영남대학교 의과대학 부속병원 외래환자에 대한 약물처방 동향의 분석

이광윤,김원준,김승훈 영남대학교 의과대학 1985 Yeungnam University Journal of Medicine Vol.2 No.1

대구 및 그 인접지역의 질병 발생 경향을 추정하고, 영남대학교 의과대학 부속병원의 약제수급 계획을 위한 참고자료를 얻기 위하여 1985년 3월부터 동년 8월까지 당 병원 외래에 내원한 환자들을 위하여 내려진 약물 처방을 전산 집계하여 다음과 같은 결과를 얻었다. 가장 빈번히 처방된 약물로 부터 100종의 약물을 처방빈도 순으로 나열하였던 바, diazepam, aluminum compound, acetaminophen, isoniazid,metoclopramide,?????????, carboxymethylcystien, ephedrine, codeine, caroverine(이하 생략) 등의 순으로 나타났으며, 이와 같이 선정된 100종의 약물을 임상용도별로 분류하여 총 처방회수 521,855회에 대한 백분율을 조사한 결과는 다음과 같다. 중추신경계약물(20.57%)이 가장 많았고, 다음은 위장관 및 평활근에 작용하는 약물(18.64%), 호흡기계약물(16.11%), 항균제(15.12%), 심혈관계약물(5.64%)의 순으로 많았으며, 그 다음은 소염제(4.33%), 단독비타민제(3.76%), 호르몬 및 항호르몬제(3.29%), 감기치료제(3.12%), 이뇨제(2.81%), 간기능이상치료제(2.02%), 자율신경계약물(1.89%), 항히스타민제(1.02%) 및 소독약(0.74%) 등의 순으로 나타났다. This report offers descriptive data about the drugs utilized in out patient department (OPD) of Yeungnam University Hospital (YUH) in the period of march to august in 1985. The data in this report were produced by the computerized totalization of the number of mentions of individual drugs included in the prescriptions. The 100 drug entries that were most frequently recorded are listed in rank order. The listing is arbiturarily restricted to the drugs that were prescribed as single preparations, the drugs of basis of compound preparations and the drugs of adjuvent or corrective of compound preparations that have significant therapeutic effects-either by generic names. And in addition, the listing also involves the compound preparations used in relatively large frequency, and the individual components of which have the unique pharmacologial actions each other by proprietary names. And all routes of administrations were allowed. The 10 drugs most frequently named are diazepam, aluminum compounds, acetaminophen, isoniazid, metoclopramide, ?????????, carboxymethylcystein, ephedrine, codeine and caroverine in order. The 521, 855 drug mentions listed as above are described by the chief therapeutic usage that each is intended to apply generally. The drugs which account the largest proportion of total mentions were those acting on the central nervous system(20.57%), including tranquillizers and sedative hypnotics(11.71%), analgesic antipyretics(5.55%), antidepressants(2.15%) etc. Gastrointestinal drugs and smooth muscle preparations(18.64%) included antacids and anti-ulcerdrugs(9.24%), antiemetics(3.57%), spasmolytics(3.14%) and others. Respiratory drugs (16.11%) included expectorants and cough preparation(10.99%) and bronchodilators(5.12%).Cardiovascular drugs (5.64%) included cardiac drugs and coronary vasodilator(4.12%) and antihypertensives and vasodilators(1.06%). And anti-inflammatory drugs(4.33%), vitamins of single preparations (3.76%), hormones and their antagonists(3.29%), common cold preparations(3.12%), diuretics(2.81%), drugs supporting liver function(2.02%), drugs affecting autonomic nervous system(1.89%) including anti-glaucomas, atropine and cerebral vasodilators, antihistamine drugs(1.02%) and disinfectants(0.74%) were following in order. The data in this report were compared to those reported by H. Koch, et al. in United States(US), 1981 as "Drugs Most Frequently Used in Office Practice: National Ambulatory Medical Case Survey, 1981." Cardiovascular drugs prescribed in YUH were much less in proportion than in US(10.56),but gastrointestinal drugs accounted the larger proportion than in US(3.72%). Expectorants and cough preparations in YUH also accounted the larger proportion than in US(2.74%). In conclusion, in the period of march to august, 1985, OPD of YUH prescribed the CNS drugs including diazepam most frequently, and gastrointestinal, repiratory and chemotherapeutic drugs in next orders. It is supposed that the eating habits of Koreans and a unique atmospheric condition in Taegu as a basin were some important factors that affected the proportions of drugs acting on gastrointestinal and repiratory tracts.

영남대학교 의과대학 부속병원 치과교정과에 내원한 부정교합 환자의 분포 및 변동추이

김종섭,박진호,윤홍식,임난희,진병로,이희경 영남대학교 의과대학 1994 Yeungnam University Journal of Medicine Vol.11 No.2

1983년부터 1994년 상반기까지 영남대학교 의과대학 부속병원 치과교정과에 내원한 1.050명의 진단기록 및 석고모형을 Angle씨 분류법으로 분류하고 성별, 연령별 분포 및 변동 추이에 대해 분석해 본 결과 다음과 같은 결론을 얻었다. 거의 매년 환자의 내원율이 증가하였으며 남자에 비해 여자의 내원율이 높았다. 8세-15세 연령군이 전체 내원 환자수의 61.4%를 나타내었으며 20세 이상의 연령균은 18.5%, 7세 이하 연령군은 8.1%를 나타내었다. class Ⅰ은 42.2%, class Ⅱ div 1은 22.5%, class Ⅱ div 2는 3.9%, class Ⅲ은 29.1%, 구순구개열 화자는 2.0%를 나타내었다. 외과적 교정 환자의 수가 증가하는 추세에 있었다. 1,050 patients who visited orthodontic dental department from 1983 to 1994, were surveyed on the yearly tendency of orthodontic patient distribution and state by Angle's classification. The results were as follows: 1. There was increased visiting rate of patient per year and higher visiting rate in female than in male. 2. 8-15 age group was 61.4% in total visiting patients and over 20 age group was 18.5%, under 7 age group was 8.1% 3. Class Ⅰ malocclusion was 42.2%, class Ⅱ div 1 was 22.5%, class Ⅱ-2 was 3.9%, class Ⅲ was 29.1% and cleft lip & palate was 2.0% in total visiting patient. 4. As showed the living distribution, Namgu and Susunggu's patients were 43.7% of the total patients. 5. There was increased tendency for the number of the patient to be recieved orthognathic surgery.

Smiling sunflowers

영남대학교의과대학 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.4

원발성 심박 악성 중배엽 상피종 1예

정문호,강면식,이동협,현명수,김영조,김종설,이철주,심봉섭 영남대학교 의과대학 1986 Yeungnam University Journal of Medicine Vol.3 No.1

저자들은 1986년 7월 2일 본 영남대학교 의과대학 부속 병원 내과에 입원한 혈액성 심낭 삼출액및 심막 비후 환자에서 심낭 개창술시 심막조직 검사상 심막 악성 중피종으로 진단되고 급격한 임상경과를 보이고 사망한 예를 경험하였다. Primary pericadial mesothelioma is a rare tumor of mesodermal origin that is infrequently diagnosed antemortem and survival is short. A 60 year old male case of peicardial mesothelioma(epitheloid type) is reported. He was admitted to Yeungnam University Hospital because of chest pain, dyspnea, orthopnea and nonprodective cough. Chest x-ray suggested pericardial effusion. 2-D echocardiography showed echo free spaces of massive pericardial effusion and areas of thick hyperrefractile echoes arising from the pericardium.pericardiocentesis was attempted and aspirated fluid was bloody exudate. Pericardial window operation with biopsy was done. Swan-Ganz catheterization showed equalization between right atrial pressure and pulmonary capillary wedge pressure. The pathologic diagnosis was established by histologic finging at pericardial biopsy.

인공고관절 치환술 전후의 CRP 및 ESR의 변화

김세동,이동철,박동구 영남대학교 의과대학 1992 Yeungnam University Journal of Medicine Vol.9 No.2

1991년 7월부터 1992년 9월까지 영남대학교 의과대학 부속병원 정형외과에서 인공고관절치환술받은 46명의 환자에서 수술전후에 측정한 ESR과 CRP의 결과는 다음과 같다. 1. 수술 전 ESR 평균치는 28.8mm/hour이었고, 수술 후 1,2,3주에는 각각69.9mm/hour, 41.4mm/hour로 점점 감소하는 경향을 보였으나, 정상치보다는 높게 나타났다. 2. 수술 전 CRP는 3례를 제외하고 모두 정상 치를 보였고, 수술 후에는 곧 상승하여 수술 후 1주, 2주, 3주의 평균치는 각각 5.82mg/dL, 1.45mg/dL, 0.74mg/dL였다. 수술 3주 후에는 2례를 제외하고 모두 정상으로 돌아왔다. 3. 골 시멘트와 수혈여부는 수술 후 ESR, CRP치의 변화에 유의한 차이를 주지 않았다. Serum C-reactive protein(CRP) levels and erythrocyte sedimentation rates(ESR) were measured in 46 patients treated with uncomplicated primary hip replacements, 39 total tip replacements and 7 bipolar hip replacements. In uncomplicated primary hip replacements, ESR levels were slightly elevated preoperatively and were variable postoperatively. But CRP was normal before surgery and elevated in postoperative course, but back to normal within three weeks in most cases. Early success of hip arthroplasty is indicated by normalization of CRP within three weeks, regardless of ESR. Since ESR seems to react somewhat differently from the CRP, both methods are useful in the monitoring of complications after hip arthroplasty.

일측 자궁 부속기 절제술 이후 발생한 복강임신 1예

김종옥 영남대학교 의과대학 1985 Yeungnam University Journal of Medicine Vol.2 No.1

1984년 3월 영남대학교 의과대학 부속병원 산부인과에 자궁외 임신 진단하에 입원하여 응급 개복수술을 시행한 환자에서 일측 자궁부속기 제거술 후 발생한 원발성으로 의심되는 초기 복강 임신 1예를 경험하였기에 문헌고찰과 함께 보고 하였다. Abdominal Pregnancy is one of the rare but extremely harzardous complications of childbearing. The diagnosis of the abdominal Pregnancy is rarely made before surgery and the management of it also has many difficult problems. I experienced a case of abdominal pregnancy developed after the previous unilateral adnexectomy and it was a suspicious primary abdominal pregnancy as though did not fulfilled the Stud-diford's the following criteria for primary abdominal pregnancy. 1) normal tubes and ovaries with no evidence of recent or remote injury, 2) absence of any evidence of uteroplacental fistula,and 3) presence of a pregnancy related exclusively to the pertioneal surface and young enough to eliminate the possibility of secondary implanation following primary nidation in the tube. And now I present a case with brief review of literatures.

만삭임부 및 신생아의 혈청 B형간염 바이러스 표식자에 관한 연구

박완석,이승호,정원영,김성림,이태형,이강원 영남대학교 의과대학 1987 Yeungnam University Journal of Medicine Vol.4 No.2

만삭 임부 및 신생아에서의 B형간염 감염실태를 알아보기 위하여 1986년 1월1일부터 1987년 6월 30일까지 영남대학교 의과대학 부속병원 산부인과에서 분만을 위해 입원한 임부 2.032명중 1,276명에 대하여 HBsAg혈증 여부를 검사하고 혈청 HBsAg 양성으로 확인된 임부 74명중 66명과 그 신생아에서 B형간염 바이러스 표식자 검사와 함께 SGOT 및 SGPT를 측정한 결과 다음과 같은 성적을 얻었다. 1.만삭 임부의 혈청 HBsAg양성율은 4.7%(53/1,279)이었다. 2.HBsAg혈증 임부의 신생아에서의 혈청 HBsAg과 anti-HBs양성율은 각각 12.1%(8/66)와 9.1%(6/66)이었다. 3.HBsAg혈증 만삭 임부에서의 혈청 anti-HBc, HBeAg, alc anti-HBe양성율은 각각 94.0%(62/66), 45.5%(30/66), 및 50%(33/66)이었으며, 혈청 anti-HBc, HBeAg, 및 anti-HBe의 모체-신생아 전차율은 각각 85.5%(53/62),90%(27/30), 및 87.9%(29/33)이었다. 혈청 anti-HBc와 anti-HBe가 신생아에서만 검출된 경우는 각각 1예와 2예가 있었으며 anti-HBe가 검출된 신생아 2영중 1예에서만 혈청 anti-HBs도 동시에 검출되었다. 4.HBsAg혈증 만삭 임부에서 모체가 혈청 HBeAg를 보유한 경우와 혈정 anti-HBe를 보유한 경우의 신생아 혈청 HBsAg 양성율은 각각 13.3%(4/30)와 9.1%(3/33)이었으며, 모체에서 혈청 HBeAg과anti-HBe가 모두 검출되지 않은 경우, 신생아 혈청 HBsAg 양성율은 33.3%(1/3)이었다. 이상의 검사성적으로 미루어 한국인 임부에서도 임신말기에 B형간염 바이러스 표식자검사가 routine screening으로 시행되어야 할 것으로 생각되었으며, B형간염 바이러스의 산전 태반을 통한 신생아 전파율이 본 연구에서는 24.2%로 추정되었다. To evaluate the status of hepatitis B virus infection in the mothers and neonates and to determine the maternal-neonatal transmission of hepatitis B virus, 2,276 term pregnant women were screened for the presence of serum HBsAg, at the Department of Obstetrics and Gynecology, Yeungnam University Hospital, during the period of 18 months from Jan. 1986 to Jun. 1987, and the sera of sixty-six HBsAg carrier mothers and their neonates were tested for HBV markers and liver enzymes. The results were as follows: 1.The prevalence rate of asymptomatic HBsAg carrier in the term pregnant women was 4.7%(53/1,279). 2.Positive rates of HBsAg and anti-HBs in the sera of sixty-six neonates born to asymptomatic HBsAg carrier mothers were 12.1% and 9.1%, respectively. Transient elevation of SGOT(three to four times of upper normal limit) was detected in one of eight HBsAg-positive neonates and one of six anti-HBs positive neonates. 3.Positive rates of anti-HBc, HBeAg and anti-HBe in the sera of sixty-six asymptomatic HBsAg carrier term pregnant women were 93.9%, 45.5% and 50%, respectively. The rates of transmission of maternal ati-HBc, HBeAg and anti-HBe to the neonates were 85.5%(53/62), 90%(27/30) and 87.9%(29/33), respectively. 4.Serum HBsAg was detected in four of thirty neonates born to HBeAg positive HBsAg carrier mother, three of thirty-three neonates born to anti-HBe positive HBsAg carrier mothers, and one of three neonates born to both HBeAg and anti-HBe negative HBsAg carrier mothers.

기본 항생제에 내성을 보인 그람 음성 간균에 대한 2차적 항생제 감수성 검사 결과

김정숙,이채훈,김경동 영남대학교 의과대학 1993 Yeungnam University Journal of Medicine Vol.10 No.1

1992년 12월부터 1993년 4월까지 영남대학교 의과대학 부속병원 임상병리과 세균검사실에 의뢰된 입원환자검체를 대상으로 1차 항생제 감수성 검사에서 모든 항생제에 내성을 보인 그람음성간균에 대해 2차 항생제 감수성 검사를 실시하여 그 결과를 분석하였다. 1차 항생제 감수성 검사에서 모든 항생제에 내성을 보인 균주의 빈도는 A. baumanni, E. cloacae, E. coli, P. aeruginosa, Serratia species순이었다. 소변에서는 기본 항생제에 내성을 보인 균종은 E. coli가, 호흡기와 창상감염에서는 A. baumanni가 가장 많았으며, P. aeruginosa는 모든 검체에서 높은 빈도로 분리되었다. 2차 항생제 감수성 검사에서 전 검체의 53%가 모든 2차 항생제에 대해 내성을 보였다. ceftazidime, aztreonam, ciprofloxacine 등은 상대적으로 항균효과가 높았으나, cefamandole은 모든 균종에서 효과가 없는 것으로 나타났다. Major pathogenic Gram-negative organisms such as P. aeruginosa, Serratia species, E. coli, Enterobacter species which are isolated from the specimens in large medical centers are greatly resistant to the commonly used antibiotics. Gram-negative bacilli, which had been isolated in Yeungnam University Hospital during the period from December 1992 to April 1993 and turned out to be resistant to the primary antibiotics susceptibility test for chloramphenicol, ampicillin, cephalothin, gentamicin, tetracyclin, amikin and tobramycin, were subjected to the secondary antibiotics susceptibility test for aztreonam, ceftazidime, ciprofloxacine, cefotaxime, cefamandole, piperacillin, ticarcillin and sulfamethoxazole trimethopime. Out of 315 tested organisms, 167 organisms (53%) were resistant to all secondary antibiotics in vitro. Antimicrobial activity of ceftazidime (37.1%), aztreonam (11.%), ciprofloxacine (7.9%) against Gram negative bacilli were slightly more active than other antibiotics tested, while cefamandole was not active to all the Gram-negative bacilli tested. According to the specimens, E. coli was the most frequently resistant organisms to the primary antibiotics from urine, A. baumanii, from respiratory system and wounds, and P. aeruginosa from various specimens. In summary, Gram negative bacilli resistant to the primarily applied antibiotics also were resistant to the secondary antibiotics. Rearrangement of the antibiotics disks for the antibiotic susceptibility test should be considered.

소아에서 신장과 혈장 Creatinine 농도를 이용한 사구체여과율 측정

박용훈,하정옥,김정란 영남대학교 의과대학 1988 Yeungnam University Journal of Medicine Vol.5 No.1

1985년 7월부터 1987년 6월까지 2년동안 영남대학교 의과대학 부속병원 소아과에 입원한 환자중 신기능에 영향을 미치는 인자가 없는 1세부터 15세까지의 남녀환아 81명을 대상으로 키와 혈장 creatinine농도를 이용한 공식 GFR=k·Ht/Pcr(k=상수)을 이용하며 실제측정된 creatinine clearance 와 Ht/Pcr에서 구해진 ??(measured k)의 적합성을 연령별로 1∼5세(Ⅰ군), 6∼10세(Ⅱ군), 11∼15세(Ⅲ군) 그리고 전 연령군으로 나누어 검정하였다. 1) 실제 측정된 creatinine clearance(㎖/min 1.73㎡)는 Ⅰ군에서 109.73±9.97, Ⅱ군에서 108.26±9.02, Ⅲ군에서 96.20±4.72 그리고 전 연령군에서는 105.48±5.23이었다. 2) Ht/Pcr과 실제 측정된 creatinine clearance를 이용한 공식에서 얻어진 ?? 값은 Ⅰ군에서 0.49±0.03, Ⅱ군에서 0.48±0.02, Ⅲ군에서 0.43±0.02 그리고 전 연령군에서는 0.47±0.02이었다. 3) Ht/Pcr(x)과 실제 측정된 creatinine clearance(y)를 이용하여 각 군별 및 전 연령군의 회귀방정식과 이들간에서 얻어진 상관계수(r)는 Ⅰ군에서 y=0.82x-65.63(r=0.99), Ⅱ군에서 y=0.61x-23.46(r=0.72), Ⅲ군에서 y=0.18x+54.44(r=0.54) 그리고 전 연령군에서는 y=0.58x-22.13(r=0.81)로 모두에게 상관관계가 높게 나왔다. 4) 이 회귀방정식을 이용하여 추정된 creatinine clearance(??)값을 정리한 후, 추정된 creatinine clearance와 Ht/Pcr에서 구한 ??(estimated k)값은 Ⅰ군에서 0.48±0.01, Ⅱ군에서 0.49±0.01, Ⅲ군에서 0.43±0.01 그리고 전 연령군에서는 0.47이었다. 5) 각 군별 ??과 ??의 적합도는 Ⅰ, Ⅱ군에서 95∼97.5%, Ⅲ군에서 90∼95% 그리고 전 연령군에서는 97.5%∼99%로 모두에게 높게 나왔다. 이상의 연구결과를 종합해 보면 Ht/Pcr과 본 연구에서 계산된 ??값을 이용한 공식을 사용하여 신속하고 간편하게 사구체여과율(GFR)을 산출하여 사구체기능을 평가할 수 있다. In clinical practice, creatinine clearance(Ccr) remains the most commonly used laboratory assessment of glomerular function despite methodological and technical problems of urine collection. Schwartz et al. in 1976, reported that an accurate estimate of glomerular filtration rate(GFR) could be obtained from the simple determinations of plasma creatinine(Pcr) and body lenght(L) : GFR(㎖/min/1.73㎡)=kL(㎝)/Por(㎎/100㎖), (k=constant). The subject of this study were 81 children admitted to our pediatric department from July, 1985 to June, 1987 and they were divided into three groups ; group Ⅰ, from 1 to 5 years old, group Ⅱ, from 6 to 10 years old, group Ⅲ, from 11 to 15 years old. The results were as following: 1) Measured creatinine clearance(??, ㎖/min/1.73㎡) were 109.73±9.97 in group Ⅰ, 108.26±9.02 in group Ⅱ, 96.20±4.72 in group Ⅲ and 105.48 ±5.23 in all age group. 2) Measured k(??) obtained from ??=k Ht/Pcr were 0.49±0.03 in group Ⅰ, 0.48±0.02 in group Ⅱ, 0.43±0.02 in group Ⅲ and 0.47±0.02 in all age group.(Ht; height) 3) Linear equations and correlation coefficients between Ht/Pcr(x) and Ccr(y) were y=0.82x-65.63(r=0.99) in group Ⅰ, y=0.61x-23.46(r=0.72) in group Ⅱ, y=0.18x+54.44(r=0.54) in group Ⅲ and y=0.58x-22.13(r=0.81)in all age group. 4) ?? was again estiamted from linear equations between Ht/Pcr and ?? and ?? was calculated with Ht/Pcr and ?? were 0.48±0.01 in groupⅠ, 0.49±0.01 in group Ⅱ, 0.43±0.01 in group Ⅲ and 0.47±0.00 in all age group. 5) Consistant values of ?? and ?? were highly significant as 95∼97.5% in groupⅠand Ⅱ, 90∼95% in group Ⅲ and 97.5%∼99% in all age group. In summary, we could estimate GFR with height, plasma creatinine and measured k(??) according to the age in easy and rapid way.

혈액과 발톱의 셀레니움 농도와 암과의 관련성

김창윤,이정길,강복수,사공준,권굉보,정종학,이경수 영남대학교 의과대학 1992 Yeungnam University Journal of Medicine Vol.9 No.1

1991년 5월 1일 부터 동년 8월 30일 사이에 영남대학교 의과대학 부속병원에서 위암 및 대장암으로 진단받은 환자 73명을 환자군으로, 건강진단을 받기 위해 동병원에 내원한 283명을 대조군으로 하여 셀레니움과 암과의 관련성을 보기 위한 환자-대조군 연구를 실시하였다. 환자군과 대조군의 성, 연령, BMI, 혈압, 혈청 총 콜레스테롤치, 음주, 흡연력을 조사하고 혈액과 손톱의 셀레니움 농도를 flameless furnace atomizer를 부착한atomic absorption spectrophotometer를 이용하여 측정하였다. 환자군의 혈중 셀레니움 농도는 143.6±10.8㎍/ℓ로서 대조군의 167±14.5㎍/ℓ에 비해 유의하게 낮았으며(p<0.05), 발톱의 셀레니움 농도는 1.04±0.62㎍/g로서 대조군의 1.15±0.55㎍/g에 비해 낮게 나타났으나 통계적으로 유의하지는 않았다. 위암과 대장암사이의 혈증 및 발톱 셀레니움 농도의 차이는 유의하지 않았으며, 전이여부에 따른 셀레니움 농도의 차이도 유의하지 않았다. Multiple logistic regression analysis에서 혈중 셀레니움 농도를 독립변수로 한 경우 혈중 셀레니움 농도(₃OR:0.888, 95% CI:0.860-0.918)와 연령, BMI 및 혈청 총 콜레스테롤치가 유의한 변수로 나타났으며, 발톱 셀레니움 농도를 독립변수로 한 경우 연령(₃OR:0.140, 95% CI:1.085-1.199)만이 유의한 변수로 나타났으며 발톱 셀레니움 농도(₃OR:0.870, 95% CI:0.389-1.950)는 유의하지 않았다. 이상의 성적은 셀레니움이 암의 발생을 억제한다는 가설과 일치하나 많은 예수, 다른 항산화작용 및 항암효과를 가지는 생화학물질들을 변수로 고려한 역학적 연구가 요망된다. A case-control study was conducted to investigate the association between the risk of cancer and selenium concentration in blood and toenails. Seventy three patients and two hundreds eighty three controls were selected at the Yeungnam University Hospital between May and September in 1991. The selected cases were patients who had been hospitalized for stomach or colon cancer at the Department of General Surgery. The controls were people who visited to check physical examination at the Automated Mediscreening Center. The selenium concentration in whole blood and toenails were measured by atomic absorption spectrophotometer equipped with graphite furnace atomizer. The following information was ascertained for all cancer patients and controls: sex, age, body mass index, blood pressure, total serum cholesterol, and history of smoking and drinking. The mean selenium concentration in blood and toenail for all cancer patients were 143.6±10.8㎍/ℓ and 1.04±0.62㎍/g and for the control. 167.0±14.5㎍/ℓ and 1.15±0.55㎍/g, respectively. The difference in blood and toenail selenium concentrations of the two cancer sites was not statistically significant. Metastasis did not influence the concentration of selenium in blood and toenails. In the multiple logistic regression analysis, the blood selenium concentration (?? : 0.888, 95% CI : 0.860-0.918), age, BMI and total serum cholesterol were significant variables for risk of cancer, but the selelenium concentration in toenail was not shown to be a significant variable in this regression analysis. The coefficient for blood selenium concentration adjusted for age, sex, diastolic blood pressure, total serum cholesterol, body mass index and smoking was -0.1184(p<0.01). Three findings suggest that low selenium concentration is associated with gastrointestinal cancers. Further epidemiologic studies including important variables such as other antioxidant micronutrients will be necessary.