12주간의 걷기 운동이 신체구성과 대사증후군 위험인자들에 미치는 영향

김세민(Sei-Min Kim),이신호(Shin-Ho Lee) 한국엔터테인먼트산업학회 2013 한국엔터테인먼트산업학회논문지 Vol.7 No.3

본 연구의 목적은 12주간의 걷기 운동이 신체구성과 대사증후군 위험인자들에 미치는 영향을 조사하였다. 총 20명의 중년여성을 미국 국립 콜레스테롤 교육 프로그램의 지침인 높은 허리둘레, 중성지방, 혈당, 수축기혈압, 이완기 혈압 그리고 낮은 고밀도콜레스테롤에 따라 정상 집단과 대사증후군 집단으로 구분하였다. 걷기 운동은 12주간 주당 3회 일회 500kcal을 소모할 수 있도록 설정하였다. 12주간의 걷기 운동은 모든 신체구성 변인들과 대사증후군 위험인자(허리둘레, 혈당, 수축기 혈압 그리고 이완기 혈압) 그리고 심폐체력을 개선시키는 것으로 나타났다. 골격근 관련 지표들과 대사증후군 위험인자들은 대부분 상관관계가 없는 것으로 나타났다. 따라서 이러한 연구결과를 종합해보면, 12주간의 걷기 운동은 신체구성과 대사증후군 위험지표 그리고 심폐체력을 개선시키는데 긍정적인 효과가 있는 것으로 판단되지만 대사증후군의 새로운 지표로 제시되고 있는 골격근량과 관련된 지표들은 대사증후군 위험지표들과 밀접한 관련성이 없는 것으로 판단된다. The goal of this study was to investigate the effects of 12 week walking exercise on body composition and metabolic syndrome indices in middle-aged women. A total of 20 middle-aged women was classified normal(NO) and metabolic syndrome(MS) group based on the guidelines of the national cholesterol education program, including elevated waist circumference(WC), triglycerides(TG), fasting blood glucose(FBG), systolic blood pressure(SBP), diastolic blood pressure(DBP), and low HDL-cholesterol(HDL-C). Walking exercise was designed to energy expenditure of 500 kcal per day, with a frequence of 3 days per week for 12 weeks. Both of the NO and MS groups had significant improvements in body composition(all variable), metabolic syndrome indices(waist circumference, fasting blood glucose, systolic blood pressure, diastolic blood pressure) and cardiorespiratory fitness(CRF). Most of all skeletal muscle indices were not significantly correlate with metabolic syndrome indices. The current findings of the study suggest that walking exercise is an effective means of improving body composition, metabolic syndrome indices and CRF with no group differences. And New indices of metabolic syndrome(skeletal muscle indices) were not correlate with metabolic syndrome indices.

식이 질 지수를 이용하여 평가한 한국 성인의 식생활과 대사 위험인자와의 관련성: 2016 ~ 2019 국민건강영양조사 자료 이용

딩총위,박필숙,박미연 대한지역사회영양학회 2022 대한지역사회영양학회지 Vol.27 No.3

Objectives: This study was designed to investigate the relationship between metabolic risk factors, Index of Nutrition Quality, and the dietary quality index score of Korean adults. Methods: The subjects were 18,652 Korean adults aged 19 years or older (7,899 males, 10,753 females) who participated in the 2016-2019 Korea National Health and Nutrition Examination Survey. Subjects were divided into normal, pre-metabolic syndrome, and metabolic syndrome (MetS) groups according to the number of their metabolic risk factors. Data were analyzed using the SPSS program. Results: About 44.7% of men in the MetS group were at least college graduates (P < 0.001), whereas 52.0% of women in the MetS group were middle school graduates or lower (P < 0.001). The frequency of fruit and dairy products intake tended to decrease as the number of metabolic risk factors increased in both men and women (P for trend < 0.001). As the number of metabolic risk factors decreased, the frequency of grain intake tended to decrease in men (P for trend < 0.001) while the frequency of intake of red meat (P for trend = 0.001), poultry (P for trend < 0.001), and eggs (P for trend < 0.001) decreased in women. The total scores of Diet Quality Index-International (DQI-I) (men P < 0.001, women P < 0.01) and Korean Healthy Eating Index (KHEI) (men and women P < 0.001) were significantly lower in the MetS group compared to the other groups, and the total score of DQI-I and KHEI tended to decrease as the number of metabolic risk factors increased. Conclusions: Dietary quality evaluation using various indices can provide more information on the dietary problems related to metabolic risk factors. Nutrients and foods that have been confirmed to be related to metabolic risk factors can be used to develop dietary guidelines for the nutritional management of metabolic diseases.

뇌사환자의 갑상선 기능, 전신대사 및 중증도에 관한 연구

이영주,정금희,왕희정,문봉기,한연희,이영석 아주대학교 의과학연구소 1999 아주의학 Vol.4 No.1

Background and Objectives : Brain death may lead to hormonal depletion, metabolic derangement and multiple organ dysfunction. We have carried out present study to examine the effects of brain death on the thyroid function, metabolic indices, and the severity scoring systems. Methods : 13 adults patients admitted for organ donation or brain death evaluation were examined after brain death was confirmed. Thyroid hormones measured were .thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and free thyroxine (FT4). The metabolic indices measured were arterial ketone body ratio (AKBR), lactic acid (LA), and base defiat (BD). as for reference to the severity scoring systems, APACHE Ⅲ and multiple organ failure score (MOFS) were assessed on the day of brain death confirmation. Arterial blood was drawn for all measurements. Results : As for the thyroid function, there were significant decreases in T3 (40.48±20.96 ng/dL) and T4 (3.47±2.15 ㎍/dL), but no significant change in FT4 (0.75±0.31 ng/dL) and TSH (1.12±1.37 uIU/mL) compared to the normal range. Significant decreases in AKBR (0.39±0.31) and BD (-9.46±5.83 m㏖/L), and significant increase in LA (2.57±2.46 m㏖/L) In metabolic indices, were shown, as for severity scoring systems, APACHE Ⅲ score (101.54±19.41) and MOF score (9.11±2.57) indicated a high mortality. There were significant correlation between thyroid hormones (r=0.565 -0.781) but no correlation among other indices. Also, significant inverse correlations were shown between base deficit and lactic acid (r=-0.660), APACHE Ⅲ score (r=-0.726) and MOF score (r=-0.604). The highest correlation was observed between APACHE Ⅲ score and MOF score (r=0.851). Conclusions : As for the thyroid function, significant decrease in T3 and T4, and almost normal range of FT4 and TSH imply the euthyroid sick syndrome. Abnormal finding of the metabolic parameters indicates an inhibition of the aerobic metabolic rate of the body as a whole. And the severity scoring parameters are compatible with high mortality.

Brain Metabolic Network Redistribution in Patients with White Matter Hyperintensities on MRI Analyzed with an Individualized Index Derived from 18F-FDG-PET/MRI

Ma Jie,Hua Xu-Yun,Zheng Mou-Xiong,Wu Jia-Jia,Huo Bei-Bei,Xing Xiang-Xin,Gao Xin,Zhang Han,Xu Jian-Guang 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.10

Objective: Whether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain metabolic network for an individual patient and preliminarily apply it to identify impaired metabolic networks in patients with WMHs, and 2) to explore the clinical and imaging features of metabolic redistribution in patients with WMHs. Materials and Methods: This study included 50 patients with WMHs and 70 healthy controls (HCs) who underwent 18F-fluorodeoxyglucose-positron emission tomography/MRI. Various global property parameters according to graph theory and an individual parameter of brain metabolic network called “individual contribution index” were obtained. Parameter values were compared between the WMH and HC groups. The performance of the parameters in discriminating between the two groups was assessed using the area under the receiver operating characteristic curve (AUC). The correlation between the individual contribution index and Fazekas score was assessed, and the interaction between age and individual contribution index was determined. A generalized linear model was fitted with the individual contribution index as the dependent variable and the mean standardized uptake value (SUVmean) of nodes in the whole-brain network or seven classic functional networks as independent variables to determine their association. Results: The means ± standard deviations of the individual contribution index were (0.697 ± 10.9) x 10-3 and (0.0967 ± 0.0545) x 10-3 in the WMH and HC groups, respectively (p < 0.001). The AUC of the individual contribution index was 0.864 (95% confidence interval, 0.785–0.943). A positive correlation was identified between the individual contribution index and the Fazekas scores in patients with WMHs (r = 0.57, p < 0.001). Age and individual contribution index demonstrated a significant interaction effect on the Fazekas score. A significant direct association was observed between the individual contribution index and the SUVmean of the limbic network (p < 0.001). Conclusion: The individual contribution index may demonstrate the redistribution of the brain metabolic network in patients with WMHs.

Triglyceride and Glucose (TyG) Index is a Clinical Surrogate Marker for the Diagnosis of Metabolic Syndrome

Kyung-A Shin 대한의생명과학회 2017 Biomedical Science Letters Vol.23 No.4

TyG (triglyceride and glucose) index using triglyceride and fasting blood glucose is recommended as a useful marker for insulin resistance. The present study evaluated the usefulness of TyG index in diagnosing metabolic syndrome and suggested an optimal cut-off value. The subjects of this study were adult 4,415 adults aged 20 to 80 years who underwent health screening at J General Hospital from January 2016 to January 2017. Metabolic syndrome was based on AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. TyG index correlated with metabolic syndrome risk factors including HOMA-IR. Compared with the participants in the lowest quartile of TyG index, odds ratios and 95% confidence intervals for metabolic syndrome were 8.5 (3.005~23.903), 20.0 (17.190~23.407) for those in the third, and the fourth quartile of TyG index. The optimal cut-off value of the metabolic syndrome was 8.81 for TyG index (sensitivity 86.7%, specificity 80.1%) and area under the ROC curve (AUC) was 0.894. In conclusion, TyG index is effective to identify individuals at risk for metabolic syndrome.

Impact of Visceral Obesity on the Risk of Incident Metabolic Syndrome in Metabolically Healthy Normal Weight and Overweight Groups: A Longitudinal Cohort Study in Korea

Yoon Hye Lee,Jiyong Park,Seran Min,Oklim Kang,Hyuktae Kwon,Seung Won Oh 대한가정의학회 2020 Korean Journal of Family Medicine Vol.41 No.4

Background: Although both obesity, measured by body mass index, and visceral obesity are known to be major risk factors of metabolic syndrome and its components, there have been debates on the relative contribution of general obesity and visceral obesity to the development of metabolic syndrome. Methods: We performed a large longitudinal cohort study of 3,093 subjects (age range, 18–65 years) who were metabolically healthy and had a normal weight who received health screenings over a 3-year follow-up period. Cox proportional hazards models were used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for incident metabolic syndrome and its components per sex-specific 1-standard deviation (SD) increase in visceral adipose tissue (VAT) and body mass index. Results: Both obesity and visceral obesity increased the risk of incident metabolic syndrome, but when HR was compared per sex-specific 1-SD, visceral obesity appeared to confer more risk than simple obesity. The HR for 1-SD of body mass index was 1.19 (95% CI, 1.07–1.32; P=0.001) in men and 1.29 (95% CI, 1.10–1.52; P=0.002) in women, while the HR for 1-SD of VAT was 1.29 (95% CI, 1.15–1.44; P<0.001) in men and 1.50 (95% CI, 1.28–1.75; P<0.001) in women. Conclusion: Visceral obesity and obesity were longitudinally associated with an increased risk of incident metabolic syndrome among metabolically healthy adults, and visceral fat accumulation appears to be better predictor of metabolic syndrome.

유산소 운동과 Glycemic Index가 젊은여성의 건강체력, 대사적 지수 및 골밀도에 미치는 영향

김희정(Kim Hee-Jung),조정호(Cho Jung-Ho),정지혜(Jung Ji-hye),신말연(Shin Mal-Ryun),최혜진(Choi Hea-Gin),이지현(Lee Ji-Hyun),최보인(Choi Bo-In),김선민(Kim Sun-Min),정재현(Jung Jae-Hyun),정상선(Jung Sang-Sun) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.3

The purpose of this study was to investigate the effects of aerobic exercise and supplementation of different glycemic index values of carbohydrate on the body composition including fat mass(FM), percent fat(%fat), body mass index(BMI), and waist-hip-ratio (WHR), health-related physical fitness including back strength, sit-up, trunk flexion, and Harvard step test, and metabolic indices including leptin, blood glucose, and insulin and bone mineral density in young female adults. 22 young female adults were participated in this study and classified as a two groups by High glycemic index group(HGI, n=12), and low glycemic index group(LGI, n=10). They performed aerobic walking programs on treadmill for 8 weeks. Health-related physical fitness was determined by measuring back strength, sit-up, trunk flexion and Harvard step test, and body composition was measured by Bioelectric Impedance Analysis(BIA). Blood leptin, blood glucose, blood insulin were measured before and 8 weeks of the program treatment. There was a significant difference on bone mineral density but there were no significant differences on body composition, health-related physical fitness, and metabolic indices between two groups. Blood leptin was significantly associated with flexibility(r=-0.37), FM(r=0.56), % fat(r=0.44), LBM(r=0.41), WHR(r=0.38), BMI(r=0.39), blood glucose(r=0.35), and insulin(r=0.30). In conclusion, aerobic exercise program and supplementation of different GI carbohydrate for 8 weeks affect on bone mineral density but don't affect on health-related physical fitness, metabolic indices in young females. Leptin significantly associated with flexibility, fat mass, percent fat, LBM, WHR, BMI, blood glucose, and insulin in young females.

Effects of Participatory Action Research on Reducing Risk of Metabolic Syndrome with Adult Women in Korea

Yong Sook Eo 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

Aim(s): Metabolic syndrome (MetS) is characterized by the clustering of three or more metabolic risk factors. The prevalence of MetS is increasing, not only in the urbanized world but also in developing countries. The purpose of this study was to evaluate the effects of participatory action research (PAR) on reducing metabolic syndrome risk factors among adult women living in communities in Korea. The PAR program investigated the education needs and program operation preferences of adult women participating in the health promotion program at a community health center. Method(s): To test the effectiveness of PAR intervention for adult women with MetS risk factors, the nonequivalent pretest-posttest control group design was used to verify the effects on empowerment, social support, and health-related quality of life, and the one-group pretest-posttest design was employed to verify the effects on metabolic-related indices. For participant recruitment, local residents participating in the health promotion program were set as the accessible population. Among the selected candidates, 60 women who agreed to actively participate in PAR intervention were enrolled into the experimental group, and 60 were enrolled in the control group. The adult women in the experimental group participated in a 5-week program involving weekly group sessions, and four-step PAR cycle was applied to each of the five topics derived from the preliminary interviews with participants. Outcomes were measured using self-reported questionnaires, and blood analyses. The intervention effects were analyzed using ANCOVA and paired t-test. Result(s): The experimental group showed significantly improvements in empowerment (individual F=9.75, p=.002, ηp2=.08; community F=53.55, p<.001, ηp2=.32), social support (F=5.68, p=.019, ηp2=.33), and health-related quality of life (F=7.35, p=.008, ηp2=.06) compared to the control group. Regarding metabolic-related indices, compared to the pre-test, the experimental group showed significant improvements in six out of eight metabolic-related indices, that is, waist circumference(t=7.02, p<.001), fasting blood glucose(t=2.57, p=.013), systolic blood pressure(t=3.27, p=.002), diastolic blood pressure(t=3.43, p=.001), total cholesterol(t=2.40, p=.020), and BMI(t=4.50, p<.001), after participation in the PAR program. Conclusion(s): As a result of applying the PAR, the experimental group’s empowerment, social support, and health-related quality of life increased significantly compared to those of the control group. Furthermore, the metabolic indices of the experimental group improved significantly in the post-test as compared to the pretest. Therefore, it is suggested to verify the long-term effects of PAR by applying a randomized control and longitudinal study design.

제조업 근로자의 대사증후군과 관련 요인: 2017년 국가건강검진 자료를 중심으로

정은숙(Jung eun sook) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.17

연구목적은 대사증후군의 유병률과 위험인자 간의 관계를 파악함으로써 대사증후군 예방과 관리를 위한 기초자료를 제공하고자 한다. 연구방법은 G지역 1개 제조업체 근로자 523명을 대상으로 2017년 국가건강검진결과와 면접표를 통해 수집된 자료를 SPSS 23.0 버전을 분석하였다. 대상자의 일반적 특성에 따른 대사증후군 군별과의 차이는 t-test, χ2 test로 파악하였고, 대사증후군 군별에 대한 교차비는 다중 로지스틱 회귀분석으로 파악하였다. 연구결과는 대사증후군 군별 유병률은 주의군은 47.2%, 대사증후군군은 10.5% 이었다. 대사증후군 군별 차이를 보인 변수는 성별, 근무년수, 근무부서, 체질량지수와 대사증후군 진단 구성요소 모두 이었으며, 통계적으로 유의하였다(p<.01). 대사증후군 군별에 영향을 미치는 요인은 주의군에서 근무년수, 체질량 지수이었고, 대사증후군에서는 근무년수, 근무부서, 체질량 지수이었다. 이에 보건관리자는 직업적 특성을 고려하여 체질량 지수를 낮출 수 있는 운동프로그램 및 식단관리를 위한 영양학적인 접근과 대사증후군의 폐해에 대한 교육 및 홍보에 이르기까지 다학제간 접근이 이루어진다면 심뇌혈관질환의 주요 요인인 대사증후군을 예방 및 관리하는데 있어 기여하는 바가 클 것으로 사료된다. The purpose of this study is to provide preliminary data for metabolic syndrome prevention and management by examining relations between the prevalence rate and risk factors of metabolic syndrome. Data collected from the results of the Korean National Health Screening 2017, which was conducted on 523 workers at a manufacturing company in the G region, and their interview table, were analyzed using SPSS 21.0 version. The differences between the metabolic syndrome risk group and the metabolic syndrome group in relation to general characteristics were identified through t-test and χ2 test, and the odds ratio of the two groups was identified through multinomial logistic regression analysis. According to the results of the study, the prevalence rates in the metabolic syndrome risk group and the metabolic syndrome group were 47.2 % and 10.5 %, respectively. Variables that showed difference between the two groups included gender, years of working, department, body mass index, and components of metabolic syndrome diagnosis; all the differences were statistically significant (p<.01). The factors affecting the metabolic syndrome risk group were years of working, and body mass index, while the factors of the metabolic syndrome group included years of working, department, and body mass index. Therefore, health administrators need to take a multidisciplinary approach that includes dietary management and education and promotion of the harmful effects of metabolic syndrome, as well as the exercise programs that helps reduce body mass index by considering the job characteristics. This will contribute greatly to the prevention and control of metabolic syndrome, one of the major causes of cardiovascular and cerebrovascular disorders.

Comparison of Surrogate Markers as Measures of Uncomplicated Insulin Resistance in Korean Adults

Tae Jong Kim,Hye Jung Kim,Young Bae Kim,이지연,이혜선,Jung Hwa Hong,Ji Won Lee 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.3

Background: Metabolic syndrome (MS) is known to increase the risk of various cardiometabolic diseases and insulinresistance (IR) has known to have central role in the development of MS. Many surrogate indices of IR havebeen proposed and the detection of MS might be a suitable model for assessing the accuracy of surrogate indices. The aims of our study are to invest the most appropriate index by assessment of the diagnostic capacity of IR amongeach surrogate index and identifying cut-off values for discriminating uncomplicated MS in Korean adults. Methods: A cross-sectional study was performed, assessing 294 Korean adults, 85 of whom were diagnosed withuncomplicated MS. The sensitivities and specificities of five surrogate IR indices were compared to discriminateMS from healthy subjects; these included fasting serum insulin, homeostasis model assessment–insulin resistanceindex, quantitative insulin sensitivity check index, McAuley index, and Disse index. Correlations between each indexvalue were assessed using Pearson’s and Spearman’s correlation methods. Results: The McAuley index showed the highest area under the curve (0.85), specificity (86.12%), accuracy(82.31%), positive predictive value (68.13%), and negative predictive value (88.67%) to distinguish MS, with a cut-offpoint of 5.3 defined. Correlation coefficients of the five indices showed that the McAuley index had the strongestcorrelation with IR. Conclusion: The McAuley index showed the best accuracy in the detection of MS as a surrogate marker of IR. Toestablish more effective and accurate standards of measuring IR, comprehensive and multi-scaled studies are required.