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Intraosseous Myelolipoma of Maxilla and Mandible
최재원,팽준영,안재명 대한구강악안면병리학회 2019 대한구강악안면병리학회지 Vol.43 No.5
Myelolipoma is a benign tumor consists of mature adipocyte and hematopoietic elements. Mostly, this tumor locates in adrenal gland and it also can be found in extra-adrenal area. However, intraosseous myelolipoma is extremely rare. The etiology of this tumor is unclear but some hypothesis proposed that altered mesenchymal stem cell functioning and hormonal events act together in the pathogenesis of myelolipoma. With radiographic view, myelolipoma shows similar characteristics of other fat-containing tumors. The histopathologic examination is necessary for the definite diagnosis. This case report includes a patient with intraosseous myelolipoma of maxilla and mandible and literature review about the clinical, histopathologic, and radiologic features of myelolipoma.
김유미,최진호,이범희,김구환,홍범식,류영준,유한욱 대한소아내분비학회 2012 Annals of Pediatirc Endocrinology & Metabolism Vol.17 No.4
Adrenal myelolipoma is an uncommon non-functioning tumor that is composed of variable amounts of mature adipose tissue and scattered islands of hematopoietic elements, including erythroid, myeloid, lymphoid series, and megakaryocytes. Adrenal myelolipoma should be differentiated from other fat-containing adrenal masses,such as teratoma, lipoma, and liposarcoma. This case report describes a 50-yearold adult who was raised as a male and developed giant adrenal myelolipomas that presented as symptomatic adrenal masses, and which were misdiagnosed as liposarcoma on radiologic examination. The patient had been raised as a male despite ambiguous genitalia, and a thorough investigation was never carried out because of his poor socioeconomic status. Physical examination showed profound short stature (<-3.0 standard deviation score), hyperpigmentation, and a micropenis without palpable gonads. Both a uterus and ovaries were evident in the pelvic cavity on abdominopelvic computed tomography. Adrenocorticotropic hormone stimulation tests confirmed adrenal insufficiency. Steroid replacement therapy was initiated before bilateral adrenalectomy and the histologic findings indicated myelolipoma. The patient’s karyotype was 46, XX and mutation analysis of the CYP21A2 gene identified compound heterozygosity consisting of p.I173N and p.Q319*. The patient was treated with once-daily 0.5 mg dexamethasone and once-daily 0.1 mg fludrocortisone. Because the subject had been raised as a male, additional procedures such as an oophorohysterectomy are currently under consideration. We here describe an adrenal myelolipoma in this case that was complicated by a 21-hydroxylase deficiency. We conclude from our analysis that patients with congenital adrenal hyperplasia should be screened for incidental adrenal masses to avoid unnecessary surgical procedures.
Masatoshi Nakagawa,Tadasu Kohno,Mingyon Mun,Tomoharu Yoshiya 대한흉부외과학회 2014 Journal of Chest Surgery (J Chest Surg) Vol.47 No.2
Myelolipoma in the mediastinum is an extremely rare entity. In this report, we present the case of a 79-year-old asymptomatic man who had three bilateral paravertebral mediastinal tumors. The three tumors were resected simultaneously using bilateral three-port video-assisted thoracoscopic surgery (VATS). There has been no evidence of recurrence within four years after the operation. Multiple bilateral mediastinal myelolipomas are extremely rare. There are no reports in the English literature of multiple bilateral thoracic myelolipomas that were resected simultaneously using bilateral VATS. We also present characteristic features of myelolipomas, which are helpful for diagnosis.
First report of splenic myelolipoma in a Schnauzer in Colombia: case report
Valentina Rueda-García,Nicolas Carrillo-Godoy,Carlos Alberto Bonilla-Gutiérrez,Alejandra Valdivieso-Valencia,Iang Schroniltgen Rondón-Barragán 대한수의학회 2022 大韓獸醫學會誌 Vol.62 No.4
Splenic myelolipoma is a rare tumor in dogs with an unclear origin. A male 13-year-old Schnauzer dog was presented because of a bump on the left side of the abdomen. Clinical examination and abdominal ultrasound revealed a mass in the spleen. A total splenectomy was carried out, and histopathology revealed a splenic myelolipoma. Before surgery, the patient showed high serum alanine aminotransferase levels, which returned to normal eight months after the resection. Unfortunately, the postoperative follow-up showed increased serum cholesterol and triglyceride levels, suggesting liver compromise. This is the first report of a splenic myelolipoma in Colombia.
Lee, Namsoon,Choi, Jihye,Yoon, Junghee The Korean Society of Veterinary Science 2022 Journal of Veterinary Science Vol.23 No.3
A 1-year-old male Persian cat was presented for castration. Liver incarcerated in a peritoneopericardial diaphragmatic hernia (PPDH) was diagnosed through pre-anesthetic tests. Multiple homogeneous hyperechoic nodules in the hepatic parenchyma were identified using ultrasound. The nodules showed decreased attenuation compared with normal hepatic parenchyma, and the herniated hepatic parenchyma showed increased arterial and decreased portal enhancement on computed tomography. From the histopathology, we diagnosed hydropic degeneration with portal fibrosis and myelolipoma. This report presents diagnostic imaging features of hepatic myelolipoma incarcerated in a PPDH in a cat. When perfusion of the hepatic parenchyma is altered, surgical treatment should be considered.
A Case of Adrenal Myelolipoma Associated with Hereditary Spherocytosis
Dahui Gug,Ha Young Park,Bo Lyun Lee,Kwang Hoon Kim,Jeong Eun Lee,Ji Kyoung Park 대한소아혈액종양학회 2021 Clinical Pediatric Hematology-Oncology Vol.28 No.2
Hereditary spherocytosis is the most common hereditary red blood cell membrane disorder. It results from a deficiency in certain proteins that are part of the red blood cell membrane cytoskeleton. We report a case of adrenal myelolipoma in a 23-year- old patient with hereditary spherocytosis. She was diagnosed with hereditary spher-ocytosis at 7 months of age. As she grew older, hemoglobin level was low, so splenec-tomy was recommended, but continuous follow up was not possible due to the cir-cumstances of the patient, so the splenectomy was delayed. Adrenal myelolipoma was discovered incidentally at the age of 23 with abdominal pain and cholecystitis with gallstones at the time. Myelolipoma is a benign tumor of the mesenchymal origin; its etiology remains unclear. Myelolipoma is composed of adipose and hematopoietic tissues and mainly arises from adrenal tissues. The mass is often detected during rou-tine radiologic examinations because myelolipoma is usually asymptomatic and not generally associated with hematologic diseases. The prevalence of myelolipoma ap-pears to be increasing due to the increased use of imaging modalities. The associa-tion of myelolipoma with hereditary spherocytosis has rarely been reported in the literature. To our best knowledge, this is the first report of adrenal myelolipoma asso-ciated with hereditary spherocytosis in the Korean population.
Myelolipomas of Both Adrenal Glands
차재성,신유섭,김명기,김형진 대한비뇨의학회 2011 Investigative and Clinical Urology Vol.52 No.8
Adrenal myelolipoma is a rare, nonfunctional benign tumor that is composed of mature adipose tissue and hematopoietic elements. In the past, these tumors were accidentally discovered at autopsy. Today, they are found much more frequently and incidentally, mainly because of the widespread use of noninvasive imaging with ultrasonography, computed tomography, and magnetic resonance imaging. Most lesions are asymptomatic, small, and unilateral, but a number of bilateral tumors have been reported. We report here on a case of a 48-year-old man with incidentally found myelolipomas of both adrenal glands. In particular, a giant myelolipoma of the left adrenal gland was treated by transperitoneal laparoscopic adrenalectomy.
Giant Adrenal Myelolipoma : Report of a Case with Review of the Literature
Hong, Ran,Suh, Chae-Hong,Jeon, Ho-Jong,Kee, Keun-Hong,Lim, Sung-Chul,Lee, Mi-Ja 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1
Adrenal myelolipoma is an unusual, nonfunctiomng benign tumor composed of mature fat and hematopoietic tissue. Most cases of adrenal myelolipomas are clinically silent and found incidentally at autopsy or radiological examinations done for other purposes. Their size is usually less than 5 ㎝ and they are managed non-operatively. We report a case of a surgically treated, giant adrenal myelolipoma in a 60-year-old man who presented with abdominal discomfort and we present a review of the literature.
이형순(Hyung Soon Lee),최새별(Sae Byeol Choi),김경식(Kyung Sik Kim) 한국간담췌외과학회 2008 한국간담췌외과학회지 Vol.12 No.4
Adrenal myelolipoma is a rare benign, non-functioning tumor that is frequently discovered incidentally. We report here on a case of a 47-year-old woman with an incidentally found adrenal tumor. She was slightly obese and had been diagnosed with diabetes. Her blood sugar level was well-controlled with oral hypoglycemic agents. All the laboratory test results were within normal limits. The abdomen CT scan revealed a well-demarcated homogenous solid mass that was 9cm in diameter, and it consisted of fat tissues. The differential diagnosis for malignant tumors was necessary, so we performed complete surgical excision. The patient recovered well without any major complications. If the diagnosis of adrenal myelolipoma is definite, then regular follow-up of this type of patient is sufficient. However, as the differential diagnosis with malignant tumors is rather difficult and as spontaneous hemorrhage can persist in the giant myelolipomas that are greater than 10cm in diameter, performing complete surgical excision is inevitable.
김다래,정윤영,유명원,전가영,홍영옥,김동희,최윤선,우정주 대한영상의학회 2016 대한영상의학회지 Vol.75 No.4
Adrenal myelolipoma is a rare, benign, and nonfunctioning tumor, which is generally small and asymptomatic and incidentally discovered at autopsy or on radiological examination. In rare cases, large tumors can produce symptoms due to their mass effect or spontaneous rupture with hemorrhage. We reported a case of a 36-yearold man who presented with retroperitoneal hemorrhage due to spontaneous rupture of a large adrenal myelolipoma discovered using multiple imaging modalities.