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      • KCI등재
      • KCI등재

        딥러닝 모형 기반 진해만 용존산소농도 재현을 위한 기초연구

        박성식,김경회 해양환경안전학회 2022 해양환경안전학회지 Vol.28 No.2

        We conducted a case study to determine the optimal model parameters and predictors of Long Short-Term Memory (LSTM) for the reproduction of dissolved oxygen (DO) concentration in Jinhae Bay. The model parameter case study indicated the lowest accuracy when the Hidden node=10, Epoch=100. This was caused by underfitting of machine learning. The accuracy increased as the Hidden node and Epoch increased. The accuracy was the highest when the Hidden node=80 and Epoch=100 with R2=0.99. In the bottom DO reproduction of Step 1 of the predictors case study, accuracy was highest when the water temperature was used as a predictor with R2=0.81. In Step 2, The R2 value increased up to 0.92 when the water temperature and SiO2 were used as a predictor. This was caused by a high correlation between the bottom DO and SiO2 concentrations. Consequently, we determined the optimal model parameters and predictors of LSTM for the reproduction of DO concentration in Jinhae Bay. 본 연구에서는 진해만의 DO 농도 재현을 목표로 LSTM 모형의 최적 매개변수 조건과 예측변수를 선별하기 위한 Case study를 진행하였다. 모형 매개변수 Case study 결과, 가장 적은 Hidden node와 Epoch인 Hidden node=10, Epoch=100에서 가장 낮은 정확도를 보였다. 이는 모형이 과소적합(Underfitting) 상태인 것으로 판단된다. Hidden node=80, Epoch=1200에서 R2 값은 0.99로 가장 높은 정확도를 보였다. 예측변수 Case study 결과, 1개의 환경변수만을 예측변수로 사용한 Step 1에서 수온을 예측변수로 했을 때 저층 DO 농도 재현의 R2 값은 0.81로 가장 높은 정확도를 보였다. 이후 2개의 환경변수를 사용한 Step 2에서는 수온과 SiO2를 예측변수로 했을 때 R2 값은 0.92로 수온만 사용했을 때보다 정확도가 급격히 증가하였다. 이는 저층 DO 농도와 SiO2 농도간의 높은 상관성에 기인한 것으로 판단된다. 상기 결과로부터 진해만의 DO 농도 재현에 적합한 LSTM 모형의 매개변수와 예측변수를 찾을 수 있었다.

      • KCI등재

        양격산화탕(凉膈散火湯) 활용(活用)에 대(對)한 임상적(臨床的) 연구(硏究)

        박성식,김지용,최재영,Park, Seong-sik,Kim, Ji-yong,Choi, Jae-young 사상체질의학회 1998 사상체질의학회지 Vol.10 No.2

        1. 연구배경 및 목적 소양인(少陽人) 신정방(新定方)의 하나인 양격산화탕(凉膈散火湯)의 효능(效能)과 활용(活用)에 대한 임상적(臨床的) 연구(硏究)를 통해 사상체질병증(四象體質病證)의 이해(理解)와 방제(方劑)의 운용(運用)에 도움을 주고자 한다. 2. 방법 1997년 3월부터 1998년 2월까지 1년간 동국대학교 분당한방병원 체질의학클리닉에 내원(來院)한 환자들 중 양격산화탕(凉膈散火湯)이 20첩 이상 투여되고 경과관찰(經過觀察)이 가능했던 65명(남자 40명, 여자 25명)을 대상으로 양격산화탕(凉膈散火湯)이 투여된 환자의 특성, 치료효과, 부작용 등에 관하여 조사하고 분석하였다. 3. 결과 소양인(少陽人)의 양격산화탕(凉膈散火湯)은 남녀 구별 없이 모든 연령층에서 사용되었으며, 대상환자들의 주소증은 흉민(胸悶), 수족병(手足病), 운동장애(運動障碍), 구건(口乾), 상열감(上熱感) 등 37종류였다. 치료효과의 분포는 호전이 58.5%, 우수가 12.3%, 별무변화가 29.3%였으며 악화는 없었다. 전신상태(全身狀態)의 특징으로는 설태(舌苔)가 백태(白苔) 또는 황태(黃苔)를 띄거나 간출이상(刊出異常)이 있는 경우가 많았다. 처방(處方)을 활용할 때는 처방의 변경없이 양격산화탕(凉膈散火湯)만을 사용한 경우가 많았으며 병증(病症)에 따라 약물을 증량(增量)하거나 가미(加味)하여 사용하였다. 양격산화탕(凉膈散火湯)의 치료효과(治療效果)에는 약물의 가감유무(加減有無)가 영향을 미쳤으며, 효과발현시간(效果發顯時間)은 연령이 젊을수록 빠른 것으로 나타났다. 부작용으로는 심계(心悸), 복통(腹痛) 및 소화불량(消化不良) 등이 있었다. Background and Purpose : We intended to be helpful to understand constitutional symptoms of a disease and an application of the prescription through a clinical study of Soyangin Yangkyuksanwhatang. Methods : We studied 65 patients(40 men and 25 women) treated with Soyangin Yangkyuksanwhatang in constitutional clinic of Dongguk Pundang Oriental Hospital. And then we investigated the characteristics of Yangkyuksanwhatang treated patients, remedial values, onset of action and side effects. Results: Soyangin Yangkyuksanwhatang was used in all age groups both men and women. There were 37 kinds of chief complaints including chest discomfort, numbness of hands and feet, motor disturbance and skin disease etc. The distributions of remedial values were slightly improved(58.5%), much improved(12.3%), no improved(29.3%) and there was no aggravated patient. Using the prescription, mostly I prescribed only Soyangin Yangkyuksanwhatang without any changing, and added some herbs to the prescription according to the symptoms of a disease. Soyangin Yangkyuksanwhatang was affected in remedial values by the addition and subtraction of herbs. The onset of action in young age group was shorter than old age group. Side effects were palpitation, abdominal pain and indigestion etc.

      • SCOPUSKCI등재

        Progesterone이 rat 자궁과 난소의 증식세포 분포에 미치는 영향에 대한 면역조직화학적 연구

        박성식,곽수동,Park, Sung-sik,Kwak, Soo-dong 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.2

        The study was designed to investigate the effects of progesterone on the reproductive system. This investigation was performed by immunohistochemical methods using anti-bromodeoxyuridine-antibody following bromodeoxyuridine(Brdur) injection for labeling proliferating cells in the uterus and ovary of rats. Sixteen female rats(Wistar), weighing initially 300g, were randomly allotted into ovariectomized and unovariectomized large groups. These two large groups were subdivided into three subgroups of control, 3-day and 6-day groups, respectively. 3-days and 6-days group were injected with 1mg of progesterone/rat/day for 3 or 6 days, respectively. In gross findings, the uterus of ovariectomized groups markedly atrophied, and were not hypertrophied by progesterone injection for 3 days or 6 days and the uterus of unovariectomized groups also were not hypertrophied. Labeling index(LI, %) was measured by counting the number of Brdur-positive cells from 300 to 3,000 cells per layer in the uterus tissue. The average LI of the uterus in unovariectomized groups was higher than that of ovariectomized groups. The subgroups with higher LI in unovariectomized groups were ordered as 6-day group, 3-day group. So progesterone considerably effected to the proliferating of the cells in the uterus of unovariectomized groups. The layers with higher LI in the uterus wall were ordered as the functional zone of endometrium, epithelial layer of endometrium, basal zone of endometrium, myometrium and perimetrium. The cell types with higher LI in the uterus of unovariectomized groups were ordered as the surface epithelial cells, stromal cells, glandular epithelial cells and muscle cells. Growing follicles with proliferating cells from secondary and tertiary follicles in the ovary of unovariectomized groups appeared to be 37.66% in control group, 39.23% in 3-day groups, 39.47% in 6-day groups. Mature follicles in the ovary were more number in control group than those in 3-day groups but not appeared in 6-day groups. So progesterone not nearly effects to the number of the growing follicles but appeared to be related to suppression of the development and protrusion of the mid-tertiary and mature follicles on the ovary surface. The cell types with higher LI in the ovary of unovariectomized groups were respectively ordered as granulosa cells, theca interns cells in secondary follicles; theca interna cells, granulosa cells, theca externa cells in tertiary follicles; fibroblasts, theca in terns cells in atretic follicles; fibroblasts, luteal cells in corpus luteum.

      • SCOPUSKCI등재

        에탄올로 조용매로 사용한 분별 결정화에 의한 Cyclodextrin 의 분리정제

        박성식,구윤모 ( Sung Sik Park,Yoon Mo Koo ) 한국화학공학회 1998 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.36 No.6

        Fractional crystallization of two homologues of cyclodextrin, α-cyclodextrin and β-cyclodextrin , was tried to isolate one from the other in the mixture. A phase diagram of α-cyclodextrin, β-cyclodextrin and solvent was constucted to obtain the necessary conditions of fractional isolation of cyclodextrin mixture. β-Cyclodextrin was easily isolated from the mixture because of low solubility in water. Addition of cosolvent was tried for the isolation of α-cyclodextrin, which has relatively lower solubility in water. Among the tested cosolvents, ethanol gave the highest yield. Yields of α-cyclodextrin and β-cyclodextrin in the fractional crystallization were 55.2 % and 63.6 %, respectively, with the purities above 96 %.

      • KCI등재

        고로슬래그와 극한미생물을 이용한 모래의 고결화 연구

        박성식,최선규,남인현 한국지반공학회 2014 한국지반공학회논문집 Vol.30 No.1

        In this study, a blast furnace slag having latent hydraulic property with an alkaline activator for resource recyclingwas used to solidify sand without using cement. Existing chemical alkaline activators such as Ca(OH)2 and NaOH wereused for cementing soils. An alkaliphilic microorganism, which is active at higher than pH 10, is tested for a newalkaline activator. The alkaliphilic microorganism was added into sand with a blast furnace slag and a chemical alkalineactivator. This is called the microorganism alkaline activator. Four different ratios of blast furnace slag (4, 8, 12, 16%)and two different chemical alkaline activators (Ca(OH)2 and NaOH) were used for preparing cemented specimens withor without the alkaliphilic microorganism. The specimens were air-cured for 7 days and then tested for the experimentof unconfined compressive strength (UCS). Experimental results showed that as a blast furnace slag increased, the watercontent and dry density increased. The UCS of a specimen increased from 178 kPa to 2,435 kPa. The UCS of a specimenmixed with Ca(OH)2 was 5-54% greater than that with NaOH. When the microorganism was added into the specimen,the UCS of a specimen with Ca(OH)2 decreased by 11-60% but one with NaOH increased by 19-121%. The C-S-Hhydrates were found in the cemented specimens, and their amounts increased as the amount of blast furnace slag increasedthrough SEM analysis.

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