연취급 근로자들의 혈중 ZPP 농도 선별기준에 따른 정확도의 변화

김용배,안현철,황보영,리갑수,이성수,안규동,이병국,Kim, Yong-Bae,Ahn, Hyun-Cheol,HwangBo, Young,Lee, Gap-Soo,Lee, Sung-Soo,Ahn, Kyu-Dong,Lee, Byung-Kook 대한예방의학회 1997 예방의학회지 Vol.30 No.4

Measurement of blood lead (PbB) and blood zinc protoporphyrin (ZPP) are most common biological indices to identify the individual at risk for excess or the health sequences by lead exposure. Because PbB is known most important and reliable index of lead exposure, PbB is often regarded as a gold standard to detect lead exposure. But in Korea PbB is a secondary test item of detailed health check-up with positive finding of screening test in most occasion. Our lead standard requires all lead workers to take annual heath-check twice a year for investigation of their health effect due to lead exposure. Blood ZPP is one of most important index to detect high lead absorption in lead workers as a screening test. Measurement of blood ZPP is known ,well to correlate with PbB in steady state of exposure in most lead workers and is often used as a primary screening test to detect high lead absorption of lead workers with the advantage of simplicity, easiness, portability and low cost. The current cut-off criteria of blood ZPP for further detailed health check-up is $100{\mu}g/d\ell$ which is supposed to match the level of $40{\mu}g/d\ell$ of PbB according to our standard. Authors tried to investigate the validity of current criteria of cut-off level $(100{\mu}g/d\ell)$ of blood ZPP and possible another better cut-off level of it to detect the lead workers whose PbB level over $40{\mu}g/d\ell$. The subjects in our study were 212 male workers in three small scale storage battery industries. Blood ZPP, PbB and hemoglobin (Hb) were selected as the indices of lead exposure. The results were as follows. 1. The mean of blood ZPP, PbB and Hb in lead workers were $79.5{\pm}46.7{\mu}g/d\ell,\;38.7{\pm}15.1{\mu}g/d\ell,\;and\;14.8{\pm}1.2g/d\ell$, respectively. There were significant differences in blood ZPP, PbB and Hb by industry (P<0.01). 2. The percents of lead workers whose blood ZPP were above $100{\mu}g/d\ell$ in the group of work duration below 1, 1-4, 5-9 and above 10 years were 8.6%, 17.2%, 47.6%, and 50.0%, respectively. The percents of lead workers whose PbB were above $40{\mu}g/d\ell$ in those were 31.4%, 40.4%, 71.4%, and 86.4%, respectively. 3. The percents of lead workers whose PbB were below $40{\mu}g/d\ell$, $40-59{\mu}g/d\ell$ and above $60{\mu}g/d\ell$ were 54.7%, 34.9% and 10.4%, respectively. Those of lead workers whose blood ZPP were below $100{\mu}g/d\ell$, $100-149{\mu}g/d\ell$ and above $150{\mu}g/d\ell$ were 79.2%, 13.7% and 7.1%, respectively. 4. Simple linear regression of PbB on blood ZPP was statistically significant (P<0.01) and as PbB was $40{\mu}g/d\ell$, blood ZPP was $82.1{\mu}g/d\ell$. 5. While the highest sensitivity and specificity of blood ZPP test to detect lead workers with PbB eve. $40{\mu}g/d\ell$ were observed in the cut-off level of $50{\mu}g/d\ell$ and $100{\mu}g/d\ell$ of blood ZPP, respectively, the highest validity (sensitivity+specificity) of blood ZPP to detect lead workers with PbB over $40{\mu}g/d\ell$ was observed in the cut-off level of around $70{\mu}g/d\ell$ of blood ZPP. But even with optimal cut-off level of around $70{\mu}g/d\ell$ of blood ZPP, still 25.0% of false negative and 20.7% false positive lead workers were found. As the result of this study, it was suggested that reconsideration of current blood ZPP cut-off of our lead standard from $100{\mu}g/d\ell$ to somewhat lower level such as around $70{\mu}g/d\ell$ and the inclusion of PbB measurement as a primary screening test for lead workers was highly recommended for the effective prevention of lead workers.

우리나라 經營參加制度에 대한 從業員 意識構造의 實證的 分析

金用培 청주대학교 대학원 1988 우암논총 Vol.4 No.-

The relations between labor and capital was rather oppitive and conflicting at the beginning of industrialization in many developed countries. But the countries have carried out the participation of the labor unions in business administration these days. I think, in order to carry out the system effectively, the employers and workers should have a positive attitude and keep their equal rights. And they should remember that they are the equal partners each other in business, especially the employers should satisfy the worker's desires. And they should pursue the common goal-economic stability and highly developed society. For this goal, the democration of economy and business management should be carried out. Since the collective bargaining is not settled in Korea, the laborer's economic rights are not guaranteed. Also, the bilateral system of collective bargaining and the joint labor-management conference-the democratic system of business management-is tenuous. To solve the foregoing problems, it is certain that we should pursue the policy of improvement of labor-management relations through activation of the joint labor-management conference.

Phenyl ester계열 강유전성 액정혼합물의 전기광학과 유전적 성질에 관한 연구

김용배,최진욱 건국대학교 기초과학연구소 2000 理學論集 Vol.25 No.-

Phenyl ester계열 강유전성 액정혼합물의 카이랄 스멕틱 C상(SmC* phase), 카이랄 스멕틱 A상(SmA* phase) 그리고 카이랄 네마틱상(N* phase)들에서의 전기광학과 유전적 성질을 연구하였다. 강유전성 액정혼합물(KU-1001)의 SmA* 상 범위에서 장 유도효과에 의한 경전효과 때문에 작은 경사각이 관찰되었다. KU-1001 혼합물의 전기광학 응답시간은 상온에서 약 50㎲이고, SmC*-SmA* 상전이 근처에서는 높은 전장에서 2㎲보다 빠르게 나타내었다. 또한 N* 상에서는 인가 전기장에 무관하며 10㎲의 응답시간을 나타내었다. 유전율 이방성은 주파수와 온도에 크게 의존하며, SmC* 상과 SmA* 상에서는 음의 값을 나타내었고, N* 상에서는 0에 접근하였다. 이 현상은 N* 상에서의 변전효과 때문에 일어난다. KU-1002 혼합물은 유전 이방성의 값이 음인 강유전성 액정물질이 높은 인가 전장영역에서 관찰되는 변칙적인 스위칭 거동을 하였다. A phenyl ester type of ferroelectric liquid crystal mixtures have discussed dielectric and electro-optic properties for chiral smectic C(SmC*), chiral smectic A(SmA*) and chiral nematic (N*) phases. The tilt angle exhibits a small tail in the SmA* phase due to field induced effect, which is an electroclinic effect. KU-1001 mixture shows a optical response time of about 50㎲ at room temperature and low electric field down to 2㎲ for high electric field close to the SmC*_SmA* phase transition. In the N* phase, the value of the optical response time is order of 10㎲ and almost independent of the applied field. The dielectric anisotropy Δε has been negative value in the SmC* and SmA* phases which strongly depends on frequency and temperature. It approaches zero in the N* phase. This is the favorable condition sought in order to exploit flexoelectric effect in the N* phase. Anomalous switching behaviour of FLC materials with negative dielectric anisotropy have been reported. KU-1002 mixture shows a minimum in response time at a sufficiently high field.

디지털 이미지 상관관계를 이용한 알루미늄 합금 판재의 성형한계도 평가

김용배,박정수,송정한,Kim, Yongbae,Park, Jungsoo,Song, Junghan 한국교통대학교 융복합기술연구소 2015 융ㆍ복합기술연구소 논문집 Vol.5 No.1

Sheet metal formability can be defined as the ability of metal to deform without necking or fracture into desired shape. Every sheet metal can be deformed without failure only up to a certain limit, which is normally known as forming limit curve(FLC). In this paper, the dome stretching tests and tensile tests have been performed to obtain forming limit curve of aluminum alloy. During the experiment, failure strain is measured using digital image correlation(DIC) method. DIC method is a whole-field measurement technique that acquires surface displacements and strains from images information which characterized a random speckle as intensity grey levels. Recently years, this DIC method is being developed and used increasingly in various research. DIC results demonstrated the usefulness and ability to determine a strain.

醫藥品 製造設計 및 操作分析의 最適化에 關한 硏究 : 錠劑製造의 最適化

金瑢培 圓光大學校大學院 1978 學位論叢 Vol.1 No.-

Tablet product design problem was structured as constrained optimization problem and subsequently solved by multiple regression analysis and Lagrangian method of optimization. Aluminium flufenamate was the drug chosen and microcrystalline cellulose and starch were the binder and disintegrant, respectively. The effect of the binder and disintegrant concentration on tablet hardness, friability, volume, in vitro release rate, and urinary excretion rate of drug in human subjects was recorded. Since a reasonably rapid release rate of drug is generally an important objective in the design of solid dosage form, optimization of this parameter was employed in studying the applicability of constrained optimization to a pharmaceutical product design problem. In addition to finding optimal solutions to constrained pharmaceutical problems, the application of sensitivity analysis studies to such problems was also illustrated. It would appear that prediction of the in vivo t'_(50)% response from a knowledge of the in vitro t_(50)% response can be made fairly accurately for the tablet system used in this study.

Cholesteryl S-Alkoxybenzene Thiocarbonate의 합성과 액정 성질에 관한 연구(1)

金容培 건국대학교 1988 學術誌 Vol.32 No.2

The Cholesteryl S-Ethoxybenzene Thiocarbonate and the Cholesteryl S-Propoxybenzene Thiocarbonate were synthesised and their liquid crystal phase transition temperature were determined by optical method. Those compounds exhibit a cholesteric mesophase which are "Polygonal texture" and "Schlieren texture."

특집/방사선치료의 진화: 고정밀방사선치료

김용배,서창옥 대한의사협회 2008 대한의사협회지 Vol.51 No.7

Technological advances that have been achieved over the last two decades in the area of treatment planning and sophisticated and complicated hardware capabilities, such as computer-controlled treatments, multileaf collimators, and incorporating imaging devices into treatment machines, enable clinical implementation of high-precision radiotherapy in field of radiation oncology. High-precision radiotherapy allows the delivery of increased tumor doses with relative sparing of normal tissues compared to 3 -dimensional radiotherapy and conventional techniques. Preliminary clinical experiences of high precision radiation therapy have been encouraging by high rates of local control and decrease of toxicity. This article provides an overview of high precision radiotherapy such as intensity-modulated radiotherapy, stereotactic radiation therapy, image-guided radiotherapy, and charged particle therapy.

人間關係管理의 技術問題

金瑢培 東亞大學校 1963 東亞論叢 Vol.1 No.-

The human actions which act in the organization as a functional being is primarily limited by the organization of management. However, it does always follow the rules of a formal organization as human being invoives various and complicated elements. Therefore, organization may be classified into two sides formal organization and informal organization. The former is an organization brought by the rules of organization and latter is brought by human elements. The management of human relations sets its key point on an in formal organizations. The human relations management usually tries to understand social relations and to find the reasonable methods through a survey of individual personality such as motive for activity, desire and attitude between a formal and informal grups The research on the management of human relations was began by Prof. E. Mayo of Harvard University. He took Hawthorne Research as the method and investigated the Western Eiectric Company. He finally concluded that the efficiency of labour mainly depends on labour's affection. Therefore, the efficiency in production can be improved by rather improvement of human relations between manager and labour or among labours than the change in rest or work. The question may be raised when Mayo's conclusions to an organization. What and how human relations can be improved in the organization for the Question, following points and methods may be recommended : 1. The method for survey of labour a. moral survey b. counselling 2. Improvement of communication 3. The improvement of work-shop a. leader-ship training b. delegation of authority 4. The method of paticipation for management a. suggestion system b. multiple management c. group approach management In conclusion, the key point of human management is that a man is livng being. Therefore a man must be treated and accomodated by the circumstances and functions of the organization.

피판의 생존증대를 위한 국소적 고압산소 요법의 이용

김용배 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.2

The hyperbaric oxygen theraphy has been cited as a sure method of helping improve chances of skin flap survival but it has yet to be widely utilized due to not only toxicity and other side effects such as renal bleeding and eardrum rupture, but also in conveniences such as infeasibility of entry into the oxygen tank for patients with poor systemic condition and infants. In contrast, regional hyperbaric oxygen theraphy shows no side effects associated with the systemic hyperbaric oxygen therapjy while having the advantage of being almost as effective as the latter method with a much simpler heatnext method for the patients. The author treated 23 compromized flaps with regional hyperbaric oxygen theraphy by using Topical Hyperbaric Oxygen Chamber(Fig. 1). In most cases, the flap survival was increase but partial necrosis of the flaps were noted in some cases(5/23) and the flap was totally lost in one flap. The mean elevation of arterial oxygen saturation after regional hyperbaric therapy was 6.9% and hereby reporting the above results, along with a discussion on related literature.

ROC 분석을 이용한 ν-glutamyltranspeptidase와 대사증후군과의 관련성 평가

김용배,함정오 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

This study was accomplished to find out the relationship between γ-glutamyl transpeptidase(γ-GTP) and metabolic syndrome, and to suggest the optimal positive cut off point of γ-GTP using receiver operating characteristic(ROC) analysis. Study subjects were 171 women who participated in health screening at health promotion center in Soonchunhyang Cheonan hospital in 2006. We measured waist circumference, blood pressure, fasting glucose, triglyceride, high density lipoprotein cholesterol and γ-GTP. ROC analysis showed an area under the curve(AUC) of 0.870(95% confidence interval : 0.801 - 0.938), indicating an excellent classification performance of the model. The sensitivity of 88% and specificity of 81% was achieved at the optimal cut off point of γ-GTP around 20.5 U/L. In conclusion, γ-GTP could be used as a screening test for diagnosis of metabolic syndrome in nondrinker.