백혈병환자에서 Liposomal Amphotericin B로 치료된 파종성 Fusarium 감염 1예

이지연,김성범,박대원,신성희,김용현,윤소영,엄중식,최철원,정희진,김우주,김준석,김장수,이갑노 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

Fusarium spp.는 사람에서 드물게 각막염, 조갑진균증, 상처나 화상부위감염 등을 유발하는 것으로 알려져 있으나 최근에는 면역저하자에서 기회감염의 원인균으로 증가하고 있는 추세이다. 면역저하자에서 파종성 감염이 있는 경우에 예후는 치명적이나, 증례가 많지 않고 진단방법이 제한되어 있어 조기 진단과 신속한 치료가 쉽지 않다. 그러나 특징적으로 피부병변의 동반이 흔하여 면역저하자에서는 피부 병변의 면밀한 관찰과 함께 Fusarium 감염을 조기에 의심하여 피부생검이나 배양을 하는 것이 진단에 도움이 되리라 생각된다. 파종성 Fusarium 감염의 치료로는 감염 부위의 국소적 외과적 절제와 전신적 항진균제의 사용이 필요하고 현재까지는 amphotericin B가 비교적 효율적인 항진균제로 알려져 있으나 면역저하자에서 이에 반응을 하지 않는 경우가 많다. 저자들은 급성골수성백혈병 환자에서 관해유도화학요법 시행 후 호중구감소상태에서 피부병변과 폐침윤이 발견되었고 피부의 중심부 궤양을 동반한 구진성 병변에서 배양검사를 통해 파종성 Fusarium 감염을 진단하였으며 liposomal amphotericin B (AmBisome )를 사용하여 성공적으로 치료한 예를 경험하여 보고하는 바이다. Fusarium spp., basically a superficial pathogen, is a newly emerging fungal pathogen of opportunistic infections in immunocompromised patients. At present, although Fusarium spp. are relatively resistant to amphotericin B, the combination of amphotericin B and surgical debridement appear to be optimal treatment for disseminated infection. Recently we experienced a 32-year-old neutropenic patient after induction chemotherapy for acute myelocytic leukemia presented with skin lesions and infiltrations in both lungs. We diagnosed with disseminated fusariosis by skin culture and successfully treated the patient with liposomal amphotericin B. We emphasize a high index of suspicion for skin lesions especially in immunocopromised patients.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

오존, 오존/超音波 및 오존/紫外線을 利用한 廢水處理

金基成,羅德寬,李禹範 순천대학교 공업기술연구소 1988 工業技術硏究所論文集 Vol.2 No.-

The wasterwater treatment using combination system of ozone/ultrasonics or ozone/ultraviolets compared with the ozone was able to increase the ozone oxidation rate and hydrogenperoxide generation. But, the patterns of interactions between ozone and ultrasonics or ultraviolets are very complex, and reaction mechanism are not understood completely. Thus, this study was conducted to evaluate fundamental factors of effective ozonization when this combination works were carried out.

강판-콘크리트 구조 벽체-지지대 접합부의 거동특성에 관한 연구

김강식,김우범,이정민 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

An experimental and analytical study on the behavior of SC(steel plate - concrete) structure's wall-support joint for nuclear power plants was performed. Nine full scale specimens were tested with horizontal monotonic load, all acting in the same plane causing uni-axial moment on the SC structure's wall-support beam joint. The major focus relates to the identification of the behavior and capacity of the SC composite joint system. The effects of variations of the location of support, the thickness of steel-plate and the depth of support were studied. The horizontal force-displacement relationship, steel-plate strains, plate deformation, support strains were observed and analyzed in order to evaluate the behavior of the system.

Intentional Replantation에 의한 상악 제 1 소구치 치료의 증례보고

김종범,한세현,정우진,이상훈 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

Intentional replantation of the posterior teeth has been performed as a last resort except extraction when it is impossible to perform the conventional endodontic or surgical endodontic treatment. Many studies have done with the prognosis, and root resorption, of which the responsibility might have been injury of periodontal ligament and remaining periodontal lesion, proved to be major cause of failure. Intentional replantation, however, can exclude anatomic difficulty, risk of nerve injury, and maxillary sinus trauma that surgical access can raise, especially in posterior teeth, and it is reported that success rate is not less than surgical endodontics, independent of replantation of traumatically avulsed teeth. The success of intentional replantation can be evaluated with, clinically, ruduction of pocket depth, pain and mobility(physical mobility), and, radiographically, hard tissue formation, reduction of periapical radiolucency. In this case report, for the maxillary left first bicuspid with dens evaginatus that had periapical lesion, painfulness, mobility and showed no reduction of mobility after even extirpation and a number of irrigation, extraction followed by extraoral root filling with calcium hydroxide and replantation was performed. Based on many studies, it is concluded that hard tissue formation capacity of calcium hydroxide, preceded exterpation before extraction, and careful extraction without injuring periodontal ligament affected successful results of this case.

K형 강관접합부의 보강효과에 관한 실험적 연구

김갑순,한병찬,성수용,김우범,정수영 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.2

In current design, the strength formula for a Gusset-Tube connections stiffened with rib-plate is proposed only in the limited case because of its complexity of the behavior. So in this study, experimental study and finite element analysis were performed to investigate the behavior and strength of a Gusset-Tube connections stiffened with rib-plate. Because of limitations in loading capacity, the specimens were fabricated with 1/3 scale of full size. Tensile coupon tests and stub column tests were also carried out. Of primary interest here are the stiffened effect of Gusset-Tube connections considering lateral force ratio, gusset plate length, eccentricity, stiffened length. Consequently, we intend to obtain accumulated database to propose practical strength equation and suggest rational reinforcing method of Gusset-tube connection.

ID-GC/MS에 의한 쌀 중의 잔류농약 인증표준물질

김유곤,김달호,백병천,이우범 國立 麗水大學校 환경문제硏究所 2001 環境硏究論文集 Vol.4 No.-

The CRM used in evaluation of effectiveness, calibration or analysis equipment when you analyse in material of rice powder or similar matrix. Analytical items were γ-HCH, p,p'-DDE, endosulfan-2, samples of achieved pertreatment analized each component indivisually. Control mode of MS used selected ion monitering(SIM). GC is 6890GC of Agilent Technology company and MS is JMS 700 of Jeol company. MS operating condition was Electron impact ionization with 70eV. 300A, GC operating condition was Column : Rtx-5MS 30m*0.25m ID*0.25um, Oven Temp 90℃(3min)-20℃/min-280℃(2min), Injection port 250℃, splitless, Carrier Gas He with 1mL/min. Water contents was 12.534% and dry mass correction factor 1.143. CRM certified values of the experiment result were p,p'-DDE 0.165±0.011,mg/kg, γ-HCH 0.0129±0.0011mg/kg, endosulfan-2 0.0216±0.0027mg/kg. The numbers following the symbol ± are the numerical values of expanded uncertainties, U=ku_(c) of measurement values preceding the symbol. The level of confidence for the expanded uncertainties are 96% with k=2.

휘발성 유기화합물의 Biokinetics 및 분해에 관한 비교연구

김종오,이우범 國立 麗水大學校 環境問題硏究所 1999 環境硏究論文集 Vol.2 No.-

Determination of biokinetic constant for volatile organic compounds(VOCs) is important because the biokinetic constants as biodegradation parameters play an significant role in mathematical design and modeling of bioremediation of VOCs. The objective of this study was to compare biokinetic of VOCs under aerobic and unaerobic conditions. After comparison of normalized k for VOCs on the basis of trichloroethylene(TCE) with methanotrophs, dichloromethane(DCM) and chloroform(CF) were very well degraded hydrocarbons whereas cis 1,2-DCE and 1,1,1-TCA were poorly degraded hydrocarbons under the aerobic conditions.

바이오 필터에 의한 벤젠과 에틸렌 처리실험에 대한 고찰

김종오,이우범 한국대기환경학회 2003 한국대기환경학회지 Vol.19 No.3

A biofilter study was conducted by changing inlet concentration and residence time for the removal of gaseous benzene and ethylene. In addition, carbon dioxide producted from the biofilters was investigated. Over 96% of benzene was removed at the residence times of 2 and 4.3 min, and inlet benzene concentrations of 220~200ppm. The ethylene biofilter was capable of achieving ethylene removal efficiency as much as 100% at a residence time of 14 min, and inlet concentrations of 99~290 ppm. At a steady state, the carbon dioxide of 409~611 ppm was produced with an ethylene inlet concentration of 290 ppm. Most of benzene and ethylene were degraded at lower part of the biofilters where more microbial activity occurred.

K형 강관접합부의 편심접합에 관한 실험적 연구

김갑순,신의균,김우범,정수영 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

A finite element analysis and experimental study were performed to investigate the behavior and strength of a connection of tubular steel member considering slenderness ratio and eccentricity. Primary interest here are ultimate strength of connections having eccentricity. In comparison with the current design standard according to which the gravity axes of the main and branch pipes coincide with each other, the inner eccentric joint where the gravity axes of the branch pipes are shifted to the gusset plate side can reduce the gusset plate size. However, in the eccentric joint where the gravity axes do not coincide, the bending moment that acts on the main pipe due to eccentricity causes a problem. As a result, in cases where the slenderness ratio is 40 or less, the buckling strength of the inner eccentric joint was similar to that of a joint without eccentricity. Therefore the possibility of use of inner eccentricity connection to reduce the gusset plate size has been verified.