넙치, Paralichthys olivaceus의 미세플라스틱 급성 노출에 따른 혈액성상 및 혈장성분의 변화

김소희,김가현,김지수,김준환,전유현,조재황,김석렬,김대희,Kim, So-Hee,Kim, Ga-Hyun,Kim, Ji-Su,Kim, Jun-Hwan,Jeon, Yu-Hyeon,Cho, Jae-Hwang,Kim, Seok-Ryel,Kim, Dae-Hee 한국환경생물학회 2021 환경생물 : 환경생물학회지 Vol.39 No.3

Juvenile olive flounder, Paralichthys olivaceus (mean weight 66.7±7.1 g; mean length 19.2±0.9 cm) in a bio-floc environment were exposed to microplastic (PE: polyethylene, size 40-48 ㎛) at 0, 4, 20, 100, 500 and 2,500 mg L^-1 for 96 hours. No P. olivaceus deaths were observed following microplastic exposure. In the plasma components, calcium was significantly decreased whereas there was no significant change with magnesium following microplastic exposure. Glucose was significantly decreased with over 100mg L^-1 at 48 hours and 20mg L^-1 at 96 hours. Cholesterol was significantly decreased with over 20mg L^-1 after 48 hours, whereas there was no significant change in the total protein content. In enzymatic plasma components, the AST(Aspartate aminotransferase) was significant decreased by microplastic exposure. The results of this study indicate that acute exposure to microplastic induces blood physiological changes in P. olivaceus.

15년간(1991~2005년) 우리나라 소아에서 분리된 폐구균의 혈청형 분포의 변화

김소희,송은경,이준호,김남희,이진아,최은화,이환종,Kim, So-Hee,Song, Eun-Kyung,Lee, Jun-Ho,Kim, Nam-Hee,Lee, Jin-A,Choi, Eun-Hwa,Lee, Hoan-Jong 대한소아감염학회 2006 Pediatric Infection and Vaccine Vol.13 No.2

목 적 : 폐구균 단백 결합 백신이 개발되었지만 이에 포함되는 혈청형은 7가지로 한정되어 있어, 지역별 주요 폐구균 혈청형의 분포에 따라 백신의 유용성에 차이가 있을 수 있다. 본 연구에서는 우리나라 소아에서 분리된 폐구균의 혈청형의 분포를 분석하고 지난 15년간 시기에 따른 변화 양상을 분석하고자 하였다. 방 법 : 1991년 1월부터 2005년 5월까지 서울대학교 어린이병원 소아 환자의 각종 임상 검체에서 분리된 폐구균 465균주의 혈청형을 quellung reaction으로 결정하였고, penicillin 감수성은 oxacillin 디스크 확산법으로 검사하였다. 연구기간은 1991~1995년(I분기), 1995~2000년(II분기), 2001~2005년(III분기) 등 3개의 분기로 나누어 분석하였다. 결 과 : 465균주의 주된 혈청형은 19F(22%), 23F(18%), 19A(10%), 6B(8%), 14(7%), 6A(7%), 9V(5%) 등이었고, 전체 균주의 79%이었다. 60개월 미만 연령군의 침습성 감염 검체에서 분리된 101균주에서의 주된 혈청형은 혈청형 23F(21%), 14(17%), 19F(15%), 19A(11%), 6B(10%), 6A(7%), 9V(7%) 등으로 총 70%이었다. 전체 균주에서 I, II, III의 각 분기별 혈청형 분포는 백신 혈청형에 포함된 혈청형 19F, 14가 감소하는 추세이었고, 교차 반응 혈청형에 포함된 혈청형 6A, 19A가 증가하는 추세이었다. 침습성 감염 균주에서 폐니실린 내성률은 백신 혈청형에서 92.6%, 교차 반응 혈청형에서 75.0%로 높았으나, 비백신 혈청형에서는 34.4%로 낮았다. 결 론 : 최근 15년간 소아의 임상 검체에서 분리된 폐구균의 혈청형은 주로 19F, 23F, 19A, 6B, 14, 6A, 9V 등이 가장 흔하였고, 최근에 혈청형 19A, 6A가 증가하는 추세이고, 혈청형 19F와 14가 감소하였다. 향후 백신 사용과 관련하여 국내 폐구균 혈청형의 분포에 관한 지속적인 관찰이 필요하다고 생각된다.

우리나라 청소년의 수면시간 및 질과 체질량지수와의 관련성

김소희,김유숙,장영희,박종,류소연,Kim, So-Hui,Kim, Yu-Suk,Jang, Young-Hee,Park, Jong,Ryu, So-Yeon 한국학교보건학회 2012 韓國學校保健學會誌 Vol.25 No.1

Purpose: This study aims to discover the relation between the sleep duration and quality of adolescents and their body mass index. Methods: The study used data obtained through the 2009 online survey on adolescents health behaviors, targeting a total of 75,066 middle and high school students (39,612 of male students and 35,454 of female students). We first performed t-test, ANOVA and Scheffe's test and then the potential variables which was possibly related to the body mass index are determined from the tests. Using the potential variable, we performed the multiple regression analysis to finally identify the relation between the duration and quality of sleep. Results: As a result, the 39.8% of male students and the 46.5% of female students most frequently respond that the sleep duration was less than 6 hours, and 36.4% of male students and the 45.3% of female students respond that the quality of sleep was not good enough. The body mass index of both the male and the female students portionally decreases to their sleep duration, but the better quality of sleep makes their body mass index higher. Conclusion: In conclusion, the body mass index has some notable relationship with the sleep duration and quality for adolescents. It is advised to consider the sleep duration and quality in the business plans for adolescents in order for the prevention of their body mass index.

베트남 결혼이주여성의 문화적응 스트레스와 자녀양육효능감의 관계에서 배우자 지지의 영향

김소희,노윤구,Kim, So Hee,Noh, Yoon Goo 한국여성건강간호학회 2018 여성건강간호학회지 Vol.24 No.2

Purpose: To identify the effects of spousal support on the relationship between acculturative stress and sense of parenting competence among married Vietnamese immigrant women. Methods: The sample for this study consisted of 175 married Vietnamese immigrant women in Gyeongsangnam-do. Data were analyzed using descriptive statistics, t-test, ANOVA, $Scheff{\acute{e}}$ test, Pearson correlations, and hierarchical multiple regression with SPSS/WIN 23.0. Results: (a) sense of parenting competence was negatively correlated with acculturative stress, whereas a positive correlation was observed with spousal support; (b) spousal support mediated the relationship between acculturative stress and sense of parenting competence. Conclusion: Results of the study suggest that spousal support decreases the negative effects of acculturative stress on sense of parenting competence. Therefore, we need to find ways to strengthen spousal support for married Vietnamese immigrant women.

시판 보냉팩 개수에 따른 진공포장 냉동 넙치(Paralichthys olivaceus) 및 고등어(Scomber japonicus) 필렛의 상온유통 중 선도유지능 비교평가

김소희,이지운,전은비,김진,박신영,이정석,So Hee Kim,Ji Un Lee,Eun Bi Jeon,Jin Kim,Pantu Kumar Roy,Shin Young Park,Jung-Suck Lee 한국수산과학회 2023 한국수산과학회지 Vol.56 No.6

The surge in online seafood consumption has increased parcel delivery, leading to a need to implement effective preservation methods. As the cold chain system is not fully established in Korea, styrofoam boxes and cold packs are commonly used for low-temperature seafood distribution. The impact of cold packs on product preservation depends on the number utilized. Herein, the freshness of vacuum-packed frozen fish fillets (Paralichthys olivaceus and Scomber japonicus) stored at 25±0.5℃ for up to 84 h was measured. Chemical (pH and volatile base nitrogen), microbiological (viable cell count), and physical (odor intensity) properties were assessed using 2 or 4 cold packs in a styrofoam box. Four cold packs yielded lower values, indicating superior freshness, and extended fish freshness by approximately 12 h compared with two cold packs. Therefore, it is recommended to use a minimum of 4 cold packs (-350 g/cold pack) in a styrofoam box for distributing approximately 300 g of frozen fish fillets at room temperature during the summer, considering an average delivery period of 2 days in Korea.

생달나무 잎 추출물 유래 항염 및 항산화 활성 성분

김소희,김정은,이남호,Kim, So Hee,Kim, Jung Eun,Lee, Nam Ho 대한화학회 2021 대한화학회지 Vol.65 No.1

In this study, the extract of Cinnamomum yabunikkei leaves were investigated for the anti-inflammatory and anti-oxidative activities and their active constituents were identified. In the anti-inflammatory tests using LPS-stimulated RAW 264.7 cells, the ethyl acetate (EtOAc) fraction inhibited the production of nitric oxide (NO) without causing cell toxicity. In addition, the EtOAc fraction reduced expression of iNOS protein and production of pro-inflammatory cytokines (TNF-α, IL-1β). Upon the anti-oxidative studies by DPPH and ABTS+ radicals, potent radical scavenging activities were observed in the EtOAc fraction. Five phytochemicals were isolated from the extract of C. yabunikkei leaves; (4S,5R)-4-hydroxy-5-isopropyl-2-methylcyclohex-2-enone (1), methoxy-(3,5-dimethoxy-4-hydroxyphenyl)ethanediol (2), afzelin (3), nicotiflorine (4) and narcissin (5). As far as we know, compounds 1-5 were isolated for the first time from this plant. In the anti-inflammatory tests for the isolates, compound 1, 3, 4 and 5 were determined to decrease NO production without causing cell toxicity. Furthermore, compound 1 reduced expression of iNOS protein and exhibited potent inhibitory activities of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Based on these results, it was suggested that the extract and isolated compounds from C. yabunikkei leaves could be potentially applicable as natural source for pharmaceutical and/or cosmetic ingredients.

Respiratory Syncytial Virus 감염의 조기 진단 kit "바이오라인 알에스브이^TM"의 평가

김소희,성지연,양미애,은병욱,이진아,최은화,이환종,Kim, So-Hee,Sung, Ji-Yeon,Yang, Mi-Ae,Eun, Byung-Wook,Lee, Jin-A,Choi, Eun-Hwa,Lee, Hoan-Jong 대한소아감염학회 2007 Pediatric Infection and Vaccine Vol.14 No.1

Purpose : This study was performed to evaluate a new rapid diagnostic kit (BIOLINE $RSV^{TM}$; Standard Diagnostics Inc., Yongin, Korea), a lateral-flow immunoassay, in the detection of respiratory syncytial virus (RSV) from the nasopharyngeal aspirates (NPA) of children with lower respiratory tract infections (LRTIs) in comparison with other diagnostic methods. Methods : Three hundred and nineteen NPAs were selected from a large pool of NPAs that had been obtained from children with LRTIs. All specimens had already been tested for RSV by culture and immunofluorescent (IF) test, and had been kept frozen. Tests with BIOLINE $RSV^{TM}$ were performed at least twice. All who conducted the experiments or interpreted the test results were blinded to the results of both culture and IF tests. Results : One hundred seven (97.3%) of 110 specimens that were positive for RSV by both culture and IF test, 29 (87.9%) of 33 that were positive by IF test only, 20 (76.9%) of 26 that were positive by culture only, and 140 (93.3%) of 150 that were negative by both methods were negative for RSV by BIOLINE $RSV^{TM}$. By combining the above results, the following 5 diagnostic values of BIOLINE $RSV^{TM}$ were determined in comparison with viral culture or IF test; sensitivity, 92.3% (156/169, 95% confidence interval [CI], 87.1-97.5%); specificity, 93.3% (140/150, 95% CI, 88.4-98.2%); positive predictive value, 94.0% (156/166, 95% CI, 89.5-98.5%); negative predictive value, 91.5% (140/143, 95% CI, 86.0-97.0%); and agreement, 95.9% (306/319, 95% CI, 92.1-99.7%), respectively. Conclusion : This study revealed that BIOLINE $RSV^{TM}$ demonstrated good sensitivity and specificity for the detection of RSV antigen from NPAs of children with LRTIs. Because of simple methods and quick results, this test may be useful for the diagnosis of RSV infection during the epidemic periods.

간호대학생의 메타인지, 학습동기, 학업적 자기효능감이 자기주도학습능력에 미치는 영향

김소희(So Hee Kim), 이정민(Jung Min Lee), 김민경(Min Gyeong Kim), 김수아(Su Ah Kim), 김주은(Ju Eun Kim), 노윤서(Yun Seo Noh), 송지민(Ji Min Song), 이다원(Da Won Lee), 이소희(So Hee Lee) 다문화건강학회 2023 다문화건강학회지 Vol.13 No.1

Purpose: This study sought to identify the influence of metacognition, learning motivation, and academic self-efficacy on the self-directed learning ability of nursing students. Methods: A descriptive study design was used, and data were collected using self-reported questionnaires from 194 nursing students. Statistical analyses, including independent t-test, one-way ANOVA, Pearson's correlation, and multiple regression analysis, were performed using SPSS 26.0. Results: Metacognition, learning motivation, and academic self-efficacy significantly predicted nursing students' self-directed learning ability, accounting for 66.3% of the variance. Conclusion: Interventions to improve the self-directed learning ability of nursing students should focus on enhancing metacognition, learning motivation, and academic self-efficacy.

수은이 Lactobacillus bulgaricus의 젖산 생성과 생육 저해작용에 대한 양파 추출물의 효과

김소희(So Hee Kim),서명자(Myung Ja Suh) 한국생약학회 1987 생약학회지 Vol.18 No.1

Onion extracts were tested for effects on the growth and lactic acid production of Lactobacillus bulgaricus in the medium containing mercury. The media containing mercury were added with onion extracts and inoculated with the bacterium and then incubated at 39 for four days. All of the onion extracts examined increased the growth and lactic acid production of the bacterium in the medium containing mercury. At the addition of the edible portion extract of onion to the medium containing 5 ppm, 10 ppm and 20 ppm mercury, the higher the concentration of the onion extract was added, the greater the increasing effect on the growth and lactic acid production. The brown peel extract of onion increased the growth and lactic acid production of the bacterium in the medium containing mercury at all concentrations. The higher the concentration of the extract added, the more effective the increasing effect. The onion solutions of edible portion and brown peel extracted at 90 to 100 showed more desirable effects than those extracted at the room temperature. Among four kinds of the onion extracts, the brown peel solution extracted at 90 to 100 was the most effective in increase of the growth and lactic acid production in the medium containing mercury.

리튬을 사용한 병력이 없는 양극성장애 환자에서의 갑상선기능저하증

김소희(So Hee Kim),하규섭(Kyoo Seob Ha),원승희(Seong Hee Won),주연호(Yeon Ho Joo),안준호(Joon Ho Ahn),조수현(Soo Hyun Joe) 대한생물치료정신의학회 2015 생물치료정신의학 Vol.21 No.3