회 논문집 Vol.2001 No.2

하부위장관 : 악성 대장 폐쇄에 대한 고식적 치료로서 자가팽창성 금속스텐트 삽입술의 유용성 및 재협착과 관련된 예측인자 분석

서정필,김상우,장재혁,허원행,권정현,남관우,박재명,조유경,이인석,최명규,정인식 대한소화기학회 2007 대한소화기학회 추계학술대회 Vol.2007 No.-

Genetic Diversity and QTLs for Grain Quality in Japonica Rice

서정필,최용환,김기종,조영찬,권수진,정영평,정지웅,최임수,김연규,최해춘,황흥구 한국육종학회 2004 한국육종학회지 Vol.36 No.1

Genetic diversity of 94 japonica rice was assessed using 81 simple sequence repeat (SSR). All 81 SSR markers generated a total of 351 alleles. The number of alleles ranged from 1 to 16 with a mean of 4.3 alleles per SSR marker. Six of 81 SSR markers showed monomorphic bands in 94 japonica rice. But several SSR markers on chromosomes 4, 9, 10 and 11 produced many alleles within the japonica rice. Japonica rice could be classified into six major groups by the clustering analysis based on 81 SSR markers. A total of 18 SSR markers which are associated significantly with four grain quality traits such as taste value (TV), alkali digestion value (ADV), amylose content (AC) and protein content (PC) were detected: nine for TV on chromosomes 1, 2, 5, 7, 8 and 11, six for AC on chromosomes 1, 2, 6, 7 and 8, eleven for PC on chromosomes 1, 2, 4, 5, 7, 8 and 11 and two for ADV on chromosomes 8 and 11. On chromosome 8 (OSR35), QTLs for four grain quality traits were identified on same locus. Based on the QTLs for TV, useful alleles for TV of Ilpumbyeo were originated from Norin 8 and Norin 6. The crossing parents possessing useful alleles associated with good grain quality could be reutilized as crossing parents to accumulate grain quality genes for improving grain quality of Korean japonica rice cultivars.

SSR Analysis of Heterosis for Cold Tolerance in Rice

서정필,조영찬,정응기,최임수,최용환,백만기,예종두,안상낙,김연규,황홍구 한국육종학회 2004 한국육종학회지 Vol.36 No.3

The genetic basis underlying heterosis for agronomic traits of rice under cold water irrigated field condition was investigated in the 143 RILs and 286 BC1F1 lines from the cross between a cold-susceptible variety, Milyang23 and a cold-tolerant variety, Stejaree45 using a SSR linkage map. A total of 22 significant QTLs for 10 traits treated cold water irrigated field condition was detected through 138 SSR markers in the backcross populations. Most of the QTLs were detected in only one of the two backcross populations. In 50% of these cases the heterozygotes had higher phenotypic values than their respective homozygotes. Four QTLs were detected with significance in both backcross populations and each pair was mapped to the same chromosomal location, and in each of all cases the phenotype of the heterozygote fell between those of the two homozygotes and in no instances were the heterozygotes found to be superior to both homozygotes. This result suggests that the complementation of dominant (including partial dominant) alleles at different loci in the F1 hybrid might be the major contributor to F1 heterosis. Digenic epistasis was not found.

잡초성벼인 강화앵미11 유래 잎도열병 저항성 유전자 탐색

서정필,조영찬,김정주,신영섭,양창인,노재환,김연규 한국육종학회 2010 한국육종학회지 Vol.42 No.4

본 연구는 국내 수집 잡초성벼에 존재하는 잎도열병 저항성 관련 유전자를 탐색하고, 이 저항성유전자와 연관된 분자마커를 탐색하는 것이다. 도열병에 감수성인 자포니카 품종인 낙동벼와 도열병에 강한 잡초성벼인 강화앵미11을 교잡하여 120개 RILs를 육성하여, 도열병 균주반응과 잎도열병 밭못자리검정을 통한 저항성 유전자 탐색에 이용하였다. 1. 총 45개 도열병 균주를 이용하여 양친들을 검정한 결과, 잡초성벼 강화앵미11은 25개 균주에 대하여 저항성 반응 A weedy rice, Ganghwaaengmi 11, shows high level of leaf blast resistance. The chromosomal number and locations of genes conferring the leaf blast resistance were detected by QTL (quantitative trait loci) analysis using SSR markers in the 120 RILs (recombinant inbred lines) derived from the cross between Nagdongbyeo and Ganghwaaengmi 11. Ganghwaaengmi 11 expressed compatibility with 20 of the 45 inoculated blast isolates, in contrast to Nagdongbyeo with 44 compatible isolates. To identify QTLs affecting partial resistance, RILs were assessed in upland blast nursery in three regions and inoculated with selected nine blast isolates. QTLs for resistance to blast isolates were identified on chromosomes 7, 11 and 12. Three QTLs associated with blast resistance in nursery test at three regions were also detected on chromosomes 7, 11 and 12. The QTL commonly detected on chromosome 12 was only increased blast resistance by Ganghwaaengmi 11 allele. This QTL accounted for 60.3~78.6% of the phenotypic variation in the blast nursery test. OSR32 and RM101 markers tightly linked to QTL for blast resistance on chromosome 12 might be useful for marker-assisted selection (MAS) and gene pyramiding to improve the blast resistance of japonica rice.