담관계암종 및 주변 전암병변의 면역조직화학적 특성

김지영,박영년,김호근 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.11

대장의 용종성 암종과 침윤성 암종에서 p53, bcl-2, c-erbB-2 및 MIB-1 단백의 면역조직화학적 발현에 관한 비교연구

문정석,박성환,신봉경,이주한,신준호,염범우 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.8

Helicobactor pylori Infection and Gastric Carcinoma in Korea

Kang, Seok Jin,Jee, Mi Kyung,Park, Yeon Joon,Choi, Yeong Jin,Kim, Byung Kee,Kim, Sun Moo CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.2

Gastric carcinoma is the most frequent malignant disease and the leading cause of cancer death in Korean. And the incidence of gastric carcinoma can change dramatically from place to place and from one generation to the next, if has been hypothesized that its incidence is determined largely by environmental rather than genetic factors. One specific histologic type of gastric carcinoma, the so-called intestinal type, is particularly prone to the regional and temporal variations of an environmentally related malignant condition. The recent identification of Helicobacter pylori (H. pylori) in chronic inflammatory conditions of the stomach, however, has stimulated interest in its potential role in carcinogenesis. H. pylori has been linked to chronic atrophic gastritis, and established precursor of intestinal type of gastric carcinoma. We designed a study to estimate the prevalence of H. pylori in 41 patients of intestinal type of gastric carcinoma and 42 patients of diffuse type gastric carcinoma and in 88 age and sex matched control persons by histologic examination of stomach in Warthin-Starry staining. The results were as follow; 1. In gastric carcinoma, 85.37% of 41 patients of intestinal type carcinoma, and 59.2% of 42 patients of diffuse type carcinoma were positive for H. pylori. In control group, 27.7% of 88 persons were positive for H. pylori. 2. To compare to control group, intestinal type of gastric carcimona was higher incidence of H. pylori infection to than that of diffuse type of gastric carcinoma. These findings suggest that H. pylori infection of stomach may be related to the gastric carcinoma in Korean. And H. pylori is more frequently found in the intestinal type of gastric carcinoma than diffuse type of gastric carcinoma.

위선암에서 장형화생의 변이형에 관한 연구

제갈승주,최영자,곽효일,노정섭,최찬 대한임상병리사협회 2001 대한임상병리사회지 Vol.21 No.1

Case Report : Hepatoid Carcinoma of the Pancreas Combined with Neuroendocrine Carcinoma

( Ji Ye Jung ),( Yoon Jae Kim ),( Hee Man Kim ),( Hong Jeoung Kim ),( Seung Woo Park ),( Si Young Song ),( Jae Bock Chung ),( Chang Moo Kang ),( Joo Yeon Pyo ),( Woo Ick Yang ),( Seung Min Bang ) The Editorial Office of Gut and Liver 2010 Gut and Liver Vol.4 No.1

Hepatoid carcinoma is a primary extrahepatic carcinoma whose morphology, immunohistochemistry, and behavior are similar to those of hepatocellular carcinoma. The most common sites of extrahepatic carcinoma are the stomach and ovary, but nine cases of hepatocellular differentiation of the pancreas have been reported in the literature. We report another case of hepatoid carcinoma of the pancreas that was associated with the development of a pancreatic endocrine carcinoma in a 46-year-old man. Serum alpha-fetoprotein (AFP) was elevated to 262.49 IU/mL and radiological examinations revealed a mass measuring 7.5 cm in diameter in the head of the pancreas. He underwent a conventional Whipple operation, and light microscopy showed adenocarcinoma that was immunopositive for AFP, hepatocyte antigen, cytokeratin, chromogranin, synaptophysin, and alpha-1 antichymotrypsin. Although hepatoid differentiation was not shown unequivocally histologically, other immunohistochemistry findings supported the diagnosis of hepatoid carcinoma combined with neuroendocrine carcinoma. The patient was healthy and had no evidence of recurrence at 4 months after the surgery. This report describes why hepatoid carcinoma should be considered as a differential diagnosis of a pancreatic mass, especially when serum AFP is elevated. (Gut Liver 2010;4:98-102)

아포크린 유방암의 임상병리적 특성

허호(Ho Hur),안영재(Young Jai Ahn),박세호(Seho Park),김주희(Joo-Hee Kim),구자승(Ja Seung Koo),박병우(Byeong Woo Park) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.1

Purpose: Apocrine carcinoma is a rare type of breast carcinoma, which has not been fully investigated. The aim of this study was to review clinicopathological features of apocrine carcinoma of the breast and to determine if there are some characteristics different from invasive ductal carcinoma. Methods: There were 4,064 breast cancer patients who had been managed in the Department of Surgery of Yonsei University College of Medicine from January 1997 to January 2008. Out of the patients, 16 patients with apocrine carcinoma and 2,997 patients with invasive ductal carcinoma were analyzed retrospectively. Results: The incidence of apocrine carcinoma was 0.4%. Most of the clinicopathologic features of apocrine carcinoma were similar to those of invasive ductal carcinoma. The percentage of estrogen receptor (ER) positivity and progesterone receptor (PR) positivity of apocrine carcinoma were all 12.5%. And the percentage of ER positivity and PR positivity of invasive ductal carcinoma were 64.2% and 55.2% respectively. Androgen receptor was only examined for eleven patients out of the 16 patients with apocrine carcinoma and the result were all positive. Conclusion: Apocrine carcinoma is also a rare disease in Korea. When compared with invasive ductal carcinoma, the disease did not appear to show any other significant difference in clinicopathologic characteristics but the percentages of ER and PR positivity of apocrine carcinoma seemed lower than those of invasive ductal carcinoma.

Pathologic Finding of Thymic Carcinoma Accompanied by Myasthenia Gravis

Kim, Se Hoon,Koh, Im Suk,Minn, Yang-Ki 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.4

<P><B>Background and Purpose</B></P><P>The World Health Organization (WHO) has classified thymic carcinoma and other thymomas (types A, AB, and B) as different neoplasms. Myasthenia gravis (MG) is an early sign of thymoma and theoretically does not accompany thymic carcinoma; however, cases of thymic carcinoma with MG have been reported. Whether thymic carcinoma can accompany MG has yet to be established.</P><P><B>Methods</B></P><P>The medical records of patients who underwent thymectomy for MG between 1990 and 2011 in a single hospital were reviewed. All cases with the diagnostic code of 'thymic carcinoma' or 'thymoma type C' (old terminology) were selected. A pathologist re-reviewed the pathologic specimens using the new WHO criteria. The rate of thymic carcinoma among these MG patients was then calculated.</P><P><B>Results</B></P><P>A total of 81 patients with MG had thymic tumors, 10 of whom had thymic carcinomas or thymoma type C. Seven cases of well-differentiated thymic carcinomas (type B3) were excluded, leaving three (3.7%) cases of thymic carcinoma with MG. All three of these cases were type B3 thymoma with a focal squamous cell carcinoma component that was very small and well demarcated. In addition, two out of the three tumors were found to be at an early clinical stage. All of the cases survived without recurrence over follow-up periods of at least 5 years.</P><P><B>Conclusions</B></P><P>Thymic carcinoma transformation from thymoma can occur during the early stages of thymoma. The association of this condition with MG is not as rare as was previously thought. Thymic carcinomas accompanying MG had a predominant B3 thymoma component with a focal thymic carcinoma area (squamous cell carcinoma).</P>

한국인 갑상선 질환의 병리학적 연구 : 1095 례의 외과적 절제물을 대상으로 Based on 1095 Surgically resected specimen

박성회,지제근,이현순,이정빈,안긍환,김용일,함의근,이상국 인제대학교 1983 仁濟醫學 Vol.4 No.4

A prospective morphological study was made on 1095 thyroid specimens which were removed surgically under various diagnoses at Seoul National University Hospital during a period of 6 years from 1976 to 1981. All thyroid specimens were carefully examined grossly by 3-5mm serial cutting after fixation. Almost entire thyroid specimen was submitted for microscopic examination. Therefore microscopic slides of one specimen ranged from 4 to 106 in number. Clinical records including operation notes were also referred to confirm the diagnosis. All of the material was examined and reviewed critically by the authors and was classified according to modified WHO classification. Among 1095 surgically removed thyroids, adenomatous goiter was the most common single disease which accounted for 43% of the entire cases. It was followed by papillary carcinoma and follicular adenoma. Of the malignant tumors, papillary carcinoma was the most frequently reported tumor, accounting for 259 cases (76%) of the entire malignancy. There were also 57 follicular carcinomas, 13 anaplastic carcinomas and 7 medullary carcinomas. Characteristic ground glass nuclei and psammoma bodies were seen fairly frequently showing the incidence of 64% and 65% of papillary carcinoma respectively. However, squamous metaplasia was present in only 17% of the papillary carcinoma. There were 56 occult sclerosing carcinomas. Most of these were detected in the thyroids of adenomatous goiter. The occult sclerosing carcinoma was found in 9.2% of adenomatous goiters while it was found in only 4.3% of follicular adenomas. It was interesting to note palpation thyroiditis seen in the thyroid specimens. It was seen in 24% of the adenomatous goiters, 17% of follicular carcinomas and 14% of the papillary carcinomas.

Identification of candidate genes in basal cell carcinoma and differences in genetic mutations between indolent and aggressive type by whole exome sequencing

( So Yeon Yun ),( Min Ji Kang ),( Soo Young Lee ),( Joo Hee Lee ),( Dong Soo Yu ),( Young Bok Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Several genetic mutations such as those in TP53 and PTCH1 are associated with basal cell carcinoma development. Objectives: The aim of this study is to identify causative gene mutations of basal cell carcinoma arising on the face in a Korean population. Methods: This study analyzed genomic mutations of basal cell carcinoma using whole-exome sequencing of DNA specimens obtained from 20 Korean patients. After histopathological evaluations, 5 basal cell carcinomas were aggressive type with infiltrative pattern and 15 basal cell carcinomas were indolent type with nodular pattern. Results: 75% of basal cell carcinomas harbored somatic mutations in HH pathway genes and 45% harbored mutations in TP53. LRP1B and SMO were the most frequently mutated genes in basal cell carcinoma samples. Whereas LRP1B was the most frequently mutated gene in aggressive type basal cell carcinomas, SMO was the most frequently mutated gene in indolent type basal cell carcinomas. Specifically, LRP1B, ROS1, PTCH1, KMT2C, NSD1, ARID1A mutations were more frequent in aggressive type basal cell carcinomas than indolent type basal cell carcinomas. However, copy number gains of ROS1 gene were observed only in indolent type basal cell carcinomas. Other basal cell carcinoma related genes found in our study include KDR, KMT2D, FAT1, FAT4, GRIN2A, ERBB4, NOTCH2, PDE4DIP, TET1, ZFHX3, and PREX2. Conclusion: These results may provide insights for understanding basal cell carcinoma and treating the disease.

Expression of survivin in squamous cell carcinoma and transitional cell carcinoma of the urinary bladder: A comparative immunohistochemical study

Rania Makboul,Abeer EL-Refaiy M. Refaiy,Fatma Ahmed Mahmoud Badary,Islam F. Abdelkawi,Axel S. Merseburger,Rabab Ahmed Ahmed Mohammed 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.1

Purpose: To compare the expression of survivin and its association with clinicopathological criteria in major types of urinary bladdercarcinoma, specifically, transitional cell carcinoma with and without squamous differentiation and squamous cell carcinoma. Materials and Methods: Immunohistochemical staining for survivin and Ki67 was performed on paraffin-embedded sections of104 carcinomas: 52 transitional cell carcinoma, 20 transitional cell carcinoma with squamous differentiation, and 32 squamous cellcarcinoma. Expression of survivin in >10% of tumor cells was described as altered survivin status. Ki67 staining in >20% of tumorcells was described as a high proliferation index. Results: Altered survivin expression was detected in 60/104 specimens (58%) and was significantly more frequent in transitionalcell carcinoma (78%) than in squamous cell carcinoma (38%) or transitional cell carcinoma with squamous differentiation (40%)(p<0.0001). In transitional cell carcinoma but not in squamous cell carcinoma, altered survivin status was associated with highertumor grade, higher proliferation index, and recurrence. In the whole specimens, altered survivin expression was significantly associatedwith advanced stage (p<0.001), recurrence (p=0.005), distant metastasis (p<0.001), and death (p=0.001). In the multivariateanalysis, altered survivin was an independent poor prognostic factor for recurrence. Conclusions: Unlike in transitional cell carcinoma, alteration of survivin expression in squamous cell carcinoma occurs less frequentlyand is not associated with features of tumor aggression or patient outcome. These findings raise a question: are urinarybladder carcinoma patients with squamous cell carcinoma type suitable candidates for survivin vaccine? This is an important questionto be answered before approving the vaccine in management.