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자유학기제 수업을 위한 학생 참여 중심의 교수,학습자료 개발 및 효과 연구 -미래사회 핵심역량의 변 화를 중심으로
백수연,신인선 한국수학교육학회 2014 뉴스레터 Vol.30 No.5
자유학기제는 학생들이 스스로 꿈과 끼를 찾고, 자신의 적성과 미래에 대해 탐색 ? 고민 설계하는 경험을 통해 지속적인 자기성찰 및 발전할 수 있는 기회를 제공하고, 지식과 경쟁 중심의 교육을 자기주도적인 창의학습 및 미래지향적 역량 함양이 가능한 교육으로 전환하여 공교육의 변화 및 신뢰회복을 통해 학생이 행복한 학교생활 을 제공하는데 그 목적이 있다 이에 본 연구는 자유학기제가 추구하는 목표와 기본방향에 부합하면서 실제 현장 에서 실천 가능한 학생 참여 중심의 교수학습 자료를 개발하여 적용하고자 한다 특히 이러한 학생 참여중심의 수업을 통해 학생들의 수학적 태도 및 미래사회에 펼요한 핵심역량 신장에 긍정적인 변화를 줄 수 있을 것인지 그 효과를 연구하는데 그 목적이 있다 이를 위해 자유학기제에 해당하는 중학교 1학년 2학기, 상반, 하반 한 학 급씩을 대상으로 통계 프로젝트 수업을 설계하여 적용해 본 후, 교사관찰일지와 모둠 포트폴리오, 수업을 촬영한 비디오 전사 자료 등을 다각적으로 분석할 것이다. 개발한 프로젝트 수업의 적용 결과로 학생들의 수학적 태도 뿐 아니라 기초학습능력, 정보처리능력, 문제해결능력, 의사소통능력, 그리고 인성과 유사한 대인관계능력과 같 은 핵심역량의 신장에 있어 긍정적인 변화가 있을 것으로 예상한다.
백수연,강수진,Toshiharu Suzuki,Masasuke Yoshida,Toshimichi Fujiwara,Hideo Akutsu 한국자기공명학회 2013 Journal of the Korean Magnetic Resonance Society Vol.17 No.2
ATP synthase produces ATP, a major energy source for metabolic processes in organisms, from ADP and inorganic phosphate in cellular membranes. ATP synthase is known as a rotary motor, in which the c-subunit ring functions as a rotor. In this work, we have tried to develop a more general preparation procedure of thermophilic Foc-ring (TFoc-ring) for NMR measurements. The expression of TFoF1 is easily affected by various experimental conditions such as temperature, shape and size of a flask, a volume of medium, and shaking rate of an incubator. Accordingly, we have tried to optimize the expression conditions of TFoF1. TFoc-rings were purified from TFoF1 according to a reported method. We modified purification procedures to improve purity and yield of TFoc. On top of them, we found a new combination of detergents for the purification at anion-exchange column chromatography. To examine the effect of lipid environments on the structure, the TFoc-rings were reconstituted into two kinds of lipid bilayers, namely, saturated and unsaturated lipid ones. Then, we have compared characteristics of the TFoc-ring structures in these membranes with solid-state NMR
Recurrent Pericardial Effusion with Feline Infectious Peritonitis in a Cat
백수연,조재금,송근호,서경원 한국임상수의학회 2017 한국임상수의학회지 Vol.34 No.6
A five-month-old, male Domestic Korean shorthair was referred to our hospital with a history of lethargy, anorexia, and globoid cardiac silhouette on thoracic radiography. Physical examination showed dehydration and anemia was revealed on blood analysis. On thoracic radiography and echocardiography, the patient showed pericardial effusion and ultrasound-guided pericardiocentesis was performed. A Rivalta test of the pericardial effusion showed a positive result. As the patient had recurrent pericardial effusion, pericardiectomy was performed. He was tentatively diagnosed with wet form feline infectious peritonitis (FIP) and treated with Polyprenyl immunostimulant (PI). Neurological signs were eventually seen and he was euthanized. Histopathologic changes with markedly expanded neutrophils, lymphocytes, plasma cells, and macrophages with fibrous connective tissue and collagenous fibers were detected. Immunohistochemistry for FIP antigen was performed and results showed FIPV-positive multifocal aggregates of cells. Pericardial effusion is an atypical condition in cats with FIP, but can be presented. This case report describes FIP with pericardial effusion in a cat, in which definitive diagnosis of FIP was done using biopsy via pericardiectomy.
백수연,권지영,이영주,곽성찬,이새별,김지선,정일용,고범석,김희정,김성배,안승도,공경업,손병호,안세현,이종원 한국유방암학회 2019 Journal of breast cancer Vol.22 No.3
Purpose: The extension of endocrine therapy beyond 5 years for recurrence-free survivors of breast cancer improves survival; however, the issue on how to clinically identify appropriate candidates remains controversial. This study aimed to identify prognostic factors for breast-cancer-specific mortality in patients who have had 5 years of tamoxifen treatment and categorize subgroups based on the risk of death using combinations of these prognostic factors to assist in the clinical decision to perform further endocrine therapy. Methods: In total, 3,158 patients with breast cancer were enrolled. Breast cancer-specific survival rates after 5 years of tamoxifen treatment were calculated, and associated prognostic factors were analyzed using a Cox proportional-hazards model. Results: An age extreme at diagnosis (i.e., < 40 or ≥ 60 years), tumor size > 2 cm, and positive lymphovascular invasion were robust independent prognostic factors for late breast cancer-specific death in tamoxifen-treated patients (hazard ratio [HR] = 2.162, 1.739, and 1.993; p = 0.001, 0.047, and 0.011, respectively). Lymph node metastasis and progesterone receptor negativity had borderline significance in this regard (HR = 1.741 and 1.638, p = 0.099 and 0.061). The study patients were classified into four groups according to the number of prognostic indicators, i.e., low, intermediate, high, and extremely high risk. The additional 5- and 10-year cumulative risks of breast cancer-specific death were 0.8% and 1.5% in the low-risk group, 0.9% and 3.9% in the intermediate-risk group, 1.3% and 7.3% in the high-risk group, and 4.8% and 13.8% in the extremely high-risk group, respectively. Conclusion: This new risk stratification system for late mortality in breast cancer can be used to identify the right candidates for extended endocrine therapy after 5 years of tamoxifen treatment.