응급실에 내원한 환자에서 어지럼증의 원인과 임상양상의 분석

문원식,정경운,위준선,문정미,전병조,김용권,소정일,류진호,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: Recently, The number of patients who have been complaining of the vertigo or dizziness has been increasing due to rapid growth of elderly population and senile disease. The differentiation of dizzy patients is not familiar to most emergency physicians. This study was designed to differentiate true vertigo and to investigate the clinical difference among central vertigo, peripheral vertigo, and other causes of dizziness. Methods: The authors analyzed the cases of 237 dizzy patients who visited the emergency department of Chonnam University Hospital during the recent 2 years. For the base of dizziness, associated past illnesses, severity, nystagmus type, and the causes of central and peripheral vertigo. Results: Female patients were 142(59.9%) and male patients were 95(40.1%). The most common age group was the 6th decade. The origin of dizziness was classified as peripheral cause(25.3%), central cause(32.9%), and others(41.8%). As to nature of the dizziness, the rotatory sense was dominant in peripheral vertigo and the floating sense and blurred vision in central vertigo. Peripheral vertigo was triggered by position change of head and body, and central vertigo by the eye movement. Audiograms I showed that most patients with central vertigo had normal hearing, but 46.7% of thoswith peripheral vertigo had an abnormal hearing disturbance. Nystagmus was more prevalent in peripheral vertigo Conclusion: History taking and physical examination played an important role in the diagnosis of dizzy patients. An important part of the diagnosis of a dizzy patient could be to evaluate the peripheral origin, the central origin and others causes. Because central vertigo may be associated with a significant neurological pathology, spectral radiological studies, including MRI and CT, are mandatory to rule out a devastating brain lesion.

공탄성시스템의 확률론적 제어에 대한 실험적 연구

김대중,박상태,정재욱,허훈,Kim, Dae-Jung,Park, Sang-Tae,Jeong, Jae-Uk,Heo, Hun 대한기계학회 1999 大韓機械學會論文集A Vol.23 No.11

A Newly proposed control methodology applied to the aeroelastic system experiencing flutter is investigated and its performance is verified experimentally. The flexible cantilever beam slicked with piezofilm sensor and piezoceramic actuator is modelled in physical domain. Dynamic moment equation for the system is derived via Ito's stochastic differential equation and F-P-K equation. Also system's characteristics in stochastic domain is analyzed simultaneously. LQG controller is designed and used in physical and stochastic domain. It is shown experimentally that the vibration of beam is controlled effectively by designed LQG controller in physical domain. By comparing the result with that of LQG controller designed in stochastic domain, it is shown that the new control method, called Heo-stochastic control technique, has better performance as a controller.

Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

열 전처리에 의한 섬유소분해효소생산 미생물의 선발

정허진,김훈,김정호 順天大學校 1996 論文集 Vol.15 No.1

30 개의 토양과 퇴비 시료로 부터 섬유소 분해효소를 생산하는 3 종류의 미생물을 분리하였다. 분리는 carboxymethyl-cellulose (CMC)를 함유하는 고체 평판배지를 이용하였으며, 분리된 3 종류 중 2 종류 (H12, H15)는 열 전처리한 시료로 부터, 1 종류 (N01)는 열 전처리하지 않은 시료로 부터 얻어졌다. H12와 H15의 섬유소분해활성은 N01보다 높은 것으로 조사되었다. H12와 H15는 액체배지에서 배양한 경우 37℃와 42℃에서 균체증식과 CMCase 생산이 좋았다. N01은 37℃에서는 잘 자라지 못 하였고, 42℃에서는 H12, H15와 비슷하게 성장하였으나 효소 생성은 거의 없었다. H12와 H15 균주에서 CMC 첨가에 따른 효소 생성의 유도는 전혀 관찰되지 않았다. 분리된 3 균주를 TSB에서 배양한 결과 LB 배지에서 보다 적어도 2배 이상의 많은 CMCase를 생산하였다. 이상의 결과는 시료의 열 전처리가 CMCase를 생산하는 균주를 선발하는 데 보다 좋은 방법일 수 있음을 시사한다. Three microorganisms producing carboxymethyl-cellulase (CMCase) were isolated from 30 soil and compost samples. CMCase activity, on plates containing CMC, of the two isolates, H12 and H15, screened by heat-pretreatment procedure, was higher than that of N01, the one screened by nonheat-treatment procedure. H12 and H15 were able to grow and produce the enzyme well at 37 and 42℃ in liquid culture media. N01 did not grow well at 37℃ but could grow moderately at a little higher temperature, 42℃. However, N01 did not produce CMCase in liquid culture media at 42℃. For H12 and H15, addition of CMC to the media did not increase the production of CMCase at all. All of the three isolates produced at least about 2 times higher CMCase activity in TSB medium than in LB medium. From these results, it is suggested that heat-pretreatment of samples can provide a better way of screening CMCase producing strains.

방광 소세포암:1예 보고

허정남,김용수,조온구,고병희,임현철,함창곡 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2

Small cell carcinoma(also known as oat cell carcinoma) of the urinary bladder is an extremely rare malignancy and is derived from neuroendocrine stem cells. It is usually biologically aggressive tumor with early vascular and muscle invasion, so it has poor prognosis. Radiological findings of small cell carcinoma are similar to other malignancies of urinary bladder, therefore it is impossible to distinguish small cell carcinoma from other malignancies. Pathologic study is an only useful method for differential diagnosis of bladder tumor. We report here the case of 74th years old woman presented with painless gross hematuria.

인구사회학적요인, 학교조직요인 및 교사의 사회심리학적요인이 직무만족도에 미치는 영향

정회욱 이화여자대학교 교육과학연구소 2006 교육과학연구 Vol.37 No.2

본 연구는 인구사회학적요인(교사의 성별, 연령, 교급, 학교위치, 보직유무), 학교조직요인(합리풍토, 인화풍토, 폐쇄풍토, 상사의 지원, 업무 스트레스), 사회심리학적요인(긍정적 성격, 부정적 성격, 자아존중감, 가정화목, 경제적 곤란)이 교사의 직무만족도에 미치는 영향을 검토하는데 그 목표를 두고 있다. 본 연구의 목표를 달성하기 위해, 전남지역 초·중·고등학교 교사 644명에게 '성취감 만족', '일 자체만족', '복지 만족'의 하위요소로 구성된 교사 직무만족 척도와 사회심리학적변인, 학교조직변인, 인구사회학적변인들에 관해 질문하는 설문지를 실시하였다. 인구사회학적변인들 중에서 학교 위치는 교사직무만족과 전혀 상관이 없었으나, 교사의 성별, 교급, 보직유무, 연령은 교사의 직무만족도와 유의하게 상관이 있었다. 학교조직변인들도 교사의 직무만족과 높은 상관관계를 나타내어, 상사의 지원이 높을수록, 학교 조직이 합리적으로 운영되고 학교조직의 인화단결이 잘될수록 교사들이 느끼는 직무만족도가 높은 것으로 나타났고, 학교가 폐쇄적 풍토를 지니고 교사들의 업무스트레스가 높을수록 교사들의 직무 만족도가 떨어지는 것으로 나타났다. 사회심리학적변인들의 경우, 교사가 긍정적 성격을 가지고 있고, 자아존중감이 높을 때, 그리고 가정이 화목할 때 직무만족도가 높은 것으로 나타났으며, 부정적 성격을 가지고 있을 때, 그리고 경제적 곤란을 느끼고 있을 때는 직무만족도가 낮은 것으로 나타났다. 인구사회 학적변인, 학교조직변인, 사회심리학적변인들을 동시에 사용하여, 중다회귀 분석한 결과를 살펴보면, 교사의 성별이나, 연령, 교급과 같은 인구사회학적요인보다는 합리풍토, 인화 풍토와 같은 학교조직요인과 교사의 긍정적, 부정적 성격과 자아존중감과 같은 교사의 사회심리학적요인이 교사직무만족도를 예측하는 데 훨씬 더 중요하게 작용하는 것으로 나타났다. The major goal of the present study was to investigate the influences of sociodemographic factors, school organizational factors, and teachers' sociopsychological factors on teachers' job satisfaction. Six hundred and forty-four elementary, middle, and high school teachers completed a questionnaire that included items on job satisfaction, sociodemographic characteristics of teachers, school organizational factors and teachers' sociopsychological factors. Among the sociodemographic variables, the location of the school was not related to teachers' job satisfaction, however, the teacher's gender, age, and the level of school were correlated with job satisfaction. School organizational factors such as the school's social closeness and supports of super-ordinates, and the teachers' sociopsychological factors such as positive personality and self-esteem were also significantly related to job satisfaction. Stepwise multiple regression analyses revealed that in general, school organizational factors and teachers' sociopschological factors play more important roles in teachers' job satisfaction than sociodemographic variables of teachers.

태권도 프로그램이 정신지체아동의 인지기능 발달에 미치는 영향

허정석,황영성,한성유,이수판,안인준 釜山大學校 附設 體育科學硏究所 2006 體育科學硏究所 論文集 Vol.22 No.1

The purpose of this study was to determine the effect of the Taekwondo program on cognitive competence of children with mental retardation. The subjects were 18 children with mental retardation. The children were devided into two groups. One group(n=9) was in an experimental group and the other group(n=9)was a control group. To find out any changes of their cognitive competence, the Taekwondo program was executed to the exercise group three times a week, for forty minutes a day over ten weeks......

제14회 부산 아시아 경기대회 남자 태권도 경기 공격기술 및 득점 분석

허정석,황영성,박재성,김도호,한성유,이수판 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

The purpose of this study was to analyze attack skills and scores in 8 weight classes of male Taekwondo athletes who participated in the semi-final and final matches(48 athletes) in the 14the Asian Games(2002, Busan). The 14th Asian Games was chosen for this study because it is in these games that the rules were revised to a variable scoring system. The results obtained from this analysis were as follows; 1. There is a sinificant difference of attack skill frequency per Korean(Foreign) male athlete was 50.00(51.38) times and scores obtained were an average of 5.06(4.25) points per athlete. 2. There is a significant difference in attack frequency between the light weight group and heavy weight group of Korean and Foreign male athletes. Korean male athletes: Between groups, in case of momtong-dolryeochagi, naraechagi and tchikeachagi, the frequency of the light weight group was shown to be higher. The frequency of momtong-dolryeochagi was shown to be higher in the heavy weight group. 3. There is a significant difference in attack frequency between Korean male athletes and Foreign male athletes in the light weight group and heavy weight group. The light weight group: Between groups, in case of momtong-dolryeochagi and eolgul-dolryeochagi, the frequency of Korean male athletes was shown to be higher and in case of naraechagi, dwitchagi and dolgaechagi, the frequency of Foreign male athletes was shown to be higher. The heavy weight group: Between groups, in case of and eolgul-dolryeochagi, naraechagi and dwitchagi, the frequency of Korean male athletes was shown to be higher and in case of momtong-dolryeochagi, tchikeachagi and dolgaechagi, the frequency of Foreign male athletes was shown to be higher.

신경회로망을 이용한 호 접수제어기

허정석,양성룡 울산대학교 1993 공학연구논문집 Vol.24 No.1

B-ISDN의 전송 및 교환 기법으로 정착되고 있는 ATM망의 폭주제어를 위하여, 신경회로망을 이용한 호 접수 제어기를 설계한다. 신경회로망을 이용한 호 접수제어는 가입자가 선언한 트래픽 기술인자의 불확실성에 대한 정보를 제어기가 가지고 있기 때문에, 실제 트래픽이 호 설정요구시 협약된 트래픽의 특성과 다소 상이하더라도 견고성(Robustness) 있는 트래픽 제어를 할 수 있는 장점을 가지고 있다. 본 연구에서는 신경회로망 제어기를 보다 효율적으로 학습시킬 수 있도록 두가지 학습 패턴 테이블(호 연결 요청 수락 패턴 테이블과 호 연결 요청 거절 패턴 테이블)을 이용하는 학습 알고리즘을 제안한다. 또한 모의 실험을 통하여, 제안한 신경회로망 호 접수 제어기의 성능을 분석한다. This paper describes a call admission controller by neural network to control the traffic in ATM network for service quality. Because the information of the traffic descriptor declared by users has a characteristic of uncertainty, the design and implementation of efficient controller in the network is very difficult task. The proposed ATM call admission controller by neural network is adaptive and easy to implement. We use two learning table for efficient learning of back-propagation neural network in controller. The performance of the proposed call admission controller is evaluated by simulation, and the results are compared with those of the other control technique.

PDGF와 LPS가 치주 인대 세포의 활성에 미치는 영향에 관한 연구

허정,김상철,임정현 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.1

PDGF와 LPS는 골 대사에 중요한 조절요소이다. 외인성 PDGF는 골 흡수를 자극하기도 하고, 또 새로운 골 형성을 자극하기도 한다. LPS는 골파괴 활성의 자극요인으로 알려져 있다. 본 연구의 목적은 골개조에 중요한 역할을 하는 치주 인대에 PDGF와 LPS의 상호 작용을 평가하기 위해서 시행되었다. 배양된 사람의 치주인대 세포에 PDGF와 LPS를 첨가 배양하여 각 농도와 시간에 따른 대조군에 대한 백분율로 환산된 세포 활성의 평균과 표준편차를 구하고 ANOVA를 시행하여 다음과 같은 결과를 얻었다. 1. PDGF를 단독으로 가한 경우 0.1ng/ml에서는 세포활성이 대조군과 차이가 없었으나 1mg/ml에서는 배양 2일째에, 10ng/ml에서는 배양 2,3일째에 유의한 세포 활성 증가를 보였다. 2. LPS 단독처리시 0.5㎍/ml 및 5㎍/ml 농도에서 배양 1일째, 2일째에는 대조군과 차이가 없었으나 배양 3일째에 유의한 활성 감소가 없었다. 3. 0.5㎍/ml 및 5㎍/ml 농도의 LPS에 1ng/ml 및 10ng/ml농도의 PDGF첨가시, 배양 3일째에 LPS단독 투여시보다 유의한 세포 활성 증가가 있었으며 특히 10ng/ml PDGF 첨가시에는 대조군보다 활성이 컸다. 이상의 연구결과로 골개조 과정에 관여하는 것으로 여겨지는 치주 인대세포에 대한 적절한 농도의 PDGF와 LPS의 복합투여는 PDGF 단독 투여 못지 않게 치주 인대세포의 활성을 증가시키는 것으로 사료된다. Platelet-derived growth factor(PDGF) and lipopolysaccharide(LPS) may be the important regualtors of bone metabolism. Exogenous PDGF is recognized to have a stimulating effect on bone resorption in organ culture, but to stimulate the formation of new bone ultimately. LPS is known to be a stimulating agent on the osteoclastic activity. The purpose of this study was to evaluate the effects and the interaction of PDGF and LPS on periodontal ligament(PDL) cells which have important roles in bone remodeling. Cultured human periodontal ligament cells were treated with various concentration of PDGF and/or LPS. The cellular viability was measured by Microtitration(MTT) assay according to the lapse time of culture. The obtained results were as follows: 1. The viability of PDL cells was not different from the control in 0.1ng/ml of PDGF, but was significantly increased to be over the level of control in 1ng/ml of PDGF at the second day of culture, and in 10ng/ml of PDGF at the second and the third day of culture. 2. The cellular viability was decreased in 0.5㎍/ml or 5㎍/ml of LPS at the third day of culture. 3. Incubation with both 1ng/ml or 10ng/ml of PDGF and 0.5㎍/ml or 5㎍/ml of LPS resulted in the increased cellular viability at the third day, which was greater than LPS only treated group. It was greater than even the control group in 10ng/ml of PDGF. From the above findings, we could summarize that the admixture of PDGF and LPS could not less increase the viability of the human periodontal ligament cells than PDGF only.