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      • KCI우수등재

        변혁적 리더십이 일중독, 직무성과 및 일․가정갈등에 미치는 영향: 상사충성도의 조절효과 검증

        김형진,심덕섭 한국경영학회 2022 經營學硏究 Vol.51 No.3

        We examine the influence of transformational leadership on workaholism, job performance and work-family conflict. Also, we attempt to verify the mediating effect of workaholism between transformational leadership and job performance, and work-family conflict. Additionally, we focuses on loyalty to supervisor as a possible moderator between transformational leadership and job performance, and work-family conflict. The major findings are 1) transformational leadership was positively associated with employees’ workaholism (driven to work, enjoyment of work). 2) Loyalty to supervisor had a positive moderating effect on the relationships between transformational leadership and driven to work. 3) Enjoyment of work is positively related to job performance but, contrary to hypothesis, is also positively related to work-family conflict. Also driven to work is related to work-family conflict, but contrary to hypothesis, does not affect job performance. 4) Enjoyment or work has turned out to have full mediation effects on the relationship between transformational leadership and job performance, and work-family conflict. Also, driven to work has turned out to have a partial mediation effect on the relationship between transformational leadership and work-family conflict. Finally, the moderated mediating effect of loyalty to supervisor was statistically significant in the mediation relationship of driven to work between transformational leadership and work-family conflict.

      • KCI등재

        Comparison of the size distributions and immunogenicity of human papillomavirus type 16 L1 virus-like particles produced in insect and yeast cells

        김형진,조서영,박민혜,김홍진 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.5

        Insect and yeast cells are considered theexpression systems of choice for producing virus-likeparticles (VLPs), and numerous types of VLPs have beenproduced in these systems. However, previous studies wererestricted to identifying the characteristics of individualVLP preparations. No direct comparison of the structuresand immunogenic properties of insect and yeast-derivedVLPs has so far been made. In the present study, the sizedistribution and immunogenic properties of human papillomavirustype 16 (HPV16) L1 VLPs produced in Spodopterafrugipedra-9 insect cells and Saccharomycescerevisiae were compared. The insect cell-derived VLPswere larger than the yeast ones (P\0.0001), with mediansizes of 34 and 26 nm, respectively. In addition, the insectderivedVLPs appeared to be more diverse in size than theyeast-derived VLPs. Immunization of mice with 30 ng perdose of VLPs elicited 2.7- and 2.4-fold higher anti-HPV16L1 IgG and anti-HPV16 neutralizing antibody titers thanimmunization with the same amounts of the yeast-derivedVLPs after the 4th immunizations, respectively. Our resultssuggest that the choice of expression system criticallyaffects the particle size and immunogenic property ofHPV16 L1 VLPs.

      • SCOPUSKCI등재

        초음파 에너지를 이용한 Polystyrene Latex 의 중합 특성

        김형진,김원일,이승범,홍인권 ( Hyung Jin Kim,Won Il Kim,Seung Bum Lee,In Kwon Hong ) 한국공업화학회 1997 공업화학 Vol.8 No.6

        Polystyrene latex를 제조하는 여러방법중에서 상업적으로는 유화중합기술이 가장 많이 사용되고 있다. 유화중합에서 사용되는 화학 개시제가 환경오염 유발의 원인이 될 수 있을 뿐만 아니라 고분자 중합 방법도 전통적 기술을 벗어나는 다양한 공정의 개발이 필요하다. 따라서 본 연구에서는 화학 개시제를 초음파 에너지 효과로 대체하여 초음파 조사시에 나타나는 공동현상에 의한 자유 라디칼(free radical)을 생성시켜 polystyrene latex를 제조하였다. 제조된 polystyrene latex를 GPC로 분석한 결과 초음파 조사시간이 증가할수록 평균분자량은 증가하였으며 분산도는 감소하였다. 또한 계면활성제로 사용된 sodium dodeccl sulfate(SDS)의 농도가 증가할수록 중합도는 증가하였으며, SDS의 농도가 전체의 2wt.%이고 반응온도가 40℃ 일때 중합도는 2.43×10⁴으로 최대값을 나타내었다. 중합이 진행되는 동안 해중합이 동시에 발생 하므로 평균분자량은 증가와 감소를 반복하는 경향을 나타내었으며, 초음파 조사시간과 계면활성제의 농도를 조절하므로써 분자량이 조절된 좁은 분자량 분포의 polystyrene latex를 제조할 수 있었다. There are many methods to synthesize polystyrene latex. Emulsion polymerization technique is commonly used commercially, but it requires a new technology to replace a traditional polymerization method because of the disadvantage of chemical initiator for environmental pollution. Since free radicals can be produced by ultrasound energy effect, polystyrene latex was synthesized using ultrasound energy instead of chemical initiator. As the ultrasonic irradiation time was increased, average molecular weight was increased and polydispersity was decreased. The degree of polymerization was increased with the concentration of SDS and maximum degree of polymerization was shown at 2 wt.% SDS concentration and the reaction temperature of 40℃. During the course of polymerization, molecular weight was repeatedly fluctuated because of occurrence of depolymerization. Narrow molecular weight distribution polystyrene latex having controlled molecular weight was synthesized by controlling ultrasonic irradiation time and the concentration of SDS.

      • KCI등재

        피하 흉터 조직에서 발견된 후천성 유피낭종

        김형진,범진식,변재경,김양우 대한성형외과학회 2007 Archives of Plastic Surgery Vol.34 No.4

        Purpose: Dermoid cysts are almost always caused by congenital events. The most widely accepted pathogenesis is that the cysts are dysembryogenetic lesions that arise from ectodermic elements entrapped during the midline fusion. We report a rare case of dermoid cyst, which occurred not congenitally but newly in the subcutaneous scar tissue secondary to trauma. Methods: A 26-year-old man had a deep submental laceration caused by a car accident and got a primary wound closure 16 months ago. There were 18 cm-long submental hypertrophic scar and newly developed palpable masses inside the subcutaneous layer at the center of the scar. Initial impression was an epidermal cyst or a thyroglossal duct cyst. Ultrasonographic finding showed two cystic masses inside the scars at the submental area, but impressed dermoid cysts. The cystic masses were completely removed with W-plasty and histological examination were followed.Results: The histological diagnosis was dermoid cysts which were mainly composed of keratotic squamous epithelium in their inner surface linings and numerous skin appendages such as sebaceous glands, sweat glands, and hair follicles in their cystic lumens histopathologically. During the follow-up period of 25 months, there was no recurrence of any subcutaneous mass in the site of scar. Conclusion: We report a very unusual case of dermoid cysts developed by an acquired cause, considering that the accidental inclusion of deep skin elements caused by a trauma can be a critical origin of dermoid cysts.

      • SCOPUSKCI등재

        초임계 Tetrahydrofuran 을 이용한 Polystyene 의 분획

        김형진,박경애,정일현,홍인권 ( Hyung Jin Kim,Kyung Ai Park,Il Hyun Jung,In Kwon Hong ) 한국공업화학회 1995 공업화학 Vol.6 No.1

        기능성 고분자 제조에는 여러 가지 방법이 있으나 본 연구에서는 다분산 고분자 물질을 단분산화시키는 `용매 추출 분획` 방법에 이론적 배경을 두고 연구하였다. 온도와 압력 조절이 가능한 고압반응기에 0.5w/v%로 용해된 polystyrene용액을 충진하고 THF의 임계온도(T_C=540.2K)와 임계압력(P_c=752.64psi) 이상에서 같은 농도의 용액을 정량펌프를 이용해 20㎖/min으로 공급하여 반응기의 압력을 일정한 간격으로 증가시키면서 연속적으로 시료를 추출하고 추출된 시료를 GPC로 분석하였다. 분석한 결과를 토대로 Schulz 분포 함수를 이용해 분자량별로 연속 분포함수를 표현하였다. 또한 UV-vis. spectrophotometer를 이용하여 각 압력에서 추출된 시료의 농도를 측정하여 분자량에 대한 누적 무게 분율을 도시하였다. 본 연구의 결과에 의하면 polystyrene의 녹는점(533.15K) 이상에서 분획이 잘됨을 알 수 있었고, 녹는점 이상인 548.15K에서 압력이 증가함에 따라 추출된 고분자의 분자량은 증가하고 분산도는 감소함을 알 수 있었다. 그러나 polystyrene의 녹는점 이하인 518.15K에서는 압력 증감에 따른 추출된 고분자의 분자량과 분산도와의 관계는 그 의존성이 작게 나타남을 알 수 있었다. There are many methods for manufacturing of functional polymer, but solvent elution fractionation is the theoretical background which can obtain the monodisperse polymer from the polydisperse polymer in this study. The high pressure reactor which can tune temperature and pressure was filled with 0.5w/v% polystyrene solution, and the same concentration solution was feed to reactor at the rate of 20㎖/min using a metering pump above critical pressure of tetrahydrofuran. The extracted samples of each pressure were collected continuously and analyzed by GPC. Continuous distribution function was predicted as a function of molecular weight using a Schulz` distribution function on the basis of acquired data. Also, cumulative weight fraction was predicted as a function of molecular weight on the basis of concentration data of sample which was obtained by UV-vis. spectrophotometer. It was predicted that the fractionation efficiency was improved, and molecular weight of extract was increased and polydispersity was decreased with increasing pressure above the melting temperature of polystyrene. But molecular weight of extract, and polydispersity had small dependency on pressure below the melting temperature of polystyrene.

      • KCI등재

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