타이어 접지형상 자동측정 시스템 개발

김영탁,정태영,탁영봉 慶尙大學校生産技術硏究所 1995 生産技術硏究所論文集 Vol.11 No.-

The contribution describes an automatic measuring system for analysing tire contact shapes and air-pressure distribution upon weight load using the computer vision. Instead of analysing the safety degree of automobiles by manually calculation the tire contact area. This system is to analyse it automatically using a computer by the image processing technique. This system is divided into three major process : i) to binarize an input image for discriminating object from background, and then to remove noise from it. ii) to extract the image contour, applying the chain code to each seperated region and then labelling them, based on the process of dilation and erosion of the image. iii) to calculate the real contact area and to set corresponding color levels upon air pressure. Representing the gray level as pseudo-color have enabled us to visualize the air-pressure distribution upon weight load. We have developed an automatic system of calculating real contact area and its ratio against total tire contact area using the image processing technique. This has reduced the measuring time and error to half of those the manual method.

액정디스플레이(LCD) 판넬유리 운반로봇의 진동저감에 대한 연구

탁태오,김헌영,전형호,오용빈 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B

The development of efficient and precise handling of an liquid crystal display (LCD) panel has been addressed as the sizes of LCD panels become much larger than ever. The majority part of LCD panel handling is conducted by industrial robots for the cost reduction and the quality control. A challenging problem, vibration of the panel, can be found when the robots are utilized for handling LCD panels. The vibration causes the poor product precision and the low productivity. The characteristics of LCD panels, which are the high size-to thickness ratio, the high elasticity, and the high brittleness, are the major sources of the vibration This paper introduces the vibration attenuation techniques to overcome the difficulties encountered in the LCD production using the industrial robots.

핵 연료봉번호 자동인식 시스템 개발

정태영,탁영봉 慶尙大學校 工科大學 自動化및컴퓨터應用技術硏究所 1998 自動化 및 컴퓨터應用技術 Vol.5 No.1

In this paper, we developed an automatic recognition system of nuclear fuel rod numbers by the computer vision using a neural network, which facilitated the automation of the production process and posterior management of fuel rods. Prior to this, workers on the line manually put fuel rod numbers on record and manafement. The recognition of fuel rod numbers is mainly divided into three processes. ⅰ) To build up a line-scanned entire image from an image captured by a CCD camera, and then to magnify and binarize the image. The regions of discrete numbers are then detected by projecting the binarized image. ⅱ) To extract features from the regions of detected discrete numbers. ⅲ) To input the extracted features into a neural network which have input nodes 33, hidden nodes 20, and output nodes 10, using the back propagation algorithm. This system made it possible to reduce the man power and to process the data faster than the conventional manual process by automatically recognizing fuel rod numbers and transmitting them to a workstation. The recognition rate was successfully tested to be 99% from almost every batch of 450 fuel rodes. The 1% incorrect recognition was mainly due to bad font appearance of fuel rod numbers.

CC Chemokine CKβ8의 발현 조절 물질 탐색 및 저해활성 물질 분석

김탁용,이태훈,백남인,정대균,김지영 경희대학교식량자원개발연구소 2005 硏究論文集 Vol.24 No.-

CKβ8은 CC 케모카인의 부류에 속하는 사이토카인의 일종으로, 단핵구, 호염구, 호산구, T 림프구, 자연살해세포, 수지상세포 등의 화학주성물질로 작용하는 것으로 알려져 있다. CKβ8은 염증반응 및 혈관신생 등과 같은 여러 가지 생체 반응에 역할을 하는 것으로 알려져 있다. 본 논문에서는 사람 CKβ8 유전자의 전사저해 물질을 선별하기 위하여 CKβ8/Luc 유전자를 발현하는 세포주를 확립하였다. CKβ8 유전자의 전사시작점에서 -299 부터 +10 프로모터 부위를 PCR에 의해 얻은 다음 포유세포 발현 플라스미드에 클로닝하였다. CKβ8/Lvc 유전자는 U937 세포내에서 PMA에 의해 10배 이상 발현이 증가한다. CKβ8/Luc 발현 U937 세포주는 식물 추출물에서 전사 저해제를 탐색하는데 이용되었다. 46 개의 식물 추출물 중에서 6개가 90% 이상 CKβ8/Luc의 전사를 저해하였다. 이들 물질에 대해 세포 독성 실험을 수행한 결과 그 중 한 개만이 세포 독성이 거의 없는 것으로 나타났다. 이 추출물은 붉나무에서 얻은 추출물이며 이 식물 추출물은 염증관련 질환에 대한 가능성이 있는 치료제로 이용될 수도 있을 것으로 추측된다. Ckβ8 belongs to a family of CC chemokines, which is known to act as a chemoattractant for monocytes, basophils, eosinophils, T lymphocytes, NK cells, and dendritic cells. CKβ8 is known to play roles in various biological processes such as inflammation and angiogenesis. In the present study, we developed U937 cell line expressing CKβ8/Luciferase fusion gene for screening of transcriptional inhibitors for human CKβ8 gene. Genomic sequences that contain CKβ8 promoter region from 299 to+10 nucleotide from the transcription start site was amplified by PCR and cloned into mammalian episomal plasmid. The CKβ8/Luc fusion plasmid was introduced into human promonocytic U937 cells and selected for stable U937 cells expressing the fused reporter gene. The expression of the fusion gene was induced by more than 10 folds upon treatment of phorbol myristate acetate. The stable U937 transfectant cells were used for searching transcriptional inhibitors for human CKβ8 gene from plant extracts. Among 46 plant extracts tested, six extracts exerted more than 90% inhibition of PMA-induced CKβ8 transcription. Cytotoxic tests demonstrated that one of extracts, which was extracted from Rhus chinensis Mill, had little cytotoxic effect. The extract may be used for developing a potential therapeutic agent for inflammatory diseases.

복지위원제도 도입을 위한 모형 개발에 관한 연구

박태영,채현탁 한국사회복지정책학회 2005 사회복지정책 Vol.21 No.-

본 논문은 사회복지전달체계에 있어 지역내 요지원자를 포함한 지역주민과 사회복지관계자간의 연결 고리를 형성할 수 있는 공식매개체로서 복지워원제도의 도입 및 활성화 방안을 모색하여 지역사회내 복지위원제도의 정착을 위한 모형을 개발하고자 마련된 것이다. 현재 우리사회는 지역내 요지원자를 위안 사전 예방적이며 주민 참여적이고 사회복지관계자간의 다양한 연계·협력을 유도할 수 있는 가장 근원적인 연결매개체를 필요로 하고 있다. 복지위원제도는 이러한 시대적 요청을 반영할 수 있는 제도로 그 도입이 시급히 요청된다. 본 연구는 복지위원제도의 도입 모형을 개발하고자 지역별 사회복지전 문가의 의견청취를 통해 모형 구성에 필요한 다양한 아이디어를 수집하고 참여자의 경험과 신념의 풍부한 이해를 이끌어 내기 위하여 초점집단면접(Focus Croup Interview)을 실시하였다. 전라남도 장성(농촌지역), 대구광역시 칠곡(도농복합지역), 경기도 시흥(도시지역)의 지역 특성이 분명한 세 지역을 유의표집하여 관할 지역내의 사회복지전문가 28명을 대상으로 3회에 걸쳐 복지위원제도 도입 전반에 대안 사항을 심층 면접하였다. 이를 통해 복지위원제도 도입과 관련한 모형 요인을 설정하였고 이를 바탕으로 제도 도입 모형을 준비 체계, 운영 체계, 관리체계로 구성아였다. 우선 준비체계에서는 제도 도입 추진위원회, 운영조례, 운영 예산과 관련한 사항을 구체화하였으며, 운용체계에서는 표준운영체계를 설정하고 이에 근거하여 특정 실시주체 중심의 운영 체계를 마련하였다. 그리고 관리체계는 모집, 선정, 교육, 활동, 평가로 구성하여 직접적인 실천이 가능한 모형을 개발하고자 하였다. 본 연구는 우리나라에 복지위원제도 도입에 따른 실천 지침과 공공 및 민간 사회복지분야에서 주민 조직화의 활성화를 위한 실천 방향을 제시하였으며, 또한 지역복지계획에 있어 주민 참여 방안 마련을 위한 기초 자료를 제공하였다는 점에서 의의를 지닌다. This study is to examine the possibility or methodology for the actualization of Community Welfare Committee Institution(CWCI). The core role of CWCI is connection between the various clients and the diverse social welfare phenomena. Therefore, CWCI is important to our community welfare situation. Present society really require CWCI. This study use the Focus Group Interview(FGI) for the construction of CWCI model. FGI is the very useful tool for the listening of various social welfare professionals' opinions. The objects of FGI are three communities; Jangseung Gun, Jeunranam Do(purely rural community), Chilgok, Daegu City(rural-urban complex community), and Siheung, Gyeounggi Do(urban community). This study interviewed 28 social welfare professionals at three times. On this research, CWCI model consists of three systems; the preparatory system, the working system, and the management system. This study will be a touchstone in our community welfare practices.

급성 심근경색 : Gd-DTPA 조영증강 자기공명영상 Gd-DTPA Enhanced Magnetic Resonance Imaging

정경일,김제현,이창호,이영주,김한수,소동문,이영돈,박경주,왕희정,탁승제,이철주,김선용,김옥화,임태환,문창현,최병일,서정호 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1

This study was undertaken to determine the value of gadolinium dimeglumine (Gd-DTPA) enhanced MRI in the diagnosis of acute myocardial infarction. Seven cats were subjected to 2 hours of left anterior descending coronary arteryocclusion (group 1) and 8 cats to 1 hour of occlusion (group 2). Reperfusion was followed by taking Tl-weighted MR images at 5, 15, 30, 45, 60 minutes after Gd-DTPA (0.2 mmol/kg) injection. Myocardial enhancement patterns were categorized into three zones (central ischemic, peripheral ischemic, and normal) or two zones (ischemic and normal) and the presence of injured myocardium in each zone was confirmed by 2,3,5-triphenyltetrazolium chloride (TTC) staining. Signal intensity (SI) of each zone was evaluated relative to back muscle in regard to its chronological changes and difference among the zones. Group 1 displayed three zones of enhancement in 6 cats whereas 1 cat in group 1 and all in group 2 showed two zones of enhancement. Intermediate SI central zone was compatible but smaller than TTC nonstained area, and determined to be a persistently occlusive injury. High SI peripheral zone in group 1 and high SI ischemic zone in group 2 were stained and determined as reperfused injury although reversibility was not definite. The peak SI, occurring 15 minutes after Gd-DTPA injection, of 2.47±0.48 at peripheral zone was greater than that of 1.66±0.36 at central zone in group 1 and of 1.81±0.41 at ischemic zone in group 2 (p < 0.05). SI of injured myocardium increased more rapidly and decreased more gradually than that of normal myocardium. That the features of SI change with time in injured myocardium was compatible with the results of other studies using different contrast agents. Gd-DTPA enhanced MRI differentiated persistently occlusive injury as central intermediate SI, and reperfused injury as homogenous high SI, with the maximal contrast between the two at 15 minutes after contrast injection, thus indicating the value of Gd-DTPA enhanced MRI in the diagnosis of acute myocardial infarction.

A Phase 3 Study of TAF Compared with TDF in Patients with HBeAg-Positive CHB: Week48 Efficacy Results of Korea Patients

( Young-Suk Lim ),( Hyung Joon Kim ),( Ki Tae Yoon ),( Won Young Tak ),( Jae-Seok Hwang ),( Sang Hoon Ahn ),( Kwan Soo Byun ),( Seung Woon Paik ),( Sook-Hyang Jeong ),( Yoon Jun Kim ),( So Young Kwon 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: In this randomized, double-blind study in HBeAg-positive patients, the efficacy of TAF was demonstrated to be non-inferior to that of TDF at Week48 in the proportion with HBV DNA<29 IU/mL with improved bone and renal effects. Here we present the subgroup efficacy analysis of Korean patients in the study. Methods: In this study, patients with HBeAg-positive CHB were randomized 2:1 to TAF 25mg or TDF 30mg, with matching placebo, and treated for 96weeks. The primary efficacy analysis was the percent of patients with HBV DNA<29 IU/mL at Week48. The results of primary efficacy analysis of Korean patients were separately analyzed. Results: 873 patients were randomized and treated, including 173 subjects(20%) in the Korea population (TAF 120 subjects; TDF 53 subjects). Comparison across the 3 subject populations (Korea, nonKorea, and overall) showed that Korea subjects were older, a higher proportion were female and ≥ 50 years of age at baseline, a lower mean baseline HBV DNA level, and similar portion of treatment-experienced subjects. Nearly all were genotype C. Key efficacy end points are summarized in the Table. The percentages of Korean subjects with HBV DNA levels <29 IU/mL at Week48 were higher than the non-Korea population (74% with TAF and 76% with TDF). Smaller percentage of Korean patients treated with TAF achieved normalization of serum ALT values and HBeAg seroconversion rates were similar(TAF 10%; TDF 9%). The rates of treatment discontinuations and serious AEs were low and similar, consistent with overall population. Korea subjects treated with TAF showed smaller declines in hip and spine BMD and smaller changes in CrCl at Week48 compare with TDF arm. No viral resistance was observed. Conclusions: Compared to TDF 300mg, the efficacy of TAF 25mg in patients with HBeAg-positive CHB was non-inferior. Week48 efficacy results of Korean population were consistent with those of the nonKorea and overall populations.

Improved Bone and Renal Safety at 1Year after Switch-ing from TDF to TAF: In Chronic HepatitisB(CHB) Patients from East Asia

( Young-Suk Lim ),( Hyung Joon Kim ),( Ki Tae Yoon ),( Won Young Tak ),( Jae-Seok Hwang ),( Sang Hoon Ahn ),( Kwan Soo Byun ),( Seung Woon Paik ),( Sook-Hyang Jeong ),( Yoon Jun Kim ),( So Young Kwon 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: TAF has shown similar efficacy to TDF with less bone and renal effects in 2 large multinational Phase 3 studies after 96weeks(2 years) of double-blind (DB) treatment. Here we evaluated efficacy and safety, including bone and renal parameters, in the subset of patients from East Asia(EA) who completed 2years of DB treatment with TAF 25mg or TDF 300mg once daily and were switched to open label(OL) TAF 25mg once daily for 1year. Methods: In 2 identically-designed studies, 1298 CHB patients who were HBeAgnegative (Study 108; N=425) or HBeAgpositive(Study 110; N=873) were randomized and treated. At Week96, 540(42%; TAF 360; TDF 180) patients including 240(18%; TAF 156; TDF 84) EA patients, had completed 2years of DB TAF or TDF treatment and been switched to OL TAF. Safety including bone(serial DXA scans of spine and hip) and renal(CrCl by Cockcroft-Gault [eGFR_CG]) parameters, viral suppression and biochemical response were assessed at Year 3. Results: In EA patients on DB TDF switched to OL TAF(TDF^®TAF), eGFRCG improved at Year 3 vs. Year 2 (median [Q1, Q3] change = +3.0 [-3.0, +8.4] ml/min); and was stable in those continuing TAF(TAF^®TAF)(figure). BMD also improved at Year 3 vs. Year 2 in TDF^®TAF patients (mean[SD]% change: spine = +2.2%[3.48]; hiP=+0.7%[2.44]) while BMD changes were stable for TAF^®TAF patients (figure). High rates of virologic control (HBV DNA<29IU/mL) were maintained in those on treatment at Year3 vs Year2(TDF^®TAF 96% and 95% and TAF^®TAF 90% and 93%); ALT normalization (AASLD criteria) increased in TDF^®TAF patients and was similar to TAF^®TAF patients at 1 year following switch(46% vs 42%; M=F). Conclusions: EA patients switched to TAF after 2 years of TDF had improved bone and renal safety; virologic control was maintained and ALT normalization increased. The results in EA patients are comparable to those seen in the overall population.

The Influence of Spondylolisthesis Reduction on the Adjacent Lumbar Segment

Park Tae-Hwan,Choi Yunhee,Kim Tae-Shin,Kim Jun-Hoe,Lee Chang-Hyun,Kim Sum,Kim Young Rak,Ko Yong San,Yuh Woon Tak,Rhee John M.,Kim Kyoung-Tae,Chung Chun Kee,Kim Chi-Heon 대한말초신경학회 2023 The Nerve Vol.9 No.2

Objective: Mild to moderate stenosis at the adjacent level sometimes co-occurs with lumbar spondylolisthesis, but whether to include the adjacent level during surgery for the index level is a matter of debate. Spondylolisthesis causes anterior slipping of the vertebra and reduces the segmental angle at the index level, and the adjacent level may compensate for this change through hyperextension to maintain spinal balance. This study investigated the radiological changes and clinical outcomes of adjacent segment stenosis in patients with lumbar spondylolisthesis. Methods: Forty consecutive patients (12 men and 28 women, age 66.6±10.4 years) underwent single-level oblique lumbar interbody fusion for L4-5 or L5-S1 spondylolisthesis. Lumbar central stenosis at the cranial adjacent segment was present in 16 patients (stenosis group) and absent in 24 patients (no-stenosis group). Clinical and radiological parameters were longitudinally compared between the stenosis and no-stenosis groups. Results: Both groups showed similar and significant clinical improvement. The segmental angle at the index level significantly improved in both groups (p<0.05), but the segmental angle at the cranial adjacent segment significantly decreased only in the stenosis group (p<0.05). The spinal canal area at the adjacent level significantly improved only in the stenosis group (p<0.05). Conclusion: Realigned spondylolisthesis may reduce hyperextension of the adjacent segment. If mild lumbar spinal stenosis is present at an adjacent level to spondylolisthesis, it may not be essential to include it in surgery.

서울 경기 일부지역 고등학생의 목통증호소와 관련요인에 관한 연구

정영훈 ( Young Hoon Chung ),엄태웅 ( Tae Woong Eom ),문태웅 ( Tae Woong Moon ),조태영 ( Tae Young Cho ),이시하 ( Ki Ha Lee ),고영타 ( Young Tak Ko ) 한방재활의학과학회 2007 한방재활의학과학회지 Vol.17 No.4

Objectives :The purpose of this study is to evaluate the status of neck pain and related factors among high school students, and to establish neck pain prevention program based on conclusion made from this study. Methods : The study population consisted of high school students in the vicinity of Seoul and Kyung Ki province. Total number of self-reporting questionnaire provided was 500 but only 493 questionnaires submitted for evaluation. Among those submitted there were 2 questionnaires which were incompleted and not counted in for evaluation. The above data have been collected from June 2007 through August 2007. Total 491 subjects were consisted of male and female students from 4 different high schools. A participant was classified into the pain group or into the no pain group according to the frequency of neck pain. The data were analyzed in frequency, percentile scores, X2-test in SPSS 10.0 for windows. Results : Among 491 subjects, the prevalence rate of the neck pain have showed 61.1%. In relation to general characteristic, sex was insignificant. In relation to school activity and habit, the level of sitting time in a day(p<0.05), PC time in a day(p<0.001) were significant. In relation to health habit, sleep time in a day(p<0.001) was significant. In relation to disturbance of daily life, reading disturbance(p<0.001), leisure activity disturbance(p<0.001) were significant. Conclusions : Based on the above evaluation, it shows that high school students have a relatively high prevalence of neck pain. Therefore, proper neck pain prevention program and early management of the neck pain are well indicated since neck pain could influence student`s school life