정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

활성탄상의 heptafluoropropane 합성에서 반응온도의 효과

김재덕,이윤우,임종성,이경환,이윤용 社團法人 韓國火災 ·消防學會 1998 한국화재소방학회논문지 Vol.12 No.1

크롬(Ⅵ)의 체내 흡수와 소실속도에 관한 연구

김현영,이성배,임철홍,이권섭,정용현,이종성,한정희,전윤석,황호순,이용묵 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

The CrO3 mostly used in plating. metal surface disposal, leather, cosmetic manufacturing, as an experiment material by repeatedly inhaling and exposure the male S.D. rats at a 0.00, 0.2., 0.50, 1.25 mg/㎡ concentration(particle size: 0.5-0.5 aerosol)6hours a day, 5day a week in 13weeks comparing with 2weeks, 8weeks of recovery group about the noxiousness of the experiment animal and the reduce scale of the CrO3 in the internal organ especially in blook and respiratory organ with the period of convalescent and clearance. The experiment results which we received are as follows. 1. In blood the RBC, HGB and HCT experiment, rats with 0.20, 0.50 mg/㎡ concentration showed that there were some decreases but not dependent. The kidneys absolute weight compared with control group was reduced intentionally(p〈0.05) and the lungs absolute weight compared with control group showed intentional increase(p〉0.05). 2. After the exposure of the experiment material, the whole blook, l\blood plasma and red blood cell in blood by (x): the period of convalescent, per (y); the decreasing of Cr concentration, was y=66.51 e -0.057x, y=67.2 e-0.101x, y=70.01 e-0.030 in 0.50 mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life (day)was estimated 12.0, 6086, 23.0 each. 3, After the exposure of the experiment material, the experiment animals lung, liver and kidneys by(x); the period of convalescent, per (y); the decreasing of Cr conentration, was y=1808 e-0.00493x, y=12.02e-0.0297x, y=67.61 e-0.0292x in 0.50mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life(day)was estimated 140.6, 23.3, 23.7, each, and including lung, liver with all of the experiment internal organs, the Cr clearance decreased as the exposure concentration increased.

SD Rats를 이용 1-hexene의 흡입독성 연구

김현영,임철홍,정용현,이권섭,이성배,이준연,한정희,전윤석,이용묵 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.4

The purpose of this study was to investigate the acute (4 hours) and repeated-dose (6 hours a day, 5 days a week, 4 weeks) toxic effects of I -hexene on Sprague- Dawley (SD) rats which were treated by inhalation. The results were as follows; I. The median lethal concentration (LC_(50)) was estimated 52,694 ppm (confidence limit 95%; 49,494~55,447 ppm) in acute inhalation. Abnormal clinical signs related to the l-Hexene were not observed with the acute inhalation dose. Gross findings of necropsy revealed on evidence of specific toxicity related to the 1-hexene, II. By repeated inhalation exposure the body weight of male were more or less reduced by the dose of 2,500 ppm and 5,000 ppm compared with control group. However there were no significant variation hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-hexene were not shown. In conclusion when we exposed I-hexene to SD rats for 4 weeks, 5 days per week, 6 hours per day, the Lowest observed effect level (LOEL) was over 2,500 ppm and Non observed effect level (NOEL) was below 500 ppm.

콘크리트 보수용 폴리머 시멘트 모르타르의 적정 배합비 및 두께 결정

이윤수,이기원,전철수,지경용 강원대학교 부설 석재복합신소재 제품연구센터 2000 석재연 논문집 Vol.5 No.-

피로하중, 산성비, 염해 및 동결융해 등 각종 원인에 의해 시멘트 콘크리트 구조물의 성능 저하가 건설산업분야의 문제점으로 대두되고 있다. 일반적으로 성능이 저하된 시멘트 콘크리트 구조물의 보수재로는 폴리머 복합재료가 널리 사용되고 있다. 보통 시멘트 콘크리트에 폴리머를 첨가하면, 작업성의 경우 폴리머의 혼입량이 증가 할수록 작업성이 증가하고 이에 따라 공기량이 증가하는 경향을 나타내었다. 또한 압축강도는 폴리머 시멘트비가 10%에서 가장 높은 값을 보였으며, 휨강도의 경우는 폴리머 시멘트비가 증가할수록 강도가 증가하는 경향을 나타내었다. 또한 폴리머 시멘트 모르타르의 직접인장접착강도에서는 폴리머-시멘트비 10%, 소포제 1%에서 가장 높은 접착강도가 나타났으며, 내후성 시럼 후의 직접인장접착강도 실험에서는 보두 수께 5mm가 가장 높은 접착강도를 나타내었다. 이상과 같은 실험 결과를 볼 때 보수재로 사용되는 폴리머 시멘트 모르타르의 경우는 폴리머 시멘트비 10%, 소포제1%의 배합으로 약 5mm의 두께로 보수를 하는 것이 가장 유리함을 알 수 있었다. This research was conducted to experimentally evaluate the characteristics of the tensile adhesion strength of polymer cement mortar for repair of cement concrete structures. Air content of polymer cement mortar was improved with increment of polymer cement ratio. Water absorption of polymer cement mortar was decreased with increment of polymer cement ratio. Compressive strength of polymer cement ratio 10% was higher than those of others. Flexural strength of polymer cement mortar was improved with increment of polymer cement ration. The tensile adhesion strength of polymer cement ration 10% and antiformer agent content 1% was higher than those of others. After weathering test, the tensile adhesion strength of thickness 5mm was found to be higher than those of others.

외부온도에 따른 폴리머 콘크리트의 강도특성 변화

이윤수,주명기,최만용 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

불포화 에스터 수지의 큰 이용분야의 하나로 건축재료가 있으나 여기서 가장 문제로 되어 있는 것이 바로 열적 특성의 개선이다. 따라서 본 연구에서는 외부온도가 폴리머 콘크리트의 강도특성에 미치는 영향을 검토하기 위하여 외부온도 20∼120℃ 범위로 하여 폴리머 콘크리트의 물리·역학적 특성을 구명하는데 목적이 있다. 본 연구에서는 불포화 폴리에스터 수지를 결합재로 하고 탄산칼슘을 충진재로, 규사를 잔골재로 치환하고, 굵은골재를 쇄석으로하는 폴리머 콘크리트를 제조하여 외부온도에 따른 강도특성을 검토한 바, 폴리머 콘크리트의 사용 적정온도는 50℃이내가 적당할 것으로 판단되며, 50℃이상에서 사용할 경우는 난연성이 우수한 탄소섬유를 사용해야 할 것이다. In this study, the polymer concrete was made to investigate its strength properties, in which unsaturated polyester resin was used as s binder, calcium carbonate as the filler and silica sand as th fine aggregate, and crushed stone as the coarse aggregate. The effects according to the external temperature on strength properties of polymer concrete were examined. Test result showed that the compressive, flexural and tensile strengths of the polymer concretes decreased with increasing external temperature. The elasticity of modulus of the polymer concretes decreased with increasing external temperature.

신경성 염증질환에서 지질 신호전달물질인 lactosylceramide의 역할

이윤선, 유재명, 최경미, 이용문, 홍진태, 윤여표, 유환수 충북대학교 약품자원개발연구소 2007 약학논문집 Vol.22 No.-

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발전기 고정자 권선용 마이카/에폭시 수지의 표면 및 구조분석

이상교,심재선,정의남,송우창,박하용,심상흥,임윤희,박종국,심낙순 三陟大學校 1998 論文集 Vol.31 No.1

The purpose of this study is to determine the ageing mechanism of Mica/Epoxy composite material for large generator stator windings in order to estimate remaining life of generator. X-ray analysis is performed to investigate the position and structure of mica crystal in insulation materials. The phase change of aged and sound specimen under each atmosphere isn't observed. Surface analysis of insulation materials by optical microscope also show that the sound and aged specimen, sliding phenomenon by shear and thermal stress is observed both interface between mica and epoxy.

두개저 골절 환자의 임상적 고찰

이용성,송시헌,김성호,김관태,김윤 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.9

The authors analyzed 147 cases of basal skull fracture which were treated in the Department of Neurosurgery, Chungnam National University Hospital from Janwuy 1989 to December 1992. These fractures are difficult to diagnose by ordinary X-ray examination and are freguently inferred by clinical signs. The clinical features and radiological findings were reviewed. The results of the analysis are summarized as follows 1) The basal skull fractures were more common in men than women-the ratio being 6 1 1. 2) In decreasing order of cause of basal skull fractures were traffic accident~(77%), fall down, assault and slipping. 3) The minor head injury, Glasgow Coma Scale Score(GCS) of 13 to 15, was 79 cases(54%), the moderate head injury 40 cases(27%) and the severe head injury 18 cases(1996). 4) In decreasing order of clinical features were otorrhea(71 I) rhinorrhea(4856) and raccoon eye(33%) etc. 5) In decreasing order of the combined pathologies were skull fracture(55I 1, subdural hema-toma(l7%), epidural hematoma(l6%) and intraerebral hematoma(l2I) etc. 6) The facial nerve, vestibulocochlear nerve and optic nerve were the most commonly injured cranial nerve. 7) CSF leakage was noted in 139 cases and among them immediate type was far more common(%%) than the delayed type. 8) The incidence of meningitis was 5.4% and most of them associated with CSF leakage and the prophylatic antibiotic treatment has no effect to decrease infection rate. 9) In decreasing order of the frequency associated injuries were facial bone fracture (47%), clavicle fracture(19%), lower extremitics fracture(9%) and upper extremcties fracture(7%) etc.

대학교수의 생활체육 참여와 직무만족의 관계

이용식,오연풍,이범제 師範大學 體育硏究所 1997 서울大學校 體育硏究所論集 Vol.18 No.1

The purpose of this study was to examine relation of participation in sport for all and job satisfaction of professors. The subjects of the study were 119 professors who worked at "S" university located in seoul. A questionnaire was designed to measure relation of participation in sport for all and job satisfaction. The questionnaire consisted of three main sections: (a) sochi-demographic characteristics, (b) questions concerning participation in sport for all, (c) job satisfaction. The reliability coefficients of the questionnaire was .7549. The data were analysis with covariance analysis and multiple classification analysis. Results obtained from this research are as follows: 1. Participation in sport for all has positive effect on job satisfaction. 2. The degree (frequency, duration, intensity) of participation in sport for all has no effect on job satisfaction.